{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:01:29Z","timestamp":1794258089815,"version":"4.9.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intensive and Critical Care Nursing"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.iccn.2022.103334","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T01:02:47Z","timestamp":1666832567000},"page":"103334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"special_numbering":"C","title":["Early mobilisation for prevention and treatment of delirium in critically ill patients: Systematic review and meta-analysis"],"prefix":"10.1016","volume":"74","author":[{"given":"Peter","family":"Nydahl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Madlen","family":"Jeitziner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Vater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayantha","family":"Sivarajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Howroyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McWilliams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Osterbrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.iccn.2022.103334_b0005","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.jcrc.2016.09.002","article-title":"Occupational therapy for delirium management in elderly patients without mechanical ventilation in an intensive care unit: a pilot randomized clinical trial","volume":"37","author":"\u00c1lvarez","year":"2017","journal-title":"Journal of critical care"},{"key":"10.1016\/j.iccn.2022.103334_b0010","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.iccn.2011.12.006","article-title":"Mobilisation in critical care: a concept analysis","volume":"28","author":"Amidei","year":"2012","journal-title":"Intensive Crit Care Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0110","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0140-6736(15)60690-0","article-title":"Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial","volume":"386","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.iccn.2022.103334_b0015","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1097\/CCM.0000000000000129","article-title":"Effectiveness and safety of the awakening and breathing coordination, delirium monitoring\/management, and early exercise\/mobility bundle","volume":"42","author":"Balas","year":"2014","journal-title":"Crit Care Med"},{"issue":"Suppl 1","key":"10.1016\/j.iccn.2022.103334_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00101-015-0071-1","article-title":"S2e guideline: positioning and early mobilisation in prophylaxis or therapy of pulmonary disorders : Revision 2015: S2e guideline of the German Society of Anaesthesiology and Intensive Care Medicine (DGAI)","volume":"64","author":"Bein","year":"2015","journal-title":"Anaesthesist"},{"key":"10.1016\/j.iccn.2022.103334_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.iccn.2020.102925","article-title":"Prevalence and management of delirium in intensive care units in the Netherlands: An observational multicentre study","volume":"61","author":"Berger","year":"2020","journal-title":"Intensive Crit Care Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0030","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/thoraxjnl-2020-215093","article-title":"Functional electrical stimulation in-bed cycle ergometry in mechanically ventilated patients: a multicentre randomised controlled trial","volume":"76","author":"Berney","year":"2021","journal-title":"Thorax"},{"key":"10.1016\/j.iccn.2022.103334_b0035","unstructured":"Bernhardt J, Churilov L, Ellery F, Collier J, Chamberlain J, Langhorne P, Lindley RI, Moodie M, Dewey H, Thrift AG, Donnan G & Group AC (2016). Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT). Neurology; 86: 2138-45."},{"key":"10.1016\/j.iccn.2022.103334_b0040","doi-asserted-by":"crossref","unstructured":"Bloomer MJ, Woszczeiko C & Hutchinson AM (2022). Older age, delirium, dementia, frailty, and critical care: Care priorities. Intensive Crit Care Nurs: 103297.","DOI":"10.1016\/j.iccn.2022.103297"},{"key":"10.1016\/j.iccn.2022.103334_b0045","doi-asserted-by":"crossref","first-page":"535","DOI":"10.4037\/ajcc2016209","article-title":"Effect of ABCDE Bundle Implementation on Prevalence of Delirium in Intensive Care Unit Patients","volume":"25","author":"Bounds","year":"2016","journal-title":"Am J Crit Care"},{"key":"10.1016\/j.iccn.2022.103334_b0050","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.hrtlng.2018.04.004","article-title":"Defining new barriers to mobilisation in a highly active intensive care unit \u2013 have we found the ceiling? An observational study","volume":"47","author":"Brock","year":"2018","journal-title":"Heart Lung"},{"key":"10.1016\/j.iccn.2022.103334_b0055","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s00134-013-3136-0","article-title":"Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial","volume":"40","author":"Brummel","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0060","series-title":"The Effect of the ABCDEF Bundle on Incidence of Delirium in Critically Ill Patients","author":"Chai","year":"2017"},{"key":"10.1016\/j.iccn.2022.103334_b0065","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40560-018-0355-z","article-title":"Early mobilisation in mechanically ventilated patients: a systematic integrative review of definitions and activities","volume":"7","author":"Clarissa","year":"2019","journal-title":"J Intensive Care"},{"key":"10.1016\/j.iccn.2022.103334_b0070","doi-asserted-by":"crossref","DOI":"10.1007\/s00134-018-5204-y","article-title":"Prevalence and risk factors related to haloperidol use for delirium in adult intensive care patients: the multinational AID-ICU inception cohort study","author":"Collet","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0075","first-page":"594","article-title":"Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up","volume":"72","author":"Denehy","year":"2017","journal-title":"Thorax BMJ"},{"key":"10.1016\/j.iccn.2022.103334_b0080","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1097\/CCM.0000000000003299","article-title":"Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation\/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU","volume":"46","author":"Devlin","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0085","unstructured":"DGAI (2021). Analgesie, Sedierung und Delirmanagement in der Intensivmedizin (DAS-Leitlinie). https:\/\/www.awmf.org\/leitlinien\/detail\/ll\/001-012.html, 19.Oct.2021."},{"key":"10.1016\/j.iccn.2022.103334_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0262779","article-title":"Cardiorespiratory response to early rehabilitation in critically ill adults: A secondary analysis of a randomised controlled trial","volume":"17","author":"Eggmann","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.iccn.2022.103334_b0095","doi-asserted-by":"crossref","DOI":"10.1111\/nicc.12740","article-title":"The impact of ABCDE bundle implementation on patient outcomes: A nationwide cohort study","author":"Frade-Mera","year":"2022","journal-title":"Nurs Crit Care."},{"key":"10.1016\/j.iccn.2022.103334_b0100","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1056\/NEJMoa1808217","article-title":"Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness","volume":"379","author":"Girard","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.iccn.2022.103334_b0105","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S2213-2600(18)30062-6","article-title":"Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study","volume":"6","author":"Girard","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.iccn.2022.103334_b0115","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1503\/cmaj.1031920","article-title":"Tips for learners of evidence-based medicine: 4. Assessing heterogeneity of primary studies in systematic reviews and whether to combine their results","volume":"172","author":"Hatala","year":"2005","journal-title":"Cmaj"},{"key":"10.1016\/j.iccn.2022.103334_b0120","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s00134-014-3218-7","article-title":"Energy expenditure in the critically ill performing early physical therapy","volume":"40","author":"Hickmann","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0125","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ & (editors) WV (2022). Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane, 2022."},{"key":"10.1016\/j.iccn.2022.103334_b0130","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1186\/s13054-014-0658-y","article-title":"Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults","volume":"18","author":"Hodgson","year":"2014","journal-title":"Crit Care"},{"key":"10.1016\/j.iccn.2022.103334_b0135","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1097\/CCM.0000000000001643","article-title":"A Binational Multicenter Pilot Feasibility Randomized Controlled Trial of Early Goal-Directed Mobilization in the ICU","volume":"44","author":"Hodgson","year":"2016","journal-title":"Crit Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0140","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/nicc.12629","article-title":"Delirium in adult and paediatric ICU patients: what is the way forward?","volume":"26","author":"Ista","year":"2021","journal-title":"Nurs Crit Care"},{"key":"10.1016\/j.iccn.2022.103334_b0145","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.gerinurse.2015.12.003","article-title":"The effect of range of motion exercises on delirium prevention among patients aged 65 and over in intensive care units","volume":"37","author":"Karadas","year":"2016","journal-title":"Geriatr Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10122607","article-title":"Risk Factors of Patient-Related Safety Events during Active Mobilization for Intubated Patients in Intensive Care Units-A Multi-Center Retrospective Observational Study","volume":"10","author":"Katsukawa","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.iccn.2022.103334_b0155","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00134-015-3763-8","article-title":"Early physical rehabilitation in intensive care patients with sepsis syndromes: a pilot randomised controlled trial","volume":"41","author":"Kayambu","year":"2015","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0160","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jcrc.2020.01.017","article-title":"Risk factors and outcomes among delirium subtypes in adult ICUs: A systematic review","volume":"56","author":"Krewulak","year":"2020","journal-title":"J Crit Care"},{"key":"10.1016\/j.iccn.2022.103334_b0165","doi-asserted-by":"crossref","first-page":"3692","DOI":"10.1111\/jan.14865","article-title":"Patients' experiences of delirium: A systematic review and meta-summary of qualitative research","volume":"77","author":"Kuusisto-Gussmann","year":"2021","journal-title":"J Adv Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0170","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/jan.14267","article-title":"Effects of the ABCDE bundle on the prevention of post-intensive care syndrome: A retrospective study","volume":"76","author":"Lee","year":"2020","journal-title":"J Adv Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0175","doi-asserted-by":"crossref","unstructured":"Lindroth H, Khan BA, Carpenter JS, Gao S, Perkins AJ, Khan SH, Wang S, Jones RN & Boustani MA (2020). Delirium Severity Trajectories and Outcomes in ICU Patients: Defining a Dynamic Symptom Phenotype. Ann Am Thorac Soc.","DOI":"10.1513\/AnnalsATS.201910-764OC"},{"key":"10.1016\/j.iccn.2022.103334_b0180","article-title":"Implementation of the ABCDEF Bundle for Critically Ill ICU Patients During the COVID-19 Pandemic: A Multi-National 1-Day Point Prevalence Study","volume":"8","author":"Liu","year":"2021","journal-title":"Frontiers in Medicine"},{"key":"10.1016\/j.iccn.2022.103334_b0185","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4037\/ccn2017531","article-title":"Implementing a Multicomponent Intervention to Prevent Delirium Among Critically Ill Patients","volume":"37","author":"Mart\u00ednez","year":"2017","journal-title":"Critical Care Nurse"},{"key":"10.1016\/j.iccn.2022.103334_b0190","first-page":"20200027","article-title":"Impact of a Rehabilitation Protocol and a Dedicated Therapist in the Intensive Care Unit on Physical Function and Activities of Daily Living","volume":"5","author":"Matsuki","year":"2020","journal-title":"Prog Rehabil Med"},{"key":"10.1016\/j.iccn.2022.103334_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.iccn.2022.103221","article-title":"Do we care? Physically restrained patients in the intensive care unit","volume":"70","author":"Mattiussi","year":"2022","journal-title":"Intensive Crit Care Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0200","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jcrc.2014.09.018","article-title":"Enhancing rehabilitation of mechanically ventilated patients in the intensive care unit: a quality improvement project","volume":"30","author":"McWilliams","year":"2015","journal-title":"J Crit Care"},{"key":"10.1016\/j.iccn.2022.103334_b0205","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s13063-015-0709-y","article-title":"Criteria for Reporting the Development and Evaluation of Complex Interventions in healthcare: revised guideline (CReDECI 2)","volume":"16","author":"M\u00f6hler","year":"2015","journal-title":"Trials"},{"key":"10.1016\/j.iccn.2022.103334_b0210","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.ijnurstu.2015.04.021","article-title":"The effects of a tailored intensive care unit delirium prevention protocol: A randomized controlled trial","volume":"52","author":"Moon","year":"2015","journal-title":"Int J Nurs Stud"},{"key":"10.1016\/j.iccn.2022.103334_b0215","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.h1258","article-title":"Process evaluation of complex interventions: Medical Research Council guidance","volume":"350","author":"Moore","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.iccn.2022.103334_b0220","doi-asserted-by":"crossref","unstructured":"Morris PE, Berry MJ, Files DC, Thompson JC, Hauser J, Flores L, Dhar S, Chmelo E, Lovato J, Case LD, Bakhru RN, Sarwal A, Parry SM, Campbell P, Mote A, Winkelman C, Hite RD, Nicklas B, Chatterjee A & Young MP (2016). Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial.","DOI":"10.1001\/jama.2016.7201"},{"key":"10.1016\/j.iccn.2022.103334_b0225","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1001\/jama.2014.5559","article-title":"How to read a systematic review and meta-analysis and apply the results to patient care: users' guides to the medical literature","volume":"312","author":"Murad","year":"2014","journal-title":"Jama"},{"key":"10.1016\/j.iccn.2022.103334_b0230","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.apmr.2010.01.002","article-title":"Early physical medicine and rehabilitation for patients with acute respiratory failure: a quality improvement project","volume":"91","author":"Needham","year":"2010","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.iccn.2022.103334_b0235","series-title":"Volume 2022. National Insitute for Health and Care Excellence","article-title":"Delirium: prevention, diagnosis and management (CG 103)","author":"NICE","year":"2021"},{"key":"10.1016\/j.iccn.2022.103334_b0240","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/nicc.12299","article-title":"Survey among critical care nurses and physicians about delirium management","volume":"23","author":"Nydahl","year":"2018","journal-title":"Nurs Crit Care"},{"key":"10.1016\/j.iccn.2022.103334_b0245","doi-asserted-by":"crossref","unstructured":"Nydahl P, G\u00fcnther U, Hansen HC, Meyne J, Osterbrink J & Margraf NG (2021). Fallstricke in der Diagnostik des Delirs. Med Klin Intensivmed Notfmed.","DOI":"10.1007\/s00063-021-00846-9"},{"key":"10.1016\/j.iccn.2022.103334_b0250","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1513\/AnnalsATS.201611-843SR","article-title":"Safety of Patient Mobilization and Rehabilitation in the Intensive Care Unit. Systematic Review with Meta-Analysis","volume":"14","author":"Nydahl","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.iccn.2022.103334_b0255","article-title":"PROtocol-based MObilizaTION on Intensive Care Units: stepped-wedge, cluster-randomized pilot study (Pro-Motion)","author":"Nydahl","year":"2019","journal-title":"Nurs Crit Care"},{"key":"10.1016\/j.iccn.2022.103334_b0260","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/nicc.12438","article-title":"PROtocol-based MObilizaTION on intensive care units: stepped-wedge, cluster-randomized pilot study (Pro-Motion)","volume":"25","author":"Nydahl","year":"2020","journal-title":"Nurs Crit Care"},{"key":"10.1016\/j.iccn.2022.103334_b0265","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/nicc.12638","article-title":"Mobilization in the evening to prevent delirium: A pilot randomized trial","volume":"27","author":"Nydahl","year":"2022","journal-title":"Nurs Crit Care"},{"key":"10.1016\/j.iccn.2022.103334_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.iccn.2021.103159","article-title":"Nurse staffing levels are not associated with appearance, duration or solution of delirium in stroke patients","volume":"68","author":"Nydahl","year":"2022","journal-title":"Intensive Crit Care Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0275","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1136\/bmjqs-2015-004411","article-title":"SQUIRE 2.0 (Standards for QUality Improvement Reporting Excellence): revised publication guidelines from a detailed consensus process","volume":"25","author":"Ogrinc","year":"2016","journal-title":"BMJ Qual Saf"},{"key":"10.1016\/j.iccn.2022.103334_b0280","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1001\/jama.2017.12067","article-title":"Delirium in Older Persons: Advances in Diagnosis and Treatment","volume":"318","author":"Oh","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.iccn.2022.103334_b0285","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"Bmj"},{"key":"10.1016\/j.iccn.2022.103334_b0290","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1177\/1745691616646366","article-title":"What Should Researchers Expect When They Replicate Studies? A Statistical View of Replicability in Psychological Science","volume":"11","author":"Patil","year":"2016","journal-title":"Perspect Psychol Sci"},{"key":"10.1016\/j.iccn.2022.103334_b0295","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/01.NAJ.0000450430.97383.64","article-title":"JBI's Systematic Reviews: Study selection and critical appraisal","volume":"114","author":"Porritt","year":"2014","journal-title":"Am J Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0300","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/CCM.0000000000003482","article-title":"Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults","volume":"47","author":"Pun","year":"2019","journal-title":"Crit Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0305","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.202101-0082OC","article-title":"The Impact of Nursing Delirium Preventive Interventions in the Intensive Care Unit: A Multicenter Cluster Randomized Controlled Trial","author":"Rood","year":"2021","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1016\/j.iccn.2022.103334_b0310","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1097\/CCM.0000000000005028","article-title":"A Core Outcome Set for Research Evaluating Interventions to Prevent and\/or Treat Delirium in Critically Ill Adults: An International Consensus Study (Del-COrS)","volume":"49","author":"Rose","year":"2021","journal-title":"Crit Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0315","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(16)31637-3","article-title":"Early, goal-directed mobilisation in the surgical intensive care unit: a randomised controlled trial","volume":"388","author":"Schaller","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.iccn.2022.103334_b0320","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/S0140-6736(09)60658-9","article-title":"Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial","volume":"373","author":"Schweickert","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.iccn.2022.103334_b0325","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1161\/STROKEAHA.119.025015","article-title":"Occurrence Rate of Delirium in Acute Stroke Settings: Systematic Review and Meta-Analysis","volume":"50","author":"Shaw","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.iccn.2022.103334_b0330","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/0885066617728486","article-title":"Mobilization of Mechanically Ventilated Patients in Switzerland","volume":"35","author":"Sibilla","year":"2020","journal-title":"J Intensive Care Med."},{"key":"10.1016\/j.iccn.2022.103334_b0335","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s00134-017-4791-3","article-title":"Critical illness: the brain is always in the line of fire","volume":"43","author":"Smith","year":"2017","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0340","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"343","author":"Sterne","year":"2011","journal-title":"Bmj"},{"key":"10.1016\/j.iccn.2022.103334_b0345","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00134-021-06503-1","article-title":"Delirium in critical illness: clinical manifestations, outcomes, and management","volume":"47","author":"Stollings","year":"2021","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.iccn.2022.103334_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.iccn.2021.103029","article-title":"Delirium in ICU patients with COVID-19. Any difference?","volume":"64","author":"van den Boogaard","year":"2021","journal-title":"Intensive Crit Care Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijnurstu.2020.103708","article-title":"Effects of early mobilization on the prognosis of critically ill patients: A systematic review and meta-analysis","volume":"110","author":"Wang","year":"2020","journal-title":"Int J Nurs Stud"},{"key":"10.1016\/j.iccn.2022.103334_b0360","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41572-020-00223-4","volume":"6","author":"Wilson","year":"2020","journal-title":"Delirium. Nature Reviews Disease Primers"},{"key":"10.1016\/j.iccn.2022.103334_b0365","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.iccn.2012.02.007","article-title":"Examining the positive effects of exercise in intubated adults in ICU: a prospective repeated measures clinical study","volume":"28","author":"Winkelman","year":"2012","journal-title":"Intensive Crit Care Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0370","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1177\/1099800418780492","article-title":"Dose of Early Therapeutic Mobility: Does Frequency or Intensity Matter?","volume":"20","author":"Winkelman","year":"2018","journal-title":"Biol Res Nurs"},{"key":"10.1016\/j.iccn.2022.103334_b0375","first-page":"1353","article-title":"Effect of early off-bed mobility on delirium in mechanical ventilated patients in intensive care unit: a prospective randomized controlled study","volume":"33","author":"Wu","year":"2021","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"}],"container-title":["Intensive and Critical Care Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0964339722001379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0964339722001379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T14:31:27Z","timestamp":1760797887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0964339722001379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":75,"alternative-id":["S0964339722001379"],"URL":"https:\/\/doi.org\/10.1016\/j.iccn.2022.103334","relation":{},"ISSN":["0964-3397"],"issn-type":[{"value":"0964-3397","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early mobilisation for prevention and treatment of delirium in critically ill patients: Systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Intensive and Critical Care Nursing","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iccn.2022.103334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103334"}}