{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:31:21Z","timestamp":1793392281695,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Intensive and Critical Care Nursing"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.iccn.2026.104479","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:42:31Z","timestamp":1787802151000},"page":"104479","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Management of liquid pharmaceutical residues in the intensive care unit: an ancillary analysis of the multicenter observational GAME-OVER study"],"prefix":"10.1016","volume":"98","author":[{"given":"Erwan","family":"d'Aranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Julien","family":"Cungi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Le Marec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Giannoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludivine","family":"Marecal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Mayeur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Mitri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Cesana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Chelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.iccn.2026.104479_bb0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.mib.2021.10.005","article-title":"Role of pollution on the selection of antibiotic resistance and bacterial pathogens in the environment","volume":"64","author":"Buelow","year":"2021","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.iccn.2026.104479_bb0010","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.scitotenv.2018.04.351","article-title":"Occurrence and ecotoxicological assessment of pharmaceuticals: is there a risk for the Mediterranean aquatic environment?","volume":"639","author":"Desbiolles","year":"2018","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.iccn.2026.104479_bb0015","series-title":"Pharmaceutical residues in freshwater. OECD Studies on Water","author":"The Organisation for Economic Cooperation and Development","year":"2019"},{"key":"10.1016\/j.iccn.2026.104479_bb0020","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/S2542-5196(22)00254-6","article-title":"Antibiotic concentrations and antibiotic resistance in aquatic environments of the WHO Western Pacific and South-East Asia regions: a systematic review and probabilistic environmental hazard assessment","volume":"7","author":"Hanna","year":"2023","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.iccn.2026.104479_bb0025","author":"Protecting the environment and oceans with the Green Deal - European Commission"},{"key":"10.1016\/j.iccn.2026.104479_bb0030","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0378-4274(02)00041-3","article-title":"Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data","volume":"131","author":"Heberer","year":"2002","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.iccn.2026.104479_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2023.139647","article-title":"Pharmaceutical residues in the ecosystem: antibiotic resistance, health impacts, and removal techniques","volume":"339","author":"Husain Khan","year":"2023","journal-title":"Chemosphere"},{"key":"10.1016\/j.iccn.2026.104479_bb0040","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.chemosphere.2014.01.016","article-title":"Pharmaceuticals in hospital wastewater: their ecotoxicity and contribution to the environmental hazard of the effluent","volume":"115","author":"Fr\u00e9d\u00e9ric","year":"2014","journal-title":"Chemosphere"},{"key":"10.1016\/j.iccn.2026.104479_bb0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10916-020-01634-2","article-title":"Water pollution and environmental concerns in Anesthesiology","volume":"44","author":"Kostrubiak","year":"2020","journal-title":"J Med Syst"},{"key":"10.1016\/j.iccn.2026.104479_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2022.114609","article-title":"An assessment of hospital wastewater and biomedical waste generation, existing legislations, risk assessment, treatment processes, and scenario during COVID-19","volume":"308","author":"Parida","year":"2022","journal-title":"J Environ Manag"},{"key":"10.1016\/j.iccn.2026.104479_bb0055","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/S0043-1354(97)00121-8","article-title":"Biodegradability of the anti-tumour agent ifosfamide and its occurrence in hospital effluents and communal sewage","volume":"31","author":"K\u00fcmmerer","year":"1997","journal-title":"Water Res"},{"key":"10.1016\/j.iccn.2026.104479_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.155388","article-title":"Holistic approach to chemical and microbiological quality of aquatic ecosystems impacted by wastewater effluent discharges","volume":"835","author":"Sanseverino","year":"2022","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.iccn.2026.104479_bb0065","doi-asserted-by":"crossref","first-page":"9207","DOI":"10.1007\/s11356-017-9662-5","article-title":"Two-year survey of specific hospital wastewater treatment and its impact on pharmaceutical discharges","volume":"25","author":"Wiest","year":"2018","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.iccn.2026.104479_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0306933","article-title":"Anesthetics drug wastage and preventive strategies: systematic review","volume":"19","author":"Habte","year":"2024","journal-title":"PLoS ONE"},{"key":"10.1016\/j.iccn.2026.104479_bb0075","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s00134-023-07317-z","article-title":"Five sustainable tips about water in the ICU: reduction of water use and decrease of the amount of antibiotics in wastewater","volume":"50","author":"Hunfeld","year":"2024","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.iccn.2026.104479_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114219","article-title":"Pharmaceutical residues: one of the significant problems in achieving \u2018clean water for all\u2019 and its solution","volume":"215","author":"Sharma","year":"2022","journal-title":"Environ Res"},{"key":"10.1016\/j.iccn.2026.104479_bb0085","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13054-025-05299-6","article-title":"Discarded intravenous medication in the ICU: the GAME-OVER multicenter prospective observational study","volume":"29","author":"d\u2019Aranda","year":"2025","journal-title":"Crit Care"},{"key":"10.1016\/j.iccn.2026.104479_bb0090","author":"L\u00e9gifrance D\u00e9chets d'activit\u00e9s de soins \u00e0 risques infectieux et assimil\u00e9s"},{"key":"10.1016\/j.iccn.2026.104479_bb0095","author":"Minist\u00e8re de la Sant\u00e9 et de la Pr\u00e9vention"},{"key":"10.1016\/j.iccn.2026.104479_bb0100","author":"Institut National de Recherche et de S\u00e9curit\u00e9"},{"key":"10.1016\/j.iccn.2026.104479_bb0105","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ijheh.2019.01.004","article-title":"The impact of on-site hospital wastewater treatment on the downstream communal wastewater system in terms of antibiotics and antibiotic resistance genes","volume":"222","author":"Paulus","year":"2019","journal-title":"Int J Hyg Environ Health"},{"key":"10.1016\/j.iccn.2026.104479_bb0110","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s40264-024-01497-3","article-title":"Call to action: pharmaceutical residues in the environment: threats to ecosystems and human health","volume":"48","author":"Lunghi","year":"2025","journal-title":"Drug Saf"},{"key":"10.1016\/j.iccn.2026.104479_bb0115","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1213\/ANE.0b013e31824ea491","article-title":"Propofol wastage in Anesthesia","volume":"114","author":"Mankes","year":"2012","journal-title":"Anesth Analg"},{"key":"10.1016\/j.iccn.2026.104479_bb0120","author":"Direction g\u00e9n\u00e9rale de la sant\u00e9"},{"key":"10.1016\/j.iccn.2026.104479_bb0125","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1007\/s00134-023-07091-y","article-title":"Transforming waste management in intensive care units: a path towards environmental sustainability and resource optimization","volume":"49","author":"Martin","year":"2023","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.iccn.2026.104479_bb0130","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13054-024-04937-9","article-title":"Past, present, and future of sustainable intensive care: narrative review and a large hospital system experience","volume":"28","author":"Masud","year":"2024","journal-title":"Crit Care"},{"key":"10.1016\/j.iccn.2026.104479_bb0135","first-page":"78","article-title":"How much do we throw away in the intensive care unit? An observational point prevalence study of Australian and New Zealand ICUs","volume":"25","author":"Anstey","year":"2023","journal-title":"Crit Care Resusc"},{"key":"10.1016\/j.iccn.2026.104479_bb0140","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1007\/s00134-023-07015-w","article-title":"Create intensive care green teams, there is no time to waste","volume":"49","author":"Trent","year":"2023","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.iccn.2026.104479_bb0145","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.resconrec.2017.08.027","article-title":"The circular economy: new or refurbished as CE 3.0? \u2014 exploring controversies in the conceptualization of the circular economy through a focus on history and resource value retention options","volume":"135","author":"Reike","year":"2018","journal-title":"Resour Conserv Recycl"},{"key":"10.1016\/j.iccn.2026.104479_bb0150","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1007\/s00228-020-02885-1","article-title":"Pharmaceuticals and environment: a web-based decision support for considering environmental aspects of medicines in use","volume":"76","author":"Ramstr\u00f6m","year":"2020","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.iccn.2026.104479_bb0155","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/CCM.0000000000006944","article-title":"Sustainable intensive care: do not forget IV to Oral switch!","volume":"54","author":"d\u2019Aranda","year":"2026","journal-title":"Crit Care Med"},{"key":"10.1016\/j.iccn.2026.104479_bb0160","article-title":"Sustainability in critical care units: an opinion paper from the SFAR (French society of anaesthesia and critical care) sustainability and critical care committees","volume":"44","author":"Pons","year":"2025","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.iccn.2026.104479_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.iccn.2023.103403","article-title":"Antimicrobial residual drug error in the intensive care unit; a single blinded prospective observational study","volume":"77","author":"Jarrett","year":"2023","journal-title":"Intensive Crit Care Nurs"}],"container-title":["Intensive and Critical Care Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0964339726001473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0964339726001473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T19:34:47Z","timestamp":1793388887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0964339726001473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":33,"alternative-id":["S0964339726001473"],"URL":"https:\/\/doi.org\/10.1016\/j.iccn.2026.104479","relation":{},"ISSN":["0964-3397"],"issn-type":[{"value":"0964-3397","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of liquid pharmaceutical residues in the intensive care unit: an ancillary analysis of the multicenter observational GAME-OVER study","name":"articletitle","label":"Article Title"},{"value":"Intensive and Critical Care Nursing","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.iccn.2026.104479","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104479"}}