{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:37:21Z","timestamp":1792654641521,"version":"4.5.0"},"reference-count":173,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Infectious Disease Clinics of North America"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.idc.2007.12.013","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T12:33:13Z","timestamp":1209558793000},"page":"217-234","source":"Crossref","is-referenced-by-count":171,"title":["Biology of Infection with Borrelia burgdorferi"],"prefix":"10.1016","volume":"22","author":[{"given":"Kit","family":"Tilly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.idc.2007.12.013_bib1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1126\/science.7043737","article-title":"Lyme disease\u2014a tick-borne spirochetosis?","volume":"216","author":"Burgdorfer","year":"1982","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM200107123450207","article-title":"Lyme disease","volume":"345","author":"Steere","year":"2001","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib3","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S1369-5274(00)00202-2","article-title":"Host-pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes","volume":"4","author":"Wooten","year":"2001","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib4","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/37551","article-title":"Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi","volume":"390","author":"Fraser","year":"1997","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib5","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1046\/j.1365-2958.2000.01698.x","article-title":"A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi","volume":"35","author":"Casjens","year":"2000","journal-title":"Mol Microbiol"},{"issue":"23","key":"10.1016\/j.idc.2007.12.013_bib6","first-page":"573","article-title":"Lyme disease\u2014United States, 2003\u20132005","volume":"56","author":"Centers for Disease Control and Prevention","year":"2007","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.idc.2007.12.013_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.1780200102","article-title":"Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three Connecticut communities","volume":"20","author":"Steere","year":"1977","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.idc.2007.12.013_bib8","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1099\/00207713-34-4-496","article-title":"Borrelia burgdorferi sp. nov.: etiologic agent of Lyme disease","volume":"34","author":"Johnson","year":"1984","journal-title":"Int J Syst Bacteriol"},{"key":"10.1016\/j.idc.2007.12.013_bib9","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1099\/00207713-42-3-378","article-title":"Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov., and group VS461 associated with Lyme borreliosis","volume":"42","author":"Baranton","year":"1992","journal-title":"Int J\u00a0Syst Bacteriol"},{"key":"10.1016\/j.idc.2007.12.013_bib10","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/clinids\/17.4.708","article-title":"Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis","volume":"17","author":"van Dam","year":"1993","journal-title":"Clin Infect Dis"},{"issue":"5375","key":"10.1016\/j.idc.2007.12.013_bib11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1126\/science.281.5375.375","article-title":"Complete genome sequence of Treponema pallidum, the syphilis spirochete","volume":"281","author":"Fraser","year":"1998","journal-title":"Science"},{"issue":"20","key":"10.1016\/j.idc.2007.12.013_bib12","doi-asserted-by":"crossref","first-page":"6038","DOI":"10.1093\/nar\/gkh953","article-title":"Comparative analysis of the Borrelia garinii genome","volume":"32","author":"Gl\u00f6ckner","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.idc.2007.12.013_bib13","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/1471-2164-7-211","article-title":"Comparative genome analysis: selection pressure on the Borrelia vls cassettes is essential for infectivity","volume":"7","author":"Gl\u00f6ckner","year":"2006","journal-title":"BMC Genomics"},{"key":"10.1016\/j.idc.2007.12.013_bib14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.3603026","article-title":"Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends","volume":"237","author":"Barbour","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.idc.2007.12.013_bib15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0923-2508(89)90083-1","article-title":"Linear chromosome of Borrelia burgdorferi","volume":"140","author":"Baril","year":"1989","journal-title":"Res Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib16","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1073\/pnas.86.15.5969","article-title":"Megabase-sized linear DNA in the bacterium Borrelia burgdorferi, the Lyme disease agent","volume":"86","author":"Ferdows","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.idc.2007.12.013_bib17","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1128\/JCM.26.10.2203-2205.1988","article-title":"Characterization of a circular plasmid from Borrelia burgdorferi, etiologic agent of Lyme disease","volume":"26","author":"Hyde","year":"1988","journal-title":"J Clin Microbiol"},{"issue":"9","key":"10.1016\/j.idc.2007.12.013_bib18","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1128\/JB.182.9.2476-2480.2000","article-title":"Distribution of twelve linear extrachromosomal DNAs in natural isolates of Lyme disease spirochetes","volume":"182","author":"Palmer","year":"2000","journal-title":"J Bacteriol"},{"issue":"17","key":"10.1016\/j.idc.2007.12.013_bib19","doi-asserted-by":"crossref","first-page":"6124","DOI":"10.1128\/JB.00459-06","article-title":"Comparative genome hybridization reveals substantial variation among clinical isolates of Borrelia burgdorferi sensu stricto with different pathogenic properties","volume":"188","author":"Terekhova","year":"2006","journal-title":"J Bacteriol"},{"key":"10.1016\/j.idc.2007.12.013_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF00195949","article-title":"Genetic heterogeneity of the genes coding for the outer surface protein C (OspC) and the flagellin of Borrelia burgdorferi","volume":"182","author":"Jauris-Heipke","year":"1993","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.idc.2007.12.013_bib21","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2958.1995.mmi_18020257.x","article-title":"Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia","volume":"18","author":"Livey","year":"1995","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0092-8674(00)80206-8","article-title":"Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes","volume":"89","author":"Zhang","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.idc.2007.12.013_bib23","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1128\/IAI.61.5.2182-2191.1993","article-title":"Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi","volume":"61","author":"Wilske","year":"1993","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/BF01713341","article-title":"Immunological and molecular variability of OspA and OspC. Implications for Borrelia vaccine development","volume":"24","author":"Wilske","year":"1996","journal-title":"Infection"},{"issue":"5510","key":"10.1016\/j.idc.2007.12.013_bib25","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/255656a0","article-title":"Enhanced translational motion of Leptospira in viscous environments","volume":"255","author":"Kaiser","year":"1975","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib26","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1128\/JB.132.1.356-358.1977","article-title":"Motility of flagellated bacteria in viscous environments","volume":"132","author":"Greenberg","year":"1977","journal-title":"J\u00a0Bacteriol"},{"issue":"5702","key":"10.1016\/j.idc.2007.12.013_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/278349a0","article-title":"Movement of microorganisms in viscous environments","volume":"278","author":"Berg","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.idc.2007.12.013_bib28","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/infdis\/162.5.1205","article-title":"Motility of Lyme disease spirochetes in fluids as viscous as the extracellular matrix","volume":"162","author":"Kimsey","year":"1990","journal-title":"J Infect Dis"},{"key":"10.1016\/j.idc.2007.12.013_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrmicro1086","article-title":"The burgeoning molecular genetics of the Lyme disease spirochaete","volume":"3","author":"Rosa","year":"2005","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.gene.2005.05.013","article-title":"Genetic and physiological characterization of 23S rRNA and ftsJ mutants of Borrelia burgdorferi isolated by mariner transposition","volume":"357","author":"Morozova","year":"2005","journal-title":"Gene"},{"issue":"10","key":"10.1016\/j.idc.2007.12.013_bib31","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1128\/AEM.70.10.5973-5979.2004","article-title":"Genome-wide transposon mutagenesis of Borrelia burgdorferi for identification of phenotypic mutants","volume":"70","author":"Stewart","year":"2004","journal-title":"Appl Environ Microbiol"},{"issue":"12","key":"10.1016\/j.idc.2007.12.013_bib32","doi-asserted-by":"crossref","first-page":"6690","DOI":"10.1128\/IAI.00993-06","article-title":"Identification of potential virulence determinants by HimarI transposition of infectious Borrelia burgdorferi B31","volume":"74","author":"Botkin","year":"2006","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib33","first-page":"627","article-title":"Avian and mammalian hosts for spirochete-infected ticks and insects in a Lyme disease focus in Connecticut","volume":"57","author":"Anderson","year":"1984","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.idc.2007.12.013_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4269\/ajtmh.1985.34.355","article-title":"Mice as reservoirs of the Lyme disease spirochete","volume":"34","author":"Levine","year":"1985","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib35","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1128\/IAI.51.2.394-396.1986","article-title":"Involvement of birds in the epidemiology of the Lyme disease agent Borrelia burgdorferi","volume":"51","author":"Anderson","year":"1986","journal-title":"Infect Immun"},{"key":"10.1016\/j.idc.2007.12.013_bib36","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4269\/ajtmh.1987.36.92","article-title":"Reservoir competence of white-footed mice for Lyme disease spirochetes","volume":"36","author":"Donahue","year":"1987","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.idc.2007.12.013_bib37","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1126\/science.1604318","article-title":"Lyme disease in California: a novel enzootic transmission cycle of Borrelia burgdorferi","volume":"256","author":"Brown","year":"1992","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.4269\/ajtmh.1996.54.92","article-title":"Reservoir competence of the southeastern five-lined skink (Eumeces inexpectatus) and the green anole (Anolis carolinensis) for Borrelia burgdorferi","volume":"54","author":"Levin","year":"1996","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib39","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1128\/AEM.71.5.2616-2625.2005","article-title":"Molecular identification and analysis of Borrelia burgdorferi sensu lato in lizards in the southeastern United States","volume":"71","author":"Clark","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib40","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1146\/annurev.en.36.010191.003103","article-title":"Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and Europe","volume":"36","author":"Lane","year":"1991","journal-title":"Annu Rev Entomol"},{"key":"10.1016\/j.idc.2007.12.013_bib41","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4269\/ajtmh.1985.34.925","article-title":"The western black-legged tick, Ixodes pacificus, a vector of Borrelia burgdorferi","volume":"34","author":"Burgdorfer","year":"1985","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.idc.2007.12.013_bib42","series-title":"Lyme borreliosis: biology, epidemiology and control","first-page":"149","article-title":"Ecology of Borrelia burgdorferi sensu lato in Europe","author":"Gern","year":"2002"},{"key":"10.1016\/j.idc.2007.12.013_bib43","series-title":"Lyme borreliosis: biology, epidemiology and control","first-page":"175","article-title":"Ecology of Borrelia burgdorferi sensu lato in Russia","author":"Korenberg","year":"2002"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib44","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/oxfordjournals.aje.a115306","article-title":"Comparing the relative potential of rodents as reservoirs of the Lyme disease spirochete (Borrelia burgdorferi)","volume":"130","author":"Mather","year":"1989","journal-title":"Am J Epidemiol"},{"issue":"Suppl 6","key":"10.1016\/j.idc.2007.12.013_bib45","doi-asserted-by":"crossref","first-page":"S1442","DOI":"10.1093\/clinids\/11.Supplement_6.S1442","article-title":"Pathophysiology of the Lyme disease spirochete, Borrelia burgdorferi, in ixodid ticks","volume":"11","author":"Burgdorfer","year":"1989","journal-title":"Rev Infect Dis"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib46","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/jmedent\/34.1.52","article-title":"Absence of Lyme disease spirochetes in larval progeny of naturally infected Ixodes scapularis (Acari: Ixodidae) fed on dogs","volume":"34","author":"Patrican","year":"1997","journal-title":"J Med Entomol"},{"key":"10.1016\/j.idc.2007.12.013_bib47","first-page":"161","article-title":"Bloodsucking ticks (Ixodoidea)\u2014vectors of diseases of man and animals","volume":"8","author":"Balashov","year":"1972","journal-title":"Miscellaneous Publications of the Entomological Society of America"},{"key":"10.1016\/j.idc.2007.12.013_bib48","doi-asserted-by":"crossref","first-page":"532","DOI":"10.2307\/3282168","article-title":"The midgut hemolysin of Ixodes dammini (Acari: Ixodidae)","volume":"74","author":"Ribeiro","year":"1988","journal-title":"J Parasitol"},{"key":"10.1016\/j.idc.2007.12.013_bib49","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1073\/pnas.92.7.2909","article-title":"Induction of an outer surface protein on Borrelia burgdorferi during tick feeding","volume":"92","author":"Schwan","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.idc.2007.12.013_bib50","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1128\/IAI.67.7.3181-3187.1999","article-title":"Effects of environmental pH on membrane proteins in Borrelia burgdorferi","volume":"67","author":"Carroll","year":"1999","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib51","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/JCM.38.1.382-388.2000","article-title":"Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice","volume":"39","author":"Schwan","year":"2000","journal-title":"J Clin Microbiol"},{"issue":"12","key":"10.1016\/j.idc.2007.12.013_bib52","doi-asserted-by":"crossref","first-page":"6677","DOI":"10.1128\/IAI.68.12.6677-6684.2000","article-title":"Identification of 11 pH-regulated genes in Borrelia burgdorferi localizing to linear plasmids","volume":"68","author":"Carroll","year":"2000","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib53","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1046\/j.1365-2958.2000.02104.x","article-title":"Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi","volume":"37","author":"Yang","year":"2000","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib54","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0966-842X(94)90800-1","article-title":"Animal models of Lyme disease: pathogenesis and immunoprophylaxis","volume":"2","author":"Philipp","year":"1994","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib55","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1128\/JCM.20.6.1099-1101.1984","article-title":"Infection of Syrian hamsters with Lyme disease spirochetes","volume":"20","author":"Johnson","year":"1984","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib56","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1128\/IAI.56.9.2336-2342.1988","article-title":"Induction of Lyme arthritis in LSH hamsters","volume":"56","author":"Schmitz","year":"1988","journal-title":"Infect Immun"},{"issue":"7","key":"10.1016\/j.idc.2007.12.013_bib57","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1128\/IAI.62.7.2825-2833.1994","article-title":"Development of destructive arthritis in vaccinated hamsters challenged with Borrelia burgdorferi","volume":"62","author":"Lim","year":"1994","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib58","first-page":"609","article-title":"The New Zealand white rabbit: an experimental host for infecting ticks with Lyme disease spirochetes","volume":"57","author":"Burgdorfer","year":"1984","journal-title":"Yale J Biol Med"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib59","first-page":"613","article-title":"Infection in rabbits with the Lyme disease spirochete","volume":"57","author":"Kornblatt","year":"1984","journal-title":"Yale J Biol Med"},{"key":"10.1016\/j.idc.2007.12.013_bib60","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/infdis\/167.3.651","article-title":"Experimental Lyme disease in dogs produces arthritis and persistent infection","volume":"167","author":"Appel","year":"1993","journal-title":"J Infect Dis"},{"issue":"7","key":"10.1016\/j.idc.2007.12.013_bib61","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1128\/IAI.61.7.3047-3059.1993","article-title":"Early and early disseminated phases of Lyme disease in the rhesus monkey: a model for infection in humans","volume":"61","author":"Philipp","year":"1993","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib62","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1212\/WNL.45.1.165","article-title":"Inoculation of nonhuman primates with the N40 strain of Borrelia burgdorferi leads to a model of Lyme neuroborreliosis faithful to the human disease","volume":"45","author":"Pachner","year":"1995","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib63","first-page":"146","article-title":"Chronic Lyme disease in the rhesus monkey","volume":"72","author":"Roberts","year":"1995","journal-title":"Lab Invest"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib64","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1086\/515357","article-title":"Pathogenesis of Lyme neuroborreliosis in the rhesus monkey: the early disseminated and chronic phases of disease in the peripheral nervous system","volume":"178","author":"Roberts","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.idc.2007.12.013_bib65","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1128\/JCM.26.5.893-895.1988","article-title":"The urinary bladder, a consistent source of Borrelia burgdorferi in experimentally infected white-footed mice (Peromyscus leucopus)","volume":"26","author":"Schwan","year":"1988","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib66","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/infdis\/162.1.133","article-title":"Lyme borreliosis in selected strains and ages of laboratory mice","volume":"162","author":"Barthold","year":"1990","journal-title":"J Infect Dis"},{"issue":"8","key":"10.1016\/j.idc.2007.12.013_bib67","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1128\/IAI.65.8.3107-3111.1997","article-title":"T-helper-cell cytokines in the early evolution of murine Lyme arthritis","volume":"65","author":"Kang","year":"1997","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib68","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/IAI.66.1.161-168.1998","article-title":"Distinct characteristics of resistance to Borrelia burgdorferi-induced arthritis in C57BL\/6N mice","volume":"66","author":"Ma","year":"1998","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib69","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1128\/IAI.67.4.1967-1973.1999","article-title":"Genetic control of experimental Lyme arthritis in the absence of specific immunity","volume":"67","author":"Brown","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib70","doi-asserted-by":"crossref","first-page":"948","DOI":"10.4049\/jimmunol.162.2.948","article-title":"Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease","volume":"162","author":"Weis","year":"1999","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.idc.2007.12.013_bib71","doi-asserted-by":"crossref","first-page":"4797","DOI":"10.4049\/jimmunol.165.9.4797","article-title":"Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi","volume":"165","author":"Kumar","year":"2000","journal-title":"J Immunol"},{"issue":"7","key":"10.1016\/j.idc.2007.12.013_bib72","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/sj.gene.6363801","article-title":"Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses","volume":"2","author":"Roper","year":"2001","journal-title":"Genes Immun"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib73","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0002-9440(10)62050-0","article-title":"Bb2Bb3 regulation of murine Lyme arthritis is distinct from Ncf1 and independent of the phagocyte nicotinamide adenine dinucleotide phosphate oxidase","volume":"167","author":"Crandall","year":"2005","journal-title":"Am J Pathol"},{"issue":"11","key":"10.1016\/j.idc.2007.12.013_bib74","doi-asserted-by":"crossref","first-page":"7637","DOI":"10.1128\/IAI.73.11.7637-7643.2005","article-title":"Aggravated Lyme carditis in CD11a\u2212\/\u2212 and CD11c\u2212\/\u2212 mice","volume":"73","author":"Guerau-de-Arellano","year":"2005","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.idc.2007.12.013_bib75","doi-asserted-by":"crossref","first-page":"7930","DOI":"10.4049\/jimmunol.177.11.7930","article-title":"Gene expression profiling reveals unique pathways associated with differential severity of Lyme arthritis","volume":"177","author":"Crandall","year":"2006","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib76","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.4049\/jimmunol.163.5.2382","article-title":"Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2","volume":"163","author":"Hirschfeld","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.idc.2007.12.013_bib77","doi-asserted-by":"crossref","first-page":"348","DOI":"10.4049\/jimmunol.168.1.348","article-title":"Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi","volume":"168","author":"Wooten","year":"2002","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib78","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0378-1097(03)00960-1","article-title":"Impaired host defense to infection and toll-like receptor 2-independent killing of Borrelia burgdorferi clinical isolates in TLR2-deficient C3H\/HeJ mice","volume":"231","author":"Wang","year":"2004","journal-title":"FEMS Microbiol Lett"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib79","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.4049\/jimmunol.173.3.2003","article-title":"MyD88 plays a unique role in host defense but not arthritis development in Lyme disease","volume":"173","author":"Bolz","year":"2004","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib80","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1128\/IAI.72.6.3195-3203.2004","article-title":"Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice","volume":"72","author":"Liu","year":"2004","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib81","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1128\/IAI.74.3.1462-1470.2006","article-title":"MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi","volume":"74","author":"Behera","year":"2006","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib82","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1128\/IAI.74.4.2154-2160.2006","article-title":"MyD88 deficiency enhances acquisition and transmission of Borrelia burgdorferi by Ixodes scapularis ticks","volume":"74","author":"Bockenstedt","year":"2006","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib83","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1128\/IAI.66.3.1248-1251.1998","article-title":"Serum complement sensitivity as a key factor in Lyme disease ecology","volume":"66","author":"Kurtenbach","year":"1998","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.idc.2007.12.013_bib84","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1128\/IAI.71.8.4432-4440.2003","article-title":"Effect of complement component C3 deficiency on experimental Lyme borreliosis in mice","volume":"71","author":"Lawrenz","year":"2003","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib85","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1128\/IAI.01923-06","article-title":"Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection","volume":"75","author":"Woodman","year":"2007","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib86","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1128\/JCM.26.6.1138-1141.1988","article-title":"Serologic analyses of Peromyscus leucopus, a rodent reservoir for Borrelia burgdorferi, in northeastern United States","volume":"26","author":"Magnarelli","year":"1988","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib87","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1128\/IAI.57.11.3445-3451.1989","article-title":"Antibody response in white-footed mice (Peromyscus leucopus) experimentally infected with the Lyme disease spirochete (Borrelia burgdorferi)","volume":"57","author":"Schwan","year":"1989","journal-title":"Infect Immun"},{"key":"10.1016\/j.idc.2007.12.013_bib88","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1128\/IAI.61.11.4696-4702.1993","article-title":"Passive immunizing activity of sera from mice infected with Borrelia burgdorferi","volume":"61","author":"Barthold","year":"1993","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib89","first-page":"57","article-title":"Serum-mediated resolution of Lyme arthritis in mice","volume":"74","author":"Barthold","year":"1996","journal-title":"Lab Invest"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib90","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/intimm\/6.5.671","article-title":"Protection against Borrelia burgdorferi infection in SCID mice is conferred by presensitized spleen cells and partially by B but not T cells alone","volume":"6","author":"Schaible","year":"1994","journal-title":"Int Immunol"},{"key":"10.1016\/j.idc.2007.12.013_bib91","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4269\/ajtmh.1992.47.605","article-title":"Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency","volume":"47","author":"Barthold","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.idc.2007.12.013_bib92","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1139\/m91-074","article-title":"Changes in antigenic reactivity of Borrelia burgdorferi, the Lyme disease spirochete, during persistent infection in mice","volume":"37","author":"Schwan","year":"1991","journal-title":"Can J Microbiol"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib93","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1073\/pnas.032667699","article-title":"DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete","volume":"99","author":"Revel","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib94","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1128\/IAI.71.4.1689-1705.2003","article-title":"Profiling temperature-induced changes in Borrelia burgdorferi gene expression using whole genome arrays","volume":"71","author":"Ojaimi","year":"2003","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.idc.2007.12.013_bib95","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1128\/IAI.72.9.5419-5432.2004","article-title":"Combined effects of blood and temperature shift on Borrelia burgdorferi gene expression as determined by whole genome DNA array","volume":"72","author":"Tokarz","year":"2004","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib96","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1128\/IAI.71.6.3371-3383.2003","article-title":"Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals","volume":"71","author":"Brooks","year":"2003","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.idc.2007.12.013_bib97","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1128\/JB.184.11.3122-3125.2002","article-title":"Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding","volume":"184","author":"Narasimhan","year":"2002","journal-title":"J Bacteriol"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib98","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.20020770","article-title":"Molecular adaptation of Borrelia burgdorferi in the murine host","volume":"196","author":"Liang","year":"2002","journal-title":"J Exp Med"},{"issue":"7","key":"10.1016\/j.idc.2007.12.013_bib99","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1128\/IAI.70.7.3382-3388.2002","article-title":"Borrelia burgdorferi population kinetics and selected gene expression at the host-vector interface","volume":"70","author":"Hodzic","year":"2002","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.idc.2007.12.013_bib100","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1128\/IAI.71.9.5042-5055.2003","article-title":"Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice","volume":"71","author":"Hodzic","year":"2003","journal-title":"Infect Immun"},{"issue":"26","key":"10.1016\/j.idc.2007.12.013_bib101","doi-asserted-by":"crossref","first-page":"15953","DOI":"10.1073\/pnas.2432412100","article-title":"Borrelia burgdorferi transcriptome in the central nervous system of non-human primates","volume":"100","author":"Narasimhan","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.idc.2007.12.013_bib102","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1128\/IAI.71.6.3419-3428.2003","article-title":"Antigenic composition of Borrelia burgdorferi during infection of SCID mice","volume":"71","author":"Crother","year":"2003","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.idc.2007.12.013_bib103","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1128\/IAI.72.9.5063-5072.2004","article-title":"Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin","volume":"72","author":"Crother","year":"2004","journal-title":"Infect Immun"},{"key":"10.1016\/j.idc.2007.12.013_bib104","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1128\/IAI.56.8.1831-1836.1988","article-title":"Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation","volume":"56","author":"Schwan","year":"1988","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib105","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1128\/IAI.63.6.2206-2212.1995","article-title":"High- and low-infectivity phenotypes of clonal populations of in vitro-cultured Borrelia burgdorferi","volume":"63","author":"Norris","year":"1995","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.idc.2007.12.013_bib106","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1128\/IAI.64.9.3870-3876.1996","article-title":"Correlation of plasmids with infectivity of Borrelia burgdorferi sensu stricto type strain B31","volume":"64","author":"Xu","year":"1996","journal-title":"Infect Immun"},{"issue":"25","key":"10.1016\/j.idc.2007.12.013_bib107","doi-asserted-by":"crossref","first-page":"13865","DOI":"10.1073\/pnas.97.25.13865","article-title":"Correlation between plasmid content and infectivity in Borrelia burgdorferi","volume":"97","author":"Purser","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib108","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1128\/IAI.69.1.446-455.2001","article-title":"Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28-1","volume":"69","author":"Labandeira-Rey","year":"2001","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib109","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1046\/j.1365-2958.2003.03452.x","article-title":"A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host","volume":"48","author":"Purser","year":"2003","journal-title":"Mol Microbiol"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib110","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1365-2958.2007.05746.x","article-title":"The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi","volume":"64","author":"Jewett","year":"2007","journal-title":"Mol Microbiol"},{"issue":"5471","key":"10.1016\/j.idc.2007.12.013_bib111","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1126\/science.288.5471.1651","article-title":"Lack of a role for iron in the Lyme disease pathogen","volume":"288","author":"Posey","year":"2000","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib112","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.20011870","article-title":"An immune evasion mechanism for spirochetal persistence in Lyme borreliosis","volume":"195","author":"Liang","year":"2002","journal-title":"J Exp Med"},{"issue":"9","key":"10.1016\/j.idc.2007.12.013_bib113","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1073\/pnas.0306845101","article-title":"Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals","volume":"101","author":"Grimm","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib114","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1128\/IAI.01950-05","article-title":"Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection","volume":"74","author":"Tilly","year":"2006","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib115","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1128\/IAI.00158-06","article-title":"Delineating the requirement for the Borrelia burgdorferi virulence factor OspC in the mammalian host","volume":"74","author":"Stewart","year":"2006","journal-title":"Infect Immun"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib116","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1128\/IAI.01725-06","article-title":"Rapid clearance of Lyme disease spirochetes lacking OspC from skin","volume":"75","author":"Tilly","year":"2007","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.idc.2007.12.013_bib117","doi-asserted-by":"crossref","first-page":"4608","DOI":"10.1128\/IAI.71.8.4608-4613.2003","article-title":"The absence of linear plasmid 25 or 28-1 of Borrelia burgdorferi dramatically alters the kinetics of experimental infection via distinct mechanisms","volume":"71","author":"Labandeira-Rey","year":"2003","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib118","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1365-2958.2007.05895.x","article-title":"The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens","volume":"65","author":"Bankhead","year":"2007","journal-title":"Mol Microbiol"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib119","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1172\/JCI200419894","article-title":"OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands","volume":"113","author":"Pal","year":"2004","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijmm.2006.11.003","article-title":"Complementation of a Borrelia afzelii OspC mutant highlights the crucial role of OspC for dissemination of Borrelia afzelii in Ixodes ricinus","volume":"297","author":"Fingerle","year":"2007","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib121","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1084\/jem.183.1.261","article-title":"Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease","volume":"183","author":"Montgomery","year":"1996","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib122","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s004300050083","article-title":"Expression of outer surface proteins A and C of Borrelia burgdorferi in Ixodes ricinus ticks removed from humans","volume":"187","author":"Fingerle","year":"1998","journal-title":"Med Microbiol Immunol"},{"issue":"10","key":"10.1016\/j.idc.2007.12.013_bib123","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1128\/IAI.72.10.5759-5767.2004","article-title":"Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses","volume":"72","author":"Liang","year":"2004","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib124","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/emboj\/20.5.971","article-title":"Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi","volume":"20","author":"Kumaran","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.idc.2007.12.013_bib125","doi-asserted-by":"crossref","first-page":"10010","DOI":"10.1074\/jbc.M010062200","article-title":"Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi","volume":"276","author":"Eicken","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.idc.2007.12.013_bib126","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1128\/JCM.33.1.103-109.1995","article-title":"Phenotypic analysis of outer surface protein C (OspC) of Borrelia burgdorferi sensu lato by monoclonal antibodies: relationship to genospecies and OspA serotype","volume":"33","author":"Wilske","year":"1995","journal-title":"J Clin Microbiol"},{"issue":"1","key":"10.1016\/j.idc.2007.12.013_bib127","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/genetics\/151.1.15","article-title":"Genetic diversity of ospC in a local population of Borrelia burgdorferi sensu stricto","volume":"151","author":"Wang","year":"1999","journal-title":"Genetics"},{"issue":"7","key":"10.1016\/j.idc.2007.12.013_bib128","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1128\/IAI.67.7.3518-3524.1999","article-title":"Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans","volume":"67","author":"Seinost","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib129","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1534\/genetics.104.028738","article-title":"ospC diversity in Borrelia burgdorferi: different hosts are different niches","volume":"168","author":"Brisson","year":"2004","journal-title":"Genetics"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib130","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1128\/JCM.43.4.1879-1884.2005","article-title":"Borrelia burgdorferi ospC heterogeneity among human and murine isolates from a defined region of northern Maryland and southern Pennsylvania: lack of correlation with invasive and noninvasive genotypes","volume":"43","author":"Alghaferi","year":"2005","journal-title":"J Clin Microbiol"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib131","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.micinf.2005.08.017","article-title":"Borrelia burgdorferi sensu stricto invasiveness is correlated with OspC-plasminogen affinity","volume":"8","author":"Lagal","year":"2006","journal-title":"Microbes Infect"},{"issue":"12","key":"10.1016\/j.idc.2007.12.013_bib132","doi-asserted-by":"crossref","first-page":"7869","DOI":"10.1128\/IAI.73.12.7869-7877.2005","article-title":"Demonstration of OspC type diversity in invasive human Lyme disease isolates and identification of previously uncharacterized epitopes that define the specificity of the OspC murine antibody response","volume":"73","author":"Earnhart","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.idc.2007.12.013_bib133","doi-asserted-by":"crossref","first-page":"12594","DOI":"10.1073\/pnas.91.26.12594","article-title":"The outer surface protein A of the spirochete Borrelia burgdorferi is a plasmin(ogen) receptor","volume":"91","author":"Fuchs","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"10.1016\/j.idc.2007.12.013_bib134","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1128\/IAI.63.9.3491-3496.1995","article-title":"Binding of human plasminogen to Borrelia burgdorferi","volume":"63","author":"Hu","year":"1995","journal-title":"Infect Immun"},{"key":"10.1016\/j.idc.2007.12.013_bib135","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0092-8674(00)80298-6","article-title":"Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice","volume":"89","author":"Coleman","year":"1997","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.idc.2007.12.013_bib136","doi-asserted-by":"crossref","first-page":"7800","DOI":"10.1128\/IAI.69.12.7800-7809.2001","article-title":"Further characterization of complement regulator-acquiring surface proteins of Borrelia burgdorferi","volume":"69","author":"Kraiczy","year":"2001","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.idc.2007.12.013_bib137","doi-asserted-by":"crossref","first-page":"8427","DOI":"10.1074\/jbc.M007994200","article-title":"The complement regulator factor H binds to the surface protein OspE of Borrelia burgdorferi","volume":"276","author":"Hellwage","year":"2001","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib138","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1128\/IAI.69.6.3685-3691.2001","article-title":"Complement evasion by Borrelia burgdorferi: serum-resistant strains promote C3b inactivation","volume":"69","author":"Alitalo","year":"2001","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib139","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/IAI.70.2.491-497.2002","article-title":"Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: a possible mechanism underlying the expansive host range of Lyme disease spirochetes","volume":"70","author":"Stevenson","year":"2002","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib140","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1074\/jbc.M308343200","article-title":"Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins","volume":"279","author":"Kraiczy","year":"2004","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib141","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1365-2958.2006.05318.x","article-title":"Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1","volume":"61","author":"Hartmann","year":"2006","journal-title":"Mol Microbiol"},{"issue":"11","key":"10.1016\/j.idc.2007.12.013_bib142","doi-asserted-by":"crossref","first-page":"6577","DOI":"10.1128\/IAI.72.11.6577-6585.2004","article-title":"Effects of vlsE complementation on the infectivity of Borrelia burgdorferi lacking the linear plasmid lp28-1","volume":"72","author":"Lawrenz","year":"2004","journal-title":"Infect Immun"},{"issue":"8","key":"10.1016\/j.idc.2007.12.013_bib143","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.tim.2007.06.003","article-title":"Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix","volume":"15","author":"Cabello","year":"2007","journal-title":"Trends Microbiol"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib144","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1365-2958.2005.04759.x","article-title":"Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete","volume":"57","author":"Coburn","year":"2005","journal-title":"Mol Microbiol"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib145","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1046\/j.1365-2958.1998.01103.x","article-title":"Decorin-binding adhesins from Borrelia burgderferi","volume":"30","author":"Guo","year":"1998","journal-title":"Mol Microbiol"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib146","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1365-2958.1998.01127.x","article-title":"Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31","volume":"30","author":"Probert","year":"1998","journal-title":"Mol Microbiol"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib147","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1128\/IAI.74.5.3016-3020.2006","article-title":"Bgp, a secreted GAG-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice","volume":"74","author":"Parveen","year":"2006","journal-title":"Infect Immun"},{"issue":"12","key":"10.1016\/j.idc.2007.12.013_bib148","doi-asserted-by":"crossref","first-page":"7301","DOI":"10.1073\/pnas.1131117100","article-title":"Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin av\u00df3","volume":"100","author":"Coburn","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.idc.2007.12.013_bib149","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1128\/IAI.00740-06","article-title":"The dbpBA locus of Borrelia burgdorferi is not essential for infection of mice","volume":"74","author":"Shi","year":"2006","journal-title":"Infect Immun"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib150","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/j.1365-2958.2005.05042.x","article-title":"Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi","volume":"59","author":"Seshu","year":"2006","journal-title":"Mol Microbiol"},{"issue":"6","key":"10.1016\/j.idc.2007.12.013_bib151","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1128\/IAI.02035-05","article-title":"Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity","volume":"74","author":"Li","year":"2006","journal-title":"Infect Immun"},{"issue":"22","key":"10.1016\/j.idc.2007.12.013_bib152","doi-asserted-by":"crossref","first-page":"12724","DOI":"10.1073\/pnas.231442498","article-title":"Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway","volume":"98","author":"H\u00fcbner","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"10.1016\/j.idc.2007.12.013_bib153","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1073\/pnas.0408536102","article-title":"Borrelia burgdorferi sigma54 is required for mammalian infection and vector transmission but not for tick colonization","volume":"102","author":"Fisher","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"19","key":"10.1016\/j.idc.2007.12.013_bib154","doi-asserted-by":"crossref","first-page":"11001","DOI":"10.1073\/pnas.1834315100","article-title":"The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi","volume":"100","author":"Yang","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib155","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1111\/j.1365-2958.2007.05860.x","article-title":"Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle","volume":"65","author":"Caimano","year":"2007","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib156","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4269\/ajtmh.1990.42.352","article-title":"Growth kinetics of the Lyme disease spirochete (Borrelia burgdorferi) in vector ticks (Ixodes dammini)","volume":"42","author":"Piesman","year":"1990","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.idc.2007.12.013_bib157","doi-asserted-by":"crossref","first-page":"397","DOI":"10.4269\/ajtmh.1995.53.397","article-title":"Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding","volume":"53","author":"de Silva","year":"1995","journal-title":"Am J Trop Med Hyg"},{"issue":"11","key":"10.1016\/j.idc.2007.12.013_bib158","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1128\/JCM.39.11.4145-4148.2001","article-title":"Use of quantitative PCR to measure density of Borrelia burgdorferi in the midgut and salivary glands of feeding tick vectors","volume":"39","author":"Piesman","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.idc.2007.12.013_bib159","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1084\/jem.183.1.271","article-title":"Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine","volume":"183","author":"de Silva","year":"1996","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib160","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1073\/pnas.98.2.670","article-title":"Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks","volume":"98","author":"Ohnishi","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.idc.2007.12.013_bib161","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1128\/IAI.65.8.3146-3150.1997","article-title":"OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks","volume":"65","author":"de Silva","year":"1997","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib162","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI9427","article-title":"Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A","volume":"106","author":"Pal","year":"2000","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.idc.2007.12.013_bib163","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1084\/jem.20031960","article-title":"Essential role for OspA\/B in the life cycle of the Lyme disease spirochete","volume":"199","author":"Yang","year":"2004","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib164","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1128\/IAI.72.3.1755-1759.2004","article-title":"OspB antibody prevents Borrelia burgdorferi colonization of Ixodes scapularis","volume":"72","author":"Fikrig","year":"2004","journal-title":"Infect Immun"},{"issue":"20","key":"10.1016\/j.idc.2007.12.013_bib165","doi-asserted-by":"crossref","first-page":"11684","DOI":"10.1073\/pnas.2032956100","article-title":"Borrelia oxidative stress response regulator, BosR: a distinctive Zn-dependent transcriptional activator","volume":"100","author":"Boylan","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib166","doi-asserted-by":"crossref","first-page":"E33","DOI":"10.1371\/journal.ppat.0030033","article-title":"Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks","volume":"3","author":"Neelakanta","year":"2007","journal-title":"PLoS Pathog"},{"issue":"19","key":"10.1016\/j.idc.2007.12.013_bib167","doi-asserted-by":"crossref","first-page":"6972","DOI":"10.1073\/pnas.0502565102","article-title":"bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector","volume":"102","author":"Revel","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.idc.2007.12.013_bib168","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/j.1365-2958.2006.05550.x","article-title":"The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks","volume":"63","author":"Li","year":"2007","journal-title":"Mol Microbiol"},{"issue":"2","key":"10.1016\/j.idc.2007.12.013_bib169","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ibmb.2005.11.005","article-title":"An annotated catalog of salivary gland transcripts from Ixodes scapularis ticks","volume":"36","author":"Ribeiro","year":"2006","journal-title":"Insect Biochem Mol Biol"},{"issue":"4","key":"10.1016\/j.idc.2007.12.013_bib170","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2004.10.027","article-title":"TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi","volume":"119","author":"Pal","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.idc.2007.12.013_bib171","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S1074-7613(02)00325-4","article-title":"Salp15, an Ixodes scapularis salivary protein, inhibits CD4 + T cell activation","volume":"16","author":"Anguita","year":"2002","journal-title":"Immunity"},{"issue":"7050","key":"10.1016\/j.idc.2007.12.013_bib172","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature03812","article-title":"The Lyme disease agent exploits a tick protein to infect the mammalian host","volume":"436","author":"Ramamoorthi","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.idc.2007.12.013_bib173","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.chom.2007.06.001","article-title":"A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector","volume":"2","author":"Narasimhan","year":"2007","journal-title":"Cell Host Microbe"}],"container-title":["Infectious Disease Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891552007001316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891552007001316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T20:47:12Z","timestamp":1684356432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0891552007001316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":173,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0891552007001316"],"URL":"https:\/\/doi.org\/10.1016\/j.idc.2007.12.013","relation":{},"ISSN":["0891-5520"],"issn-type":[{"value":"0891-5520","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}