{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:53:26Z","timestamp":1773417206400,"version":"3.50.1"},"reference-count":101,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infectious Disease Clinics of North America"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.idc.2023.06.005","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T16:09:21Z","timestamp":1690906161000},"page":"793-822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Penicillin Allergy Impact and Management"],"prefix":"10.1016","volume":"37","author":[{"given":"Rebekah H.","family":"Wrenn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Trubiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10167","key":"10.1016\/j.idc.2023.06.005_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(18)32218-9","article-title":"Antibiotic allergy","volume":"393","author":"Blumenthal","year":"2019","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib2","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1093\/jac\/dkw008","article-title":"Antimicrobial allergy 'labels' drive inappropriate antimicrobial prescribing: lessons for stewardship","volume":"71","author":"Trubiano","year":"2016","journal-title":"Journal of antimicrobial chemotherapy"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib3","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/jama.2017.6510","article-title":"Penicillin Allergy Is Not Necessarily Forever","volume":"318","author":"Trubiano","year":"2017","journal-title":"JAMA"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/QCO.0000000000000006","article-title":"Antimicrobial stewardship's new weapon? A review of antibiotic allergy and pathways to 'de-labeling'","volume":"26","author":"Trubiano","year":"2013","journal-title":"Curr Opin Infect Dis"},{"issue":"20","key":"10.1016\/j.idc.2023.06.005_bib5","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1001\/jama.1993.03510200062033","article-title":"Clinical experience with penicillin skin testing in a large inner-city STD clinic","volume":"270","author":"Gadde","year":"1993","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib6","doi-asserted-by":"crossref","first-page":"ofw155","DOI":"10.1093\/ofid\/ofw155","article-title":"Implementation of an Infectious Disease Fellow-Managed Penicillin Allergy Skin Testing Service","volume":"3","author":"Heil","year":"2016","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/cid\/cix244","article-title":"Impact of an Integrated Antibiotic Allergy Testing Program on Antimicrobial Stewardship: A Multicenter Evaluation","volume":"65","author":"Trubiano","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib8","doi-asserted-by":"crossref","first-page":"e219820","DOI":"10.1001\/jamanetworkopen.2021.9820","article-title":"Evaluation of a Pharmacist-Led Penicillin Allergy Assessment Program and Allergy Delabeling in a Tertiary Care Hospital","volume":"4","author":"Turner","year":"2021","journal-title":"JAMA Netw Open"},{"issue":"11","key":"10.1016\/j.idc.2023.06.005_bib9","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1080\/14787210.2020.1792775","article-title":"The democratization of de-labeling: a review of direct oral challenge in adults with low-risk penicillin allergy","volume":"18","author":"Rose","year":"2020","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib10","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/cid\/ciaa653","article-title":"The Penicillin Allergy Delabeling Program: A Multicenter Whole-of-Hospital Health Services Intervention and Comparative Effectiveness Study","volume":"73","author":"Chua","year":"2020","journal-title":"Clinical infectious diseases"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1081-1206(10)60358-4","article-title":"Factors associated with repeated use of epinephrine for the treatment of anaphylaxis","volume":"103","author":"Manivannan","year":"2009","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib12","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.jaci.2022.08.028","article-title":"Drug allergy: A 2022 practice parameter update","volume":"150","author":"Khan","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.idc.2023.06.005_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.aller.2014.04.008","article-title":"Determinants of nocebo effect during oral drug provocation tests","volume":"43","author":"Bavbek","year":"2015","journal-title":"Allergol Immunopathol"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib14","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jaip.2016.09.041","article-title":"Identifying Allergic Drug Reactions Through Placebo-Controlled Graded Challenges","volume":"5","author":"Iammatteo","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.idc.2023.06.005_bib15","first-page":"159","article-title":"Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock","volume":"38","author":"Idsoe","year":"1968","journal-title":"Bull World Health Organ"},{"issue":"18","key":"10.1016\/j.idc.2023.06.005_bib16","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1001\/archinte.160.18.2819","article-title":"The incidence of antimicrobial allergies in hospitalized patients: implications regarding prescribing patterns and emerging bacterial resistance","volume":"160","author":"Lee","year":"2000","journal-title":"Arch Intern Med"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib17","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jaci.2014.08.045","article-title":"Patients with positive skin test results to penicillin should not undergo penicillin or amoxicillin challenge","volume":"135","author":"Park","year":"2014","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib18","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/cid\/cix794","article-title":"The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk","volume":"66","author":"Blumenthal","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.idc.2023.06.005_bib19","doi-asserted-by":"crossref","first-page":"k2400","DOI":"10.1136\/bmj.k2400","article-title":"Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study","volume":"361","author":"Blumenthal","year":"2018","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.idc.2023.06.005_bib20","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s11606-019-04991-y","article-title":"Recorded Penicillin Allergy and Risk of Mortality: a Population-Based Matched Cohort Study","volume":"34","author":"Blumenthal","year":"2019","journal-title":"J\u00a0Gen Intern Med"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib21","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jaci.2013.09.021","article-title":"Health care use and serious infection prevalence associated with penicillin \"allergy\" in hospitalized patients: A cohort study","volume":"133","author":"Macy","year":"2014","journal-title":"Journal of allergy and clinical immunology"},{"issue":"24","key":"10.1016\/j.idc.2023.06.005_bib22","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1056\/NEJMra1807761","article-title":"Penicillin Allergy","volume":"381","author":"Castells","year":"2019","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib23","doi-asserted-by":"crossref","first-page":"192","DOI":"10.18773\/austprescr.2019.065","article-title":"Penicillin allergy: a practical approach to assessment and prescribing","volume":"42","author":"Devchand","year":"2019","journal-title":"Aust Prescr"},{"issue":"5 Pt 1","key":"10.1016\/j.idc.2023.06.005_bib24","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S0091-6749(99)70439-2","article-title":"Natural evolution of skin test sensitivity in patients allergic to beta-lactam antibiotics","volume":"103","author":"Blanca","year":"1999","journal-title":"Journal of allergy and clinical immunology"},{"key":"10.1016\/j.idc.2023.06.005_bib25","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0002-9343(65)90161-0","article-title":"Results of Comparative Skin Tests with Penicilloyl-Polylysine and Penicillin in Patients with Penicillin Allergy","volume":"38","author":"Finke","year":"1965","journal-title":"Am J Med"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2146\/ajhp150288","article-title":"Implementation of a penicillin allergy screening tool to optimize aztreonam use","volume":"73","author":"Staicu","year":"2016","journal-title":"Am J Health Syst Pharm"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib27","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.jaip.2018.07.048","article-title":"Pathways to improved antibiotic allergy and antimicrobial stewardship practice: The validation of a beta-lactam antibiotic allergy assessment tool","volume":"7","author":"Devchand","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib28","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/jac\/dkz082","article-title":"Evaluation of a pharmacist-led penicillin allergy de-labelling ward-round \u2013 A novel antimicrobial stewardship intervention","volume":"74","author":"Devchand","year":"2019","journal-title":"J\u00a0Antimicrob Chemother"},{"issue":"12","key":"10.1016\/j.idc.2023.06.005_bib29","doi-asserted-by":"crossref","first-page":"ofy306","DOI":"10.1093\/ofid\/ofy306","article-title":"The Safety and Efficacy of an Oral Penicillin Challenge Program in Cancer Patients: A Multicenter Pilot Study","volume":"5","author":"Trubiano","year":"2018","journal-title":"Open Forum Infect Dis"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib30","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1016\/j.jaip.2019.02.046","article-title":"External validation of beta-lactam antibiotic allergy assessment tools: implications for clinical practice and workforce capacity","volume":"7","author":"Caughey","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/jpc.15657","article-title":"ESCAPE-Allergy: Evaluating screening for children and adolescents with penicillin allergy","volume":"58","author":"Rischin","year":"2021","journal-title":"J\u00a0Paediatr Child Health"},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib32","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/j.jaip.2019.04.006","article-title":"Risk-based pathway for outpatient penicillin allergy evaluations","volume":"7","author":"Blumenthal","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib33","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.anai.2020.03.013","article-title":"Preoperative penicillin allergy testing in patients undergoing cardiac surgery","volume":"124","author":"Plager","year":"2020","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"2","key":"10.1016\/j.idc.2023.06.005_bib34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1001\/jama.2018.19283","article-title":"Evaluation and Management of Penicillin Allergy: A Review","volume":"321","author":"Shenoy","year":"2019","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/pharmacy9030127","article-title":"Effectiveness and Feasibility of Pharmacist-Driven Penicillin Allergy De-Labeling Pilot Program without Skin Testing or Oral Challenges","volume":"9","author":"Song","year":"2021","journal-title":"Pharmacy (Basel)"},{"issue":"2","key":"10.1016\/j.idc.2023.06.005_bib36","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4212\/cjhp.v74i2.3096","article-title":"Assessing Use of a Standardized Allergy History Questionnaire for Patients with Reported Allergy to Penicillin","volume":"74","author":"Manning","year":"2021","journal-title":"Can J Hosp Pharm"},{"issue":"2","key":"10.1016\/j.idc.2023.06.005_bib37","doi-asserted-by":"crossref","first-page":"E394","DOI":"10.9778\/cmajo.20200077","article-title":"Amoxicillin oral provocation challenge in a primary care clinic: a descriptive analysis","volume":"9","author":"Gateman","year":"2021","journal-title":"CMAJ Open"},{"issue":"4","key":"10.1016\/j.idc.2023.06.005_bib38","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.jaip.2017.11.012","article-title":"Use of a Penicillin Allergy Screening Algorithm and Penicillin Skin Testing for Transitioning Hospitalized Patients to First-Line Antibiotic Therapy","volume":"6","author":"Ramsey","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13223-020-00501-6","article-title":"First pediatric electronic algorithm to stratify risk of penicillin allergy","volume":"16","author":"Roberts","year":"2020","journal-title":"Allergy, asthma, and clinical immunology"},{"issue":"4","key":"10.1016\/j.idc.2023.06.005_bib40","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/cea.13576","article-title":"De-labelling antibiotic allergy through five key questions","volume":"50","author":"Reichel","year":"2020","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib41","doi-asserted-by":"crossref","first-page":"e86","DOI":"10.1017\/ash.2022.55","article-title":"Impact of an inpatient nurse-initiated penicillin allergy delabeling questionnaire","volume":"2","author":"Bediako","year":"2022","journal-title":"Antimicrob Steward Healthc Epidemiol"},{"issue":"10","key":"10.1016\/j.idc.2023.06.005_bib42","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1111\/all.15453","article-title":"Non-invasive delabeling and refining of beta-lactam allergy labels in inpatients to optimize antimicrobial stewardship","volume":"77","author":"Van De Sijpe","year":"2022","journal-title":"Allergy"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jaip.2017.04.045","article-title":"Designing Predictive Models for Beta-Lactam Allergy Using the Drug Allergy and Hypersensitivity Database","volume":"6","author":"Chiriac","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/imj.15532","article-title":"Penicillin Allergy Delabeling Program: an exploratory economic evaluation in the Australian context","volume":"53","author":"Brusco","year":"2021","journal-title":"Intern Med J"},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib45","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.jaip.2019.03.015","article-title":"Identifying Low-Risk Beta-Lactam Allergy Patients in a UK Tertiary Centre","volume":"7","author":"Siew","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.idc.2023.06.005_bib46","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jaip.2019.09.025","article-title":"Multicenter Australian Study to Determine Criteria for Low- and High-Risk Penicillin Testing in Outpatients","volume":"8","author":"Stevenson","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib47","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1001\/jamainternmed.2020.0403","article-title":"Development and Validation of a Penicillin Allergy Clinical Decision Rule","volume":"180","author":"Trubiano","year":"2020","journal-title":"JAMA Intern Med"},{"issue":"2","key":"10.1016\/j.idc.2023.06.005_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2022.12.192","article-title":"Evaluating a Penicillin Allergy Clinical Decision-Making Tool to Enhance Penicillin Allergy De-labeling","volume":"151","author":"Su","year":"2023","journal-title":"J\u00a0Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.anai.2021.07.005","article-title":"Predictive factors of amoxicillin immediate hypersensitivity and validation of PEN-FAST clinical decision rule","volume":"128","author":"Piotin","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib50","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13223-023-00770-x","article-title":"Virtually supported penicillin allergy de-labelling during COVID-19","volume":"19","author":"Ghassemian","year":"2023","journal-title":"Allergy, asthma, and clinical immunology"},{"issue":"9","key":"10.1016\/j.idc.2023.06.005_bib51","doi-asserted-by":"crossref","first-page":"e2233703","DOI":"10.1001\/jamanetworkopen.2022.33703","article-title":"Validation of the PEN-FAST Score in a Pediatric Population","volume":"5","author":"Copaescu","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib52","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.jaip.2022.03.025","article-title":"Safety of direct oral challenge to amoxicillin in pregnant patients at a Canadian tertiary hospital","volume":"10","author":"Mak","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"10","key":"10.1016\/j.idc.2023.06.005_bib53","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1016\/j.jaip.2021.05.037","article-title":"Urticaria: The 1-1-1 Criterion for Optimized Risk Stratification in beta-Lactam Allergy Delabeling","volume":"9","author":"Sabato","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.idc.2023.06.005_bib54","unstructured":"Clarke J, Graham N. Paediatric antibiotic allergy assessment, testing and de-labelling. 2020; https:\/\/www.childrens.health.qld.gov.au\/wp-content\/uploads\/PDF\/guidelines\/gdl-01076.pdf."},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib55","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.jaip.2020.02.033","article-title":"Direct Challenges to Penicillin-Based Antibiotics in the Inpatient Setting","volume":"8","author":"Ramsey","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.anai.2021.07.005","article-title":"Predictive factors of amoxicillin IgE-mediated hypersensitivity and validation of PEN-FAST clinical decision rule","volume":"128","author":"Piotin","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"11","key":"10.1016\/j.idc.2023.06.005_bib57","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1365-2222.2011.03837.x","article-title":"The clinical evaluation of penicillin allergy: what is necessary, sufficient and safe given the materials currently available?","volume":"41","author":"Macy","year":"2011","journal-title":"Clin Exp Allergy"},{"issue":"9","key":"10.1016\/j.idc.2023.06.005_bib58","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/all.13168","article-title":"Clinical outcomes following inpatient penicillin allergy testing: A systematic review and meta-analysis","volume":"72","author":"Sacco","year":"2017","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib59","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1086\/502212","article-title":"A\u00a0prospective observational study of the effect of penicillin skin testing on antibiotic use in the intensive care unit","volume":"24","author":"Arroliga","year":"2003","journal-title":"Infection control and hospital epidemiology"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib60","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.annemergmed.2008.12.034","article-title":"The use of penicillin skin testing to assess the prevalence of penicillin allergy in an emergency department setting","volume":"54","author":"Raja","year":"2009","journal-title":"Ann Emerg Med"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib61","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S1081-1206(10)61100-3","article-title":"Safety and effectiveness of a preoperative allergy clinic in decreasing vancomycin use in patients with a history of penicillin allergy","volume":"97","author":"Park","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib62","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000319209","article-title":"Collaboration between allergists and pharmacists increases \u03b2-lactam antibiotic prescriptions in patients with a history of penicillin allergy","volume":"154","author":"Park","year":"2011","journal-title":"Int Arch Allergy Immunol"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib63","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11882-023-01069-y","article-title":"Management of the Pregnant Patient with Beta-Lactam Allergy","volume":"23","author":"Wolfson","year":"2023","journal-title":"Curr Allergy Asthma Rep"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib64","first-page":"480","article-title":"Management of group B Streptococcus in pregnant women with penicillin allergy","volume":"52","author":"Philipson","year":"2007","journal-title":"J\u00a0Reprod Med"},{"issue":"2","key":"10.1016\/j.idc.2023.06.005_bib65","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jaci.2005.10.032","article-title":"Immediate allergic reactions to cephalosporins: evaluation of cross-reactivity with a panel of penicillins and cephalosporins","volume":"117","author":"Antunez","year":"2006","journal-title":"Journal of allergy and clinical immunology"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib66","first-page":"331","article-title":"Cross-reactivity and tolerability of cephalosporins in patients with cell-mediated allergy to penicillins","volume":"24","author":"Buonomo","year":"2014","journal-title":"Journal of investigational allergology & clinical immunology"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib67","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jaip.2020.07.056","article-title":"Testing Strategies and Predictors for Evaluating Immediate and Delayed Reactions to Cephalosporins","volume":"9","author":"Stone","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"2","key":"10.1016\/j.idc.2023.06.005_bib68","first-page":"171","article-title":"Nonirritating concentration for skin testing with cephalosporins","volume":"20","author":"Testi","year":"2010","journal-title":"Journal of investigational allergology & clinical immunology"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib69","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/all.12142","article-title":"Skin test concentrations for systemically administered drugs -- an ENDA\/EAACI Drug Allergy Interest Group position paper","volume":"68","author":"Brockow","year":"2013","journal-title":"Allergy"},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib70","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/j.jaip.2019.06.001","article-title":"Cephalosporin Allergy: Current Understanding and Future Challenges","volume":"7","author":"Khan","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib71","doi-asserted-by":"crossref","DOI":"10.1093\/jacamr\/dlaa123","article-title":"Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge: a systematic review","volume":"3","author":"Cooper","year":"2021","journal-title":"JAC-Antimicrobial Resistance"},{"issue":"4","key":"10.1016\/j.idc.2023.06.005_bib72","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.anai.2015.05.011","article-title":"Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy","volume":"115","author":"Blumenthal","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib73","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/cid\/cix512","article-title":"Point-of-care Beta-lactam Allergy Skin Testing by Antimicrobial Stewardship Programs: A Pragmatic Multicenter Prospective Evaluation","volume":"65","author":"Leis","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib74","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jaip.2017.01.023","article-title":"Amoxicillin challenge without penicillin skin testing in evaluation of penicillin allergy in a cohort of Marine recruits","volume":"5","author":"Tucker","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib75","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11882-019-0854-6","article-title":"Evaluating Penicillin Allergies Without Skin Testing","volume":"19","author":"Banks","year":"2019","journal-title":"Curr Allergy Asthma Rep"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib76","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jaip.2018.05.008","article-title":"Safety and Outcomes of Oral Graded Challenges to Amoxicillin without Prior Skin Testing","volume":"7","author":"Iammatteo","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib77","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2500\/aap.2019.40.4184","article-title":"Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy","volume":"40","author":"Kuruvilla","year":"2019","journal-title":"Allergy Asthma Proc"},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib78","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.jaip.2019.05.037","article-title":"Comparing Direct Challenge to Penicillin Skin Testing for the Outpatient Evaluation of Penicillin Allergy: A Randomized Controlled Trial","volume":"7","author":"Mustafa","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib79","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1016\/j.bja.2018.09.009","article-title":"Penicillin allergy de-labelling ahead of elective surgery: feasibility and barriers","volume":"123","author":"Savic","year":"2019","journal-title":"British journal of anaesthesia"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib80","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1017\/ice.2019.50","article-title":"Outcomes from an inpatient beta-lactam allergy guideline across a large US health system","volume":"40","author":"Blumenthal","year":"2019","journal-title":"Infection control and hospital epidemiology"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib81","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/jac\/dky575","article-title":"Implementation of a pharmacist-led penicillin allergy de-labelling service in a public hospital","volume":"74","author":"du Plessis","year":"2019","journal-title":"Journal of antimicrobial chemotherapy"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib82","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.anai.2019.08.005","article-title":"Safety of direct drug provocation testing in adults with penicillin allergy and association with health and economic benefits","volume":"123","author":"Li","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"12","key":"10.1016\/j.idc.2023.06.005_bib83","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1164\/rccm.202001-0089LE","article-title":"Risk-stratified Management to Remove Low-Risk Penicillin Allergy Labels in the ICU","volume":"201","author":"Stone","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.idc.2023.06.005_bib84","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/all.15169","article-title":"Direct oral penicillin challenge for penicillin allergy delabeling as a health services intervention: A multicenter cohort study","volume":"77","author":"Trubiano","year":"2022","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.idc.2023.06.005_bib85","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jhin.2019.10.007","article-title":"Antimicrobial stewardship intervention: optimizing antibiotic treatment in hospitalized patients with reported antibiotic allergy","volume":"104","author":"Lin","year":"2020","journal-title":"J\u00a0Hosp Infect"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib86","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1186\/s12879-021-06794-1","article-title":"De-labelling penicillin allergy in acutely hospitalized patients: a pilot study","volume":"21","author":"Steenvoorden","year":"2021","journal-title":"BMC Infect Dis"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib87","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1159\/000521708","article-title":"Safe De-Labeling of Patients at Low Risk of Penicillin Allergy in Denmark","volume":"183","author":"Fransson","year":"2022","journal-title":"Int Arch Allergy Immunol"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib88","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1016\/j.jaip.2022.01.041","article-title":"Low-risk penicillin allergy delabeling through a direct oral challenge in immunocompromised and\/or multiple drug allergy labeled patients in a critical care setting","volume":"10","author":"Koo","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib89","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/j.jaip.2019.05.051","article-title":"Beta-Lactam and Sulfonamide Allergy Testing Should Be a Standard of Care in Immunocompromised Hosts","volume":"7","author":"Trubiano","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"5","key":"10.1016\/j.idc.2023.06.005_bib90","doi-asserted-by":"crossref","first-page":"e13955","DOI":"10.1111\/tid.13955","article-title":"Antibiotic allergy labels in immunocompromised populations","volume":"24","author":"Waldron","year":"2022","journal-title":"Transpl Infect Dis"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib91","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2500\/aap.2010.31.3382","article-title":"Predicting which medication classes interfere with allergy skin testing","volume":"31","author":"Shah","year":"2010","journal-title":"Allergy Asthma Proc"},{"issue":"1","key":"10.1016\/j.idc.2023.06.005_bib92","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1710-1492-6-2","article-title":"Skin prick testing in patients using beta-blockers: a retrospective analysis","volume":"6","author":"Fung","year":"2010","journal-title":"Allergy, asthma, and clinical immunology"},{"key":"10.1016\/j.idc.2023.06.005_bib93","first-page":"ciad156","article-title":"The Who, What, When and Where of Inpatient Direct Oral Penicillin Challenge - Implications for health services implementation","author":"Trubiano","year":"2023","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib94","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1001\/archinte.162.7.822","article-title":"Lack of penicillin resensitization in patients with a history of penicillin allergy after receiving repeated penicillin courses","volume":"162","author":"Solensky","year":"2002","journal-title":"Arch Intern Med"},{"issue":"7","key":"10.1016\/j.idc.2023.06.005_bib95","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1093\/cid\/ciw462","article-title":"Impact of Reported Beta-Lactam Allergy on Inpatient Outcomes: A Multicenter Prospective Cohort Study","volume":"63","author":"MacFadden","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib96","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.jaip.2017.06.017","article-title":"The 3 Cs of Antibiotic Allergy-Classification, Cross-Reactivity, and Collaboration","volume":"5","author":"Trubiano","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"8","key":"10.1016\/j.idc.2023.06.005_bib97","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1016\/j.jaip.2019.05.038","article-title":"Cross-reactivity to cephalosporins and carbapenems in penicillin-allergic patients: Two systematic reviews and meta-analyses","volume":"7","author":"Picard","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib98","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1128\/AAC.02504-13","article-title":"Tolerability of cefazolin after immune-mediated hypersensitivity reactions to nafcillin in the outpatient setting","volume":"58","author":"Blumenthal","year":"2014","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib99","doi-asserted-by":"crossref","first-page":"e532","DOI":"10.1016\/j.bja.2019.09.011","article-title":"Cross-reactivity to penicillins in cephalosporin anaphylaxis","volume":"123","author":"Li","year":"2019","journal-title":"British journal of anaesthesia"},{"issue":"6","key":"10.1016\/j.idc.2023.06.005_bib100","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.jaip.2016.05.011","article-title":"Cefazolin Hypersensitivity: Toward Optimized Diagnosis","volume":"4","author":"Uyttebroek","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.idc.2023.06.005_bib101","series-title":"Therapeutic guidelines: antibiotic","year":"2019"}],"container-title":["Infectious Disease Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891552023000491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0891552023000491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:32:59Z","timestamp":1760196779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0891552023000491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":101,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0891552023000491"],"URL":"https:\/\/doi.org\/10.1016\/j.idc.2023.06.005","relation":{},"ISSN":["0891-5520"],"issn-type":[{"value":"0891-5520","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Penicillin Allergy Impact and Management","name":"articletitle","label":"Article Title"},{"value":"Infectious Disease Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.idc.2023.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}