{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T06:10:14Z","timestamp":1744524614147,"version":"3.40.4"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IDCases"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.idcr.2025.e02178","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T16:37:52Z","timestamp":1738687072000},"page":"e02178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tropheryma whipplei infection presenting as indolent endophthalmitis"],"prefix":"10.1016","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8280-6638","authenticated-orcid":false,"given":"Rami","family":"Waked","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey K.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon","family":"Winward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Ham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard W.","family":"Hoyt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leyla","family":"Azis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.idcr.2025.e02178_bib1","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/S1473-3099(15)00537-X","article-title":"Tropheryma whipplei infection and whipple\u2019s disease","volume":"16","author":"Marth","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"5","key":"10.1016\/j.idcr.2025.e02178_bib2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/MD.0b013e3181f204a8","article-title":"Systemic tropheryma whipplei: clinical presentation of 142 patients with infections diagnosed or confirmed in a reference center","volume":"89","author":"Lagier","year":"2010","journal-title":"Med"},{"issue":"9","key":"10.1016\/j.idcr.2025.e02178_bib3","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.7326\/L20-1470","article-title":"Detection of tropheryma whipplei genome from the aqueous humor by metagenomic sequencing","volume":"174","author":"Gonzales","year":"2021","journal-title":"Ann Intern Med"},{"issue":"12","key":"10.1016\/j.idcr.2025.e02178_bib4","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/S0161-6420(01)00818-1","article-title":"Ocular whipple\u2019s disease: earlier definitive diagnosis","volume":"108","author":"Chan","year":"2001","journal-title":"Ophthalmology"},{"issue":"7","key":"10.1016\/j.idcr.2025.e02178_bib5","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.ophtha.2012.01.024","article-title":"Ocular whipple\u2019s disease: therapeutic strategy and long-term follow-up","volume":"119","author":"Touitou","year":"2012","journal-title":"Ophthalmology"},{"issue":"6","key":"10.1016\/j.idcr.2025.e02178_bib6","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1086\/528693","article-title":"Prevalence of asymptomatic tropheryma whipplei carriage among humans and nonhuman primates","volume":"197","author":"Fenollar","year":"2008","journal-title":"J Infect Dis"},{"issue":"5","key":"10.1016\/j.idcr.2025.e02178_bib7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1086\/590559","article-title":"Value of tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of whipple disease: usefulness of saliva and stool specimens for first-line screening","volume":"47","author":"Fenollar","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"7","key":"10.1016\/j.idcr.2025.e02178_bib8","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1053\/j.gastro.2009.01.051","article-title":"The HLA alleles DRB1*\u200913 and DQB1*\u200906 are associated to whipple\u2019s disease","volume":"136","author":"Martinetti","year":"2009","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.idcr.2025.e02178_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2559.1992.tb00337.x","article-title":"Whipple\u2019s disease: a histological, immunocytochemical and electronmicroscopic study of the immune response in the small intestinal mucosa","volume":"21","author":"Ectors","year":"1992","journal-title":"Histopathology"},{"issue":"2","key":"10.1016\/j.idcr.2025.e02178_bib10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1128\/JCM.05531-11","article-title":"High frequency of tropheryma whipplei in culture-negative endocarditis","volume":"50","author":"Geissd\u00f6rfer","year":"2012","journal-title":"J Clin Microbiol"},{"issue":"5","key":"10.1016\/j.idcr.2025.e02178_bib11","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1309\/8YGR-FE7L-39LL-L37C","article-title":"Diagnosis of Wihipple disease by immunohistochemical analysis: a sensitive and specific method for the detection of Tropheryma whipplei (the Whipple bacillus) in paraffin-embedded tissue","volume":"118","author":"Baisden","year":"2002","journal-title":"Am J Clin Pathol"},{"issue":"11","key":"10.1016\/j.idcr.2025.e02178_bib12","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1128\/JCM.01703-13","article-title":"Validation of an rpoB gene PCR assay for detection of tropheryma whipplei: 10 years\u2019 experience in a National reference laboratory","volume":"51","author":"Moter","year":"2013","journal-title":"J Clin Microbiol"},{"issue":"2","key":"10.1016\/j.idcr.2025.e02178_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.01457-22","article-title":"Contribution of PCR to differential diagnosis between patients with whipple disease and tropheryma whipplei carriers","volume":"61","author":"Meyer","year":"2023","journal-title":"J Clin Microbiol"},{"issue":"9","key":"10.1016\/j.idcr.2025.e02178_bib14","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1128\/JCM.00635-17","article-title":"Laboratory diagnosis of infective endocarditis","volume":"55","author":"Liesman","year":"2017","journal-title":"J Clin Microbiol"},{"issue":"12","key":"10.1016\/j.idcr.2025.e02178_bib15","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.4330\/wjc.v6.i12.1278","article-title":"Complicated Whipple\u2019s disease and endocarditis following tumor necrosis factor inhibitors","volume":"6","author":"Marth","year":"2014","journal-title":"World J Cardiol"},{"issue":"7","key":"10.1016\/j.idcr.2025.e02178_bib16","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1080\/09273948.2018.1518461","article-title":"Ocular whipple disease: report of three cases","volume":"27","author":"Testi","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"issue":"8","key":"10.1016\/j.idcr.2025.e02178_bib17","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s00415-016-8184-2","article-title":"Whipple\u2019s disease without gastrointestinal symptoms: a challenging diagnosis","volume":"263","author":"Campagnolo","year":"2016","journal-title":"J Neurol"},{"issue":"1","key":"10.1016\/j.idcr.2025.e02178_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10620-018-5033-4","article-title":"Tropheryma whipplei Infection (Whipple Disease) in the USA","volume":"64","author":"Hujoel","year":"2019","journal-title":"Dig Dis Sci"},{"issue":"8","key":"10.1016\/j.idcr.2025.e02178_bib19","article-title":"Bilateral panuveitis in Whipple\u2019s disease: case report","volume":"47","author":"Loiseau","year":"2024","journal-title":"J Fr Ophtalmol"},{"issue":"3","key":"10.1016\/j.idcr.2025.e02178_bib20","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jinf.2012.12.004","article-title":"Intravenous ceftriaxone, followed by 12 or three months of oral treatment with trimethoprim-sulfamethoxazole in whipple\u2019s disease","volume":"66","author":"Feurle","year":"2013","journal-title":"J Infect"}],"container-title":["IDCases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214250925000332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214250925000332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,13]],"date-time":"2025-04-13T05:57:41Z","timestamp":1744523861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214250925000332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":20,"alternative-id":["S2214250925000332"],"URL":"https:\/\/doi.org\/10.1016\/j.idcr.2025.e02178","relation":{},"ISSN":["2214-2509"],"issn-type":[{"type":"print","value":"2214-2509"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tropheryma whipplei infection presenting as indolent endophthalmitis","name":"articletitle","label":"Article Title"},{"value":"IDCases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.idcr.2025.e02178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"e02178"}}