{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:19:42Z","timestamp":1790443182130,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.identj.2024.05.003","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T11:24:21Z","timestamp":1721301861000},"page":"1081-1087","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early Implant Failure in Patients Using Antihypertensive Medications: A Retrospective Cohort Study"],"prefix":"10.1016","volume":"75","author":[{"given":"Daya","family":"Masri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dror","family":"Bar-Hai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiba","family":"Masri-Iraqi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-4978","authenticated-orcid":false,"given":"Gavriel","family":"Chaushu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Chaushu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.identj.2024.05.003_bib0001","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","article-title":"The global epidemiology of hypertension","volume":"16","author":"Mills","year":"2020","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"10.1016\/j.identj.2024.05.003_bib0002","doi-asserted-by":"crossref","first-page":"351","DOI":"10.7326\/M17-3203","article-title":"Prevention, detection, evaluation, and management of high blood pressure in adults: synopsis of the 2017 American College of Cardiology\/American Heart Association Hypertension Guideline","volume":"168","author":"Carey","year":"2018","journal-title":"Annals Intern Med"},{"key":"10.1016\/j.identj.2024.05.003_bib0003","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/CIRCULATIONAHA.117.032582","article-title":"Potential US population impact of the 2017 ACC\/AHA high blood pressure guideline","volume":"137","author":"Muntner","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.identj.2024.05.003_bib0004","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1161\/01.HYP.0000252676.46043.18","article-title":"Prevalence, awareness, treatment, and control of hypertension among United States adults 1999\u20132004","volume":"49","author":"Ong","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.identj.2024.05.003_bib0005","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1056\/NEJM198606263142602","article-title":"The effects of antihypertensive therapy on the quality of life","volume":"314","author":"Croog","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1016\/j.identj.2024.05.003_bib0006","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1573402052952843","article-title":"Effect of the antihypertensive treatment on the bone mineral density and osteoporotic fracture","volume":"1","author":"Perez-Castrillon","year":"2005","journal-title":"Curr Hypertens Rev"},{"key":"10.1016\/j.identj.2024.05.003_bib0007","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0002-9343(99)00028-5","article-title":"The association between low bone mass at the menopause and cardiovascular mortality","volume":"106","author":"von der Recke","year":"1999","journal-title":"Am J Med"},{"key":"10.1016\/j.identj.2024.05.003_bib0008","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0306-4522(91)90094-5","article-title":"Effects of neonatal sympathectomy and capsaicin treatment on bone remodeling in rats","volume":"44","author":"Hill","year":"1991","journal-title":"Neuroscience"},{"key":"10.1016\/j.identj.2024.05.003_bib0009","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0003-9969(90)90020-B","article-title":"The early effects of surgical sympathectomy on bone resorption in the rat incisor socket","volume":"35","author":"Sandhu","year":"1990","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.identj.2024.05.003_bib0010","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/ar.1092190107","article-title":"Effect of surgical sympathectomy on bone remodeling at rat incisor and molar root sockets","volume":"219","author":"Sandhu","year":"1987","journal-title":"Anat Rec"},{"issue":"12","key":"10.1016\/j.identj.2024.05.003_bib0011","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1111\/jcpe.12632","article-title":"Propranolol enhances bone healing and implant osseointegration in rats tibiae","volume":"43","author":"Al-Subaie","year":"2016","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2024.05.003_bib0012","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s12020-014-0167-4","article-title":"Antihypertensive medications, bone mineral density, and fractures: a review of old cardiac drugs that provides new insights into osteoporosis","volume":"46","author":"Ghosh","year":"2014","journal-title":"Endocrine"},{"key":"10.1016\/j.identj.2024.05.003_bib0013","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/hr.2009.99","article-title":"Prevention of osteoporosis by angiotensin-converting enzyme inhibitor in spontaneous hypertensive rats","volume":"32","author":"Shimizu","year":"2009","journal-title":"Hypertens Res"},{"key":"10.1016\/j.identj.2024.05.003_bib0014","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1096\/fj.07-098954","article-title":"Angiotensin II accelerates osteoporosis by activating osteoclasts","volume":"22","author":"Shimizu","year":"2018","journal-title":"FASEB J"},{"key":"10.1016\/j.identj.2024.05.003_bib0015","doi-asserted-by":"crossref","first-page":"19902","DOI":"10.1074\/jbc.M411961200","article-title":"Thiazide-sensitive NaCl-cotransporter in the intestine: possible role of hydr(2008) ochlorothiazide in the intestinal Ca2+ uptake","volume":"280","author":"Bazzini","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.identj.2024.05.003_bib0016","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1681\/ASN.2007030348","article-title":"Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone","volume":"18","author":"Dvorak","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.identj.2024.05.003_bib0017","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","article-title":"Seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure","volume":"42","author":"Chobanian","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.identj.2024.05.003_bib0018","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/cvr\/cvz201","article-title":"Periodontitis is associated with hypertension: a systematic review and meta-analysis","volume":"116","author":"Munoz Aguilera","year":"2020","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.identj.2024.05.003_bib0019","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2174\/1573403X10666140416094901","article-title":"Is there an association between periodontitis and hypertension?","volume":"10","author":"Paizan","year":"2014","journal-title":"Curr Cardiol Rev"},{"key":"10.1016\/j.identj.2024.05.003_bib0020","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00210-013-0886-8","article-title":"Olmesartan decreases IL-1\u03b2 and TNF-\u03b1 levels; downregulates MMP-2, MMP-9, COX-2, and RANKL; and upregulates OPG in experimental periodontitis","volume":"386","author":"Ara\u00fajo","year":"2013","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.identj.2024.05.003_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134601","article-title":"Functional local renin-angiotensin system in human and rat periodontal tissue","volume":"10","author":"Santos","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.identj.2024.05.003_bib0022","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/jcpe.12160","article-title":"Effect of telmisartan on levels of IL-1, TNF-\u03b1, down-regulated COX-2, MMP-2, MMP-9 and RANKL\/RANK in an experimental periodontitis model","volume":"40","author":"Ara\u00fajo","year":"2013","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2024.05.003_bib0023","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1902\/jop.2016.160354","article-title":"Angiotensin II type 1 receptor knockdown impairs interleukin-1\u03b2-induced cytokines in human periodontal fibroblasts","volume":"88","author":"Gabriele","year":"2017","journal-title":"J Periodontol"},{"key":"10.1016\/j.identj.2024.05.003_bib0024","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1016\/S0142-9612(99)00160-X","article-title":"Understanding and controlling the bone-implant interface","volume":"20","author":"Puleo","year":"1999","journal-title":"Biomaterials"},{"key":"10.1016\/j.identj.2024.05.003_bib0025","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1016\/j.joms.2009.07.050","article-title":"Characteristics of early versus late implant failure: a retrospective study","volume":"67","author":"Manor","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"issue":"5","key":"10.1016\/j.identj.2024.05.003_bib0026","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1097\/ALN.0000000000003947","article-title":"The evolution, current value, and future of the American Society of Anesthesiologists Physical Status Classification System","volume":"135","author":"Horvath","year":"2021","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.identj.2024.05.003_bib0027","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s40729-020-00231-9","article-title":"Influence of antihypertensive medications on the clinical parameters of anodized dental implants: a retrospective cohort study","volume":"6","author":"Seki","year":"2020","journal-title":"Int J Implant Dent"},{"issue":"2","key":"10.1016\/j.identj.2024.05.003_bib0028","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10006-023-01167-1","article-title":"Do antihypertensive medications have an effect on dental implants? A systematic review","volume":"28","author":"Mishra","year":"2024","journal-title":"Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.identj.2024.05.003_bib0029","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1902\/jop.2002.73.2.153","article-title":"Smoking and complications of endosseous dental implants","volume":"73","author":"Schwartz-Arad","year":"2002","journal-title":"J Periodontol"},{"key":"10.1016\/j.identj.2024.05.003_bib0030","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00006254-200002000-00022","article-title":"Study of osteoporotic fractures research group. High blood pressure and bone-mineral loss in elderly white women: a prospective study","volume":"55","author":"Cappuccio","year":"2000","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.identj.2024.05.003_bib0031","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2147\/CIA.S60669","article-title":"Long-term effects of antihypertensive medications on bone mineral density in men older than 55 years","volume":"9","author":"A\u011fa\u00e7ayak","year":"2014","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.identj.2024.05.003_bib0032","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/cid.12560","article-title":"Age-related new bone formation following the use of cancellous bone-block allografts for reconstruction of atrophic alveolar ridges","volume":"20","author":"Nissan","year":"2018","journal-title":"Clin Implant Dent Relat Res"},{"key":"10.1016\/j.identj.2024.05.003_bib0033","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/jcpe.12153","article-title":"Membranes over the lateral window in sinus augmentation procedures: a two-arm and split-mouth randomized clinical trials","volume":"40","author":"Torres Garc\u00eda-Denche","year":"2013","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2024.05.003_bib0034","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1111\/cid.12414","article-title":"Antihypertensive medications and the survival rate of osseointegrated dental implants: a cohort study","volume":"18","author":"Wu","year":"2016","journal-title":"Clin Implant Dent Relat Res"},{"key":"10.1016\/j.identj.2024.05.003_bib0035","doi-asserted-by":"crossref","first-page":"501","DOI":"10.11607\/jomi.9425","article-title":"Successful osseointegrated implants in hypertensive patients: retrospective clinical study","volume":"37","author":"Rawen Tonini","year":"2022","journal-title":"Int J Oral Maxillofac Implants"},{"key":"10.1016\/j.identj.2024.05.003_bib0036","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/jcpe.12372","article-title":"Evaluation of a topical herbal patch for soft tissue wound healing: an animal study","volume":"42","author":"Chaushu","year":"2015","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2024.05.003_bib0037","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1007\/s00784-020-03304-6","article-title":"The dynamics of closure following excisional mid-palatal mucoperiosteal wound in a rat model","volume":"24","author":"Weinberg","year":"2020","journal-title":"Clin Oral Investig"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924001382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924001382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:52:36Z","timestamp":1748969556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653924001382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0020653924001382"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2024.05.003","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Implant Failure in Patients Using Antihypertensive Medications: A Retrospective Cohort Study","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2024.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}]}}