{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:54:15Z","timestamp":1780556055654,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.identj.2024.05.004","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T04:40:46Z","timestamp":1718080846000},"page":"1438-1446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Periodontitis and Preeclampsia: A Bidirectional Mendelian Randomisation Analysis"],"prefix":"10.1016","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1684-9629","authenticated-orcid":false,"given":"Jiao","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7387-3657","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.identj.2024.05.004_bib0001","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1177\/0022034520908533","article-title":"Global, regional, and national levels and trends in Burden of Oral Conditions from 1990 to 2017: a systematic analysis for the Global Burden of Disease 2017 Study","volume":"99","year":"2020","journal-title":"J Dent Res"},{"issue":"10159","key":"10.1016\/j.identj.2024.05.004_bib0002","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0140-6736(18)32225-6","volume":"392","year":"2018","journal-title":"Lancet"},{"issue":"10194","key":"10.1016\/j.identj.2024.05.004_bib0003","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: a global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.identj.2024.05.004_bib0004","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/prd.12202","article-title":"What exactly distinguishes aggressive from chronic periodontitis: is it mainly a difference in the degree of bacterial invasiveness?","volume":"75","author":"Van der Velden","year":"2017","journal-title":"Periodontol 2000"},{"issue":"4","key":"10.1016\/j.identj.2024.05.004_bib0005","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/jcpe.13266","article-title":"Global prevalence of aggressive periodontitis: a systematic review and meta-analysis","volume":"47","author":"Bouziane","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"1","key":"10.1016\/j.identj.2024.05.004_bib0006","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/prd.12435","article-title":"Viruses, periodontitis, and comorbidities","volume":"89","author":"Teles","year":"2022","journal-title":"Periodontol 2000"},{"issue":"1","key":"10.1016\/j.identj.2024.05.004_bib0007","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12344","article-title":"Clinical and public health implications of periodontal and systemic diseases: an overview","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontol 2000"},{"issue":"B","key":"10.1016\/j.identj.2024.05.004_bib0008","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3889\/oamjms.2021.7601","article-title":"Oral anaerobic microflora and pregnancy complication","volume":"9","author":"Andonova","year":"2021","journal-title":"Open Access Maced J Med Sci"},{"issue":"6","key":"10.1016\/j.identj.2024.05.004_bib0009","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/AOG.0000000000003892","article-title":"Gestational hypertension and preeclampsia: ACOG practice bulletin summary, number 222","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"10297","key":"10.1016\/j.identj.2024.05.004_bib0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0140-6736(20)32335-7","article-title":"Pre-eclampsia","volume":"398","author":"Chappell","year":"2021","journal-title":"Lancet"},{"issue":"19","key":"10.1016\/j.identj.2024.05.004_bib0011","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMra2109523","article-title":"Preeclampsia","volume":"386","author":"Magee","year":"2022","journal-title":"N Engl J Med"},{"issue":"2S","key":"10.1016\/j.identj.2024.05.004_bib0012","doi-asserted-by":"crossref","first-page":"S844","DOI":"10.1016\/j.ajog.2021.11.1356","article-title":"The etiology of preeclampsia","volume":"226","author":"Jung","year":"2022","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.identj.2024.05.004_bib0013","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41572-023-00417-6","article-title":"Pre-eclampsia","volume":"9","author":"Dimitriadis","year":"2023","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"10.1016\/j.identj.2024.05.004_bib0014","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1447-0756.2012.01957.x","article-title":"Association of maternal periodontal health with adverse pregnancy outcome","volume":"39","author":"Kumar","year":"2013","journal-title":"J Obstet Gynaecol Res"},{"issue":"11","key":"10.1016\/j.identj.2024.05.004_bib0015","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1902\/jop.2012.110256","article-title":"Periodontitis as a risk factor for preeclampsia","volume":"83","author":"Moura da Silva","year":"2012","journal-title":"J Periodontol"},{"issue":"3","key":"10.1016\/j.identj.2024.05.004_bib0016","doi-asserted-by":"crossref","first-page":"321","DOI":"10.4103\/0972-124X.134569","article-title":"Poor periodontal health as a risk factor for development of pre-eclampsia in pregnant women","volume":"18","author":"Varshney","year":"2014","journal-title":"J Indian Soc Periodontol"},{"issue":"5","key":"10.1016\/j.identj.2024.05.004_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2009.03.003","article-title":"Periodontal disease and adverse pregnancy outcomes: is there an association?","volume":"200","author":"Srinivas","year":"2009","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.identj.2024.05.004_bib0018","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1902\/jop.2011.110342","article-title":"Periodontal disease is not associated with preeclampsia in Canadian pregnant women","volume":"83","author":"Taghzouti","year":"2012","journal-title":"J Periodontol"},{"issue":"4 Suppl","key":"10.1016\/j.identj.2024.05.004_bib0019","first-page":"S164","article-title":"Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","volume":"84","author":"Sanz","year":"2013","journal-title":"J Periodontol"},{"issue":"6","key":"10.1016\/j.identj.2024.05.004_bib0020","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/aogs.14529","article-title":"Oral and periodontal assessment at the first trimester of pregnancy: the PERISCOPE longitudinal study","volume":"102","author":"Thomas","year":"2023","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.identj.2024.05.004_bib0021","doi-asserted-by":"crossref","first-page":"k601","DOI":"10.1136\/bmj.k601","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"BMJ"},{"issue":"11","key":"10.1016\/j.identj.2024.05.004_bib0022","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"10","key":"10.1016\/j.identj.2024.05.004_bib0023","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1681\/ASN.2020121760","article-title":"Mendelian randomization analysis as a tool to gain insights into causes of diseases: a primer","volume":"32","author":"Tin","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.identj.2024.05.004_bib0024","doi-asserted-by":"crossref","first-page":"n2233","DOI":"10.1136\/bmj.n2233","article-title":"Strengthening the reporting of observational studies in epidemiology using Mendelian randomisation (STROBE-MR): explanation and elaboration","volume":"375","author":"Skrivankova","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.identj.2024.05.004_bib0025","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1038\/s41467-019-10630-1","article-title":"Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data","volume":"10","author":"Shungin","year":"2019","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.identj.2024.05.004_bib0026","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/jcpe.12154","article-title":"Genome-wide association study of chronic periodontitis in a general German population","volume":"40","author":"Teumer","year":"2013","journal-title":"J Clin Periodontol"},{"issue":"13","key":"10.1016\/j.identj.2024.05.004_bib0027","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1093\/hmg\/ddx151","article-title":"A genome-wide association study identifies nucleotide variants at SIGLEC5 and DEFA1A3 as risk loci for periodontitis","volume":"26","author":"Munz","year":"2017","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.identj.2024.05.004_bib0028","article-title":"No genetic causal association between periodontitis and arthritis: a bidirectional two-sample Mendelian randomization analysis","volume":"13","author":"Yin","year":"2022","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.identj.2024.05.004_bib0029","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"4","key":"10.1016\/j.identj.2024.05.004_bib0030","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/ije\/dyy101","article-title":"Improving the visualization, interpretation and analysis of two-sample summary data Mendelian randomization via the radial plot and radial regression","volume":"47","author":"Bowden","year":"2018","journal-title":"Int J Epidemiol"},{"issue":"5","key":"10.1016\/j.identj.2024.05.004_bib0031","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"issue":"4","key":"10.1016\/j.identj.2024.05.004_bib0032","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"6","key":"10.1016\/j.identj.2024.05.004_bib0033","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1093\/ije\/dyx102","article-title":"Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption","volume":"46","author":"Hartwig","year":"2017","journal-title":"Int J Epidemiol"},{"issue":"21","key":"10.1016\/j.identj.2024.05.004_bib0034","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1002\/sim.6522","article-title":"Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome","volume":"34","author":"Greco","year":"2015","journal-title":"Stat Med"},{"issue":"5","key":"10.1016\/j.identj.2024.05.004_bib0035","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.identj.2024.05.004_bib0036","first-page":"1961","article-title":"Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic","volume":"45","author":"Bowden","year":"2016","journal-title":"Int J Epidemiol"},{"issue":"16","key":"10.1016\/j.identj.2024.05.004_bib52","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.identj.2024.05.004_bib0037","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jogc.2016.02.012","article-title":"Periodontal disease and adverse pregnancy outcomes: a prospective study in a low-risk population","volume":"38","author":"Soucy-Gigu\u00e8re","year":"2016","journal-title":"J Obstet Gynaecol Can"},{"issue":"3","key":"10.1016\/j.identj.2024.05.004_bib0038","doi-asserted-by":"crossref","first-page":"601","DOI":"10.4314\/ahs.v18i3.18","article-title":"The association between periodontal disease and adverse pregnancy outcomes in Northern Tanzania: a cross-sectional study","volume":"18","author":"Gesase","year":"2018","journal-title":"Afr Health Sci"},{"issue":"1","key":"10.1016\/j.identj.2024.05.004_bib0039","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/prd.12295","article-title":"Periodontal diseases and adverse pregnancy outcomes: mechanisms","volume":"83","author":"Figuero","year":"2020","journal-title":"Periodontol 2000"},{"issue":"1","key":"10.1016\/j.identj.2024.05.004_bib0040","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/prd.12294","article-title":"Periodontal disease and adverse pregnancy outcomes","volume":"83","author":"Bobetsis","year":"2020","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.identj.2024.05.004_bib0041","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1070917","article-title":"The bidirectional relationship between periodontal disease and pregnancy via the interaction of oral microorganisms, hormone and immune response","volume":"14","author":"Wen","year":"2023","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.identj.2024.05.004_bib0042","doi-asserted-by":"crossref","DOI":"10.1080\/14767058.2023.2183767","article-title":"Periodontitis & preeclampsia: were outer membrane vesicles a potential connection?","volume":"36","author":"Wang","year":"2023","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"7","key":"10.1016\/j.identj.2024.05.004_bib0043","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41579-023-00875-5","article-title":"Composition and functions of bacterial membrane vesicles","volume":"21","author":"Toyofuku","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.identj.2024.05.004_bib0044","article-title":"The role and mechanisms of Gram-negative bacterial outer membrane vesicles in inflammatory diseases","volume":"14","author":"Chen","year":"2023","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.identj.2024.05.004_bib0045","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1002\/jcp.31138","article-title":"Porphyromonas gingivalis outer membrane vesicles shape trophoblast cell metabolism impairing functions associated to adverse pregnancy outcome","volume":"238","author":"Lara","year":"2023","journal-title":"J Cell Physiol"},{"issue":"3","key":"10.1016\/j.identj.2024.05.004_bib0046","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1081\/PRG-200030334","article-title":"Tumor necrosis factor-alpha in whole blood cultures of preeclamptic patients and healthy pregnant and nonpregnant women","volume":"23","author":"Beckmann","year":"2004","journal-title":"Hypertens Pregnancy"},{"issue":"4","key":"10.1016\/j.identj.2024.05.004_bib0047","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1600-051X.2007.01173.x","article-title":"A systematic review and meta-analyses on C-reactive protein in relation to periodontitis","volume":"35","author":"Paraskevas","year":"2008","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2024.05.004_bib0048","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.bpobgyn.2016.03.008","article-title":"Polycystic ovary syndrome: endometrial markers","volume":"37","author":"Piltonen","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"12","key":"10.1016\/j.identj.2024.05.004_bib0049","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1056\/NEJM200103223441209","article-title":"Risk factors for preeclampsia","volume":"344","author":"Broughton Pipkin","year":"2001","journal-title":"N Engl J Med"},{"issue":"10022","key":"10.1016\/j.identj.2024.05.004_bib0050","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(15)00070-7","article-title":"Pre-eclampsia","volume":"387","author":"Mol","year":"2016","journal-title":"Lancet"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924001400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924001400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T08:03:36Z","timestamp":1730534616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653924001400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S0020653924001400"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2024.05.004","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association Between Periodontitis and Preeclampsia: A Bidirectional Mendelian Randomisation Analysis","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2024.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}]}}