{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:55:55Z","timestamp":1787630155091,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","award":["2022-1607"],"award-info":[{"award-number":["2022-1607"]}],"id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102221,81970981"],"award-info":[{"award-number":["82102221,81970981"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.identj.2024.05.013","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T23:08:34Z","timestamp":1723244914000},"page":"352-362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Novel Therapeutic Calcium Peroxide Loaded Injectable Bio-adhesive Hydrogel Against Periodontitis"],"prefix":"10.1016","volume":"75","author":[{"given":"Shaojie","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.identj.2024.05.013_bib0001","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int Dent J"},{"key":"10.1016\/j.identj.2024.05.013_bib0002","first-page":"34","article-title":"Periodontal diagnostics","volume":"15","author":"Kinane","year":"2000","journal-title":"Ann R Australas Coll Dent Surg"},{"issue":"1","key":"10.1016\/j.identj.2024.05.013_bib0003","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.amepre.2022.08.006","article-title":"Oral health and mortality among older adults: a doubly robust survival analysis","volume":"64","author":"Yu","year":"2023","journal-title":"Am J Prevent Med"},{"key":"10.1016\/j.identj.2024.05.013_bib0004","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0757.2012.00457.x","article-title":"Risk factors for periodontal disease","volume":"62","author":"Genco","year":"2013","journal-title":"Periodontology 2000"},{"key":"10.1016\/j.identj.2024.05.013_bib0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13290","article-title":"Treatment of stage I-III periodontitis\u2014the EFP S3 level clinical practice guideline","volume":"47","author":"Sanz","year":"2020","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2024.05.013_bib0006","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.apcsb.2019.12.001","article-title":"Roles of Porphyromonas gingivalis and its virulence factors in periodontitis","volume":"120","author":"Xu","year":"2020","journal-title":"Adv Protein Chem Struct Biol"},{"issue":"1","key":"10.1016\/j.identj.2024.05.013_bib0007","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","article-title":"Periodontitis and diabetes: a two-way relationship","volume":"55","author":"Preshaw","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.identj.2024.05.013_bib0008","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1034\/j.1600-051X.29.s3.1.x","article-title":"Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review","volume":"29","author":"Mombelli","year":"2002","journal-title":"J Clin Periodontol"},{"issue":"4","key":"10.1016\/j.identj.2024.05.013_bib0009","first-page":"359","article-title":"Progress in mechanism of Porphyromonas gingivalis immune escape","volume":"28","author":"Luo","year":"2012","journal-title":"Immunol J"},{"issue":"4","key":"10.1016\/j.identj.2024.05.013_bib0010","first-page":"404","article-title":"Periodontitis, Porphyromonas gingivalis y su relaci\u00f3n con la expresi\u00f3n de quorum sensing X1\u2014periodontitis, Porphyromonas gingivalis and its relation to quorum sensing expression","volume":"47","author":"D\u00edaz Caballero","year":"2010","journal-title":"Revista Cubana de Estomatolog\u00eda"},{"issue":"4","key":"10.1016\/j.identj.2024.05.013_bib0011","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4103\/0970-9290.167636","article-title":"Scope of photodynamic therapy in periodontics","volume":"26","author":"Kumar","year":"2015","journal-title":"Indian J Dent Res"},{"issue":"7","key":"10.1016\/j.identj.2024.05.013_bib0012","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41415-020-2173-7","article-title":"Evidence-based, personalised and minimally invasive treatment for periodontitis patients\u2014the new EFP S3-level clinical treatment guidelines","volume":"229","author":"Kebschull","year":"2020","journal-title":"Br Dent J"},{"issue":"1","key":"10.1016\/j.identj.2024.05.013_bib0013","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1139\/bcb-2020-0052","article-title":"Lactoferrin and oral pathologies: a therapeutic treatment","volume":"99","author":"Rosa","year":"2021","journal-title":"Biochem Cell Biol"},{"issue":"1","key":"10.1016\/j.identj.2024.05.013_bib0014","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12967-022-03487-4","article-title":"Advances of exosomes in periodontitis treatment","volume":"20","author":"Lin","year":"2022","journal-title":"J Translat Med"},{"issue":"7","key":"10.1016\/j.identj.2024.05.013_bib0015","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1002\/adma.201405166","article-title":"Novel mussel-inspired injectable self-healing hydrogel with anti-biofouling property","volume":"27","author":"Li","year":"2015","journal-title":"Adv Mater"},{"issue":"5","key":"10.1016\/j.identj.2024.05.013_bib0016","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1021\/acsnano.5b01433","article-title":"Nanocomposite hydrogels: 3D polymer-nanoparticle synergies for on-demand drug delivery","volume":"9","author":"Merino","year":"2015","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.identj.2024.05.013_bib0017","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.actbio.2009.06.015","article-title":"Chemico-physical characterization of gelatin films modified with oxidized alginate","volume":"6","author":"Boanini","year":"2010","journal-title":"Acta Biomater"},{"key":"10.1016\/j.identj.2024.05.013_bib0018","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.foodchem.2017.06.145","article-title":"The functional properties and application of gelatin derived from the skin of channel catfish (Ictalurus punctatus)","volume":"239","author":"Duan","year":"2018","journal-title":"Food Chem"},{"key":"10.1016\/j.identj.2024.05.013_bib0019","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.foodchem.2017.05.045","article-title":"Molecular interactions in gelatin\/chitosan composite films","volume":"235","author":"Qiao","year":"2017","journal-title":"Food Chem"},{"issue":"1","key":"10.1016\/j.identj.2024.05.013_bib0020","article-title":"Physical, mechanical, and barrier properties of sodium alginate\/gelatin emulsion based-films incorporated with canola oil","volume":"101","author":"Syarifuddin","year":"2017","journal-title":"IOP Conference Series Earth and Environmental Science"},{"issue":"4","key":"10.1016\/j.identj.2024.05.013_bib0021","first-page":"997","article-title":"Preparation and properties of gelatin\/sodium alginate (cross-linked with genipin) interpenetrating polymeric network films","volume":"32","author":"Liu","year":"2015","journal-title":"Acta Materiae Compositae Sinica"},{"key":"10.1016\/j.identj.2024.05.013_bib0022","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.msec.2019.02.091","article-title":"Alginate\/gelatin blended hydrogel fibers cross-linked by Ca2+ and oxidized starch: preparation and properties","volume":"99","author":"Wang","year":"2019","journal-title":"Mater Sci Eng"},{"key":"10.1016\/j.identj.2024.05.013_bib0023","doi-asserted-by":"crossref","first-page":"119900","DOI":"10.1016\/j.carbpol.2022.119900","article-title":"Double-network composites based on inorganic fillers reinforced dextran-based hydrogel with high strength","volume":"296","author":"Chen","year":"2022","journal-title":"Carbohydr Polym"},{"key":"10.1016\/j.identj.2024.05.013_bib0024","doi-asserted-by":"crossref","first-page":"567","DOI":"10.2147\/IDR.S142397","article-title":"Antimicrobial use of reactive oxygen therapy: current insights","volume":"11","author":"Memar","year":"2018","journal-title":"Infect Drug Resist"},{"issue":"4","key":"10.1016\/j.identj.2024.05.013_bib0025","first-page":"1323","article-title":"Periodontal disease in diabetic patients\u2014clinical and histopathological aspects","volume":"57","author":"Puscu","year":"2016","journal-title":"Roman J Morphol Embryol"},{"issue":"1","key":"10.1016\/j.identj.2024.05.013_bib0026","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12344","article-title":"Clinical and public health implications of periodontal and systemic diseases: an overview","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontology 2000"},{"issue":"4","key":"10.1016\/j.identj.2024.05.013_bib0027","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.oooo.2021.07.007","article-title":"Demographic, cardiological, microbiologic, and dental profiles of Brazilian patients who developed oral bacteria-related endocarditis","volume":"132","author":"Montano","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol,"},{"key":"10.1016\/j.identj.2024.05.013_bib0028","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1111\/jcpe.12089","article-title":"Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases","volume":"40","author":"Tonetti","year":"2013","journal-title":"J Clin Periodontol"},{"issue":"12","key":"10.1016\/j.identj.2024.05.013_bib0029","first-page":"mgen000905","article-title":"Genome-wide association studies reveal distinct genetic correlates and increased heritability of antimicrobial resistance in Vibrio cholerae under anaerobic conditions","volume":"8","author":"Creasy-Marrazzo","year":"2022","journal-title":"Microbial Genom"},{"key":"10.1016\/j.identj.2024.05.013_bib0030","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jcis.2022.08.125","article-title":"The combination of in situ photodynamic promotion and ion-interference to improve the efficacy of cancer therapy","volume":"629","author":"Yang","year":"2023","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.identj.2024.05.013_bib0031","doi-asserted-by":"crossref","first-page":"26835","DOI":"10.1038\/srep26835","article-title":"Decreased extracellular pH inhibits osteogenesis through proton-sensing GPR4-mediated suppression of yes-associated protein","volume":"6","author":"Tao","year":"2016","journal-title":"Scient Rep"},{"issue":"4","key":"10.1016\/j.identj.2024.05.013_bib0032","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101590","article-title":"Regulation of inflammatory response and osteogenesis to citrate-based biomaterials through incorporation of alkaline fragments","volume":"11","author":"Mao","year":"2022","journal-title":"Adv Healthcare Mater"},{"issue":"11","key":"10.1016\/j.identj.2024.05.013_bib0033","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1002\/jbm.a.36154","article-title":"Dissolution behavior of CaO-MgO-SiO2-based multiphase bioceramic powders and effects of the released ions on osteogenesis","volume":"105","author":"Zhang","year":"2017","journal-title":"J Biomed Mater Res Part A"},{"issue":"15","key":"10.1016\/j.identj.2024.05.013_bib0034","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1039\/C8TB00306H","article-title":"Microenvironment construction of strontium-calcium-based biomaterials for bone tissue regeneration: the equilibrium effect of calcium to strontium","volume":"6","author":"Xie","year":"2018","journal-title":"J Mater Chem B"},{"issue":"1","key":"10.1016\/j.identj.2024.05.013_bib0035","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/jre.12810","article-title":"Autophagy and its significance in periodontal disease","volume":"56","author":"Yang","year":"2021","journal-title":"J Periodontal Res"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924001503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924001503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T22:58:59Z","timestamp":1778626739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653924001503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0020653924001503"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2024.05.013","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Novel Therapeutic Calcium Peroxide Loaded Injectable Bio-adhesive Hydrogel Against Periodontitis","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2024.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}]}}