{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:28:08Z","timestamp":1793017688891,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.identj.2024.09.015","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T22:45:04Z","timestamp":1727822704000},"page":"605-612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Periodontitis and Hepatocellular Carcinoma: A Two-Sample Mendelian Randomisation Study"],"prefix":"10.1016","volume":"75","author":[{"given":"Irina","family":"Sergeeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanzhi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.identj.2024.09.015_bib0001","first-page":"S173","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.identj.2024.09.015_bib0002","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.identj.2024.09.015_bib0003","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int Dent J"},{"issue":"7","key":"10.1016\/j.identj.2024.09.015_bib0004","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"10.1016\/j.identj.2024.09.015_bib0005","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/prd.12431","article-title":"Association between periodontitis and chronic kidney disease","volume":"89","author":"Parsegian","year":"2022","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.identj.2024.09.015_bib0006","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3389\/fnins.2018.00483","article-title":"Implications of systemic inflammation and periodontitis for major depression","volume":"12","author":"Hashioka","year":"2018","journal-title":"Front Neurosci"},{"issue":"1","key":"10.1016\/j.identj.2024.09.015_bib0007","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1038\/s41572-020-00240-3","article-title":"Hepatocellular carcinoma","volume":"7","author":"Llovet","year":"2021","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"10.1016\/j.identj.2024.09.015_bib0008","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1002\/hep.32447","article-title":"Emerging immunotherapy for HCC: a guide for hepatologists","volume":"75","author":"Foerster","year":"2022","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.identj.2024.09.015_bib0009","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1016\/j.gendis.2022.04.003","article-title":"Application and progress of the detection technologies in hepatocellular carcinoma","volume":"10","author":"Yan","year":"2023","journal-title":"Genes Dis"},{"issue":"Suppl 1","key":"10.1016\/j.identj.2024.09.015_bib0010","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/hep.31288","article-title":"Epidemiology of hepatocellular carcinoma","volume":"73","author":"McGlynn","year":"2021","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.identj.2024.09.015_bib0011","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1093\/annonc\/mdx019","article-title":"Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis","volume":"28","author":"Maisonneuve","year":"2017","journal-title":"Ann Oncol"},{"issue":"10","key":"10.1016\/j.identj.2024.09.015_bib0012","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1902\/jop.2016.150597","article-title":"Periodontal disease and incident lung cancer risk: a meta-analysis of cohort studies","volume":"87","author":"Zeng","year":"2016","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.identj.2024.09.015_bib0013","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/epirev\/mxx006","article-title":"Periodontal disease, tooth loss, and cancer risk","volume":"39","author":"Michaud","year":"2017","journal-title":"Epidemiol Rev"},{"issue":"9","key":"10.1016\/j.identj.2024.09.015_bib0014","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1177\/2050640619858043","article-title":"The association between self-reported poor oral health and gastrointestinal cancer risk in the UK Biobank: a large prospective cohort study","volume":"7","author":"Jord\u00e3o","year":"2019","journal-title":"United European Gastroenterol J"},{"issue":"8","key":"10.1016\/j.identj.2024.09.015_bib0015","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s10552-017-0906-y","article-title":"Tooth loss and liver cancer incidence in a Finnish cohort","volume":"28","author":"Yang","year":"2017","journal-title":"Cancer Causes Control"},{"issue":"11","key":"10.1016\/j.identj.2024.09.015_bib0016","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/j.1600-051X.2011.01777.x","article-title":"Stage of hepatocellular carcinoma is associated with periodontitis","volume":"38","author":"Tamaki","year":"2011","journal-title":"J Clin Periodontol"},{"issue":"8","key":"10.1016\/j.identj.2024.09.015_bib0017","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1158\/1055-9965.EPI-17-0212","article-title":"Periodontal disease and incident cancer risk among postmenopausal women: results from the women's health initiative observational cohort","volume":"26","author":"Nwizu","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.identj.2024.09.015_bib0018","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1186\/1471-2458-13-814","article-title":"Association between tooth loss and orodigestive cancer mortality in an 80-year-old community-dwelling Japanese population: a 12-year prospective study","volume":"13","author":"Ansai","year":"2013","journal-title":"BMC Public Health"},{"issue":"11","key":"10.1016\/j.identj.2024.09.015_bib0019","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1902\/jop.2000.71.11.1699","article-title":"Evidence of a substantial genetic basis for risk of adult periodontitis","volume":"71","author":"Michalowicz","year":"2000","journal-title":"J Periodontol"},{"issue":"2","key":"10.1016\/j.identj.2024.09.015_bib0020","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jhep.2009.11.015","article-title":"Risk of HCC: genetic heterogeneity and complex genetics","volume":"52","author":"Dragani","year":"2010","journal-title":"J Hepatol"},{"issue":"19","key":"10.1016\/j.identj.2024.09.015_bib0021","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.identj.2024.09.015_bib0022","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.identj.2024.09.015_bib0023","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int J Epidemiol"},{"issue":"11","key":"10.1016\/j.identj.2024.09.015_bib0024","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1038\/s41588-021-00954-4","article-title":"A generalized linear mixed model association tool for biobank-scale data","volume":"53","author":"Jiang","year":"2021","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.identj.2024.09.015_bib0025","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.2041-1014.2012.00663.x","article-title":"Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology","volume":"27","author":"Hajishengallis","year":"2012","journal-title":"Mol Oral Microbiol"},{"issue":"2","key":"10.1016\/j.identj.2024.09.015_bib0026","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/0394632015586144","article-title":"The prevalence rate of Porphyromonas gingivalis and its association with cancer: a systematic review and meta-analysis","volume":"28","author":"Sayehmiri","year":"2015","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"3","key":"10.1016\/j.identj.2024.09.015_bib0027","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003933","article-title":"Oral bacteria and cancer","volume":"10","author":"Whitmore","year":"2014","journal-title":"PLoS Pathog"},{"issue":"1","key":"10.1016\/j.identj.2024.09.015_bib0028","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/prd.12427","article-title":"Periodontitis, chronic liver diseases, and the emerging oral-gut-liver axis","volume":"89","author":"Albuquerque-Souza","year":"2022","journal-title":"Periodontol 2000"},{"issue":"11","key":"10.1016\/j.identj.2024.09.015_bib0029","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1177\/0022034510375830","article-title":"Oxidative stress, systemic inflammation, and severe periodontitis","volume":"89","author":"D'Aiuto","year":"2010","journal-title":"J Dent Res"},{"issue":"5","key":"10.1016\/j.identj.2024.09.015_bib0030","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1093\/carcin\/bgs112","article-title":"Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality","volume":"33","author":"Ahn","year":"2012","journal-title":"Carcinogenesis"},{"issue":"5","key":"10.1016\/j.identj.2024.09.015_bib0031","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1158\/1055-9965.EPI-07-2761","article-title":"Teeth loss and risk of cancer at 14 common sites in Japanese","volume":"17","author":"Hiraki","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.identj.2024.09.015_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2017.07.003","article-title":"Different frequencies of Porphyromonas gingivalis infection in cancers of the upper digestive tract","volume":"404","author":"Yuan","year":"2017","journal-title":"Cancer Lett"},{"key":"10.1016\/j.identj.2024.09.015_bib0033","doi-asserted-by":"crossref","first-page":"n2233","DOI":"10.1136\/bmj.n2233","article-title":"Strengthening the reporting of observational studies in epidemiology using Mendelian randomisation (STROBE-MR): explanation and elaboration","volume":"375","author":"Skrivankova","year":"2021","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.identj.2024.09.015_bib0034","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1007\/s00784-021-04000-9","article-title":"Periodontitis and pulmonary function: a Mendelian randomization study","volume":"25","author":"Baumeister","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.identj.2024.09.015_bib0035","article-title":"A Mendelian randomisation analysis reveals no relationship between periodontitis and coronary atherosclerosis","author":"Li","year":"2024","journal-title":"Int Dent J"},{"issue":"1","key":"10.1016\/j.identj.2024.09.015_bib0036","doi-asserted-by":"crossref","first-page":"18620","DOI":"10.1038\/s41598-023-45527-z","article-title":"Deciphering genetic causality between inflammatory bowel disease and periodontitis through bi-directional two-sample Mendelian randomization","volume":"13","author":"Yu","year":"2023","journal-title":"Sci Rep"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002065392401503X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002065392401503X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T12:54:51Z","timestamp":1748955291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002065392401503X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S002065392401503X"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2024.09.015","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Periodontitis and Hepatocellular Carcinoma: A Two-Sample Mendelian Randomisation Study","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2024.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}]}}