{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T17:41:48Z","timestamp":1789839708167,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.identj.2024.11.010","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T12:26:43Z","timestamp":1736425603000},"page":"1420-1430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Pyrroloquinazoline Analogue Regulated Streptococcus mutans and Streptococcus sanguinis Dual-Species Biofilms"],"prefix":"10.1016","volume":"75","author":[{"given":"Keke","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaozhe","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangzheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihuai","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.identj.2024.11.010_bib0001","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10140-018-01663-y","article-title":"Dental caries on CT in the ER population: prevalence and reporting practices","volume":"26","author":"Brandfass","year":"2019","journal-title":"Emerg Radiol"},{"key":"10.1016\/j.identj.2024.11.010_bib0002","article-title":"Influence of fluoride-resistant Streptococcus mutans within antagonistic dual-species biofilms under fluoride in vitro","volume":"12","author":"Zhang","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.identj.2024.11.010_bib0003","doi-asserted-by":"crossref","first-page":"17030","DOI":"10.1038\/nrdp.2017.30","article-title":"Dental caries","volume":"3","author":"Pitts","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.identj.2024.11.010_bib0004","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/s41396-020-00823-8","article-title":"Candida albicans promotes tooth decay by inducing oral microbial dysbiosis","volume":"15","author":"Du","year":"2021","journal-title":"ISME J"},{"issue":"Suppl 1","key":"10.1016\/j.identj.2024.11.010_bib0005","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000377732","article-title":"Ecological approaches to oral biofilms: control without killing","volume":"49","author":"Marsh","year":"2015","journal-title":"Caries Res"},{"issue":"21","key":"10.1016\/j.identj.2024.11.010_bib0006","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01262-20","article-title":"Competition and caries on enamel of a dual-species biofilm model with Streptococcus mutans and Streptococcus sanguinis","volume":"86","author":"Diaz-Garrido","year":"2020","journal-title":"Appl Environ Microbiol"},{"issue":"6","key":"10.1016\/j.identj.2024.11.010_bib0007","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1159\/000159608","article-title":"Streptococcus mutans and Streptococcus sanguinis colonization correlated with caries experience in children","volume":"42","author":"Ge","year":"2008","journal-title":"Caries Res"},{"issue":"2","key":"10.1016\/j.identj.2024.11.010_bib0008","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000260196","article-title":"Establishment and symbiosis of Actinomyces viscosus, Streptococcus sanguis and Streptococcus mutans in germ-free osborne-mendel rats","volume":"10","author":"Mikx","year":"1976","journal-title":"Caries Res"},{"issue":"7","key":"10.1016\/j.identj.2024.11.010_bib0009","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1128\/IAI.68.7.4018-4023.2000","article-title":"Natural history of Streptococcus sanguinis in the oral cavity of infants: evidence for a discrete window of infectivity","volume":"68","author":"Caufield","year":"2000","journal-title":"Infect Immun"},{"issue":"21","key":"10.1016\/j.identj.2024.11.010_bib0010","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1128\/JB.187.21.7193-7203.2005","article-title":"Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm","volume":"187","author":"Kreth","year":"2005","journal-title":"J Bacteriol"},{"issue":"4","key":"10.1016\/j.identj.2024.11.010_bib0011","doi-asserted-by":"crossref","first-page":"281","DOI":"10.17796\/1053-4628-40.4.281","article-title":"Association between S. mutans and S. sanguinis in severe early childhood caries and caries-free children a quantitative real-time PCR analysis","volume":"40","author":"Mitrakul","year":"2016","journal-title":"J Clin Pediatr Dent"},{"issue":"2","key":"10.1016\/j.identj.2024.11.010_bib0012","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/1574-6968.12317","article-title":"Effect of nicotine on dual-species biofilms of Streptococcus mutans and Streptococcus sanguinis","volume":"350","author":"Li","year":"2014","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.identj.2024.11.010_bib0013","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/1950790","article-title":"Effects of norspermidine on dual-species biofilms composed of Streptococcus mutans and Streptococcus sanguinis","volume":"2019","author":"Sun","year":"2019","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.identj.2024.11.010_bib0014","article-title":"The inhibitory effects of ficin on Streptococcus mutans biofilm formation","volume":"2021","author":"Sun","year":"2021","journal-title":"Biomed Res Int"},{"issue":"14","key":"10.1016\/j.identj.2024.11.010_bib0015","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0960-894X(99)00339-X","article-title":"Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists","volume":"9","author":"Ahn","year":"1999","journal-title":"Bioorg Med Chem Lett"},{"issue":"15","key":"10.1016\/j.identj.2024.11.010_bib0016","doi-asserted-by":"crossref","first-page":"7766","DOI":"10.1158\/0008-5472.CAN-05-3897","article-title":"Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation","volume":"66","author":"Goerge","year":"2006","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.identj.2024.11.010_bib0017","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.3892\/mmr.2017.6303","article-title":"PAR1-mediated c-Jun activation promotes heat stress-induced early stage apoptosis of human umbilical vein endothelial cells","volume":"15","author":"Zhang","year":"2017","journal-title":"Mol Med Rep"},{"issue":"6","key":"10.1016\/j.identj.2024.11.010_bib0018","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/jac\/dky033","article-title":"SCH79797 improves outcomes in experimental bacterial pneumonia by boosting neutrophil killing and direct antibiotic activity","volume":"73","author":"Gupta","year":"2018","journal-title":"J Antimicrob Chemother"},{"issue":"7","key":"10.1016\/j.identj.2024.11.010_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.05.005","article-title":"A dual-mechanism antibiotic kills gram-negative bacteria and avoids drug resistance","volume":"181","author":"Martin","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.identj.2024.11.010_bib0020","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2022.2061113","article-title":"The suppression effect of SCH-79797 on Streptococcus mutans biofilm formation","volume":"14","author":"Zhang","year":"2022","journal-title":"J Oral Microbiol"},{"issue":"11","key":"10.1016\/j.identj.2024.11.010_bib0021","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3390\/nu9111242","article-title":"Effect of a Lactobacillus Salivarius probiotic on a double-species Streptococcus mutans and Candida abicans caries biofilm","volume":"9","author":"Krzy\u015bciak","year":"2017","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.identj.2024.11.010_bib0022","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/mabi.201200214","article-title":"Effect of polymer degree of conversion on Streptococcus mutans biofilms","volume":"12","author":"Kraigsley","year":"2012","journal-title":"Macromol Biosci"},{"issue":"1","key":"10.1016\/j.identj.2024.11.010_bib0023","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1128\/AAC.00919-15","article-title":"Molecule targeting glucosyltransferase inhibits Streptococcus mutans biofilm formation and virulence","volume":"60","author":"Ren","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"10.1016\/j.identj.2024.11.010_bib0024","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1128\/AEM.01299-08","article-title":"Structural and molecular basis of the role of starch and sucrose in Streptococcus mutans biofilm development","volume":"75","author":"Klein","year":"2009","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"10.1016\/j.identj.2024.11.010_bib0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000324084","article-title":"Effect of Galla chinensis on growth and metabolism of microcosm biofilms","volume":"45","author":"Cheng","year":"2011","journal-title":"Caries Res"},{"issue":"9","key":"10.1016\/j.identj.2024.11.010_bib0026","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/0022034513498598","article-title":"Involvement of gshAB in the interspecies competition within oral biofilm","volume":"92","author":"Zheng","year":"2013","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.identj.2024.11.010_bib0027","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3390\/pathogens11010070","article-title":"Regulatory effect of Irresistin-16 on competitive dual-species biofilms composed of Streptococcus mutans and Streptococcus sanguinis","volume":"11","author":"Hu","year":"2022","journal-title":"Pathogens"},{"issue":"3","key":"10.1016\/j.identj.2024.11.010_bib0028","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10103-019-02903-4","article-title":"Exposure of Streptococcus mutans and Streptococcus sanguinis to blue light in an oral biofilm model","volume":"35","author":"Vaknin","year":"2019","journal-title":"Lasers Med Sci"},{"issue":"2","key":"10.1016\/j.identj.2024.11.010_bib0029","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000490950","article-title":"Streptococcus mutans and Streptococcus sanguinis expression of competition-related genes, under sucrose","volume":"53","author":"Lozano","year":"2019","journal-title":"Caries Res"},{"issue":"15","key":"10.1016\/j.identj.2024.11.010_bib0030","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00496-17","article-title":"Effects of arginine on Streptococcus mutans growth, virulence gene expression, and stress tolerance","volume":"83","author":"Chakraborty","year":"2017","journal-title":"Appl Environ Microbiol"},{"issue":"3","key":"10.1016\/j.identj.2024.11.010_bib0031","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1128\/IAI.74.3.1631-1642.2006","article-title":"Multilevel control of competence development and stress tolerance in Streptococcus mutans UA159","volume":"74","author":"Ahn","year":"2016","journal-title":"Infect Immun"},{"issue":"4","key":"10.1016\/j.identj.2024.11.010_bib0032","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ijos.2016.34","article-title":"Alanine racemase is essential for the growth and interspecies competitiveness of Streptococcus mutans","volume":"8","author":"Wei","year":"2016","journal-title":"Int J Oral Sci"},{"issue":"4","key":"10.1016\/j.identj.2024.11.010_bib0033","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1159\/000447309","article-title":"Ecological hypothesis of dentin and root caries","volume":"50","author":"Takahashi","year":"2016","journal-title":"Caries Res"},{"issue":"Pt 2","key":"10.1016\/j.identj.2024.11.010_bib0034","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1099\/mic.0.25932-0","article-title":"Quantitative variation of biofilms among strains in natural populations of Candida albicans","volume":"149","author":"Li","year":"2003","journal-title":"Microbiology (Reading)"},{"issue":"3","key":"10.1016\/j.identj.2024.11.010_bib0035","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01637-21","article-title":"Improved formazan dissolution for bacterial MTT assay","volume":"9","author":"Benov","year":"2021","journal-title":"Microbiol Spectr"},{"issue":"3","key":"10.1016\/j.identj.2024.11.010_bib0036","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02076-21","article-title":"Raffinose inhibits Streptococcus mutans biofilm formation by targeting glucosyltransferase","volume":"10","author":"Ham","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.identj.2024.11.010_bib0037","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.3389\/fmicb.2018.01154","article-title":"A novel regulator modulates glucan production, cell aggregation and biofilm formation in Streptococcus sanguinis SK36","volume":"9","author":"Zhu","year":"2018","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.identj.2024.11.010_bib0038","article-title":"TetR family regulator brpT modulates biofilm formation in Streptococcus sanguinis","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.identj.2024.11.010_bib0039","doi-asserted-by":"crossref","first-page":"17183","DOI":"10.1038\/s41598-017-17383-1","article-title":"ciaR impacts biofilm formation by regulating an arginine biosynthesis pathway in Streptococcus sanguinis SK36","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.identj.2024.11.010_bib0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/omi.12044","article-title":"The effect of arginine on oral biofilm communities","volume":"29","author":"Nascimento","year":"2014","journal-title":"Mol Oral Microbiol"},{"issue":"5","key":"10.1016\/j.identj.2024.11.010_bib0041","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41396-020-0592-8","article-title":"Pyruvate secretion by oral streptococci modulates hydrogen peroxide dependent antagonism","volume":"14","author":"Redanz","year":"2020","journal-title":"ISME J"},{"issue":"7","key":"10.1016\/j.identj.2024.11.010_bib0042","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/antibiotics11070970","article-title":"Activation of a bacterial mechanosensitive channel, MscL, underlies the membrane permeabilization of dual-targeting antibacterial compounds","volume":"11","author":"Wray","year":"2022","journal-title":"Antibiotics (Basel)"},{"issue":"1","key":"10.1016\/j.identj.2024.11.010_bib0043","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1038\/s41598-019-43081-1","article-title":"Effect of D-cysteine on dual-species biofilms of Streptococcus mutans and Streptococcus sanguinis","volume":"9","author":"Guo","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.identj.2024.11.010_bib0044","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/0022034514561259","article-title":"Combinatorial effects of arginine and fluoride on oral bacteria","volume":"94","author":"Zheng","year":"2015","journal-title":"J Dent Res"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924015958?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924015958?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:56:02Z","timestamp":1748969762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653924015958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0020653924015958"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2024.11.010","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Pyrroloquinazoline Analogue Regulated Streptococcus mutans and Streptococcus sanguinis Dual-Species Biofilms","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2024.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}]}}