{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:18:05Z","timestamp":1782821885762,"version":"3.54.5"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["[2021]215"],"award-info":[{"award-number":["[2021]215"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970783"],"award-info":[{"award-number":["31970783"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270888"],"award-info":[{"award-number":["32270888"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.identj.2024.11.016","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T16:11:02Z","timestamp":1734019862000},"page":"363-374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Bibliometric Analysis of Macrophage Research Associated with Periodontitis Over the Past Two Decades"],"prefix":"10.1016","volume":"75","author":[{"given":"Yu","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2579-8384","authenticated-orcid":false,"given":"Deqin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.identj.2024.11.016_bib0001","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/JPER.17-0377","article-title":"Influence of periodontal treatment on subgingival and salivary microbiotas","volume":"89","author":"Belstrom","year":"2018","journal-title":"J Periodontol"},{"issue":"Suppl 1","key":"10.1016\/j.identj.2024.11.016_bib0002","first-page":"S159","article-title":"Staging and grading of periodontitis: framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti","year":"2018","journal-title":"J Periodontol"},{"key":"10.1016\/j.identj.2024.11.016_bib0003","first-page":"1","article-title":"Impaired innate immune signaling due to combined Toll-like receptor 2 and 4 deficiency affects both periodontitis and atherosclerosis in response to polybacterial infection","volume":"76","author":"Chukkapalli","year":"2018","journal-title":"Pathog Dis"},{"key":"10.1016\/j.identj.2024.11.016_bib0004","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ismej.2012.174","article-title":"The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation","volume":"7","author":"Abusleme","year":"2013","journal-title":"ISME J"},{"key":"10.1016\/j.identj.2024.11.016_bib0005","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1177\/00220345211044681","article-title":"Trem1 induces periodontal inflammation via regulating M1 polarization","volume":"101","author":"Wu","year":"2022","journal-title":"J Dent Res"},{"key":"10.1016\/j.identj.2024.11.016_bib0006","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.intimp.2018.03.005","article-title":"Targeting macrophage immunometabolism: Dawn in the darkness of sepsis","volume":"58","author":"Kumar","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.identj.2024.11.016_bib0007","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.3389\/fimmu.2018.02379","article-title":"Pattern recognition receptors and the host cell death molecular machinery","volume":"9","author":"Amarante-Mendes","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.identj.2024.11.016_bib0008","doi-asserted-by":"crossref","first-page":"330","DOI":"10.3389\/fimmu.2020.00330","article-title":"Disruption of monocyte and macrophage homeostasis in periodontitis","volume":"11","author":"Almubarak","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.identj.2024.11.016_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.763334","article-title":"Polarized macrophages in periodontitis: characteristics, function, and molecular signaling","volume":"12","author":"Sun","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.identj.2024.11.016_bib0010","doi-asserted-by":"crossref","first-page":"e12973","DOI":"10.1111\/cpr.12973","article-title":"NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation","volume":"54","author":"Chen","year":"2021","journal-title":"Cell Prolif"},{"key":"10.1016\/j.identj.2024.11.016_bib0011","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1177\/0022034520913250","article-title":"Effects of sulfonylureas on periodontopathic bacteria-induced inflammation","volume":"99","author":"Kawahara","year":"2020","journal-title":"J Dent Res"},{"key":"10.1016\/j.identj.2024.11.016_bib0012","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s12951-022-01757-3","article-title":"Roles of extracellular vesicles in periodontal homeostasis and their therapeutic potential","volume":"20","author":"Deng","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.identj.2024.11.016_bib0013","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.18007","article-title":"A Bibliometric analysis of top-cited journal articles in obstetrics and gynecology","volume":"2","author":"Brandt","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.identj.2024.11.016_bib0014","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1089\/ars.2019.7952","article-title":"Reactive oxygen species and their impact in neurodegenerative diseases: literature landscape analysis","volume":"34","author":"Yeung","year":"2021","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.identj.2024.11.016_bib0015","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"van Eck","year":"2010","journal-title":"Scientometrics"},{"issue":"Suppl 1","key":"10.1016\/j.identj.2024.11.016_bib0016","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1073\/pnas.0307513100","article-title":"Searching for intellectual turning points: progressive knowledge domain visualization","volume":"101","author":"Chen","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.identj.2024.11.016_bib0017","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri3785","article-title":"Periodontitis: from microbial immune subversion to systemic inflammation","volume":"15","author":"Hajishengallis","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.identj.2024.11.016_bib0018","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/0022034518805984","article-title":"Induction of M2 macrophages prevents bone loss in murine periodontitis models","volume":"98","author":"Zhuang","year":"2019","journal-title":"J Dent Res"},{"key":"10.1016\/j.identj.2024.11.016_bib0019","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.archoralbio.2017.03.006","article-title":"Enhanced activity of macrophage M1\/M2 phenotypes in periodontitis","volume":"96","author":"Yang","year":"2018","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.identj.2024.11.016_bib0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41368-019-0064-z","article-title":"The cytokine network involved in the host immune response to periodontitis","volume":"11","author":"Pan","year":"2019","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.identj.2024.11.016_bib0021","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/odi.12983","article-title":"Macrophage polarization in human gingival tissue in response to periodontal disease","volume":"25","author":"Zhou","year":"2019","journal-title":"Oral Dis"},{"key":"10.1016\/j.identj.2024.11.016_bib0022","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/jcpe.13156","article-title":"Characterization of macrophage polarization in periodontal disease","volume":"46","author":"Garaicoa-Pazmino","year":"2019","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2024.11.016_bib0023","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1902\/jop.2016.160081","article-title":"Enhanced Activity of the Macrophage M1\/M2 phenotypes and phenotypic switch to M1 in periodontal infection","volume":"87","author":"Yu","year":"2016","journal-title":"J Periodontol"},{"key":"10.1016\/j.identj.2024.11.016_bib0024","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.identj.2024.11.016_bib0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12344","article-title":"Clinical and public health implications of periodontal and systemic diseases: an overview","volume":"83","author":"Genco","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.identj.2024.11.016_bib0026","unstructured":"National Health Commission of the People's Republic of China. 2019. Interpretation of oral health action plan (2019-2025). http:\/\/www.nhc.gov.cn\/jkj\/s5879\/201902\/b6d4468373db4c0285fcbde91b1e11a7.shtml. Accessed 28 October 2024."},{"key":"10.1016\/j.identj.2024.11.016_bib0027","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jare.2022.10.003","article-title":"SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis","volume":"50","author":"Wang","year":"2023","journal-title":"J Adv Res"},{"key":"10.1016\/j.identj.2024.11.016_bib0028","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10456-013-9381-6","article-title":"Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo","volume":"17","author":"Jetten","year":"2014","journal-title":"Angiogenesis"},{"key":"10.1016\/j.identj.2024.11.016_bib0029","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.4049\/jimmunol.2000692","article-title":"Interplay between NOD1 and TLR4 receptors in macrophages: nonsynergistic activation of signaling pathways results in synergistic induction of proinflammatory gene expression","volume":"206","author":"Budikhina","year":"2021","journal-title":"J Immunol"},{"key":"10.1016\/j.identj.2024.11.016_bib0030","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jss.2020.06.062","article-title":"Maresin1 promotes M2 Macrophage polarization through peroxisome proliferator-activated receptor-gamma activation to expedite resolution of acute lung injury","volume":"256","author":"Qiao","year":"2020","journal-title":"J Surg Res"},{"key":"10.1016\/j.identj.2024.11.016_bib0031","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1096\/fj.201601222R","article-title":"Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms","volume":"31","author":"Serhan","year":"2017","journal-title":"FASEB J"},{"key":"10.1016\/j.identj.2024.11.016_bib0032","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12250","article-title":"Cellular therapy in periodontal regeneration","volume":"79","author":"Nunez","year":"2019","journal-title":"Periodontol"},{"key":"10.1016\/j.identj.2024.11.016_bib0033","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/sctm.18-0181","article-title":"Concise review: periodontal tissue regeneration using stem cells: strategies and translational considerations","volume":"8","author":"Xu","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.identj.2024.11.016_bib0034","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2020.06.009","article-title":"Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential","volume":"41","author":"Song","year":"2020","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.identj.2024.11.016_bib0035","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1327405","article-title":"Oral mesenchymal stem\/progenitor cells: the immunomodulatory masters","volume":"2020","author":"Zhou","year":"2020","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.identj.2024.11.016_bib0036","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13287-023-03242-6","article-title":"Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration","volume":"14","author":"Chen","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.identj.2024.11.016_bib0037","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s13287-019-1409-4","article-title":"Macrophage polarization in periodontal ligament stem cells enhanced periodontal regeneration","volume":"10","author":"Liu","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.identj.2024.11.016_bib0038","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1177\/0022034516657817","article-title":"DPSCs from inflamed pulp modulate macrophage function via the TNF-alpha\/IDO Axis","volume":"95","author":"Lee","year":"2016","journal-title":"J Dent Res"},{"key":"10.1016\/j.identj.2024.11.016_bib0039","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/0022034513513026","article-title":"Allogeneic bone marrow mesenchymal stem cell transplantation for periodontal regeneration","volume":"93","author":"Du","year":"2014","journal-title":"J Dent Res"},{"key":"10.1016\/j.identj.2024.11.016_bib0040","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13287-023-03287-7","article-title":"Mesenchymal stromal\/stem cell (MSC)-derived exosomes in clinical trials","volume":"14","author":"Lotfy","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.identj.2024.11.016_bib0041","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.semcancer.2020.08.007","article-title":"Extracellular vesicles as natural therapeutic agents and innate drug delivery systems for cancer treatment: recent advances, current obstacles, and challenges for clinical translation","volume":"80","author":"Pirisinu","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.identj.2024.11.016_bib0042","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.identj.2024.11.016_bib0043","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2147\/IJN.S350869","article-title":"Lipopolysaccharide-preconditioned dental follicle stem cells derived small extracellular vesicles treating periodontitis via reactive oxygen species\/mitogen-activated protein kinase signaling-mediated antioxidant effect","volume":"17","author":"Huang","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.identj.2024.11.016_bib0044","doi-asserted-by":"crossref","first-page":"20662","DOI":"10.1002\/jcp.28671","article-title":"Exosomal microRNA-155-5p from PDLSCs regulated Th17\/Treg balance by targeting sirtuin-1 in chronic periodontitis","volume":"234","author":"Zheng","year":"2019","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.identj.2024.11.016_bib0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106030","article-title":"Role of gingival mesenchymal stem cell exosomes in macrophage polarization under inflammatory conditions","volume":"81","author":"Wang","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.identj.2024.11.016_bib0046","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.actbio.2020.12.046","article-title":"Exosomes from TNF-alpha-treated human gingiva-derived MSCs enhance M2 macrophage polarization and inhibit periodontal bone loss","volume":"122","author":"Nakao","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.identj.2024.11.016_bib0047","first-page":"1113","article-title":"Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism","volume":"5","author":"Shen","year":"2020","journal-title":"Bioact Mater"},{"key":"10.1016\/j.identj.2024.11.016_bib0048","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1089\/ten.tea.2020.0141","article-title":"Bone marrow mesenchymal stem cell-derived small extracellular vesicles promote periodontal regeneration","volume":"27","author":"Liu","year":"2021","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.identj.2024.11.016_bib0049","article-title":"Melatonin engineering M2 macrophage-derived exosomes mediate endoplasmic reticulum stress and immune reprogramming for periodontitis therapy","volume":"10","author":"Cui","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.identj.2024.11.016_bib0050","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.identj.2024.11.016_bib0051","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb2878","article-title":"Interference with pancreatic sympathetic signaling halts the onset of diabetes in mice","volume":"6","author":"Christoffersson","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.identj.2024.11.016_bib0052","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1182\/blood-2016-11-753202","article-title":"Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice","volume":"129","author":"Chen","year":"2017","journal-title":"Blood"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924016113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924016113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:27:03Z","timestamp":1778639223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653924016113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0020653924016113"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2024.11.016","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Bibliometric Analysis of Macrophage Research Associated with Periodontitis Over the Past Two Decades","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2024.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}]}}