{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:58:12Z","timestamp":1789509492498,"version":"build-2803163510"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.identj.2024.11.017","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T12:21:45Z","timestamp":1736770905000},"page":"1068-1080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Toothpaste Containing Polylysine and Funme Peptide on Oral Microbiome and Oral Health"],"prefix":"10.1016","volume":"75","author":[{"given":"Xu","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengfan","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.identj.2024.11.017_bib0001","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tim.2005.09.006","article-title":"Oral microbial communities in sickness and in health","volume":"13","author":"Jenkinson","year":"2005","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.identj.2024.11.017_bib0002","doi-asserted-by":"crossref","first-page":"E791","DOI":"10.1073\/pnas.1522149113","article-title":"Biogeography of a human oral microbiome at the micron scale","volume":"113","author":"Mark Welch","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.identj.2024.11.017_bib0003","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41368-022-00163-7","article-title":"Oral microbiota in human systematic diseases","volume":"14","author":"Peng","year":"2022","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.identj.2024.11.017_bib0004","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.cden.2010.03.002","article-title":"Microbiology of dental plaque biofilms and their role in oral health and caries","volume":"54","author":"Marsh","year":"2010","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.identj.2024.11.017_bib0005","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1021\/acsinfecdis.9b00365","article-title":"Cariogenic streptococcus mutans produces tetramic acid strain-specific antibiotics that impair commensal colonization","volume":"6","author":"Tang","year":"2020","journal-title":"ACS Infect"},{"key":"10.1016\/j.identj.2024.11.017_bib0006","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/ijerph19010108","article-title":"The effect of mechanical tongue cleaning on oral malodor and tongue coating","volume":"19","author":"Choi","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.identj.2024.11.017_bib0007","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1111\/jre.12931","article-title":"Interdental and subgingival microbiota may affect the tongue microbial ecology and oral malodour in health, gingivitis and periodontitis","volume":"56","author":"Stephen","year":"2021","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.identj.2024.11.017_bib0008","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12951-023-02042-7","article-title":"Recent advances in metal nanoparticles to treat periodontitis","volume":"21","author":"Nasiri","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.identj.2024.11.017_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.111567","article-title":"Oral care product formulations, properties and challenges","volume":"200","author":"Aspinall","year":"2021","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.identj.2024.11.017_bib0010","doi-asserted-by":"crossref","first-page":"362","DOI":"10.4103\/jisp.jisp_340_19","article-title":"A comparative evaluation of manual and powered brushing on oral health and microbial status of mentally challenged individuals","volume":"24","author":"Vandana","year":"2020","journal-title":"J Indian Soc Periodontol"},{"key":"10.1016\/j.identj.2024.11.017_bib0011","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3764936","article-title":"The efficacy and safety of a herbal toothpaste in reducing gingivitis: a double-blind, randomized, placebo-controlled, parallel allocation clinical trial","volume":"2019","author":"He","year":"2019","journal-title":"Evid-Based Compl Alt"},{"key":"10.1016\/j.identj.2024.11.017_bib0012","first-page":"1","article-title":"Antimicrobial peptides: mechanism of action, activity and clinical potential","volume":"8","author":"Zhang","year":"2021","journal-title":"Mil Med Res"},{"key":"10.1016\/j.identj.2024.11.017_bib0013","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.3390\/pharmaceutics15092278","article-title":"The contribution of antimicrobial peptides to immune cell function: a review of recent advances","volume":"15","author":"Li","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.identj.2024.11.017_bib0014","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3390\/polym12061218","article-title":"Antibacterial effect of the natural polymer \u03b5-polylysine against oral pathogens associated with periodontitis and caries","volume":"12","author":"Dima","year":"2020","journal-title":"Polymers"},{"key":"10.1016\/j.identj.2024.11.017_bib0015","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.procbio.2006.03.013","article-title":"Optimization of cell growth and poly (\u025b-lysine) production in batch and fed-batch cultures by Streptomyces albulus IFO 14147","volume":"41","author":"Shih","year":"2006","journal-title":"Proc Biochem"},{"key":"10.1016\/j.identj.2024.11.017_bib0016","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13068-022-02166-2","article-title":"Recent advances in microbial \u03b5-poly-L-lysine fermentation and its diverse applications","volume":"15","author":"Li","year":"2022","journal-title":"Biotechnol Biofuels Bioprod"},{"key":"10.1016\/j.identj.2024.11.017_bib0017","doi-asserted-by":"crossref","first-page":"7758","DOI":"10.1128\/AEM.02204-14","article-title":"The antimicrobial mechanism of action of epsilon-poly-l-lysine","volume":"80","author":"Hyldgaard","year":"2014","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.identj.2024.11.017_bib0018","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1271\/bbb.110201","article-title":"Occurrence, biosynthesis, biodegradation, and industrial and medical applications of a naturally occurring \u03b5-poly-L-lysine","volume":"75","author":"Hamano","year":"2011","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.identj.2024.11.017_bib0019","doi-asserted-by":"crossref","first-page":"e14153","DOI":"10.1111\/jfpp.14153","article-title":"Review of the application of \u03b5-poly-L-lysine in improving food quality and preservation","volume":"43","author":"Tuersuntuoheti","year":"2019","journal-title":"J Food Process Preserv"},{"key":"10.1016\/j.identj.2024.11.017_bib0020","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1016\/j.ijbiomac.2018.07.094","article-title":"Effects of \u03b5-Poly-l-lysine on the cell wall of saccharomyces cerevisiae and its involved antimicrobial mechanism","volume":"118","author":"Tan","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.identj.2024.11.017_bib0021","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.foodres.2018.08.030","article-title":"Antibacterial activity and its mechanisms of a recombinant Funme peptide against cronobacter sakazakii in powdered infant formula","volume":"116","author":"Chen","year":"2019","journal-title":"Food Res Int"},{"key":"10.1016\/j.identj.2024.11.017_bib0022","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1002\/imt2.23","article-title":"The sampling strategy of oral microbiome","volume":"1","author":"Lu","year":"2022","journal-title":"Imeta"},{"key":"10.1016\/j.identj.2024.11.017_bib0023","doi-asserted-by":"crossref","DOI":"10.1002\/VIW.20230118","article-title":"Succession of the oral microbiome with the increasing severity of periodontitis","volume":"5","author":"Mi","year":"2024","journal-title":"View"},{"key":"10.1016\/j.identj.2024.11.017_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-021-02094-5","article-title":"Full-length 16S rRNA gene amplicon analysis of human gut microbiota using MinION\u2122 nanopore sequencing confers species-level resolution","volume":"21","author":"Matsuo","year":"2021","journal-title":"BMC microbiol"},{"key":"10.1016\/j.identj.2024.11.017_bib0025","first-page":"41","article-title":"Clinical method for evaluating the anti-halitosis effect of oral healthcare products","volume":"32","year":"2022","journal-title":"Oral Care Industry"},{"key":"10.1016\/j.identj.2024.11.017_bib0026","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2147\/CCIDE.S257411","article-title":"Efficacy of a hybrid toothbrush versus comparative manual toothbrush for plaque removal\u2013randomized in-use study","volume":"12","author":"Favrel","year":"2020","journal-title":"Clin Cosmet Investig Dent"},{"key":"10.1016\/j.identj.2024.11.017_bib0027","doi-asserted-by":"crossref","first-page":"e16161","DOI":"10.1016\/j.heliyon.2023.e16161","article-title":"Effects of modified triangular flap for third molar extraction on distal periodontal health of second molar: a randomized controlled study","volume":"9","author":"Zhao","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.identj.2024.11.017_bib0028","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jpor.2017.06.006","article-title":"The effects of lactobacillus reuteri probiotics combined with azithromycin on peri-implantitis: a randomized placebo-controlled study","volume":"62","author":"Tada","year":"2018","journal-title":"J Prosthodont Res"},{"key":"10.1016\/j.identj.2024.11.017_bib0029","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/iej.14043","article-title":"Harnessing antimicrobial peptides in endodontics","volume":"57","author":"Kong","year":"2024","journal-title":"Int Endod J"},{"key":"10.1016\/j.identj.2024.11.017_bib0030","doi-asserted-by":"crossref","DOI":"10.1002\/anbr.202300080","article-title":"The high potential of \u03b5-Poly-l-Lysine for the development of antimicrobial biomaterials","volume":"3","author":"Lebaudy","year":"2023","journal-title":"Adv Nanobiomed Res"},{"key":"10.1016\/j.identj.2024.11.017_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164653","article-title":"Dental composites with calcium\/strontium phosphates and polylysine","volume":"11","author":"Panpisut","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.identj.2024.11.017_bib0032","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3390\/app9030557","article-title":"Peptide mediated antimicrobial dental adhesive system","volume":"9","author":"Xie","year":"2019","journal-title":"Appl Sci"},{"key":"10.1016\/j.identj.2024.11.017_bib0033","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7258380","article-title":"Comparative evaluation of combinatory interaction between endocannabinoid system compounds and poly-L-lysine against Streptococcus mutans growth and biofilm formation","volume":"2020","author":"Feldman","year":"2020","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.identj.2024.11.017_bib0034","first-page":"1","article-title":"Functional mechanism of antimicrobial peptide bomidin and its safety for macrobrachium rosenbergii","author":"Zhang","year":"2022","journal-title":"Probiotics Antimicro Prot"},{"key":"10.1016\/j.identj.2024.11.017_bib0035","article-title":"Bomidin: An optimized antimicrobial peptide with broad antiviral activity against enveloped viruses","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.identj.2024.11.017_bib0036","doi-asserted-by":"crossref","first-page":"14321","DOI":"10.3390\/ijms241814321","article-title":"Natural product-derived compounds for targeting multidrug resistance in cancer and microorganisms","volume":"24","author":"U Ferreira","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.identj.2024.11.017_bib0037","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.3390\/life12111740","article-title":"Combined therapy of probiotic microcapsules and bomidin in vibrio parahaemolyticus\u2013infected rats","volume":"12","author":"Zhou","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.identj.2024.11.017_bib0038","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1472-765X.2007.02157.x","article-title":"\u03b5-Poly-l-lysine and nisin a act synergistically against gram-positive food-borne pathogens bacillus cereus and listeria monocytogenes","volume":"45","author":"Najjar","year":"2007","journal-title":"Lett Appl Microbiol"},{"key":"10.1016\/j.identj.2024.11.017_bib0039","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3389\/fphar.2018.00281","article-title":"Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds","volume":"9","author":"Pfalzgraff","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.identj.2024.11.017_bib0040","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1039\/D1TB02617H","article-title":"Antimicrobial peptide-based materials: opportunities and challenges","volume":"10","author":"Rai","year":"2022","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.identj.2024.11.017_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111423","article-title":"Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis","volume":"127","author":"Wu","year":"2024","journal-title":"Int Immunopharmacol"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924016125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924016125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T16:56:15Z","timestamp":1748969775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653924016125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S0020653924016125"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2024.11.017","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of Toothpaste Containing Polylysine and Funme Peptide on Oral Microbiome and Oral Health","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2024.11.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}]}}