{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:11:16Z","timestamp":1787987476065,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2024BSSXM19"],"award-info":[{"award-number":["2024BSSXM19"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991502"],"award-info":[{"award-number":["81991502"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001047"],"award-info":[{"award-number":["82001047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81991500"],"award-info":[{"award-number":["81991500"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2021C03074"],"award-info":[{"award-number":["2021C03074"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017529","name":"Major Scientific and Technological Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017529","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.identj.2024.12.014","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T23:24:07Z","timestamp":1735601047000},"page":"2194-2203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Autoimmune Thyroid disease and Oral Lichen Planus: A Multi-Omic Genetic Analysis"],"prefix":"10.1016","volume":"75","author":[{"given":"Jie","family":"Ni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhou","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.identj.2024.12.014_bib0001","doi-asserted-by":"crossref","first-page":"970","DOI":"10.3390\/foods10050970","article-title":"Oral mucosa as a potential site for diagnosis and treatment of allergic and autoimmune diseases","volume":"10","author":"Gomez-Casado","year":"2021","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0002","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mucimm.2023.11.006","article-title":"Exploring the oral-gut linkage: Interrelationship between oral and systemic diseases","volume":"17","author":"Yamazaki","year":"2024","journal-title":"Mucosal Immunol"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0003","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40257-023-00814-3","article-title":"Oral lichen planus: an update on diagnosis and management","volume":"25","author":"Louisy","year":"2024","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.identj.2024.12.014_bib0004","first-page":"13","article-title":"Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment","author":"Deng","year":"2023","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.identj.2024.12.014_bib0005","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3390\/cancers16030608","article-title":"An evidence-based update on the potential for malignancy of oral lichen planus and related conditions: a systematic review and meta-analysis","volume":"16","author":"Gonz\u00e1lez-Moles","year":"2024","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.identj.2024.12.014_bib0006","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.it.2023.03.007","article-title":"Autoimmune thyroid diseases as a cost of physiological autoimmune surveillance","volume":"44","author":"Milo","year":"2023","journal-title":"Trends Immunol"},{"key":"10.1016\/j.identj.2024.12.014_bib0007","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6309238","article-title":"Possible mechanisms involved in the cooccurrence of oral lichen planus and hashimoto's thyroiditis","volume":"2020","author":"Wu","year":"2020","journal-title":"Mediators Inflamm"},{"issue":"3","key":"10.1016\/j.identj.2024.12.014_bib0008","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/odi.13572","article-title":"Association between oral lichen planus and systemic conditions and medications: Case\u2013control study","volume":"27","author":"Dave","year":"2021","journal-title":"Oral Dis"},{"key":"10.1016\/j.identj.2024.12.014_bib0009","article-title":"Association of hashimoto's thyroiditis and anti-thyroid antibodies with oral lichen planus: a cross-sectional study","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.identj.2024.12.014_bib0010","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00330","article-title":"Correlation between oral lichen planus and thyroid disease in china: a case\u2013control study","volume":"9","author":"Zhou","year":"2018","journal-title":"Front Endocrinol"},{"issue":"3","key":"10.1016\/j.identj.2024.12.014_bib0011","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/odi.14591","article-title":"Association between oral lichen planus and hashimoto thyroiditis: a systematic review","volume":"30","author":"Serni","year":"2023","journal-title":"Oral Dis"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0012","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3390\/biomedicines12010077","article-title":"Crossroads between skin and endocrine glands: the interplay of lichen planus with thyroid anomalies","volume":"12","author":"Radu","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.identj.2024.12.014_bib0013","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3724\/zdxbyxb-2021-0124","article-title":"IMMUNE MECHANISMS INVOLVED IN THE COEXISTENCE OF ORAL LICHEN PLANUS AND AUTOIMMUNE THYROID DISEases","volume":"50","author":"Wang","year":"2021","journal-title":"J Zhejiang Univ Med Sci"},{"issue":"2","key":"10.1016\/j.identj.2024.12.014_bib0014","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000442438","article-title":"Thyroid disease and oral lichen planus as comorbidity: a prospective case-control study","volume":"232","author":"Garcia-Pola","year":"2016","journal-title":"Dermatology"},{"issue":"Suppl 3","key":"10.1016\/j.identj.2024.12.014_bib0015","first-page":"S2159","article-title":"Prevalence of oral lichen planus in patients with hypothyroidism versus nonhypothyroidism","volume":"16","author":"Bansal","year":"2024","journal-title":"J Pharm Bioallied Sci"},{"key":"10.1016\/j.identj.2024.12.014_bib0016","doi-asserted-by":"crossref","first-page":"RP92895","DOI":"10.7554\/eLife.92895.3","article-title":"Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care","volume":"12","author":"Ye","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.identj.2024.12.014_bib0017","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3389\/fendo.2017.00146","article-title":"Thyroid Autoimmunity and Lichen","volume":"8","author":"Guarneri","year":"2017","journal-title":"Front Endocrinol"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0018","doi-asserted-by":"crossref","first-page":"7342","DOI":"10.1038\/s41467-021-26280-1","article-title":"Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome","volume":"12","author":"Storm","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0019","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1186\/s12967-023-04559-9","article-title":"Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: insights from a two-sample Mendelian randomization study","volume":"21","author":"Ye","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.identj.2024.12.014_bib0020","article-title":"Appraising the life-course impact of Epstein-Barr virus exposure and its genetic signature on periodontitis","author":"Ye","year":"2024","journal-title":"J Periodontol"},{"key":"10.1016\/j.identj.2024.12.014_bib0021","doi-asserted-by":"crossref","first-page":"n2233","DOI":"10.1136\/bmj.n2233","article-title":"Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration","volume":"375","author":"Skrivankova","year":"2021","journal-title":"BMJ"},{"issue":"7822","key":"10.1016\/j.identj.2024.12.014_bib0022","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41586-020-2436-0","article-title":"FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease","volume":"584","author":"Saevarsdottir","year":"2020","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.identj.2024.12.014_bib0023","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0024","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/s41467-024-44701-9","article-title":"Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications","volume":"15","author":"Sterenborg","year":"2024","journal-title":"Nat Commun"},{"issue":"7944","key":"10.1016\/j.identj.2024.12.014_bib0025","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.identj.2024.12.014_bib0026","article-title":"Causal effects of circulating inflammatory proteins on oral phenotypes: Deciphering immune-mediated profiles in the host-oral axis","volume":"139","author":"Ye","year":"2024","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"10.1016\/j.identj.2024.12.014_bib0027","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/liv.15532","article-title":"Causal effect of lower birthweight on non-alcoholic fatty liver disease and mediating roles of insulin resistance and metabolites","volume":"43","author":"Kong","year":"2023","journal-title":"Liver Int"},{"issue":"11","key":"10.1016\/j.identj.2024.12.014_bib0028","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.identj.2024.12.014_bib0029","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev","year":"2016","journal-title":"Nat Genet"},{"issue":"4","key":"10.1016\/j.identj.2024.12.014_bib0030","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1111\/odi.14127","article-title":"Autoimmune disorders in oral lichen planus: a systematic review and meta-analysis","volume":"29","author":"De Porras-Carrique","year":"2023","journal-title":"Oral Dis"},{"issue":"6","key":"10.1016\/j.identj.2024.12.014_bib0031","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/odi.13339","article-title":"Does autoimmune thyroid disorder act as a predisposing factor in the development of oral lichen planus?","volume":"26","author":"Hirota","year":"2020","journal-title":"Oral Dis"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0032","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jds.2023.11.004","article-title":"Possible interplay of diabetes mellitus and thyroid diseases in oral lichen planus: A pooled prevalence analysis","volume":"19","author":"Wang","year":"2024","journal-title":"J Dent Sci"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0033","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00784-012-0767-4","article-title":"Possible link between Hashimoto's thyroiditis and oral lichen planus: a novel association found","volume":"17","author":"Lo Muzio","year":"2013","journal-title":"Clin Oral Investig"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0034","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1186\/s12903-023-03326-y","article-title":"Assessing the thyroid autoimmunity association with recurrent aphthous stomatitis","volume":"23","author":"Karimi","year":"2023","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.identj.2024.12.014_bib0035","doi-asserted-by":"crossref","DOI":"10.1111\/jre.13240","article-title":"Periodontitis and thyroid function: a bidirectional mendelian randomization study","author":"Gao","year":"2024","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.identj.2024.12.014_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.jormas.2024.101836","article-title":"CXCL9 mediating the effect of thyroid disorders on oral and oropharyngeal cancer risk: a mediation mendelian randomization study","author":"Zheng","year":"2024","journal-title":"J Stomatol Oral Maxillofac Surg"},{"key":"10.1016\/j.identj.2024.12.014_bib0037","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1225494","article-title":"Thyroid hormones and minerals in immunocorrection of disorders in autoimmune thyroid diseases","volume":"14","author":"Kravchenko","year":"2023","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.identj.2024.12.014_bib0038","first-page":"13","article-title":"Improvement of lipoplexes with a sialic acid mimetic to target the C1858T PTPN22 variant for","author":"Arena","year":"2022","journal-title":"Immunother Endocrine Autoimmunity. Front Immunol"},{"issue":"3","key":"10.1016\/j.identj.2024.12.014_bib0039","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1210\/clinem\/dgac664","article-title":"DNA methylation in autoimmune thyroid disease","volume":"108","author":"Lafontaine","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.identj.2024.12.014_bib0040","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3390\/biomedicines11030955","article-title":"Aberrant activation of the STING-TBK1 Pathway in \u03b3\u03b4 T cells regulates immune responses in oral lichen planus","volume":"11","author":"Huang","year":"2023","journal-title":"Biomedicines"},{"issue":"3, Supplement","key":"10.1016\/j.identj.2024.12.014_bib0041","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1532-3382(12)70051-9","article-title":"Oral manifestations of systemic autoimmune and inflammatory diseases: diagnosis and clinical management","volume":"12","author":"Mays","year":"2012","journal-title":"J Evid Based Dent Pract"},{"issue":"1","key":"10.1016\/j.identj.2024.12.014_bib0042","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/odi.14181","article-title":"Clinical investigation on oral lichen planus and associated comorbidities needs a holistic concept","volume":"29","author":"Liu","year":"2023","journal-title":"Oral Dis"},{"issue":"2","key":"10.1016\/j.identj.2024.12.014_bib0043","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1010596","article-title":"Strategies to investigate and mitigate collider bias in genetic and Mendelian randomisation studies of disease progression","volume":"19","author":"Mitchell","year":"2023","journal-title":"PLOS Genet"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924016344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653924016344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:47:19Z","timestamp":1778636839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653924016344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S0020653924016344"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2024.12.014","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association Between Autoimmune Thyroid disease and Oral Lichen Planus: A Multi-Omic Genetic Analysis","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2024.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}]}}