{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:09:18Z","timestamp":1778630958521,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023915","name":"Faculty of Dentistry, Chulalongkorn University","doi-asserted-by":"publisher","award":["DRF-67015"],"award-info":[{"award-number":["DRF-67015"]}],"id":[{"id":"10.13039\/501100023915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.identj.2025.03.022","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T20:07:57Z","timestamp":1746216477000},"page":"100813","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Cockle Shell to Bioceramic Root Canal Sealer: The Manufacturing and its Physical and Biological Properties"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7895-7366","authenticated-orcid":false,"given":"Chanathip","family":"Chatphatthanasiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-9726","authenticated-orcid":false,"given":"Thanakorn","family":"Wasanapiarnpong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-765X","authenticated-orcid":false,"given":"Theerapat","family":"Chanamuangkon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3808-0013","authenticated-orcid":false,"given":"Pavena","family":"Chivatxaranukul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4413-3070","authenticated-orcid":false,"given":"Pairoj","family":"Linsuwanont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3 Suppl 1","key":"10.1016\/j.identj.2025.03.022_bib0001","first-page":"S128","article-title":"Bioceramics in endodontics\u2014a review","volume":"51","author":"Raghavendra","year":"2017","journal-title":"J Istanb Univ Fac Dent"},{"key":"10.1016\/j.identj.2025.03.022_bib0002","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/9753210","article-title":"Bioceramic-based root canal sealers: a review","volume":"2016","author":"Al-Haddad","year":"2016","journal-title":"Int J Biomater"},{"issue":"8","key":"10.1016\/j.identj.2025.03.022_bib0003","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.adaj.2022.01.004","article-title":"Tricalcium silicate cement sealers: do the potential benefits of bioactivity justify the drawbacks?","volume":"153","author":"Aminoshariae","year":"2022","journal-title":"J Am Dent Assoc"},{"issue":"22","key":"10.1016\/j.identj.2025.03.022_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27227946","article-title":"Extraction of hydroxyapatite from camel bone for bone tissue engineering application","volume":"27","author":"Khurshid","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.identj.2025.03.022_bib0005","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.15711","article-title":"Development, physicochemical characterization and in-vitro biocompatibility study of dromedary camel dentine derived hydroxyapatite for bone repair","volume":"11","author":"Khurshid","year":"2023","journal-title":"PeerJ"},{"issue":"3","key":"10.1016\/j.identj.2025.03.022_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/ma15031176","article-title":"Development and analysis of a hydroxyapatite supplemented calcium silicate cement for endodontic treatment","volume":"15","author":"Yong","year":"2022","journal-title":"Materials"},{"issue":"14","key":"10.1016\/j.identj.2025.03.022_bib0007","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.3390\/app9142897","article-title":"Cockle shell-derived calcium carbonate (aragonite) nanoparticles: a dynamite to nanomedicine","volume":"9","author":"Muhammad Mailafiya","year":"2019","journal-title":"Appl Sci (Basel)"},{"key":"10.1016\/j.identj.2025.03.022_bib0008","first-page":"237","article-title":"Preparation and characterization of cockle shell aragonite nanocomposite porous 3D scaffolds for bone repair","volume":"10","author":"Mahmood","year":"2017","journal-title":"Biochem Biophys Rep"},{"issue":"2","key":"10.1016\/j.identj.2025.03.022_bib0009","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1055\/s-0040-1719215","article-title":"The effect of Anadara granosa Shell's-Stichopus hermanni scaffold on CD44 and IL-10 expression to decrease osteoclasts in socket healing","volume":"15","author":"Sari","year":"2021","journal-title":"Eur J Dent"},{"issue":"4","key":"10.1016\/j.identj.2025.03.022_bib0010","first-page":"26","article-title":"The increase of tooth enamel surface hardness after application blood cockle shells (Anadara granosa) paste as remineralization agent","volume":"11","author":"Nugroho","year":"2019","journal-title":"Int J App Pharm"},{"key":"10.1016\/j.identj.2025.03.022_bib0011","series-title":"Solid state chemistry and its applications","author":"West","year":"2022"},{"issue":"1","key":"10.1016\/j.identj.2025.03.022_bib0012","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.msea.2003.09.099","article-title":"Thermal reaction behavior of ZrSiO4 and CaCO3 mixtures for high-temperature refractory applications","volume":"368","author":"Yeo","year":"2004","journal-title":"Mater Sci Eng A Struct Mater"},{"key":"10.1016\/j.identj.2025.03.022_bib0013","series-title":"Dental root canal sealing materials","year":"2012"},{"key":"10.1016\/j.identj.2025.03.022_bib0014","series-title":"Biological evaluation of medical devices \u2013 part 5: tests for in vitro cytotoxicity","year":"2009"},{"key":"10.1016\/j.identj.2025.03.022_bib0015","series-title":"Biological evaluation of medical devices \u2013 part 12: sample preparation and reference materials","year":"2012"},{"issue":"1","key":"10.1016\/j.identj.2025.03.022_bib0016","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/s-0042-1745774","article-title":"Characterization, physical properties, and biocompatibility of novel tricalcium silicate-chitosan endodontic sealer","volume":"17","author":"Maharti","year":"2023","journal-title":"Eur J Dent"},{"key":"10.1016\/j.identj.2025.03.022_bib0017","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/8541653","article-title":"Evaluation of setting time, flowability, film thickness, and radiopacity of experimental monocalcium silicate-based root canal sealers","volume":"2024","author":"Juntha","year":"2024","journal-title":"Int J Dent"},{"issue":"6","key":"10.1016\/j.identj.2025.03.022_bib0018","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.joen.2012.02.029","article-title":"Evaluation of radiopacity, pH, release of calcium ions, and flow of a bioceramic root canal sealer","volume":"38","author":"Candeiro","year":"2012","journal-title":"J Endod"},{"issue":"10","key":"10.1016\/j.identj.2025.03.022_bib0019","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.joen.2013.06.012","article-title":"Physical properties of 5 root canal sealers","volume":"39","author":"Zhou","year":"2013","journal-title":"J Endod"},{"issue":"3","key":"10.1016\/j.identj.2025.03.022_bib0020","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5624\/isd.2012.42.3.163","article-title":"Assessment of radiopacity of restorative composite resins with various target distances and exposure times and a modified aluminum step wedge","volume":"42","author":"Poorsattar Bejeh Mir","year":"2012","journal-title":"Imaging Sci Dent"},{"key":"10.1016\/j.identj.2025.03.022_bib0021","doi-asserted-by":"crossref","first-page":"e080","DOI":"10.1590\/1807-3107bor-2020.vol34.0080","article-title":"Radiopacity of endodontic materials using two models for conversion to millimeters of aluminum","volume":"34","author":"Ochoa-Rodr\u00cdguez","year":"2020","journal-title":"Braz Oral Res"},{"issue":"1","key":"10.1016\/j.identj.2025.03.022_bib0022","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0300-5712(98)00025-6","article-title":"Aluminium radiopacity standards for dentistry: an international survey","volume":"27","author":"Watts","year":"1999","journal-title":"J Dent"},{"issue":"3","key":"10.1016\/j.identj.2025.03.022_bib0023","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2341\/12.166-L","article-title":"Radiopacity of flowable composite by a digital technique","volume":"38","author":"Duki\u0107","year":"2013","journal-title":"Oper Dent"},{"issue":"4","key":"10.1016\/j.identj.2025.03.022_bib0024","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1532-849X.2012.00936.x","article-title":"Evaluation of the radiopacity of luting cements by digital radiography","volume":"22","author":"Altintas","year":"2013","journal-title":"J Prosthodont"},{"issue":"2","key":"10.1016\/j.identj.2025.03.022_bib0025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/jerd.12059","article-title":"Evaluation of the radiopacity of esthetic root canal posts","volume":"26","author":"Rodrigues","year":"2014","journal-title":"J Esthet Restor Dent"},{"issue":"5","key":"10.1016\/j.identj.2025.03.022_bib0026","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2591.2011.01992.x","article-title":"Changes in the surface of four calcium silicate-containing endodontic materials and an epoxy resin-based sealer after a solubility test","volume":"45","author":"Borges","year":"2012","journal-title":"Int Endod J"},{"issue":"10","key":"10.1016\/j.identj.2025.03.022_bib0027","doi-asserted-by":"crossref","first-page":"e1189","DOI":"10.4317\/jced.54040","article-title":"Solubility and pH of bioceramic root canal sealers: a comparative study","volume":"9","author":"Poggio","year":"2017","journal-title":"J Clin Exp Dent"},{"issue":"12","key":"10.1016\/j.identj.2025.03.022_bib0028","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.joen.2010.08.038","article-title":"Effects of iRoot SP on mineralization-related genes expression in MG63 cells","volume":"36","author":"Zhang","year":"2010","journal-title":"J Endod"},{"issue":"2","key":"10.1016\/j.identj.2025.03.022_bib0029","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4103\/0972-0707.153054","article-title":"Biotoxicity of commonly used root canal sealers: a meta-analysis","volume":"18","author":"Kaur","year":"2015","journal-title":"J Conserv Dent"},{"issue":"9","key":"10.1016\/j.identj.2025.03.022_bib0030","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/BF00151034","article-title":"Properties and mechanisms of fast-setting calcium phosphate cements","volume":"6","author":"Ishikawa","year":"1995","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.identj.2025.03.022_bib0031","first-page":"111","article-title":"[Effects of ethylene\/vinyl chloride\/vinyl laurate redispersible terpolymer on pore structure and properties of cement mortar]","volume":"16","author":"Zhang","year":"2013","journal-title":"Jianzhu Cailiao Xuebao\/J Build Mater"},{"issue":"23","key":"10.1016\/j.identj.2025.03.022_bib0032","doi-asserted-by":"crossref","first-page":"4847","DOI":"10.1016\/j.biomaterials.2005.01.006","article-title":"The effect of calcium ion concentration on osteoblast viability, proliferation and differentiation in monolayer and 3D culture","volume":"26","author":"Maeno","year":"2005","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.identj.2025.03.022_bib0033","doi-asserted-by":"crossref","first-page":"167","DOI":"10.17219\/dmp\/105561","article-title":"SEM and EDS study of TotalFill BC sealer and GuttaFlow Bioseal root canal sealers","volume":"56","author":"Reszka","year":"2019","journal-title":"Dent Med Probl"},{"issue":"10","key":"10.1016\/j.identj.2025.03.022_bib0034","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1111\/iej.13353","article-title":"MTT versus other cell viability assays to evaluate the biocompatibility of root canal filling materials: a systematic review","volume":"53","author":"Pintor","year":"2020","journal-title":"Int Endod J"},{"issue":"5","key":"10.1016\/j.identj.2025.03.022_bib0035","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.joen.2011.01.003","article-title":"Setting properties and cytotoxicity evaluation of a premixed bioceramic root canal sealer","volume":"37","author":"Loushine","year":"2011","journal-title":"J Endod"},{"issue":"1","key":"10.1016\/j.identj.2025.03.022_bib0036","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.joen.2014.09.012","article-title":"In vitro cytotoxicity of calcium silicate\u2013containing endodontic sealers","volume":"41","author":"Zhou","year":"2015","journal-title":"J Endod"},{"issue":"3","key":"10.1016\/j.identj.2025.03.022_bib0037","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00784-020-03453-8","article-title":"Microstructural composition, ion release, and bioactive potential of new premixed calcium silicate-based endodontic sealers indicated for warm vertical compaction technique","volume":"25","author":"Sanz","year":"2021","journal-title":"Clin Oral Investig"},{"issue":"9","key":"10.1016\/j.identj.2025.03.022_bib0038","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/01.don.0000155227.86046.a2","article-title":"Induction of interleukin-6 and interleukin-8 gene expression by root canal sealers in human osteoblastic cells","volume":"31","author":"Huang","year":"2005","journal-title":"J Endod"},{"issue":"1","key":"10.1016\/j.identj.2025.03.022_bib0039","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.joen.2018.09.006","article-title":"Anti-inflammatory and osteogenic effects of calcium silicate-based root canal sealers","volume":"45","author":"Lee","year":"2019","journal-title":"J Endod"},{"issue":"4","key":"10.1016\/j.identj.2025.03.022_bib0040","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1016\/j.jds.2022.12.019","article-title":"Hydraulic calcium silicate-based root canal sealers mitigate proinflammatory cytokine synthesis and promote osteogenesis in vitro","volume":"18","author":"Alchawoosh","year":"2023","journal-title":"J Dent Sci"},{"issue":"4","key":"10.1016\/j.identj.2025.03.022_bib0041","doi-asserted-by":"crossref","DOI":"10.1177\/0300060519894801","article-title":"In vitro cytocompatibility and osteogenic potential of calcium silicate-based dental cements in a root canal-filling model","volume":"48","author":"Jing","year":"2020","journal-title":"J Int Med Res"},{"issue":"10","key":"10.1016\/j.identj.2025.03.022_bib0042","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/iej.13805","article-title":"Cytocompatibility and bioactive potential of AH Plus Bioceramic sealer: an in\u2009vitro study","volume":"55","author":"Sanz","year":"2022","journal-title":"Int Endod J"},{"issue":"1","key":"10.1016\/j.identj.2025.03.022_bib0043","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s00784-023-05402-7","article-title":"A comparative study of biological properties of three root canal sealers","volume":"28","author":"Yan","year":"2023","journal-title":"Clin Oral Investig"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925001029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925001029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:15:23Z","timestamp":1778627723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653925001029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S0020653925001029"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2025.03.022","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From Cockle Shell to Bioceramic Root Canal Sealer: The Manufacturing and its Physical and Biological Properties","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2025.03.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"100813"}}