{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:43:58Z","timestamp":1791927838490,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T00:00:00Z","timestamp":1748131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["23YXYJ0151"],"award-info":[{"award-number":["23YXYJ0151"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008387","name":"Xi'an Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["xzy012024106"],"award-info":[{"award-number":["xzy012024106"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.identj.2025.100863","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T07:26:26Z","timestamp":1752737186000},"page":"100863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["ARA290 Attenuates Apical Periodontitis via SIRT1\/NF-\u03baB\/IL-1\u03b2 Pathway Modulation"],"prefix":"10.1016","volume":"75","author":[{"given":"Yuting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenlan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7846-9170","authenticated-orcid":false,"given":"Abdelrahman","family":"Seyam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiezhou","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0542-5011","authenticated-orcid":false,"given":"Xiaoyue","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.identj.2025.100863_bib0001","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/odi.15103","article-title":"Ginsenoside Rb1 ameliorates apical periodontitis via suppressing macrophage pyroptosis","volume":"31","author":"Guan","year":"2025","journal-title":"Oral Dis"},{"issue":"9","key":"10.1016\/j.identj.2025.100863_bib0002","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/iej.13133","article-title":"Potential role of TP63 in apical periodontitis development","volume":"52","author":"Souza","year":"2019","journal-title":"Int Endod J"},{"issue":"5","key":"10.1016\/j.identj.2025.100863_bib0003","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/iej.13467","article-title":"The global prevalence of apical periodontitis: a systematic review and meta-analysis","volume":"54","author":"Tiburcio-Machado","year":"2021","journal-title":"Int Endod J"},{"issue":"Suppl 2)","key":"10.1016\/j.identj.2025.100863_bib0004","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/iej.13897","article-title":"Factors that affect the outcomes of root canal treatment and retreatment-A reframing of the principles","volume":"56","author":"Gulabivala","year":"2023","journal-title":"Int Endod J"},{"issue":"Suppl 3)","key":"10.1016\/j.identj.2025.100863_bib0005","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/iej.13808","article-title":"Effectiveness of root resection techniques compared with root canal retreatment or apical surgery for the treatment of apical periodontitis and tooth survival: a systematic review","volume":"56","author":"Corbella","year":"2023","journal-title":"Int Endod J"},{"issue":"11","key":"10.1016\/j.identj.2025.100863_bib0006","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/iej.14125","article-title":"The immune landscape in apical periodontitis: from mechanism to therapy","volume":"57","author":"Wen","year":"2024","journal-title":"Int Endod J"},{"issue":"3","key":"10.1016\/j.identj.2025.100863_bib0007","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14676","article-title":"Erythropoietin-derived peptide ARA290 mediates brain tissue protection through the beta-common receptor in mice with cerebral ischemic stroke","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"10.1016\/j.identj.2025.100863_bib0008","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s10753-022-01737-7","article-title":"Mechanistic approach for protective effect of ARA290, a specific ligand for the erythropoietin\/CD131 heteroreceptor, against cisplatin-induced nephrotoxicity, the involvement of apoptosis and inflammation pathways","volume":"46","author":"Ghassemi-Barghi","year":"2023","journal-title":"Inflammation"},{"issue":"10","key":"10.1016\/j.identj.2025.100863_bib0009","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1097\/TP.0000000000003284","article-title":"Improvement of islet allograft function using cibinetide, an innate repair receptor ligand","volume":"104","author":"Yao","year":"2020","journal-title":"Transplantation"},{"key":"10.1016\/j.identj.2025.100863_bib0010","article-title":"Nonerythropoietic erythropoietin mimetic peptide ARA290 ameliorates chronic stress-induced depression-like behavior and inflammation in mice","volume":"13","author":"Xu","year":"2022","journal-title":"Front Pharmacol"},{"issue":"7","key":"10.1016\/j.identj.2025.100863_bib0011","doi-asserted-by":"crossref","first-page":"3854","DOI":"10.3390\/ijms25073854","article-title":"The role of macrophage efferocytosis in the pathogenesis of apical periodontitis","volume":"25","author":"Guan","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.identj.2025.100863_bib0012","article-title":"Regulation of SIRT1 and its roles in inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.identj.2025.100863_bib0013","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1681\/ASN.2017111218","article-title":"Sirtuins in renal health and disease","volume":"29","author":"Morigi","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.identj.2025.100863_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.779177","article-title":"SIRT1: a potential therapeutic target in autoimmune diseases","volume":"12","author":"Shen","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.identj.2025.100863_bib0015","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12964-023-01077-5","article-title":"Role of oxidative stress and inflammation-related signaling pathways in doxorubicin-induced cardiomyopathy","volume":"21","author":"Shi","year":"2023","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.identj.2025.100863_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.122117","article-title":"Kukoamine A protects mice against osteoarthritis by inhibiting chondrocyte inflammation and ferroptosis via SIRT1\/GPX4 signaling pathway","volume":"332","author":"Sun","year":"2023","journal-title":"Life Sci"},{"issue":"9","key":"10.1016\/j.identj.2025.100863_bib0017","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","article-title":"NF-kappaB: blending metabolism, immunity, and inflammation","volume":"43","author":"Capece","year":"2022","journal-title":"Trends Immunol"},{"issue":"1","key":"10.1016\/j.identj.2025.100863_bib0018","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-kappaB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.identj.2025.100863_bib0019","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12974-021-02172-5","article-title":"miR-19a\/b-3p promotes inflammation during cerebral ischemia\/reperfusion injury via SIRT1\/FoxO3\/SPHK1 pathway","volume":"18","author":"Zhou","year":"2021","journal-title":"J Neuroinflam"},{"issue":"11","key":"10.1016\/j.identj.2025.100863_bib0020","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1002\/JPER.21-0657","article-title":"Apoptotic extracellular vesicles alleviate Pg-LPS induced inflammatory responses of macrophages via AMPK\/SIRT1\/NF-kappaB pathway and inhibit osteoclast formation","volume":"93","author":"Ye","year":"2022","journal-title":"J Periodontol"},{"key":"10.1016\/j.identj.2025.100863_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110192","article-title":"Glycolytic reprogramming controls periodontitis-associated macrophage pyroptosis via AMPK\/SIRT1\/NF-kappaB signaling pathway","volume":"119","author":"He","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"7","key":"10.1016\/j.identj.2025.100863_bib0022","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/iej.12894","article-title":"A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis","volume":"51","author":"Kudo","year":"2018","journal-title":"Int Endod J"},{"issue":"3","key":"10.1016\/j.identj.2025.100863_bib0023","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2334\/josnusd.17-0412","article-title":"Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas","volume":"60","author":"Kudo","year":"2018","journal-title":"J Oral Sci"},{"key":"10.1016\/j.identj.2025.100863_bib0024","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.freeradbiomed.2023.08.020","article-title":"Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2\/FSP1\/ROS pathway","volume":"208","author":"Yang","year":"2023","journal-title":"Free Radical Bio Med"},{"issue":"5","key":"10.1016\/j.identj.2025.100863_bib0025","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00784-024-05691-6","article-title":"The effects of NLRP3 inflammasome inhibition or knockout in experimental apical periodontitis induced in mice","volume":"28","author":"Pucinelli","year":"2024","journal-title":"Clin Oral Invest"},{"key":"10.1016\/j.identj.2025.100863_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1214990","article-title":"Modulation of blood redox status by the progression of induced apical periodontitis in rats","volume":"14","author":"Frazao","year":"2023","journal-title":"Front Physiol"},{"issue":"3","key":"10.1016\/j.identj.2025.100863_bib0027","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3390\/cells10030671","article-title":"A mouse model for studying the development of apical periodontitis with age","volume":"10","author":"Goldman","year":"2021","journal-title":"Cells."},{"issue":"1","key":"10.1016\/j.identj.2025.100863_bib0028","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12906-022-03670-6","article-title":"Identification of core genes associated with the anti-atherosclerotic effects of Salvianolic acid B and immune cell infiltration characteristics using bioinformatics analysis","volume":"22","author":"Jin","year":"2022","journal-title":"BMC Complement Med Ther"},{"issue":"2","key":"10.1016\/j.identj.2025.100863_bib0029","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nbt1284","article-title":"Relating protein pharmacology by ligand chemistry","volume":"25","author":"Keiser","year":"2007","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.identj.2025.100863_bib0030","article-title":"Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking","volume":"14","author":"He","year":"2023","journal-title":"Front Pharmacol"},{"issue":"2","key":"10.1016\/j.identj.2025.100863_bib0031","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.identj.2024.07.1213","article-title":"Ginsenoside RB1 influences macrophage-DPSC interactions in inflammatory conditions","volume":"75","author":"Li","year":"2025","journal-title":"Int Dent J"},{"key":"10.1016\/j.identj.2025.100863_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.672054","article-title":"Therapeutic effects of naringin in rheumatoid arthritis: network pharmacology and experimental validation","volume":"12","author":"Aihaiti","year":"2021","journal-title":"Front Pharmacol"},{"issue":"W1","key":"10.1016\/j.identj.2025.100863_bib0033","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab447","article-title":"KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis","volume":"49","author":"Bu","year":"2021","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"10.1016\/j.identj.2025.100863_bib0034","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1111\/iej.14062","article-title":"Nlrp3 inflammasome drives regulatory T cell depletion to accelerate periapical bone erosion","volume":"57","author":"Wang","year":"2024","journal-title":"Int Endod J"},{"issue":"7","key":"10.1016\/j.identj.2025.100863_bib0035","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1111\/jcmm.13608","article-title":"Non-erythropoietic erythropoietin-derived peptide protects mice from systemic lupus erythematosus","volume":"22","author":"Huang","year":"2018","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.1016\/j.identj.2025.100863_bib0036","doi-asserted-by":"crossref","first-page":"969","DOI":"10.2119\/molmed.2015.00267","article-title":"ARA290 improves insulin release and glucose tolerance in type 2 diabetic Goto-Kakizaki rats","volume":"21","author":"Muller","year":"2016","journal-title":"Mol Med"},{"issue":"4","key":"10.1016\/j.identj.2025.100863_bib0037","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00004770-200204000-00011","article-title":"Microbiota of periapical lesions refractory to endodontic therapy","volume":"28","author":"Sunde","year":"2002","journal-title":"J Endod"},{"issue":"10","key":"10.1016\/j.identj.2025.100863_bib0038","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1111\/iej.13957","article-title":"Lipopolysaccharides from Porphyromonas endodontalis and Porphyromonas gingivalis promote angiogenesis via Toll-like-receptors 2 and 4 pathways in vitro","volume":"56","author":"Fernandez","year":"2023","journal-title":"Int Endod J"},{"issue":"5","key":"10.1016\/j.identj.2025.100863_bib0039","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/08923973.2024.2392196","article-title":"Blocking Gremlin1 inhibits M1 macrophage polarization through Notch1\/Hes1 signaling pathway in apical periodontitis","volume":"46","author":"Guan","year":"2024","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"2","key":"10.1016\/j.identj.2025.100863_bib0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41368-018-0015-0","article-title":"Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss","volume":"10","author":"Hirai","year":"2018","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.identj.2025.100863_bib0041","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.molimm.2018.05.008","article-title":"MicroRNA-21 down-regulates inflammation and inhibits periodontitis","volume":"101","author":"Zhou","year":"2018","journal-title":"Mol Immunol"},{"issue":"7","key":"10.1016\/j.identj.2025.100863_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119521","article-title":"NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF-kappaB pathway in macrophages","volume":"1870","author":"Zhang","year":"2023","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.identj.2025.100863_bib0043","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.freeradbiomed.2023.08.020","article-title":"Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2\/FSP1\/ROS pathway","volume":"208","author":"Yang","year":"2023","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.identj.2025.100863_bib0044","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1038\/s41598-021-82167-7","article-title":"Inhibition of the CXCL9-CXCR3 axis suppresses the progression of experimental apical periodontitis by blocking macrophage migration and activation","volume":"11","author":"Hasegawa","year":"2021","journal-title":"Sci Rep"},{"issue":"7\u20138","key":"10.1016\/j.identj.2025.100863_bib0045","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1177\/17534259211062553","article-title":"Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-kappaB","volume":"27","author":"An","year":"2021","journal-title":"Innate Immun"},{"issue":"9","key":"10.1016\/j.identj.2025.100863_bib0046","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/s41423-019-0257-6","article-title":"MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy","volume":"17","author":"Li","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.identj.2025.100863_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111713","article-title":"ED-71 ameliorates OVX-induced osteoporosis by regulating calcium homeostasis and SIRT1-mediated mitochondrial function, alleviating osteoblast senescence and suppressing osteoclastogenesis","volume":"131","author":"Zhang","year":"2025","journal-title":"Cell Signal"},{"key":"10.1016\/j.identj.2025.100863_bib0048","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1479-5876-11-9","article-title":"ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia\/reperfusion injury","volume":"11","author":"van Rijt","year":"2013","journal-title":"J Transl Med"},{"issue":"3","key":"10.1016\/j.identj.2025.100863_bib0049","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/TP.0000000000001026","article-title":"A nonhematopoietic erythropoietin analogue, ARA 290, inhibits macrophage activation and prevents damage to transplanted islets","volume":"100","author":"Watanabe","year":"2016","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.identj.2025.100863_bib0050","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/ijms23010055","article-title":"The non-erythropoietic EPO analogue cibinetide inhibits osteoclastogenesis in vitro and increases bone mineral density in mice","volume":"23","author":"Awida","year":"2022","journal-title":"Int J Mol Sci"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925001522?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925001522?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:08:29Z","timestamp":1762182509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653925001522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0020653925001522"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2025.100863","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ARA290 Attenuates Apical Periodontitis via SIRT1\/NF-\u03baB\/IL-1\u03b2 Pathway Modulation","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2025.100863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"100863"}}