{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:04:12Z","timestamp":1770743052495,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["202403021222228"],"award-info":[{"award-number":["202403021222228"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401176"],"award-info":[{"award-number":["82401176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.identj.2025.100894","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T08:54:22Z","timestamp":1752569662000},"page":"100894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Forkhead Box O1 Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells in Hypoxia\/Reoxygenation Environments by Regulating Heme Oxygenase-1 Scavenging of Reactive Oxygen Species"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0286-7869","authenticated-orcid":false,"given":"Yujia","family":"Ye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2605-4714","authenticated-orcid":false,"given":"Jinqiao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3703-6456","authenticated-orcid":false,"given":"Yanning","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.identj.2025.100894_bib0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12344","article-title":"Clinical and public health implications of periodontal and systemic diseases: an overview","volume":"83","author":"Genco","year":"2020","journal-title":"Periodontology 2000"},{"issue":"1","key":"10.1016\/j.identj.2025.100894_bib0002","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/prd.12435","article-title":"Viruses, periodontitis, and comorbidities","volume":"89","author":"Teles","year":"2022","journal-title":"Periodontology 2000"},{"issue":"3","key":"10.1016\/j.identj.2025.100894_bib0003","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.identj.2021.05.004","article-title":"Knowledge and attitude of dentists towards obstructive sleep apnea","volume":"72","author":"Alzahrani","year":"2022","journal-title":"Int Dent J"},{"issue":"4","key":"10.1016\/j.identj.2025.100894_bib0004","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13616","article-title":"Obstructive sleep apnea: transition from pathophysiology to an integrative disease model","volume":"31","author":"McNicholas","year":"2022","journal-title":"J Sleep Res"},{"issue":"7","key":"10.1016\/j.identj.2025.100894_bib0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271738","article-title":"Incidence and risk of periodontitis in obstructive sleep apnea: a meta-analysis","volume":"17","author":"Zhang","year":"2022","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.identj.2025.100894_bib0006","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s11325-022-02668-1","article-title":"A meta-analysis on the association between obstructive sleep apnea and periodontitis","volume":"27","author":"Zhu","year":"2023","journal-title":"Sleep Breath"},{"issue":"Suppl 4","key":"10.1016\/j.identj.2025.100894_bib0007","doi-asserted-by":"crossref","first-page":"S3367","DOI":"10.4103\/jpbs.jpbs_844_24","article-title":"Determination of the association between obstructive sleep apnea and chronic periodontal disease: a cross-sectional study","volume":"16","author":"Pallavi","year":"2024","journal-title":"J Pharm Bioallied Sci"},{"issue":"2","key":"10.1016\/j.identj.2025.100894_bib0008","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s11325-020-02200-3","article-title":"Serum matrix metalloproteinase-2 as a predictor of level of hypoxemia and severity of obstructive sleep apnea","volume":"25","author":"Franczak","year":"2021","journal-title":"Sleep Breath"},{"issue":"3","key":"10.1016\/j.identj.2025.100894_bib0009","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3390\/cells11030552","article-title":"Oxidative stress in human pathology and aging: molecular mechanisms and perspectives","volume":"11","author":"Hajam","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.identj.2025.100894_bib0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12342","article-title":"Periodontitis is an inflammatory disease of oxidative stress: we should treat it that way","volume":"84","author":"Sczepanik","year":"2020","journal-title":"Periodontology 2000"},{"issue":"2","key":"10.1016\/j.identj.2025.100894_bib0011","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11626-998-0095-9","article-title":"A simplified model of hypoxic injury in primary cultured rat hepatocytes","volume":"34","author":"Kamiya","year":"1998","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"10.1016\/j.identj.2025.100894_bib0012","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/378484","article-title":"Differential microRNA profiling in a cellular hypoxia reoxygenation model upon posthypoxic propofol treatment reveals alterations in autophagy signaling network","volume":"2013","author":"Chen","year":"2013","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"10.1016\/j.identj.2025.100894_bib0013","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/iub.2081","article-title":"Overexpression of lncRNA Gm2691 attenuates apoptosis and inflammatory response after myocardial infarction through PI3K\/Akt signaling pathway","volume":"71","author":"Li","year":"2019","journal-title":"IUBMB Life"},{"issue":"2","key":"10.1016\/j.identj.2025.100894_bib0014","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11914-011-0054-3","article-title":"FoxOs: unifying links between oxidative stress and skeletal homeostasis","volume":"9","author":"Kousteni","year":"2011","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.identj.2025.100894_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4939-8900-3_1","article-title":"Introduction to FOXO biology","volume":"1890","author":"Link","year":"2019","journal-title":"Methods Mol Biol (Clifton, NJ)"},{"issue":"10","key":"10.1016\/j.identj.2025.100894_bib0016","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1210\/me.2015-1133","article-title":"Sirtuin1 suppresses osteoclastogenesis by deacetylating FoxOs","volume":"29","author":"Kim","year":"2015","journal-title":"Mol Endocrinol (Baltimore, MD)"},{"issue":"1","key":"10.1016\/j.identj.2025.100894_bib0017","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cell.2014.04.043","article-title":"Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man","volume":"158","author":"Jais","year":"2014","journal-title":"Cell"},{"issue":"40","key":"10.1016\/j.identj.2025.100894_bib0018","doi-asserted-by":"crossref","first-page":"31055","DOI":"10.1074\/jbc.M109.079962","article-title":"Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis","volume":"285","author":"Teixeira","year":"2010","journal-title":"J Biol Chem"},{"issue":"5","key":"10.1016\/j.identj.2025.100894_bib0019","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.bone.2011.01.019","article-title":"FOXO1 modulates osteoblast differentiation","volume":"48","author":"Siqueira","year":"2011","journal-title":"Bone"},{"key":"10.1016\/j.identj.2025.100894_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110438","article-title":"FOXO1 differentially regulates bone formation in young and aged mice","volume":"99","author":"Xiong","year":"2022","journal-title":"Cell Signal"},{"key":"10.1016\/j.identj.2025.100894_bib0021","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7690960","article-title":"Effects of hypoxic environment on periodontal tissue through the ROS\/TXNIP\/NLRP3 inflammasome pathway","volume":"2022","author":"Zhu","year":"2022","journal-title":"BioMed Res Int"},{"issue":"1","key":"10.1016\/j.identj.2025.100894_bib0022","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s13018-023-04120-w","article-title":"FOXO1 regulates osteogenic differentiation of periodontal ligament stem cells through the METTL3 signaling pathway","volume":"18","author":"Wang","year":"2023","journal-title":"J Orthop Surg Res"},{"issue":"5","key":"10.1016\/j.identj.2025.100894_bib0023","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00784-024-05670-x","article-title":"Oxidative stress and FOXO-1 relationship in stage III periodontitis","volume":"28","author":"Gurbuz","year":"2024","journal-title":"Clin Oral Investig"},{"issue":"7","key":"10.1016\/j.identj.2025.100894_bib0024","first-page":"954","article-title":"Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K\/AKT\/Nrf2 signaling pathway","volume":"23","author":"Xiong","year":"2020","journal-title":"Iran J Basic Med Sci"},{"issue":"4","key":"10.1016\/j.identj.2025.100894_bib0025","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/cbin.11513","article-title":"The optimization conditions of establishing an H9c2 cardiomyocyte hypoxia\/reoxygenation injury model based on an AnaeroPack system","volume":"45","author":"Wen","year":"2021","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.identj.2025.100894_bib0026","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00003086-199705000-00033","article-title":"Generation of free radicals during anoxia and reoxygenation in perfused osteoblast like cells","volume":"338","author":"Gasbarrini","year":"1997","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"10.1016\/j.identj.2025.100894_bib0027","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1600-0765.2007.01032.x","article-title":"Cellular responses of rat periodontal ligament cells under hypoxia and re-oxygenation conditions in vitro","volume":"43","author":"Amemiya","year":"2008","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.identj.2025.100894_bib0028","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bone.2017.07.007","article-title":"Periodontal ligament fibroblasts as a cell model to study osteogenesis and osteoclastogenesis in fibrodysplasia ossificans progressiva","volume":"109","author":"de Vries","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.identj.2025.100894_bib0029","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/939751","article-title":"Role of forkhead transcription factors in diabetes-induced oxidative stress","volume":"2012","author":"Ponugoti","year":"2012","journal-title":"Exp Diabetes Res"},{"issue":"10","key":"10.1016\/j.identj.2025.100894_bib0030","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1089\/scd.2014.0484","article-title":"The role of reactive oxygen species in mesenchymal stem cell adipogenic and osteogenic differentiation: a review","volume":"24","author":"Atashi","year":"2015","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.identj.2025.100894_bib0031","doi-asserted-by":"crossref","first-page":"3773","DOI":"10.1038\/ncomms4773","article-title":"FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation","volume":"5","author":"Bartell","year":"2014","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.identj.2025.100894_bib0032","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI200318859","article-title":"A crucial role for thiol antioxidants in estrogen-deficiency bone loss","volume":"112","author":"Lean","year":"2003","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.identj.2025.100894_bib0033","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.identj.2024.11.013","article-title":"Osteogenic induction activity of magnesium chloride on human periodontal ligament stem cells","volume":"75","author":"Lumbikananda","year":"2025","journal-title":"Int Dent J"},{"issue":"13","key":"10.1016\/j.identj.2025.100894_bib0034","first-page":"1110","article-title":"Influence of hypoxia and hypoxia-reoxygenation environment on the viability, apoptosis and related gene expression of osteoblast","volume":"42","author":"Huang","year":"2021","journal-title":"J Qiqihar Med Univ"},{"issue":"7","key":"10.1016\/j.identj.2025.100894_bib0035","doi-asserted-by":"crossref","first-page":"583","DOI":"10.7150\/ijms.11839","article-title":"Effects of remifentanil preconditioning on osteoblasts under hypoxia-reoxygenation condition","volume":"12","author":"Baik","year":"2015","journal-title":"Int J Med Sci"},{"issue":"9","key":"10.1016\/j.identj.2025.100894_bib0036","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1902\/jop.2007.060519","article-title":"Hypoxia and reoxygenation augment bone-resorbing factor production from human periodontal ligament cells","volume":"78","author":"Motohira","year":"2007","journal-title":"J Periodontol"},{"key":"10.1016\/j.identj.2025.100894_bib0037","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fphys.2017.00351","article-title":"Pathways that regulate ROS scavenging enzymes, and their role in defense against tissue destruction in periodontitis","volume":"8","author":"Kanzaki","year":"2017","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.identj.2025.100894_bib0038","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cmet.2010.01.001","article-title":"FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts","volume":"11","author":"Rached","year":"2010","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.identj.2025.100894_bib0039","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cmet.2009.12.009","article-title":"FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice","volume":"11","author":"Ambrogini","year":"2010","journal-title":"Cell Metab"},{"issue":"15\u201316","key":"10.1016\/j.identj.2025.100894_bib0040","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1089\/scd.2023.0013","article-title":"FoxO1 agonists promote bone regeneration in periodontitis by protecting the osteogenesis of periodontal ligament stem cells","volume":"32","author":"Huang","year":"2023","journal-title":"Stem Cells Dev"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925001832?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925001832?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T06:23:36Z","timestamp":1758003816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653925001832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0020653925001832"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2025.100894","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Forkhead Box O1 Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells in Hypoxia\/Reoxygenation Environments by Regulating Heme Oxygenase-1 Scavenging of Reactive Oxygen Species","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2025.100894","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"100894"}}