{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T19:28:30Z","timestamp":1777750110806,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1998"],"award-info":[{"award-number":["2023NSFSC1998"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.identj.2025.100937","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T14:24:27Z","timestamp":1754403867000},"page":"100937","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Novel DSPP Mutation in Dentinogenesis Imperfecta Shields Type II: Clinical, Genetic and Stem Cell Perspectives"],"prefix":"10.1016","volume":"75","author":[{"given":"Qianhua","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongren","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kehong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JiYun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.identj.2025.100937_bib0001","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/0003-9969(73)90075-7","article-title":"A proposed classification for heritable human dentine defects with a description of a new entity","volume":"18","author":"Shields","year":"1973","journal-title":"Arch Oral Biol"},{"issue":"8","key":"10.1016\/j.identj.2025.100937_bib0002","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1177\/0022034519854029","article-title":"Mutant dentin sialophosphoprotein causes dentinogenesis imperfecta","volume":"98","author":"Liang","year":"2019","journal-title":"J Dent Res"},{"issue":"2","key":"10.1016\/j.identj.2025.100937_bib0003","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/84765","article-title":"DSPP mutation in dentinogenesis imperfecta shields type II","volume":"27","author":"Zhang","year":"2001","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.identj.2025.100937_bib0004","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/mgg3.176","article-title":"The dentin phosphoprotein repeat region and inherited defects of dentin","volume":"4","author":"Yang","year":"2016","journal-title":"Mol Genet Genomic Med"},{"issue":"3","key":"10.1016\/j.identj.2025.100937_bib0005","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1177\/00220345000790030901","article-title":"The non-collagenous dentin matrix proteins are involved in dentinogenesis imperfecta type II (DGI-II)","volume":"79","author":"Thotakura","year":"2000","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.identj.2025.100937_bib0006","first-page":"17","article-title":"Mutation of dentin sialophosphoprotein and hereditary malformations of dentin","volume":"58","author":"Zhu","year":"2023","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"issue":"27","key":"10.1016\/j.identj.2025.100937_bib0007","doi-asserted-by":"crossref","first-page":"24874","DOI":"10.1074\/jbc.M303908200","article-title":"Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III","volume":"278","author":"Sreenath","year":"2003","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.identj.2025.100937_bib0008","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1177\/154405910208100806","article-title":"Stem cell properties of human dental pulp stem cells","volume":"81","author":"Gronthos","year":"2002","journal-title":"J Dent Res"},{"issue":"10","key":"10.1016\/j.identj.2025.100937_bib0009","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1073\/pnas.0937635100","article-title":"SHED: stem cells from human exfoliated deciduous teeth","volume":"100","author":"Miura","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.identj.2025.100937_bib0010","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2174\/1574888X15666200929125840","article-title":"Guiding lineage specific differentiation of SHED for target tissue\/organ regeneration","volume":"16","author":"Han","year":"2021","journal-title":"Curr Stem Cell Res Ther"},{"issue":"7","key":"10.1016\/j.identj.2025.100937_bib0011","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1007\/s00784-023-05009-y","article-title":"Identification of DSPP novel variants and phenotype analysis in dentinogenesis dysplasia shields type II patients","volume":"27","author":"Du","year":"2023","journal-title":"Clin Oral Investig"},{"issue":"22","key":"10.1016\/j.identj.2025.100937_bib0012","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.21037\/atm-21-5369","article-title":"Phenotype and molecular characterizations of a family with dentinogenesis imperfecta shields type II with a novel DSPP mutation","volume":"9","author":"Du","year":"2021","journal-title":"Ann Transl Med"},{"issue":"3","key":"10.1016\/j.identj.2025.100937_bib0013","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1601-0825.2010.01760.x","article-title":"Identification of the DSPP mutation in a new kindred and phenotype-genotype correlation","volume":"17","author":"Lee","year":"2011","journal-title":"Oral Dis"},{"issue":"Suppl 1","key":"10.1016\/j.identj.2025.100937_bib0014","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-0722.2011.00874.x","article-title":"Enamel malformations associated with a defined dentin sialophosphoprotein mutation in two families","volume":"119","author":"Wang","year":"2011","journal-title":"Eur J Oral Sci"},{"issue":"10","key":"10.1016\/j.identj.2025.100937_bib0015","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1369\/0022155413502056","article-title":"Dentin sialophosphoprotein (DSPP) plays an essential role in the postnatal development and maintenance of mouse mandibular condylar cartilage","volume":"61","author":"Liu","year":"2013","journal-title":"J Histochem Cytochem"},{"issue":"5","key":"10.1016\/j.identj.2025.100937_bib0016","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1046\/j.0909-8836.1998.eos106510.x","article-title":"Dentin sialoprotein, dentin phosphoprotein, enamelysin and ameloblastin: tooth-specific molecules that are distinctively expressed during murine dental differentiation","volume":"106","author":"Begue-Kirn","year":"1998","journal-title":"Eur J Oral Sci"},{"issue":"3","key":"10.1016\/j.identj.2025.100937_bib0017","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s00439-004-1223-6","article-title":"Mutational hot spot in the DSPP gene causing dentinogenesis imperfecta type II","volume":"116","author":"Kim","year":"2005","journal-title":"Hum Genet"},{"issue":"1","key":"10.1016\/j.identj.2025.100937_bib0018","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/0022034508328168","article-title":"A novel mutation in the DSPP gene associated with dentinogenesis imperfecta type II","volume":"88","author":"Lee","year":"2009","journal-title":"J Dent Res"},{"issue":"6","key":"10.1016\/j.identj.2025.100937_bib0019","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1600-0722.2009.00683.x","article-title":"De novo mutation in the DSPP gene associated with dentinogenesis imperfecta type II in a Japanese family","volume":"117","author":"Kida","year":"2009","journal-title":"Eur J Oral Sci"},{"issue":"1","key":"10.1016\/j.identj.2025.100937_bib0020","first-page":"17","article-title":"The role of DSPP in dentine formation and hereditary dentine defects","volume":"27","author":"Jia","year":"2024","journal-title":"Chin J Dent Res"},{"key":"10.1016\/j.identj.2025.100937_bib0021","doi-asserted-by":"crossref","first-page":"724098","DOI":"10.3389\/fphys.2021.724098","article-title":"Enamel defects associated with dentin sialophosphoprotein mutation in mice","volume":"12","author":"Liang","year":"2021","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.identj.2025.100937_bib0022","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s12903-025-05912-8","article-title":"A family study of dentinogenesis imperfecta shields type II caused by a novel DSPP mutation and investigations on the isolated stem cells from human exfoliated deciduous teeth","volume":"25","author":"Gao","year":"2025","journal-title":"BMC Oral Health"},{"issue":"12","key":"10.1016\/j.identj.2025.100937_bib0023","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/humu.20783","article-title":"A comprehensive analysis of normal variation and disease-causing mutations in the human DSPP gene","volume":"29","author":"McKnight","year":"2008","journal-title":"Hum Mutat"},{"issue":"5","key":"10.1016\/j.identj.2025.100937_bib0024","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/genes13050858","article-title":"The modified shields classification and 12 families with defined DSPP mutations","volume":"13","author":"Simmer","year":"2022","journal-title":"Genes (Basel)"},{"issue":"12","key":"10.1016\/j.identj.2025.100937_bib0025","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1177\/154405910808701217","article-title":"Overlapping DSPP mutations cause dentin dysplasia and dentinogenesis imperfecta","volume":"87","author":"McKnight","year":"2008","journal-title":"J Dent Res"},{"issue":"4","key":"10.1016\/j.identj.2025.100937_bib0026","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/odi.12801","article-title":"Dental properties, ultrastructure, and pulp cells associated with a novel DSPP mutation","volume":"24","author":"Porntaveetus","year":"2018","journal-title":"Oral Dis"},{"issue":"21","key":"10.1016\/j.identj.2025.100937_bib0027","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1093\/hmg\/11.21.2559","article-title":"Mutation of the signal peptide region of the bicistronic gene DSPP affects translocation to the endoplasmic reticulum and results in defective dentine biomineralization","volume":"11","author":"Rajpar","year":"2002","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.identj.2025.100937_bib0028","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1002\/jbmr.1573","article-title":"Rough endoplasmic reticulum trafficking errors by different classes of mutant dentin sialophosphoprotein (DSPP) cause dominant negative effects in both dentinogenesis imperfecta and dentin dysplasia by entrapping normal DSPP","volume":"27","author":"von Marschall","year":"2012","journal-title":"J Bone Miner Res"},{"issue":"1","key":"10.1016\/j.identj.2025.100937_bib0029","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1038\/s41598-023-33362-1","article-title":"Dentin defects caused by a DSPP(-1) frameshift mutation are associated with the activation of autophagy","volume":"13","author":"Liang","year":"2023","journal-title":"Sci Rep"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925002242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925002242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:54:10Z","timestamp":1777463650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653925002242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S0020653925002242"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2025.100937","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Novel DSPP Mutation in Dentinogenesis Imperfecta Shields Type II: Clinical, Genetic and Stem Cell Perspectives","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2025.100937","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"100937"}}