{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:44:21Z","timestamp":1771847061658,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T00:00:00Z","timestamp":1754352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.identj.2025.103879","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:22:49Z","timestamp":1756858969000},"page":"103879","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decoding Epigenetic Enhancer\u2013Promoter Interactions in Periodontitis via Transformer-GAN: A Deep Learning Framework for Inflammatory Gene Regulation and Biomarker Discovery"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-0465","authenticated-orcid":false,"given":"Prabhu Manickam","family":"Natarajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-4123","authenticated-orcid":false,"given":"Pradeep Kumar","family":"Yadalam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.identj.2025.103879_bib0001","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5455\/jice.20160122065556","article-title":"Herbs as an antioxidant arsenal for periodontal diseases","volume":"5","author":"Ramesh","year":"2016","journal-title":"J Intercult Ethnopharmacol"},{"issue":"3","key":"10.1016\/j.identj.2025.103879_bib0002","doi-asserted-by":"crossref","DOI":"10.1097\/SCS.0000000000002524","article-title":"Adjunctive effect of autologus platelet-rich fibrin to barrier membrane in the treatment of periodontal intrabony defects","volume":"27","author":"Panda","year":"2016","journal-title":"J Craniofac Surg"},{"issue":"1","key":"10.1016\/j.identj.2025.103879_bib0003","doi-asserted-by":"crossref","DOI":"10.4103\/0970-9290.49061","article-title":"Analysis of the association between interleukin -1\u03b2 (+3954) gene polymorphism and chronic periodontitis in a sample of the south Indian population","volume":"20","author":"Kaarthikeyan","year":"2009","journal-title":"Indian J Dent Res"},{"issue":"2","key":"10.1016\/j.identj.2025.103879_bib0004","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.identj.2025.02.005","article-title":"The transformative role of artificial intelligence in dentistry: a comprehensive overview. Part 1: fundamentals of AI, and its contemporary applications in dentistry","volume":"75","author":"Samaranayake","year":"2025","journal-title":"Int Dent J"},{"issue":"2","key":"10.1016\/j.identj.2025.103879_bib0005","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.identj.2025.02.006","article-title":"The transformative role of artificial intelligence in dentistry: a comprehensive overview part 2: the promise and perils, and the international dental federation communique","volume":"75","author":"Tuygunov","year":"2025","journal-title":"Int Dent J"},{"key":"10.1016\/j.identj.2025.103879_bib0006","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1133775","article-title":"Predicting enhancer-promoter interaction based on epigenomic signals","volume":"14","author":"Zheng","year":"2023","journal-title":"Front Genet"},{"issue":"9","key":"10.1016\/j.identj.2025.103879_bib0007","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046440","article-title":"Gene expression profiles in paired gingival biopsies from periodontitis-affected and healthy tissues revealed by massively parallel sequencing","volume":"7","author":"Davanian","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.identj.2025.103879_bib0008","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/jcpe.13504","article-title":"Differential DNA methylation and mRNA transcription in gingival tissues in periodontal health and disease","volume":"48","author":"Kim","year":"2021","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2025.103879_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1132018","article-title":"iEnhancer-DCSV: predicting enhancers and their strength based on DenseNet and improved convolutional block attention module","volume":"14","author":"Jia","year":"2023","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.identj.2025.103879_bib0010","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s12859-024-05784-9","article-title":"EPI-Trans: an effective transformer-based deep learning model for enhancer promoter interaction prediction","volume":"25","author":"Ahmed","year":"2024","journal-title":"BMC Bioinformatics"},{"issue":"15\u201316","key":"10.1016\/j.identj.2025.103879_bib0011","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1089\/ten.tea.2016.0441","article-title":"* CRISPR-based epigenome editing of cytokine receptors for the promotion of cell survival and tissue deposition in inflammatory environments","volume":"23","author":"Farhang","year":"2017","journal-title":"Tissue Eng Part A"},{"issue":"12","key":"10.1016\/j.identj.2025.103879_bib0012","doi-asserted-by":"crossref","DOI":"10.3390\/genes15121511","article-title":"GATv2EPI: predicting enhancer\u2013promoter interactions with a dynamic graph attention network","volume":"15","author":"Zhang","year":"2024","journal-title":"Genes (Basel)"},{"issue":"2","key":"10.1016\/j.identj.2025.103879_bib0013","doi-asserted-by":"crossref","first-page":"142","DOI":"10.4103\/0972-124X.145784","article-title":"The epigenetic paradigm in periodontitis pathogenesis","volume":"19","author":"Lavu","year":"2015","journal-title":"J Indian Soc Periodontol"},{"issue":"1","key":"10.1016\/j.identj.2025.103879_bib0014","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13059-023-02955-4","article-title":"Decoding enhancer complexity with machine learning and high-throughput discovery","volume":"24","author":"Smith","year":"2023","journal-title":"Genome Biol"},{"key":"10.1016\/j.identj.2025.103879_bib0015","first-page":"2731","article-title":"Predicting mandibular bone growth using artificial intelligence and machine learning: a systematic review","volume":"4","author":"Dashti","year":"2024","journal-title":"Adv Artif Intell Mach Learn"},{"issue":"3","key":"10.1016\/j.identj.2025.103879_bib0016","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1016\/j.identj.2024.12.018","article-title":"Systematic review and meta-analysis on the accuracy of artificial intelligence algorithms in individuals gender detection using orthopantomograms","volume":"75","author":"Dashti","year":"2025","journal-title":"Int Dent J"},{"issue":"6","key":"10.1016\/j.identj.2025.103879_bib0017","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1109\/TCBB.2021.3109488","article-title":"EPIHC: improving enhancer-promoter interaction prediction by using hybrid features and communicative learning","volume":"19","author":"Liu","year":"2022","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"issue":"5","key":"10.1016\/j.identj.2025.103879_bib0018","doi-asserted-by":"crossref","first-page":"btae716","DOI":"10.1093\/bioinformatics\/btae716","article-title":"EPIPDLF: a pretrained deep learning framework for predicting enhancer\u2013promoter interactions","volume":"41","author":"Xiao","year":"2025","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.identj.2025.103879_bib0019","doi-asserted-by":"crossref","first-page":"vbae074","DOI":"10.1093\/bioadv\/vbae074","article-title":"Predmoter-cross-species prediction of plant promoter and enhancer regions","volume":"4","author":"Kindel","year":"2024","journal-title":"Bioinform Adv"},{"issue":"2","key":"10.1016\/j.identj.2025.103879_bib0020","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab577","article-title":"Capturing large genomic contexts for accurately predicting enhancer-promoter interactions","volume":"23","author":"Chen","year":"2022","journal-title":"Brief Bioinform"},{"issue":"3","key":"10.1016\/j.identj.2025.103879_bib0021","doi-asserted-by":"crossref","first-page":"668","DOI":"10.26599\/BDMA.2024.9020018","article-title":"EPIMR: prediction of enhancer-promoter interactions by multi-scale resnet on image representation","volume":"7","author":"Meng","year":"2024","journal-title":"Big Data Min Anal"},{"issue":"4","key":"10.1016\/j.identj.2025.103879_bib0022","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbaa254","article-title":"Predicting enhancer-promoter interactions by deep learning and matching heuristic","volume":"22","author":"Min","year":"2021","journal-title":"Brief Bioinform"},{"issue":"1","key":"10.1016\/j.identj.2025.103879_bib0023","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac801","article-title":"DeepPHiC: predicting promoter-centered chromatin interactions using a novel deep learning approach","volume":"39","author":"Agarwal","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.identj.2025.103879_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2019.00286","article-title":"DeePromoter: robust promoter predictor using deep learning","volume":"10","author":"Oubounyt","year":"2019","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.identj.2025.103879_bib0025","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1186\/s12859-020-03844-4","article-title":"Prediction of enhancer-promoter interactions using the cross-cell type information and domain adversarial neural network","volume":"21","author":"Jing","year":"2020","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.identj.2025.103879_bib0026","first-page":"1387","article-title":"Predicting enhancer-promoter interaction from genomic sequence with deep learning","volume":"19","author":"Yang","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"issue":"D1","key":"10.1016\/j.identj.2025.103879_bib0027","doi-asserted-by":"crossref","first-page":"D235","DOI":"10.1093\/nar\/gky1025","article-title":"SEdb: a comprehensive human super-enhancer database","volume":"47","author":"Jiang","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.identj.2025.103879_bib0028","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19099-3","article-title":"A machine learning technique for identifying DNA enhancer regions utilizing CIS-regulatory element patterns","volume":"12","author":"Butt","year":"2022","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.identj.2025.103879_bib0029","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.jgg.2023.02.006","article-title":"Delta.EPI: a probabilistic voting-based enhancer-promoter interaction prediction platform","volume":"50","author":"Zhang","year":"2023","journal-title":"J Genet Genomics"},{"issue":"1","key":"10.1016\/j.identj.2025.103879_bib0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s12539-024-00669-0","article-title":"RAEPI: predicting enhancer-promoter interactions based on restricted attention mechanism","volume":"17","author":"Zhang","year":"2025","journal-title":"Interdiscip Sci"},{"issue":"12","key":"10.1016\/j.identj.2025.103879_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110988","article-title":"MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines","volume":"39","author":"Corujo","year":"2022","journal-title":"Cell Rep"},{"issue":"15","key":"10.1016\/j.identj.2025.103879_bib0032","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.2174\/1381612826666201124112710","article-title":"Sequence-based deep learning frameworks on enhancer-promoter interactions prediction","volume":"27","author":"Min","year":"2021","journal-title":"Curr Pharm Des"}],"updated-by":[{"DOI":"10.1016\/j.identj.2025.103976","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000}}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925031636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925031636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:34:21Z","timestamp":1769157261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653925031636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0020653925031636"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2025.103879","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decoding Epigenetic Enhancer\u2013Promoter Interactions in Periodontitis via Transformer-GAN: A Deep Learning Framework for Inflammatory Gene Regulation and Biomarker Discovery","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2025.103879","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"103879"}}