{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T10:26:10Z","timestamp":1792923970436,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012531"],"award-info":[{"award-number":["2022A1515012531"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012222"],"award-info":[{"award-number":["2024A1515012222"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300874"],"award-info":[{"award-number":["81300874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11772361"],"award-info":[{"award-number":["11772361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.identj.2025.103941","type":"journal-article","created":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:40:43Z","timestamp":1761082843000},"page":"103941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["P. Gingivalis LPS Drives Osteoclastogenesis and Impairs Osteoblast Differentiation by Suppressing Sema3A\/Nrp1 Via TLR-4"],"prefix":"10.1016","volume":"75","author":[{"given":"Jingyi","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7936-2956","authenticated-orcid":false,"given":"Sandeth","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0462-7500","authenticated-orcid":false,"given":"Xiaoli","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6367-5863","authenticated-orcid":false,"given":"Quan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.identj.2025.103941_bib0001","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.2041-1014.2012.00657.x","article-title":"Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment","volume":"27","author":"McIntosh","year":"2012","journal-title":"Mol Oral Microbiol"},{"issue":"2","key":"10.1016\/j.identj.2025.103941_bib0002","first-page":"87","article-title":"Dental plaque biofilm in oral health and disease","volume":"14","author":"Seneviratne","year":"2011","journal-title":"Chin J Dent Res"},{"issue":"4","key":"10.1016\/j.identj.2025.103941_bib0003","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/apm.12930","article-title":"Effect of resveratrol on biofilm formation and virulence factor gene expression of Porphyromonas gingivalis in periodontal disease","volume":"127","author":"Kugaji","year":"2019","journal-title":"APMIS"},{"issue":"3","key":"10.1016\/j.identj.2025.103941_bib0004","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/21505594.2014.1000764","article-title":"Association of the invasion ability of Porphyromonas gingivalis with the severity of periodontitis","volume":"6","author":"Baek","year":"2015","journal-title":"Virulence"},{"issue":"5","key":"10.1016\/j.identj.2025.103941_bib0005","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1902\/jop.2007.060293","article-title":"1-Tetradecanol complex reduces progression of Porphyromonas gingivalis-induced experimental periodontitis in rabbits","volume":"78","author":"Hasturk","year":"2007","journal-title":"J Periodontol"},{"issue":"2","key":"10.1016\/j.identj.2025.103941_bib0006","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.archoralbio.2013.11.008","article-title":"Porphyromonas gingivalis LPS inhibits osteoblastic differentiation and promotes pro-inflammatory cytokine production in human periodontal ligament stem cells","volume":"59","author":"Kato","year":"2014","journal-title":"Arch Oral Biol"},{"issue":"1","key":"10.1016\/j.identj.2025.103941_bib0007","doi-asserted-by":"crossref","DOI":"10.1002\/cre2.70098","article-title":"Radicular cysts and periapical granulomas: data documentation for 696 cases and findings on fibrosis, and Porphyromonas gingivalis and fusobacterium nucleatum in these lesions","volume":"11","author":"Virkkunen","year":"2025","journal-title":"Clin Exp Dent Res"},{"issue":"9","key":"10.1016\/j.identj.2025.103941_bib0008","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003627","article-title":"Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD)","volume":"9","author":"Maresz","year":"2013","journal-title":"PLoS Pathog"},{"issue":"2","key":"10.1016\/j.identj.2025.103941_bib0009","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2334\/josnusd.23-0410","article-title":"Possible roles of short-chain fatty acids produced by oral bacteria in the development of alveolar osteitis","volume":"66","author":"Asayama","year":"2024","journal-title":"J Oral Sci"},{"issue":"7","key":"10.1016\/j.identj.2025.103941_bib0010","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/jcpe.12735","article-title":"Oral infection with Porphyromonas gingivalis induces peri-implantitis in a murine model: evaluation of bone loss and the local inflammatory response","volume":"44","author":"Tzach-Nahman","year":"2017","journal-title":"J Clin Periodontol"},{"issue":"2","key":"10.1016\/j.identj.2025.103941_bib0011","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1210\/jc.2011-2332","article-title":"Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives","volume":"97","author":"Baron","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.identj.2025.103941_bib0012","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1534-5807(02)00157-0","article-title":"Reaching a genetic and molecular understanding of skeletal development","volume":"2","author":"Karsenty","year":"2002","journal-title":"Dev Cell"},{"issue":"10","key":"10.1016\/j.identj.2025.103941_bib0013","doi-asserted-by":"crossref","DOI":"10.1111\/1756-185X.15357","article-title":"Osteoporosis and inflammation: cause to effect or comorbidity?","volume":"27","author":"Khoury","year":"2024","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.identj.2025.103941_bib0014","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jare.2024.12.009","article-title":"Dual regulation of phaseol on osteoclast formation and osteoblast differentiation by targeting TAK1 kinase for osteoporosis treatment","volume":"76","author":"Tan","year":"2025","journal-title":"J Adv Res"},{"issue":"3","key":"10.1016\/j.identj.2025.103941_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.31062","article-title":"Periodontal ligament-associated protein-1 knockout mice regulate the differentiation of osteoclasts and osteoblasts through TGF-beta1\/Smad signaling pathway","volume":"239","author":"Liu","year":"2024","journal-title":"J Cell Physiol"},{"issue":"5","key":"10.1016\/j.identj.2025.103941_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2025.100894","article-title":"Forkhead box O1 promotes osteogenic differentiation of periodontal ligament stem cells in hypoxia\/reoxygenation environments by regulating heme oxygenase-1 scavenging of reactive oxygen species","volume":"75","author":"Ye","year":"2025","journal-title":"Int Dent J"},{"issue":"4","key":"10.1016\/j.identj.2025.103941_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2025.04.011","article-title":"Artesunate promotes bone remodeling through TRAF6-mediated NF-kappaB signaling under orthodontic stress in diabetic rats","volume":"75","author":"Zhan","year":"2025","journal-title":"Int Dent J"},{"issue":"12","key":"10.1016\/j.identj.2025.103941_bib0018","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122150","article-title":"Neuropeptide Y1 receptor regulates glucocorticoid-induced inhibition of osteoblast differentiation in murine MC3T3-E1 cells via ERK signaling","volume":"17","author":"Yu","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.identj.2025.103941_bib0019","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/0022034510379019","article-title":"LPS promotes pre-osteoclast activity by up-regulating CXCR4 via TLR-4","volume":"90","author":"Xing","year":"2011","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.identj.2025.103941_bib0020","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/jcp.22201","article-title":"Porphyromonas gingivalis lipopolysaccharide inhibits the osteoblastic differentiation of preosteoblasts by activating Notch1 signaling","volume":"225","author":"Xing","year":"2010","journal-title":"J Cell Physiol"},{"issue":"33","key":"10.1016\/j.identj.2025.103941_bib0021","doi-asserted-by":"crossref","first-page":"20147","DOI":"10.1074\/jbc.M115.655787","article-title":"Porphyromonas gingivalis stimulates bone resorption by enhancing RANKL (receptor activator of NF-kappaB Ligand) through activation of toll-like receptor 2 in osteoblasts","volume":"290","author":"Kassem","year":"2015","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.identj.2025.103941_bib0022","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/cpr.12173","article-title":"Porphyromonas gingivalis lipopolysaccharides regulate functions of bone marrow mesenchymal stem cells","volume":"48","author":"Tang","year":"2015","journal-title":"Cell Prolif"},{"issue":"2","key":"10.1016\/j.identj.2025.103941_bib0023","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s10266-012-0068-z","article-title":"Effects of Porphyromonas gingivalis surface-associated material on osteoclast formation","volume":"101","author":"Bougas","year":"2013","journal-title":"Odontology"},{"key":"10.1016\/j.identj.2025.103941_bib0024","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.archoralbio.2016.02.011","article-title":"Thymus-expressed chemokine enhances Porphyromonas gingivalis LPS-induced osteoclast formation via NFATc1 activation","volume":"66","author":"Usui","year":"2016","journal-title":"Arch Oral Biol"},{"issue":"4","key":"10.1016\/j.identj.2025.103941_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2025.100866","article-title":"Long noncoding RNA MIR4435-2HG is involved in osteogenic differentiation and inflammation in human dental pulp stem cells","volume":"75","author":"Wu","year":"2025","journal-title":"Int Dent J"},{"issue":"3","key":"10.1016\/j.identj.2025.103941_bib0026","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.identj.2025.02.019","article-title":"KLF2 promotes osteogenic differentiation of human periodontal ligament stem cells by regulating Nrf2 expression","volume":"75","author":"Chen","year":"2025","journal-title":"Int Dent J"},{"issue":"1","key":"10.1016\/j.identj.2025.103941_bib0027","doi-asserted-by":"crossref","first-page":"6648","DOI":"10.1038\/s41467-022-34352-z","article-title":"Osteocytes directly regulate osteolysis via MYD88 signalling in bacterial bone infection","volume":"13","author":"Yoshimoto","year":"2022","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.identj.2025.103941_bib0028","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18056","article-title":"Sesamin inhibits RANKL-induced osteoclastogenesis and attenuates LPS-induced osteolysis via suppression of ERK and NF-kappaB signalling pathways","volume":"28","author":"Yu","year":"2024","journal-title":"J Cell Mol Med"},{"issue":"3","key":"10.1016\/j.identj.2025.103941_bib0029","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/omi.12425","article-title":"Loss of signal transducer and activator of transcription 3 in osteoblasts impaired the bone healing in inflammatory microenvironment","volume":"39","author":"Feng","year":"2024","journal-title":"Mol Oral Microbiol"},{"key":"10.1016\/j.identj.2025.103941_bib0030","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1533658","article-title":"Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition","volume":"15","author":"Yekani","year":"2025","journal-title":"Front Cell Infect Microbiol"},{"issue":"6600","key":"10.1016\/j.identj.2025.103941_bib0031","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/383525a0","article-title":"Semaphorin III is needed for normal patterning and growth of nerves, bones and heart","volume":"383","author":"Behar","year":"1996","journal-title":"Nature"},{"issue":"5707","key":"10.1016\/j.identj.2025.103941_bib0032","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.1105416","article-title":"Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins","volume":"307","author":"Gu","year":"2005","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.identj.2025.103941_bib0033","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2174\/1566524023666230801124826","article-title":"Sema3A alleviates the malignant behaviors of gastric cancer cells by inhibiting NRP-1","volume":"24","author":"Yang","year":"2024","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.identj.2025.103941_bib0034","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102960","article-title":"CD72-semaphorin3A axis: a new regulatory pathway in systemic lupus erythematosus","volume":"134","author":"Eiza","year":"2023","journal-title":"J Autoimmun"},{"issue":"7396","key":"10.1016\/j.identj.2025.103941_bib0035","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature11000","article-title":"Osteoprotection by semaphorin 3A","volume":"485","author":"Hayashi","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.identj.2025.103941_bib0036","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00223-025-01350-4","article-title":"Semaphorin 3A on osteoporosis: an overreview of the literature","volume":"116","author":"Zhang","year":"2025","journal-title":"Calcif Tissue Int"},{"issue":"7","key":"10.1016\/j.identj.2025.103941_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200000","article-title":"Sema3a inhibits the differentiation of Raw264.7 cells to osteoclasts under 2Gy radiation by reducing inflammation","volume":"13","author":"Huang","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.identj.2025.103941_bib0038","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3389\/fendo.2019.00562","article-title":"Sema3a as a novel therapeutic option for high glucose-suppressed osteogenic differentiation in diabetic osteopathy","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"10.1016\/j.identj.2025.103941_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2021.112595","article-title":"Glucocorticoids suppressed osteoblast differentiation by decreasing Sema3A expression via the PIK3\/Akt pathway","volume":"403","author":"Xing","year":"2021","journal-title":"Exp Cell Res"},{"issue":"7450","key":"10.1016\/j.identj.2025.103941_bib0040","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nature12115","article-title":"Sema3A regulates bone-mass accrual through sensory innervations","volume":"497","author":"Fukuda","year":"2013","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.identj.2025.103941_bib0041","first-page":"1114","article-title":"The effect of semaphorin 3A on fracture healing in osteoporotic rats","volume":"20","author":"Li","year":"2015","journal-title":"J Orthop Sci"},{"issue":"7","key":"10.1016\/j.identj.2025.103941_bib0042","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/jbm.b.33730","article-title":"SEMA3A suspended in matrigel improves titanium implant fixation in ovariectomized rats","volume":"105","author":"Li","year":"2017","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.identj.2025.103941_bib0043","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bone.2018.06.003","article-title":"A bone-targeting drug-delivery system based on Semaphorin 3A gene therapy ameliorates bone loss in osteoporotic ovariectomized mice","volume":"114","author":"Yang","year":"2018","journal-title":"Bone"},{"issue":"3","key":"10.1016\/j.identj.2025.103941_bib0044","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jcms.2018.12.010","article-title":"Investigation of the effects of semaphorin 3A on new bone formation in a rat calvarial defect model","volume":"47","author":"Kenan","year":"2019","journal-title":"J Craniomaxillofac Surg"},{"key":"10.1016\/j.identj.2025.103941_bib0045","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3389\/fphar.2016.00375","article-title":"Wedelolactone enhances osteoblastogenesis but inhibits osteoclastogenesis through Sema3A\/NRP1\/PlexinA1 pathway","volume":"7","author":"Liu","year":"2016","journal-title":"Front Pharmacol"},{"issue":"6","key":"10.1016\/j.identj.2025.103941_bib0046","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s10735-020-09941-1","article-title":"Semaphorin 3A promotes the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells in inflammatory environments by suppressing the Wnt\/beta-catenin signalling pathway","volume":"52","author":"Sun","year":"2021","journal-title":"J Mol Histol"},{"issue":"10","key":"10.1016\/j.identj.2025.103941_bib0047","first-page":"3710","article-title":"The effects of Sema3A overexpression on the proliferation and differentiation of rat gingival mesenchymal stem cells in the LPS-induced inflammatory environment","volume":"12","author":"Tian","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"10.1016\/j.identj.2025.103941_bib0048","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1631\/jzus.B2300180","article-title":"Reduced expression of semaphorin 3A in osteoclasts causes lymphatic expansion in a Gorham-Stout disease (GSD) mouse model","volume":"25","author":"Zhang","year":"2024","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.identj.2025.103941_bib0049","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.actbio.2015.11.025","article-title":"Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss","volume":"30","author":"Saad","year":"2016","journal-title":"Acta Biomater"},{"issue":"1-2","key":"10.1016\/j.identj.2025.103941_bib0050","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0006-8993(00)02700-1","article-title":"Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts","volume":"878","author":"Togari","year":"2000","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.identj.2025.103941_bib0051","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10529-012-1051-z","article-title":"In vitro immunomodulatory properties of osteogenic and adipogenic differentiated mesenchymal stem cells isolated from three inbred mouse strains","volume":"35","author":"Hashemi","year":"2013","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.identj.2025.103941_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.107102","article-title":"A review of bacterial and osteoclast differentiation in bone infection","volume":"197","author":"Dong","year":"2024","journal-title":"Microb Pathog"},{"issue":"1","key":"10.1016\/j.identj.2025.103941_bib0053","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12985-024-02510-y","article-title":"The potential use of bacteriophages as antibacterial agents in dental infection","volume":"21","author":"Hosseini Hooshiar","year":"2024","journal-title":"Virol J"},{"issue":"7","key":"10.1016\/j.identj.2025.103941_bib0054","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1128\/iai.64.7.2371-2380.1996","article-title":"Bacterially induced bone destruction: mechanisms and misconceptions","volume":"64","author":"Nair","year":"1996","journal-title":"Infect Immun"},{"key":"10.1016\/j.identj.2025.103941_bib0055","first-page":"40","article-title":"The role of semaphorin 3A in bone remodeling","volume":"11","author":"Li","year":"2017","journal-title":"Front Cell Neurosci"},{"issue":"10","key":"10.1016\/j.identj.2025.103941_bib0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endocr\/bqac126","article-title":"Osteoblast lineage cell-derived Sema3A regulates bone homeostasis independently of androgens","volume":"163","author":"Yamashita","year":"2022","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.identj.2025.103941_bib0057","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18201","article-title":"Peripheral nerve-derived Sema3A promotes osteogenic differentiation of mesenchymal stem cells through the Wnt\/\u03b2-catenin\/Nrp1 positive feedback loop","volume":"28","author":"Shi","year":"2024","journal-title":"J Cell Mol Med"},{"issue":"4","key":"10.1016\/j.identj.2025.103941_bib0058","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1359-6101(00)00011-3","article-title":"Wnt\/beta-catenin signalling","volume":"11","author":"Akiyama","year":"2000","journal-title":"Cytokine Growth Factor Rev"},{"issue":"12","key":"10.1016\/j.identj.2025.103941_bib0059","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.joen.2011.08.015","article-title":"Porphyromonas endodontalis lipopolysaccharides induce RANKL by mouse osteoblast in a way different from that of Escherichia coli lipopolysaccharide","volume":"37","author":"Tang","year":"2011","journal-title":"J Endod"},{"issue":"9","key":"10.1016\/j.identj.2025.103941_bib0060","doi-asserted-by":"crossref","DOI":"10.3390\/biology13090692","article-title":"Roles of toll-like receptor signaling in inflammatory bone resorption","volume":"13","author":"Tominari","year":"2024","journal-title":"Biology"},{"issue":"4","key":"10.1016\/j.identj.2025.103941_bib0061","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1128\/IAI.67.4.1736-1742.1999","article-title":"Lipopolysaccharides (LPS) of oral black-pigmented bacteria induce tumor necrosis factor production by LPS-refractory C3H\/HeJ macrophages in a way different from that of Salmonella LPS","volume":"67","author":"Kirikae","year":"1999","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.identj.2025.103941_bib0062","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1128\/IAI.72.9.5041-5051.2004","article-title":"Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4","volume":"72","author":"Darveau","year":"2004","journal-title":"Infect Immun"},{"issue":"1","key":"10.1016\/j.identj.2025.103941_bib0063","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41413-022-00186-0","article-title":"Sialylation of TLR2 initiates osteoclast fusion","volume":"10","author":"Dou","year":"2022","journal-title":"Bone Res"},{"key":"10.1016\/j.identj.2025.103941_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.ntm.2024.100033","article-title":"Advances of calcium phosphate nanoceramics for the osteoinductive potential and mechanistic pathways in maxillofacial bone defect repair","volume":"3","author":"Gou","year":"2024","journal-title":"Nano TransMed"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925032241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925032241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:05:33Z","timestamp":1773824733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653925032241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":64,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S0020653925032241"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2025.103941","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"P. Gingivalis LPS Drives Osteoclastogenesis and Impairs Osteoblast Differentiation by Suppressing Sema3A\/Nrp1 Via TLR-4","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2025.103941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"103941"}}