{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:34:05Z","timestamp":1785332045544,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004880","name":"Xinjiang Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.identj.2025.103948","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T04:10:06Z","timestamp":1763525406000},"page":"103948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["FBXO5 alleviates apical periodontitis by facilitating TP53 protein degradation"],"prefix":"10.1016","volume":"76","author":[{"given":"Ruihan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menglin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.identj.2025.103948_bib0001","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.joen.2023.05.017","article-title":"Histologic and electron microscopic characterization of a human immature permanent premolar with chronic apical abscess 16 years after regenerative endodontic procedures","volume":"49","author":"Kwon","year":"2023","journal-title":"J Endod"},{"key":"10.1016\/j.identj.2025.103948_bib0002","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1590\/1807-3107bor-2018.vol32.0069","article-title":"Etiologic role of root canal infection in apical periodontitis and its relationship with clinical symptomatology","volume":"32","author":"Gomes","year":"2018","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.identj.2025.103948_bib0003","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/iej.13467","article-title":"The global prevalence of apical periodontitis: a systematic review and meta-analysis","volume":"54","author":"Tib\u00farcio-Machado","year":"2021","journal-title":"Int Endod J"},{"key":"10.1016\/j.identj.2025.103948_bib0004","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.joen.2019.05.018","article-title":"Dynamics of bone loss in cases with acute or chronic apical abscess","volume":"45","author":"Jalali","year":"2019","journal-title":"J Endod"},{"key":"10.1016\/j.identj.2025.103948_bib0005","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00784-022-04754-w","article-title":"Teeth with acute apical abscess vs. teeth with chronic apical periodontitis: a quantitative and qualitative proteomic analysis","volume":"27","author":"Loureiro","year":"2023","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.identj.2025.103948_bib0006","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41368-022-00206-z","article-title":"Expert consensus on regenerative endodontic procedures","volume":"14","author":"Wei","year":"2022","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.identj.2025.103948_bib0007","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.3390\/biomedicines11072047","article-title":"Stem cells from the apical papilla (SCAPs): past, present, prospects, and challenges","volume":"11","author":"Liu","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.identj.2025.103948_bib0008","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fbioe.2018.00103","article-title":"Stem cells from the apical papilla (SCAP) as a tool for endogenous tissue regeneration","volume":"6","author":"Nada","year":"2018","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.identj.2025.103948_bib0009","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.joen.2008.03.001","article-title":"The hidden treasure in apical papilla: the potential role in pulp\/dentin regeneration and bioroot engineering","volume":"34","author":"Huang","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.identj.2025.103948_bib0010","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1186\/s13287-020-02069-9","article-title":"Potential of resveratrol in enrichment of neural progenitor-like cell induction of human stem cells from apical papilla","volume":"11","author":"Songsaad","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.identj.2025.103948_bib0011","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.joen.2007.11.021","article-title":"Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study","volume":"34","author":"Sonoyama","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.identj.2025.103948_bib0012","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/iej.12551","article-title":"Long-term exposure to pro-inflammatory cytokines inhibits the osteogenic\/dentinogenic differentiation of stem cells from the apical papilla","volume":"49","author":"Liu","year":"2016","journal-title":"Int Endod J"},{"key":"10.1016\/j.identj.2025.103948_bib0013","article-title":"Protective actions in apical periodontitis: the regenerative bioactivities led by mesenchymal stem cells","volume":"12:1737","author":"Lyu","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.identj.2025.103948_bib0014","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s40824-022-00336-9","article-title":"The complex of miRNA2861 and cell-penetrating, dimeric \u03b1-helical peptide accelerates the osteogenesis of mesenchymal stem cells","volume":"26","author":"Nam","year":"2022","journal-title":"Biomater Res"},{"key":"10.1016\/j.identj.2025.103948_bib0016","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2341\/22-023-L","article-title":"Effects of bioactive pulp-capping materials on cell viability, differentiation, and mineralization behaviors of human dental pulp stem cells in vitro","volume":"48","author":"Gungor","year":"2023","journal-title":"Oper Dent"},{"key":"10.1016\/j.identj.2025.103948_bib0017","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrc3700","article-title":"Roles of F-box proteins in cancer","volume":"14","author":"Wang","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.identj.2025.103948_bib0018","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/S1097-2765(03)00233-8","article-title":"Emi1 proteolysis: how SCF(beta-Trcp1) helps to activate the anaphase-promoting complex","volume":"11","author":"Peters","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.identj.2025.103948_bib0019","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.lfs.2015.12.031","article-title":"Melatonin, bone regulation and the ubiquitin-proteasome connection: a review","volume":"145","author":"Vriend","year":"2016","journal-title":"Life Sci"},{"key":"10.1016\/j.identj.2025.103948_bib0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13287-017-0485-6","article-title":"Differential long noncoding RNA\/mRNA expression profiling and functional network analysis during osteogenic differentiation of human bone marrow mesenchymal stem cells","volume":"8","author":"Zhang","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.identj.2025.103948_bib0022","article-title":"p53: from fundamental biology to clinical applications in cancer","volume":"11:1325","author":"Capuozzo","year":"2022","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.identj.2025.103948_bib0023","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41418-022-00989-y","article-title":"Mutant p53: it's not all one and the same","volume":"29","author":"Kennedy","year":"2022","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.identj.2025.103948_bib0024","doi-asserted-by":"crossref","first-page":"5975","DOI":"10.1038\/s41388-021-01991-3","article-title":"Spontaneous and inherited TP53 genetic alterations","volume":"40","author":"Levine","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.identj.2025.103948_bib0025","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1038\/cdd.2017.113","article-title":"p53 inhibits SP7\/Osterix activity in the transcriptional program of osteoblast differentiation","volume":"24","author":"Artigas","year":"2017","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.identj.2025.103948_bib0026","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/iej.13919","article-title":"Clinical and radiographic outcomes of regenerative endodontic procedures for traumatized permanent necrotic teeth with apical periodontitis and external root resorption","volume":"56","author":"Lu","year":"2023","journal-title":"Int Endod J"},{"key":"10.1016\/j.identj.2025.103948_bib0027","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1007\/s00784-021-04333-5","article-title":"Intracanal calcification following regenerative endodontic treatment: a systematic review and meta-analysis","volume":"26","author":"Almutairi","year":"2022","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.identj.2025.103948_bib0028","doi-asserted-by":"crossref","DOI":"10.1177\/2041731418819263","article-title":"Pulp-dentin regeneration: current approaches and challenges","volume":"10","author":"Jung","year":"2019","journal-title":"J Tissue Eng"},{"key":"10.1016\/j.identj.2025.103948_bib0029","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biocel.2016.02.005","article-title":"Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins","volume":"73","author":"Zheng","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.identj.2025.103948_bib0030","doi-asserted-by":"crossref","first-page":"28488","DOI":"10.1074\/jbc.M113.465179","article-title":"F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation","volume":"288","author":"Yumimoto","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.identj.2025.103948_bib0031","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/embor.2008.125","article-title":"A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation","volume":"9","author":"Kim","year":"2008","journal-title":"EMBO Rep"},{"key":"10.1016\/j.identj.2025.103948_bib0032","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.joen.2010.10.009","article-title":"Evaluation of the delivery of mesenchymal stem cells into the root canal space of necrotic immature teeth after clinical regenerative endodontic procedure","volume":"37","author":"Lovelace","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.identj.2025.103948_bib0033","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1007\/s00784-021-03840-9","article-title":"Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials","volume":"25","author":"Sequeira","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.identj.2025.103948_bib0034","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1111\/iej.13197","article-title":"Potential immunomodulatory effects of stem cells from the apical papilla on Treg conversion in tissue regeneration for regenerative endodontic treatment","volume":"52","author":"Liu","year":"2019","journal-title":"Int Endod J"},{"key":"10.1016\/j.identj.2025.103948_bib0035","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/embor.2013.25","article-title":"Another fork in the road\u2013life or death decisions by the tumour suppressor p53","volume":"14","author":"Carvajal","year":"2013","journal-title":"EMBO Rep"},{"key":"10.1016\/j.identj.2025.103948_bib0036","doi-asserted-by":"crossref","first-page":"e3707","DOI":"10.1371\/journal.pone.0003707","article-title":"p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner","volume":"3","author":"Molchadsky","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.identj.2025.103948_bib0037","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1089\/scd.2012.0370","article-title":"p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1","volume":"22","author":"Liu","year":"2013","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.identj.2025.103948_bib0038","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1083\/jcb.200507106","article-title":"p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling","volume":"172","author":"Wang","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.identj.2025.103948_bib0039","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41419-024-06421-2","article-title":"FBXO5-mediated RNF183 degradation prevents endoplasmic reticulum stress-induced apoptosis and promotes colon cancer progression","volume":"15","author":"Ji","year":"2024","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.identj.2025.103948_bib0040","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/ijc.34660","article-title":"TP53 induced glycolysis and apoptosis regulator and monocarboxylate transporter 4 drive metabolic reprogramming with c-MYC and NFkB activation in breast cancer","volume":"153","author":"Roche","year":"2023","journal-title":"Int J Cancer"},{"key":"10.1016\/j.identj.2025.103948_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155659","article-title":"JinLiDa granules alleviates cardiac hypertrophy and inflammation in diabetic cardiomyopathy by regulating TP53","volume":"130","author":"Fang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.identj.2025.103948_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114706","article-title":"Apigenin prevents hypertensive vascular remodeling by regulating the TP53 pathway","volume":"157","author":"Gao","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.identj.2025.103948_bib0043","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s12672-025-03069-y","article-title":"Integrative analysis identifies FBXO5 as a critical mediator of CRPC progression and bone metastatic potential","volume":"16","author":"Raut","year":"2025","journal-title":"Discov Oncol"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925032319?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925032319?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:18:59Z","timestamp":1773328739000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653925032319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0020653925032319"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2025.103948","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FBXO5 alleviates apical periodontitis by facilitating TP53 protein degradation","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2025.103948","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"103948"}}