{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:51:27Z","timestamp":1782402687466,"version":"3.54.5"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ80534"],"award-info":[{"award-number":["2025JJ80534"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["KJ-B2023082"],"award-info":[{"award-number":["KJ-B2023082"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.identj.2025.103975","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T00:47:31Z","timestamp":1761871651000},"page":"103975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Curcumin suppresses EMT to alleviate oral submucous fibrosis progression through XIST\/miR-25-3p-mediated inactivation of the TGF-\u03b21\/Smads signalling pathway"],"prefix":"10.1016","volume":"76","author":[{"given":"Qian","family":"Min","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.identj.2025.103975_bib0001","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.3390\/ijms24054992","article-title":"Oral submucous fibrosis: etiological mechanism, malignant transformation, therapeutic approaches and targets","volume":"24","author":"Qin","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.identj.2025.103975_bib0002","doi-asserted-by":"crossref","first-page":"106","DOI":"10.15713\/ins.jcri.271","article-title":"oral submucous fibrosis -an impediment for maintenance of good oral hygiene: a questionnaire-based study","volume":"6","author":"Burde","year":"2019","journal-title":"J Adv Clin Res Insights"},{"issue":"19","key":"10.1016\/j.identj.2025.103975_bib0003","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.3390\/ijms21197231","article-title":"Oral submucous fibrosis: a review on biomarkers, pathogenic mechanisms, and treatments","volume":"21","author":"Shen","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.identj.2025.103975_bib0004","article-title":"Spatial transcriptomic and metabolomic landscapes of oral submucous fibrosis-derived oral squamous cell carcinoma and its tumor microenvironment","volume":"11","author":"Zhi","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"3","key":"10.1016\/j.identj.2025.103975_bib0005","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.3390\/ijms23031637","article-title":"Molecular mechanisms of malignant transformation of oral submucous fibrosis by different betel quid constituents-does fibroblast senescence play a role?","volume":"23","author":"Zhang","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.identj.2025.103975_bib0006","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.3390\/ijms20122940","article-title":"Oral submucous fibrosis: a review on etiopathogenesis, diagnosis, and therapy","volume":"20","author":"Shih","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.identj.2025.103975_bib0007","article-title":"Is epithelial-mesenchymal transition a new roadway in the pathogenesis of oral submucous fibrosis: a comprehensive review","volume":"14","author":"Panda","year":"2022","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.identj.2025.103975_bib0008","doi-asserted-by":"crossref","first-page":"249","DOI":"10.14245\/ns.2244148.074","article-title":"Curcumin as a promising neuroprotective agent for the treatment of spinal cord injury: a review of the literature","volume":"19","author":"Lee","year":"2022","journal-title":"Neurospine"},{"key":"10.1016\/j.identj.2025.103975_bib0009","article-title":"Review of the effects and mechanism of curcumin in the treatment of inflammatory bowel disease","volume":"13","author":"Lin","year":"2022","journal-title":"Front Pharmacol"},{"issue":"4","key":"10.1016\/j.identj.2025.103975_bib0010","first-page":"509","article-title":"[Structural chromosomal damages in myelokaryocytes exposed to plutonium-239 dioxide]","volume":"28","author":"Nikolaevskaia","year":"1988","journal-title":"Radiobiologiia"},{"issue":"12","key":"10.1016\/j.identj.2025.103975_bib0011","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.jfma.2017.12.014","article-title":"Curcumin inhibits TGF-beta1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts","volume":"117","author":"Chen","year":"2018","journal-title":"J Formos Med Assoc"},{"key":"10.1016\/j.identj.2025.103975_bib0012","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.2147\/DDDT.S186726","article-title":"Ferulic acid attenuates liver fibrosis and hepatic stellate cell activation via inhibition of TGF-beta\/Smad signaling pathway","volume":"12","author":"Mu","year":"2018","journal-title":"Drug Des Devel Ther."},{"issue":"637","key":"10.1016\/j.identj.2025.103975_bib0013","doi-asserted-by":"crossref","first-page":"eaaz4028","DOI":"10.1126\/scitranslmed.aaz4028","article-title":"NUAK1 promotes organ fibrosis via YAP and TGF-beta\/SMAD signaling","volume":"14","author":"Zhang","year":"2022","journal-title":"Sci Transl Med"},{"issue":"22","key":"10.1016\/j.identj.2025.103975_bib0014","doi-asserted-by":"crossref","first-page":"8855","DOI":"10.3390\/ijms21228855","article-title":"LncRNAs in ovarian cancer progression, metastasis, and main pathways: ceRNA and alternative mechanisms","volume":"21","author":"Braga","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.identj.2025.103975_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.123400","article-title":"XIST\/let-7i\/HMGA1 axis maintains myofibroblasts activities in oral submucous fibrosis","volume":"232","author":"Yu","year":"2023","journal-title":"Int J Biol Macromol"},{"issue":"10","key":"10.1016\/j.identj.2025.103975_bib0016","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.1007\/s12035-023-03450-4","article-title":"LncRNA XIST exacerbates oxygen-glucose deprivation\/reoxygenation-induced cerebral injury through the miR-25-3p\/TRAF3 Axis","volume":"60","author":"Li","year":"2023","journal-title":"Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.identj.2025.103975_bib0017","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s11658-023-00477-2","article-title":"CRISPR\/Cas13d targeting GZMA in PARs pathway regulates the function of osteoclasts in chronic apical periodontitis","volume":"28","author":"Jia","year":"2023","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.identj.2025.103975_bib0018","article-title":"Construction and analysis of a ceRNA network in cardiac fibroblast during fibrosis based on in vivo and in vitro data","volume":"11","author":"Gao","year":"2020","journal-title":"Front Genet"},{"key":"10.1016\/j.identj.2025.103975_bib0019","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-beta\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem Biol Interact"},{"issue":"1","key":"10.1016\/j.identj.2025.103975_bib0020","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1080\/13880209.2020.1851729","article-title":"Arecoline suppresses epithelial cell viability by upregulating tropomyosin-1 through the transforming growth factor-beta\/Smad pathway","volume":"58","author":"Li","year":"2020","journal-title":"Pharm Biol"},{"issue":"1","key":"10.1016\/j.identj.2025.103975_bib0021","doi-asserted-by":"crossref","first-page":"289","DOI":"10.7314\/APJCP.2012.13.1.289","article-title":"Antifibrotic effect of curcumin in TGF-beta 1-induced myofibroblasts from human oral mucosa","volume":"13","author":"Zhang","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"10.1016\/j.identj.2025.103975_bib0022","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41405-024-00268-7","article-title":"Mechanism of curcumin in the prevention and treatment of oral submucosal fibrosis and progress in clinical application research","volume":"10","author":"She","year":"2024","journal-title":"BDJ Open"},{"key":"10.1016\/j.identj.2025.103975_bib0023","first-page":"917","article-title":"Significance of E-cadherin and Vimentin as epithelial-mesenchymal transition markers in colorectal carcinoma prognosis","volume":"19","author":"Niknami","year":"2020","journal-title":"EXCLI J"},{"issue":"2","key":"10.1016\/j.identj.2025.103975_bib0024","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10549-020-05627-0","article-title":"Expression of epithelial-mesenchymal transition-related markers and phenotypes during breast cancer progression","volume":"181","author":"Jorgensen","year":"2020","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"10.1016\/j.identj.2025.103975_bib0025","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1038\/s41598-025-87790-2","article-title":"Novel transcripts of EMT driving the malignant transformation of oral submucous fibrosis","volume":"15","author":"Shetty","year":"2025","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.identj.2025.103975_bib0026","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.7150\/ijbs.7.1056","article-title":"Diverse roles of TGF-beta\/Smads in renal fibrosis and inflammation","volume":"7","author":"Lan","year":"2011","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.identj.2025.103975_bib0027","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3389\/fonc.2018.00357","article-title":"Transforming growth factor-beta-induced cell plasticity in liver fibrosis and hepatocarcinogenesis","volume":"8","author":"Fabregat","year":"2018","journal-title":"Front Oncol"},{"issue":"2","key":"10.1016\/j.identj.2025.103975_bib0028","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3390\/biom11020310","article-title":"Organ fibrosis and autoimmunity: the role of inflammation in TGFbeta-dependent EMT","volume":"11","author":"Sisto","year":"2021","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.identj.2025.103975_bib0029","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41419-024-06753-z","article-title":"Autophagy caused by oxidative stress promotes TGF-beta1-induced epithelial-to-mesenchymal transition in human peritoneal mesothelial cells","volume":"15","author":"Oh","year":"2024","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/j.identj.2025.103975_bib0030","first-page":"474","article-title":"Curcumin suppress cardiac fibroblasts activities by regulating proliferation, migration, and the extracellular matrix","volume":"30","author":"Chung","year":"2014","journal-title":"Acta Cardiol Sin"},{"issue":"10","key":"10.1016\/j.identj.2025.103975_bib0031","first-page":"6438","article-title":"Curcumin inhibits oral squamous cell carcinoma proliferation and invasion via EGFR signaling pathways","volume":"7","author":"Zhen","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"10.1016\/j.identj.2025.103975_bib0032","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.explore.2022.04.009","article-title":"A comparative study to assess the effectiveness of curcumin, mucosamin, and chlorhexidine in chemotherapy-induced oral mucositis","volume":"19","author":"Fardad","year":"2023","journal-title":"Explore (NY)"},{"issue":"1","key":"10.1016\/j.identj.2025.103975_bib0033","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12885-023-10730-8","article-title":"Efficacy of curcumin for amelioration of radiotherapy-induced oral mucositis: a preliminary randomized controlled clinical trial","volume":"23","author":"Ramezani","year":"2023","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.identj.2025.103975_bib0034","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/jomfp.JOMFP_234_19","article-title":"Qualitative expression of hypoxia-inducible factor-1alpha in malignant transformation of oral submucous fibrosis: An immunohistochemical study","volume":"24","author":"Pereira","year":"2020","journal-title":"J Oral Maxillofac Pathol"},{"issue":"4","key":"10.1016\/j.identj.2025.103975_bib0035","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1091\/mbc.e04-08-0658","article-title":"TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition","volume":"16","author":"Valcourt","year":"2005","journal-title":"Mol Biol Cell"},{"issue":"19","key":"10.1016\/j.identj.2025.103975_bib0036","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.3390\/cancers14194845","article-title":"Regulation of TGF-beta1-Induced EMT by autophagy-dependent energy metabolism in cancer cells","volume":"14","author":"Hwang","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.identj.2025.103975_bib0037","article-title":"Curcumin and curcumol inhibit NF-kappaB and TGF-beta (1)\/Smads signaling pathways in CSE-treated RAW246.7 cells","volume":"2019","author":"Li","year":"2019","journal-title":"Evid Based Complement Alternat Med."},{"issue":"5","key":"10.1016\/j.identj.2025.103975_bib0038","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3892\/etm.2021.9908","article-title":"Long non-coding RNA XIST promotes the proliferation of cardiac fibroblasts and the accumulation of extracellular matrix by sponging microRNA-155-5p","volume":"21","author":"Zhang","year":"2021","journal-title":"Exp Ther Med"},{"issue":"10","key":"10.1016\/j.identj.2025.103975_bib0039","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201901","article-title":"MiR-25-3p targets PTEN to regulate the migration, invasion, and apoptosis of esophageal cancer cells via the PI3K\/AKT pathway","volume":"40","author":"Zhang","year":"2020","journal-title":"Biosci Rep"},{"key":"10.1016\/j.identj.2025.103975_bib0040","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.2147\/CMAR.S262245","article-title":"MiR-25-3p serves as an oncogenic MicroRNA by downregulating the expression of merlin in osteosarcoma","volume":"12","author":"Rao","year":"2020","journal-title":"Cancer Manag Res"},{"issue":"1","key":"10.1016\/j.identj.2025.103975_bib0041","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1186\/s12951-024-02888-5","article-title":"Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway","volume":"22","author":"Xue","year":"2024","journal-title":"J Nanobiotechnol"},{"issue":"6","key":"10.1016\/j.identj.2025.103975_bib0042","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1038\/s41374-020-0373-z","article-title":"TGFbeta1-Smad canonical and -Erk noncanonical pathways participate in interleukin-17-induced epithelial-mesenchymal transition in Sjogren's syndrome","volume":"100","author":"Sisto","year":"2020","journal-title":"Lab Invest"},{"issue":"14","key":"10.1016\/j.identj.2025.103975_bib0043","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147534","article-title":"The effect of liposomal curcumin as an anti-inflammatory strategy on lipopolysaccharide e from porphyromonas gingivalis treated endothelial committed neural crest derived stem cells: morphological and molecular mechanisms","volume":"22","author":"Diomede","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.identj.2025.103975_bib0044","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/jop.13547","article-title":"Curcumin is effective in managing oral inflammation: an in vitro study","volume":"53","author":"Idrees","year":"2024","journal-title":"J Oral Pathol Med"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925032587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653925032587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:15:48Z","timestamp":1773296148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653925032587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0020653925032587"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2025.103975","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin suppresses EMT to alleviate oral submucous fibrosis progression through XIST\/miR-25-3p-mediated inactivation of the TGF-\u03b21\/Smads signalling pathway","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2025.103975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"103975"}}