{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:51:02Z","timestamp":1791406262435,"version":"4.3.3"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2022R1A2C2003528"],"award-info":[{"award-number":["2022R1A2C2003528"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.identj.2026.109415","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T07:52:10Z","timestamp":1770191530000},"page":"109415","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combined Effects of Zinc Compounds and Xylitol on the Enzymatic and Anticandidal Activities of Salivary Antimicrobials"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-1708","authenticated-orcid":false,"given":"Yu-Jin","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Youn","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Wook","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9960-9892","authenticated-orcid":false,"given":"Hong-Seop","family":"Kho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.identj.2026.109415_bib0001","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1615\/JEnvironPatholToxicolOncol.v25.i3.40","article-title":"The role of zinc in life: a review","volume":"25","author":"Frassinetti","year":"2006","journal-title":"J Environ Pathol Toxicol Oncol"},{"issue":"4","key":"10.1016\/j.identj.2026.109415_bib0002","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.autrev.2014.11.008","article-title":"Zinc and its role in immunity and inflammation","volume":"14","author":"Bonaventura","year":"2015","journal-title":"Autoimmun Rev"},{"issue":"2","key":"10.1016\/j.identj.2026.109415_bib0003","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0003-9969(01)00093-0","article-title":"Inhibitory effect of ZnCl2 on glycolysis in human oral microbes","volume":"47","author":"He","year":"2002","journal-title":"Arch Oral Biol"},{"issue":"Suppl 3","key":"10.1016\/j.identj.2026.109415_bib0004","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1875-595X.2011.00047.x","article-title":"Antimicrobial effects of o-cymen-5-ol and zinc, alone & in combination in simple solutions and toothpaste formulations","volume":"61","author":"Pizzey","year":"2011","journal-title":"Int Dent J"},{"issue":"4","key":"10.1016\/j.identj.2026.109415_bib0005","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/advances\/nmz013","article-title":"The role of zinc in antiviral immunity","volume":"10","author":"Read","year":"2019","journal-title":"Adv Nutr (Bethesda, Md.)"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0006","article-title":"Zinc therapy in dermatology: a review","volume":"2014","author":"Gupta","year":"2014","journal-title":"Dermatol Res Pract"},{"issue":"4","key":"10.1016\/j.identj.2026.109415_bib0007","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3390\/ijerph7041342","article-title":"The essential toxin: impact of zinc on human health","volume":"7","author":"Plum","year":"2010","journal-title":"Int J Environ Res Public Health"},{"issue":"6 Suppl 1","key":"10.1016\/j.identj.2026.109415_bib0008","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1875-595X.2003.tb00911.x","article-title":"Anti-microbial efficacy and mode of action studies on a new zinc\/Triclosan formulation","volume":"53","author":"Brading","year":"2003","journal-title":"Int Dent J"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0009","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1574-6968.2005.00018.x","article-title":"Co-operative inhibition by fluoride and zinc of glucosyl transferase production and polysaccharide synthesis by mutans streptococci in suspension cultures and biofilms","volume":"254","author":"Koo","year":"2006","journal-title":"FEMS Microbiol Lett"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0010","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1034\/j.1601-0825.2002.1o781.x","article-title":"Clinical applications of antimicrobial host proteins, lactoperoxidase, lysozyme and lactoferrin in xerostomia: efficacy and safety","volume":"8","author":"Tenovuo","year":"2002","journal-title":"Oral Dis"},{"issue":"6","key":"10.1016\/j.identj.2026.109415_bib0011","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.archoralbio.2011.11.007","article-title":"Candidacidal activities of the glucose oxidase-mediated lactoperoxidase system","volume":"57","author":"Kho","year":"2012","journal-title":"Arch Oral Biol"},{"issue":"12","key":"10.1016\/j.identj.2026.109415_bib0012","doi-asserted-by":"crossref","first-page":"5850","DOI":"10.1007\/s12011-024-04110-x","article-title":"Effects of zinc compounds on the enzymatic activities of lysozyme and peroxidase and their antifungal activities","volume":"202","author":"Kim","year":"2024","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"10.1016\/j.identj.2026.109415_bib0013","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jds.2024.09.002","article-title":"Candidacidal activities of zinc compounds based on incubation time, pH, and ionic strength - An in vitro study","volume":"20","author":"Hwang","year":"2025","journal-title":"J Dent Sci"},{"issue":"2","key":"10.1016\/j.identj.2026.109415_bib0014","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.identj.2024.09.006","article-title":"In vitro effects of zinc compounds on the candidacidal activities of salivary antimicrobials","volume":"75","author":"Park","year":"2025","journal-title":"Int Dent J"},{"issue":"9","key":"10.1016\/j.identj.2026.109415_bib0015","doi-asserted-by":"crossref","first-page":"3900","DOI":"10.1007\/s12011-023-03972-x","article-title":"Effects of zinc compounds on lysozyme, peroxidase, and \u03b1-amylase from the perspective of oral health: a scoping review","volume":"202","author":"Kim","year":"2024","journal-title":"Biol Trace Elem Res"},{"issue":"7","key":"10.1016\/j.identj.2026.109415_bib0016","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.archoralbio.2015.03.011","article-title":"The effects of xylitol and sorbitol on lysozyme- and peroxidase-related enzymatic and candidacidal activities","volume":"60","author":"Kim","year":"2015","journal-title":"Arch Oral Biol"},{"issue":"4","key":"10.1016\/j.identj.2026.109415_bib0017","doi-asserted-by":"crossref","first-page":"155","DOI":"10.14476\/jomp.2016.41.4.155","article-title":"Candidacidal activity of xylitol and sorbitol","volume":"41","author":"Kim","year":"2016","journal-title":"J Oral Med Pain"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0018","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/1389201015666141202104347","article-title":"Bypassing microbial resistance: xylitol controls microorganisms growth by means of its anti-adherence property","volume":"16","author":"Ferreira","year":"2015","journal-title":"Curr Pharm Biotechnol"},{"issue":"5","key":"10.1016\/j.identj.2026.109415_bib0019","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/jac\/41.5.563","article-title":"Antiadhesive effects of xylitol on otopathogenic bacteria","volume":"41","author":"Kontiokari","year":"1998","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0020","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/0895937409335642","article-title":"Xylitol, mutans streptococci, and dental plaque","volume":"21","author":"S\u00f6derling","year":"2009","journal-title":"Adv Dent Res"},{"issue":"3","key":"10.1016\/j.identj.2026.109415_bib0021","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000077768","article-title":"Sugar alcohols: what is the evidence for caries preventive and caries-therapeutic effects?","volume":"38","author":"Van Loveren","year":"2004","journal-title":"Caries Res"},{"issue":"5","key":"10.1016\/j.identj.2026.109415_bib0022","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/00016359109005919","article-title":"The effect of a chewing gum on salivary secretion, oral mucosal friction, and the feeling of dry mouth in xerostomic patients","volume":"49","author":"Olsson","year":"1991","journal-title":"Acta Odontol Scand"},{"issue":"5","key":"10.1016\/j.identj.2026.109415_bib0023","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1159\/000086849","article-title":"Interactions of Streptococcus mutans glucosyltransferase B with lysozyme in solution and on the surface of hydroxyapatite","volume":"39","author":"Kho","year":"2005","journal-title":"Caries Res"},{"issue":"5","key":"10.1016\/j.identj.2026.109415_bib0024","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.biomaterials.2007.10.016","article-title":"Molecular simulation of protein adsorption and desorption on hydroxyapatite surfaces","volume":"29","author":"Shen","year":"2008","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.identj.2026.109415_bib0025","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1177\/154411130301400507","article-title":"Molecular recognition at the protein-hydroxyapatite interface","volume":"14","author":"Stayton","year":"2003","journal-title":"Crit Rev Oral Biol Med"},{"issue":"4","key":"10.1016\/j.identj.2026.109415_bib0026","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1741-2358.2009.00284.x","article-title":"Impact of ageing and drug consumption on oral health","volume":"26","author":"Gueiros","year":"2009","journal-title":"Gerodontology"},{"issue":"8","key":"10.1016\/j.identj.2026.109415_bib0027","doi-asserted-by":"crossref","first-page":"e521","DOI":"10.1016\/S2666-7568(21)00142-2","article-title":"Oral health for healthy ageing","volume":"2","author":"Patel","year":"2021","journal-title":"Lancet Healthy Longev"},{"issue":"3","key":"10.1016\/j.identj.2026.109415_bib0028","first-page":"159","article-title":"Quantitative study of the interaction of salivary acidic proline-rich proteins with hydroxyapatite","volume":"12","author":"Bennick","year":"1978","journal-title":"Caries Res"},{"key":"10.1016\/j.identj.2026.109415_bib0029","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.archoralbio.2018.02.007","article-title":"Effects of molecular weight of hyaluronic acid on its viscosity and enzymatic activities of lysozyme and peroxidase","volume":"89","author":"Kim","year":"2018","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.identj.2026.109415_bib0030","series-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard-fourth edition. CLSI Document M27","year":"2017"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0031","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0308-8146(99)00147-8","article-title":"Iron and citrate interactions with hen egg white lysozyme","volume":"68","author":"Croguennec","year":"2000","journal-title":"Food Chem"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0032","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF02941827","article-title":"Cellulose hydrolysis using zinc chloride as a solvent and catalyst","volume":"45","author":"Cao","year":"1994","journal-title":"Appl Biochem Biotechnol"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0033","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF02933408","article-title":"Acid hydrolysis of cellulose in zinc chloride solution","volume":"51","author":"Cao","year":"1995","journal-title":"Appl Biochem Biotechnol"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0034","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5012\/bkcs.2002.23.1.119","article-title":"Solution nuclear magnetic resonance spectral characterization of iron(II) porphyrin complexes of weakly coordinating anions","volume":"23","author":"Song","year":"2002","journal-title":"Bull Korean Chem Soc"},{"issue":"2","key":"10.1016\/j.identj.2026.109415_bib0035","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0006-291X(88)80568-0","article-title":"Lysozyme kinetics in low water activity media. A possible hydration memory","volume":"155","author":"Larreta-Garde","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.identj.2026.109415_bib0036","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/BF00973108","article-title":"Thermodynamics of the weak interaction between samarium cation and xylitol in water: a chemical model","volume":"23","author":"Rongere","year":"1994","journal-title":"J Solut Chem"},{"key":"10.1016\/j.identj.2026.109415_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2020.104886","article-title":"Inhibitory effects of xylitol and sorbitol on Streptococcus mutans and Candida albicans biofilms are repressed by the presence of sucrose","volume":"119","author":"Chan","year":"2020","journal-title":"Arch Oral Biol"},{"issue":"2","key":"10.1016\/j.identj.2026.109415_bib0038","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5005\/jp-journals-10024-2225","article-title":"Antifungal activity of xylitol against Candida albicans: an in vitro study","volume":"19","author":"Talattof","year":"2018","journal-title":"J Contemp Dent Pract"},{"issue":"9","key":"10.1016\/j.identj.2026.109415_bib0039","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1111\/ijfs.12158","article-title":"Antifungal properties of zinc-compounds against toxigenic fungi and mycotoxin","volume":"48","author":"Savi","year":"2013","journal-title":"Int J Food Sci Technol"},{"issue":"1","key":"10.1016\/j.identj.2026.109415_bib0040","doi-asserted-by":"crossref","first-page":"72","DOI":"10.14693\/jdi.v16i1.12","article-title":"Effect of xylitol with various concentration and duration on the growth of Candida Albicans (in vitro study)","volume":"16","author":"Leepel","year":"2009","journal-title":"J Dent Indones"},{"issue":"6","key":"10.1016\/j.identj.2026.109415_bib0041","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1365-2672.2004.02423.x","article-title":"Penicillium chrysogenum glucose oxidase \u2013 a study on its antifungal effects","volume":"97","author":"Leiter","year":"2004","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.identj.2026.109415_bib0042","doi-asserted-by":"crossref","DOI":"10.1038\/srep37356","article-title":"Direct comparison of gluco-oligosaccharide oxidase variants and glucose oxidase: substrate range and H2O2 stability","volume":"6","author":"Vuong","year":"2016","journal-title":"Sci Rep"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926000110?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926000110?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:00:13Z","timestamp":1791403213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653926000110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S0020653926000110"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2026.109415","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined Effects of Zinc Compounds and Xylitol on the Enzymatic and Anticandidal Activities of Salivary Antimicrobials","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2026.109415","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"109415"}}