{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:18:24Z","timestamp":1787851104316,"version":"build-2784847793"},"reference-count":88,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000386"],"award-info":[{"award-number":["32000386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2025byyfyjq04"],"award-info":[{"award-number":["2025byyfyjq04"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.identj.2026.109461","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:04:32Z","timestamp":1772103872000},"page":"109461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing links between dental fluorosis and oral\/systemic health via salivary microbiome in Chinese young adults"],"prefix":"10.1016","volume":"76","author":[{"given":"Qinglong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-874X","authenticated-orcid":false,"given":"Shanshan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.identj.2026.109461_bib0001","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12393","article-title":"The oral microbiome: role of key organisms and complex networks in oral health and disease","volume":"87","author":"Sedghi","year":"2021","journal-title":"Periodontol"},{"key":"10.1016\/j.identj.2026.109461_bib0002","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.biopha.2018.01.146","article-title":"Human oral microbiota and its modulation for oral health","volume":"99","author":"Zhang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.identj.2026.109461_bib0003","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/00220345231160756","article-title":"Microbial indicators of dental health, dysbiosis, and early childhood caries","volume":"102","author":"Kahharova","year":"2023","journal-title":"J Dent Res"},{"key":"10.1016\/j.identj.2026.109461_bib0004","first-page":"12","article-title":"Impact of malocclusions on Periodontopathogenic bacterial load and progression of periodontal disease: a quantitative analysis","author":"Albu","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.identj.2026.109461_bib0005","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3390\/curroncol31010011","article-title":"Mechanisms and potential clinical implications of oral microbiome in oral squamous cell carcinoma","volume":"31","author":"Wang","year":"2023","journal-title":"Curr Oncol"},{"key":"10.1016\/j.identj.2026.109461_bib0006","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2024.2355823","article-title":"The oral microbiome and oral and upper gastrointestinal diseases","volume":"16","author":"Liu","year":"2024","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0007","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41579-024-01075-5","article-title":"The oral\u2013gut microbiome axis in health and disease","volume":"22","author":"Kunath","year":"2024","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106475","article-title":"The role of oral microbiome in respiratory health and diseases","volume":"185","author":"Pathak","year":"2021","journal-title":"Respir Med"},{"key":"10.1016\/j.identj.2026.109461_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2025.04.013","article-title":"Facts and fallacies of the fluoride controversy: a contemporary perspective","volume":"75","author":"Samaranayake","year":"2025","journal-title":"Int Dent J"},{"issue":"Suppl 1","key":"10.1016\/j.identj.2026.109461_bib0010","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1002\/jbmr.5650051382","article-title":"Skeletal fluorosis: histomorphometric findings","volume":"5","author":"Boivin","year":"1990","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.identj.2026.109461_bib0011","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12940-025-01235-x","article-title":"Urinary fluoride and dental fluorosis in relation to kidney and liver function in adolescents and young adults in the United States","volume":"24","author":"Khan","year":"2025","journal-title":"Environ Health"},{"key":"10.1016\/j.identj.2026.109461_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104356","article-title":"A review on fluoride contamination in groundwater and human health implications and its remediation: a sustainable approaches","volume":"106","author":"Kumar","year":"2024","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.identj.2026.109461_bib0013","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.puhe.2017.08.013","article-title":"Association between water fluoride and the level of children\u2019s intelligence: a dose-response meta-analysis","volume":"154","author":"Duan","year":"2018","journal-title":"Public Health"},{"key":"10.1016\/j.identj.2026.109461_bib0014","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.2105\/AJPH.88.12.1774","article-title":"Health effects associated with sulfuryl fluoride and methyl bromide exposure among structural fumigation workers","volume":"88","author":"Calvert","year":"1998","journal-title":"Am J Public Health"},{"key":"10.1016\/j.identj.2026.109461_bib0015","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12011-018-1252-y","article-title":"Preliminary study of mechanisms of fluoride-induced suppression of nitric oxide synthesis in human umbilical vein endothelial cells","volume":"185","author":"Huang","year":"2018","journal-title":"Biol Trace Elem Res"},{"issue":"Spec No","key":"10.1016\/j.identj.2026.109461_bib0016","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1177\/00220345900690S135","article-title":"The nature and mechanisms of dental fluorosis in man","volume":"69","author":"Fejerskov","year":"1990","journal-title":"J Dent Res"},{"key":"10.1016\/j.identj.2026.109461_bib0017","article-title":"Oral-gut microbiome axis in gastrointestinal disease and cancer","volume":"13","author":"Park","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.identj.2026.109461_bib0018","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/prd.12301","article-title":"Oral-lung microbiome interactions in lung diseases","volume":"83","author":"Mammen","year":"2020","journal-title":"Periodontol"},{"key":"10.1016\/j.identj.2026.109461_bib0019","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1038\/s41598-021-82709-z","article-title":"Structural changes in the oral microbiome of the adolescent patients with moderate or severe dental fluorosis","volume":"11","author":"Wang","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.identj.2026.109461_bib0020","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2025.2560591","article-title":"The metagenome and metabolome signatures of dental biofilms associated with severe dental fluorosis","volume":"17","author":"Ajrithirong","year":"2025","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1296753","article-title":"Identifying the oral microbiome of adolescents with and without dental fluorosis based on full-length 16S rRNA gene sequencing","volume":"15","author":"Luo","year":"2024","journal-title":"Front Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0022","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2023.2180927","article-title":"Saliva microbiome alterations in dental fluorosis population","volume":"15","author":"Liu","year":"2023","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0023","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(19)31146-8","article-title":"Oral diseases: a global public health challenge","volume":"394","author":"Peres","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.identj.2026.109461_bib0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-014-0320-5","article-title":"Inhibitory effect of zingiber officinale towards Streptococcus mutans virulence and caries development: in vitro and in vivo studies","volume":"15","author":"Hasan","year":"2015","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0025","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/prd.12100","article-title":"Salivary biomarkers for dental caries","volume":"70","author":"Gao","year":"2016","journal-title":"Periodontol"},{"key":"10.1016\/j.identj.2026.109461_bib0026","first-page":"512","article-title":"4-acetamidobutanoic acid, a \u03b3-aminobutyric acid derivative, inhibits Streptococcus mutans growth, adhesion, and biofilm formation","author":"Liu","year":"2025","journal-title":"Chemical Engineering Journal"},{"key":"10.1016\/j.identj.2026.109461_bib0027","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cca.2013.01.013","article-title":"Comparative evaluation of saliva collection methods for proteome analysis","volume":"419","author":"Golatowski","year":"2013","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.identj.2026.109461_bib0028","doi-asserted-by":"crossref","first-page":"686","DOI":"10.21037\/atm-20-393","article-title":"Comparative evaluation of peptidome and microbiota in different types of saliva samples","volume":"8","author":"Zhu","year":"2020","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.identj.2026.109461_bib0029","first-page":"205","article-title":"The prevalence and associated risk indicators of dental fluorosis in China: findings from the 4th National Oral Health Survey","volume":"21","author":"Zhou","year":"2018","journal-title":"Chin J Dent Res"},{"key":"10.1016\/j.identj.2026.109461_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112439","article-title":"Associations of low level of fluoride exposure with dental fluorosis among U.S. children and adolescents, NHANES 2015-2016","volume":"221","author":"Dong","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.identj.2026.109461_bib0031","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00203-018-1505-3","article-title":"Insights into the human oral microbiome","volume":"200","author":"Verma","year":"2018","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0032","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ymthe.2021.08.025","article-title":"Fecal miR-142a-3p from dextran sulfate sodium-challenge recovered mice prevents colitis by promoting the growth of Lactobacillus reuteri","volume":"30","author":"He","year":"2022","journal-title":"Mol Ther"},{"key":"10.1016\/j.identj.2026.109461_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.05.002","article-title":"A global metagenomic map of urban microbiomes and antimicrobial resistance","volume":"184","author":"Danko","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.identj.2026.109461_bib0034","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1093\/bioinformatics\/btr507","article-title":"FLASH: fast length adjustment of short reads to improve genome assemblies","volume":"27","author":"Magoc","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.identj.2026.109461_bib0035","doi-asserted-by":"crossref","first-page":"e2584","DOI":"10.7717\/peerj.2584","article-title":"VSEARCH: a versatile open source tool for metagenomics","volume":"4","author":"Rognes","year":"2016","journal-title":"PeerJ"},{"key":"10.1016\/j.identj.2026.109461_bib0036","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"10.1016\/j.identj.2026.109461_bib0037","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.identj.2026.109461_bib0038","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1038\/ismej.2017.119","article-title":"Exact sequence variants should replace operational taxonomic units in marker-gene data analysis","volume":"11","author":"Callahan","year":"2017","journal-title":"ISME J"},{"key":"10.1016\/j.identj.2026.109461_bib0039","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2203894119","article-title":"Gut flora disequilibrium promotes the initiation of liver cancer by modulating tryptophan metabolism and up-regulating SREBP2","volume":"119","author":"Chen","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.identj.2026.109461_bib0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jare.2023.04.008","article-title":"Suppression of hepatocellular carcinoma by Ulva lactuca ulvan via gut microbiota and metabolite interactions","volume":"52","author":"Qiu","year":"2023","journal-title":"J Adv Res"},{"key":"10.1016\/j.identj.2026.109461_bib0041","article-title":"4-acetamidobutanoic acid, a \u03b3-aminobutyric acid derivative, inhibits Streptococcus mutans growth, adhesion, and biofilm formation","volume":"512","author":"Liu","year":"2025","journal-title":"Chem Eng J"},{"key":"10.1016\/j.identj.2026.109461_bib0042","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1038\/s41467-020-15457-9","article-title":"Metagenome-wide association of gut microbiome features for schizophrenia","volume":"11","author":"Zhu","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.identj.2026.109461_bib0043","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.identj.2026.109461_bib0044","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1875-595X.2007.tb00135.x","article-title":"Saliva as a diagnostic fluid","volume":"57","author":"Samaranayake","year":"2007","journal-title":"Int Dent J"},{"key":"10.1016\/j.identj.2026.109461_bib0045","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.identj.2024.01.012","article-title":"Microbial communities and functional genes in periodontitis and healthy controls","volume":"74","author":"Ma","year":"2024","journal-title":"Int Dent J"},{"key":"10.1016\/j.identj.2026.109461_bib0046","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/j.identj.2025.03.015","article-title":"Effect of stimulated salivary volume on dysbiosis of the salivary microbiome in children and young adults","volume":"75","author":"Shintani","year":"2025","journal-title":"Int Dent J"},{"key":"10.1016\/j.identj.2026.109461_bib0047","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1186\/s12967-024-05928-8","article-title":"Microbial and proteomic signatures of type 2 diabetes in an Arab population","volume":"22","author":"Murugesan","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.identj.2026.109461_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.05.002","article-title":"Metabolic dynamics and prediction of gestational age and time to delivery in pregnant women","volume":"181","author":"Liang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.identj.2026.109461_bib0049","article-title":"Human genetic and metabolite variation reveals that methylthioadenosine is a prognostic biomarker and an inflammatory regulator in sepsis","volume":"3","author":"Wang","year":"2017","journal-title":"Sci Adv"},{"key":"10.1016\/j.identj.2026.109461_bib0050","first-page":"105","article-title":"Associated factors of oral health-related quality of life in Chinese adolescents aged 12-15 years","volume":"24","author":"Wu","year":"2021","journal-title":"Chin J Dent Res"},{"key":"10.1016\/j.identj.2026.109461_bib0051","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41432-019-0069-7","article-title":"Home use of interdental cleaning devices and toothbrushing and their role in disease prevention","volume":"20","author":"Gallie","year":"2019","journal-title":"Evid Based Dent"},{"key":"10.1016\/j.identj.2026.109461_bib0052","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12903-015-0039-1","article-title":"Genetic polymorphisms of the Sortase A gene and social-behavioural factors associated with caries in children: a case-control study","volume":"15","author":"Yu","year":"2015","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.identj.2026.109461_bib0053","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/00016357.2021.1951349","article-title":"Association of dental caries with use of internet and social media among 12 and 15-year-olds","volume":"80","author":"Almoddahi","year":"2022","journal-title":"Acta Odontol Scand"},{"key":"10.1016\/j.identj.2026.109461_bib0054","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1037\/1082-989X.11.2.207","article-title":"Adjustments to the correction for attenuation","volume":"11","author":"Wetcher-Hendricks","year":"2006","journal-title":"Psychol Methods"},{"key":"10.1016\/j.identj.2026.109461_bib0055","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/ejhf.2535","article-title":"Factors associated with health-related quality of life in heart failure in 23 000 patients from 40 countries: results of the G-CHF research programme","volume":"24","author":"Johansson","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.identj.2026.109461_bib0056","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00784-022-04825-y","article-title":"Salivary microbiome diversity in Chinese children with various caries states","volume":"27","author":"Wu","year":"2023","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.identj.2026.109461_bib0057","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1186\/s12903-025-06405-4","article-title":"Oral microbiome diversity and composition before and after chemotherapy treatment in pediatric oncology patients","volume":"25","author":"Immonen","year":"2025","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.identj.2026.109461_bib0058","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13568-021-01199-4","article-title":"Identification of unknown acid-resistant genes of oral microbiotas in patients with dental caries using metagenomics analysis","volume":"11","author":"Cheng","year":"2021","journal-title":"AMB Express"},{"key":"10.1016\/j.identj.2026.109461_bib0059","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.959416","article-title":"Integrated analysis of the salivary microbiome and metabolome in chronic and aggressive periodontitis: a pilot study","volume":"13","author":"Wei","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0060","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3389\/fcimb.2018.00124","article-title":"The subgingival microbiome of periodontal pockets with different probing depths in chronic and aggressive periodontitis: a pilot study","volume":"8","author":"Shi","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0061","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms9112349","article-title":"Periodontal pathogens inhabit root caries lesions extending beyond the gingival margin: a next-generation sequencing analysis","volume":"9","author":"Takenaka","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.identj.2026.109461_bib0062","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0273523","article-title":"Differences in the subgingival microbiome according to stage of periodontitis: a comparison of two geographic regions","volume":"17","author":"Lafaurie","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.identj.2026.109461_bib0063","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1021\/acs.jproteome.4c00701","article-title":"Clinical response characteristics of salivary proteins in the management strategy of diabetes-associated periodontitis","volume":"24","author":"Jia","year":"2025","journal-title":"J Proteome Res"},{"key":"10.1016\/j.identj.2026.109461_bib0064","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.archoralbio.2019.01.007","article-title":"Oxytocin facilitates the proliferation, migration and osteogenic differentiation of human periodontal stem cells in vitro","volume":"99","author":"Ge","year":"2019","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.identj.2026.109461_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118794","article-title":"Extrudates of lipophilic tetracycline complexes: a new option for periodontitis therapy","volume":"572","author":"Kirchberg","year":"2019","journal-title":"Int J Pharm"},{"key":"10.1016\/j.identj.2026.109461_bib0066","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/odi.14180","article-title":"Effects of intermittent parathyroid hormone on cementoblast-mediated periodontal repair","volume":"29","author":"Cheng","year":"2023","journal-title":"Oral Dis"},{"key":"10.1016\/j.identj.2026.109461_bib0067","doi-asserted-by":"crossref","first-page":"248","DOI":"10.4103\/0970-9290.84297","article-title":"Assessment of periodontal status among dental fluorosis subjects using community periodontal index of treatment needs","volume":"22","author":"Kumar","year":"2011","journal-title":"Indian J Dent Res"},{"key":"10.1016\/j.identj.2026.109461_bib0068","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/0970-9290.32423","article-title":"Assessment of periodontal status in dental fluorosis subjects using community periodontal index of treatment needs","volume":"18","author":"Vandana","year":"2007","journal-title":"Indian J Dent Res"},{"key":"10.1016\/j.identj.2026.109461_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114985","article-title":"Immunological mechanisms of inflammatory diseases caused by gut microbiota dysbiosis: a review","volume":"164","author":"Zhao","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.identj.2026.109461_bib0070","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1038\/s41467-024-45794-y","article-title":"The gut ileal mucosal virome is disturbed in patients with Crohn\u2019s disease and exacerbates intestinal inflammation in mice","volume":"15","author":"Cao","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.identj.2026.109461_bib0071","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1053\/j.gastro.2019.03.049","article-title":"Gut microbiota in patients with irritable bowel syndrome-a systematic review","volume":"157","author":"Pittayanon","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.identj.2026.109461_bib0072","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2025.1608025","article-title":"Gut microbiota dysbiosis in inflammatory bowel disease: interaction with intestinal barriers and microbiota-targeted treatment options","volume":"15","author":"Xie","year":"2025","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0073","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens8030126","article-title":"Alteration of gut microbiota in inflammatory bowel disease (IBD): cause or consequence? IBD treatment targeting the gut microbiome","volume":"8","author":"Khan","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.identj.2026.109461_bib0074","article-title":"The role of gut microbiota in intestinal disease: from an oxidative stress perspective","volume":"15","author":"Sun","year":"2024","journal-title":"Front Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0075","article-title":"Role and mechanism of gut microbiota in human disease","volume":"11","author":"Chen","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0076","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/febs.15217","article-title":"The mutual interplay of gut microbiota, diet and human disease","volume":"287","author":"Illiano","year":"2020","journal-title":"FEBS J"},{"key":"10.1016\/j.identj.2026.109461_bib0077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13099-016-0151-z","article-title":"Mycobacterium avium subsp. paratuberculosis and associated risk factors for inflammatory bowel disease in Iranian patients","volume":"9","author":"Zamani","year":"2017","journal-title":"Gut Pathog"},{"key":"10.1016\/j.identj.2026.109461_bib0078","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1220130","article-title":"T helper cell responses in adult diarrheal patients following natural infection with enterotoxigenic Escherichia coli are primarily of the Th17 type","volume":"14","author":"Akhtar","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.identj.2026.109461_bib0079","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115388","article-title":"Interaction of environmental fluoride exposure and gut microbes: Potential implication in the development of fluorosis in human subjects","volume":"200","author":"Rawat","year":"2025","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.identj.2026.109461_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114518","article-title":"Integrated 16S rDNA sequencing and metabolomics to explore the intestinal changes in children and rats with dental fluorosis","volume":"251","author":"Zhou","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.identj.2026.109461_bib0081","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00535-2020","article-title":"Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS\/ERS\/ESCMID\/IDSA clinical practice guideline","volume":"56","author":"Daley","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.identj.2026.109461_bib0082","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1099\/ijs.0.017137-0","article-title":"Paenibacillus sputi sp. nov., isolated from the sputum of a patient with pulmonary disease","volume":"60","author":"Kim","year":"2010","journal-title":"Int J Syst Evol Microbiol"},{"key":"10.1016\/j.identj.2026.109461_bib0083","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41392-023-01684-1","article-title":"Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.identj.2026.109461_bib0084","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1926840","article-title":"The gut microbiome of COVID-19 recovered patients returns to uninfected status in a minority-dominated United States cohort","volume":"13","author":"Newsome","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.identj.2026.109461_bib0085","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1177\/15353702231157931","article-title":"Comparison of circulating bacterial profiles between mild and severe COVID-19 patients","volume":"248","author":"Sivapornnukul","year":"2023","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.identj.2026.109461_bib0086","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1186\/s12864-017-4008-8","article-title":"Genetic influences on the human oral microbiome","volume":"18","author":"Demmitt","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.identj.2026.109461_bib0087","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12091797","article-title":"Oral microbiome: a review of its impact on oral and systemic health","volume":"12","author":"Rajasekaran","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.identj.2026.109461_bib0088","doi-asserted-by":"crossref","DOI":"10.3390\/nu12082428","article-title":"Diet, stress and mental health","volume":"12","author":"Bremner","year":"2020","journal-title":"Nutrients"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926000572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926000572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:25:39Z","timestamp":1787847939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653926000572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":88,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0020653926000572"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2026.109461","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing links between dental fluorosis and oral\/systemic health via salivary microbiome in Chinese young adults","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2026.109461","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"109461"}}