{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:08:27Z","timestamp":1792112907662,"version":"4.4.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.identj.2026.109557","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T12:43:05Z","timestamp":1776516185000},"page":"109557","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mesenchymal Stem Cell-Lysate Sustained-Release Nano-Hydrogel Alleviates Spinal Cord Injury by Inhibiting Ferroptosis and Mitochondrial Intrinsic Apoptosis"],"prefix":"10.1016","volume":"76","author":[{"given":"Ming Lu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai Lei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0001","first-page":"1","article-title":"Time is spine: a review of translational advances in spinal cord injury","volume":"30","author":"Badhiwala","year":"2018","journal-title":"J Neurosurg"},{"issue":"5","key":"10.1016\/j.identj.2026.109557_bib0002","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nn.4541","article-title":"Cell transplantation therapy for spinal cord injury","volume":"20","author":"Assinck","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.identj.2026.109557_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2026.1752395","article-title":"Spinal cord injury-induced overflow incontinence reshapes the activin-follistatin-inhibin axis in mouse bladder and kidney","volume":"13","author":"Shen","year":"2026","journal-title":"Front Mol Biosci"},{"issue":"2","key":"10.1016\/j.identj.2026.109557_bib0004","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/10790268.2026.2629162","article-title":"Rigorous reporting of case reports in spinal cord injury: a collective responsibility","volume":"49","author":"Murphy","year":"2026","journal-title":"J Spinal Cord Med"},{"issue":"6","key":"10.1016\/j.identj.2026.109557_bib0005","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/s41591-019-0475-6","article-title":"Spinal cord repair: advances in biology and technology","volume":"25","author":"Courtine","year":"2019","journal-title":"Nat Med"},{"issue":"3","key":"10.1016\/j.identj.2026.109557_bib0006","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.pmr.2020.03.003","article-title":"Predicting outcomes after spinal cord injury","volume":"31","author":"Chay","year":"2020","journal-title":"Phys Med Rehabil Clin North Am"},{"issue":"2","key":"10.1016\/j.identj.2026.109557_bib0007","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3390\/jcm15020879","article-title":"The interplay between neuromodulation and stem cell therapy for sensory-motor neuroplasticity after spinal cord injury: a perspective view","volume":"15","author":"Yousak","year":"2026","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.identj.2026.109557_bib0008","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12035-022-03088-8","article-title":"The importance of using exosome-loaded miRNA for the treatment of spinal cord injury","volume":"60","author":"Shen","year":"2023","journal-title":"Mol Neurobiol"},{"issue":"2","key":"10.1016\/j.identj.2026.109557_bib0009","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1152\/physrev.00017.2017","article-title":"The Biology of Regeneration Failure and Success After Spinal Cord injury","volume":"98","author":"Tran","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.identj.2026.109557_bib0010","doi-asserted-by":"crossref","DOI":"10.1186\/s40001-026-04005-8","article-title":"Pharmacotherapy in the acute phase of secondary spinal cord injury: an updated narrative review","author":"Migliorini","year":"2026","journal-title":"Eur J Med Res"},{"issue":"22","key":"10.1016\/j.identj.2026.109557_bib0011","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS J"},{"key":"10.1016\/j.identj.2026.109557_bib0012","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.freeradbiomed.2021.08.231","article-title":"The calcium-iron connection in ferroptosis-mediated neuronal death","volume":"175","author":"Gleitze","year":"2021","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.identj.2026.109557_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104715","article-title":"Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2\/HO-1 signaling pathway","volume":"62","author":"Jiang","year":"2020","journal-title":"Toxicol In Vitro"},{"issue":"5","key":"10.1016\/j.identj.2026.109557_bib0014","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.identj.2026.109557_bib0015","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/s41418-019-0393-7","article-title":"Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism","volume":"27","author":"Chen","year":"2020","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.identj.2026.109557_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1374735","article-title":"Molecular mechanisms of mitochondria-mediated ferroptosis: a potential target for antimalarial interventions","volume":"12","author":"Adegboro","year":"2024","journal-title":"Front Cell Develop Biol"},{"issue":"2","key":"10.1016\/j.identj.2026.109557_bib0017","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis"},{"issue":"9","key":"10.1016\/j.identj.2026.109557_bib0018","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1007\/s12035-023-03423-7","article-title":"Identification and validation of ferroptosis-related genes in patients with acute spinal cord injury","volume":"60","author":"Qu","year":"2023","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.identj.2026.109557_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2019.108241","article-title":"The effects of iron overload on mitochondrial function, mitochondrial dynamics, and ferroptosis in cardiomyocytes","volume":"680","author":"Sumneang","year":"2020","journal-title":"Archiv Biochem Biophys"},{"key":"10.1016\/j.identj.2026.109557_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101328","article-title":"Insight into the mechanism of ferroptosis inhibition by ferrostatin-1","volume":"28","author":"Miotto","year":"2020","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0021","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13018-017-0526-y","article-title":"Effect of oxidative stress induced by intracranial iron overload on central pain after spinal cord injury","volume":"12","author":"Meng","year":"2017","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0022","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13018-017-0578-z","article-title":"In vivo evaluation of microglia activation by intracranial iron overload in central pain after spinal cord injury","volume":"12","author":"Meng","year":"2017","journal-title":"J Orthop Surg Res"},{"issue":"38","key":"10.1016\/j.identj.2026.109557_bib0023","doi-asserted-by":"crossref","first-page":"33960","DOI":"10.1021\/acsnano.5c09794","article-title":"Adaptive phenol-based hydrogel embedded with metformin nanoparticles targets oxidative stress and ferroptosis for spinal cord injury repair","volume":"19","author":"Feng","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.identj.2026.109557_bib0024","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fnins.2018.00252","article-title":"Therapeutic effect of platelet-rich plasma in rat spinal cord injuries","volume":"12","author":"Chen","year":"2018","journal-title":"Front Neurosci"},{"issue":"2","key":"10.1016\/j.identj.2026.109557_bib0025","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4103\/1673-5374.244796","article-title":"Melatonin combined with chondroitin sulfate ABC promotes nerve regeneration after root-avulsion brachial plexus injury","volume":"14","author":"Guo","year":"2019","journal-title":"Neural Regen Res"},{"issue":"2","key":"10.1016\/j.identj.2026.109557_bib0026","doi-asserted-by":"crossref","first-page":"454","DOI":"10.4103\/NRR.NRR-D-23-02044","article-title":"Microglia: a promising therapeutic target in spinal cord injury","volume":"20","author":"Zha","year":"2025","journal-title":"Neural Regen Res"},{"issue":"10","key":"10.1016\/j.identj.2026.109557_bib0027","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/aor.12614","article-title":"Neurocontrol of movement in humans with spinal cord injury","volume":"39","author":"Dimitrijevic","year":"2015","journal-title":"Artif Org"},{"issue":"2","key":"10.1016\/j.identj.2026.109557_bib0028","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00535-013-0901-3","article-title":"Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors","volume":"49","author":"Watanabe","year":"2014","journal-title":"J Gastroenterol"},{"issue":"4","key":"10.1016\/j.identj.2026.109557_bib0029","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nm0405-367","article-title":"Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells","volume":"11","author":"Gnecchi","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.identj.2026.109557_bib0030","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.2147\/JIR.S420741","article-title":"Umbilical cord stem cell lysate: a new biologic injectate for the putative treatment of acute temporomandibular joint inflammation","volume":"16","author":"Ward","year":"2023","journal-title":"J Inflam Res"},{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0031","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s10792-026-03947-6","article-title":"Application of umbilical cord mesenchymal stem cell lysate in dry eye syndrome and retinal injury","volume":"46","author":"Hang","year":"2026","journal-title":"Int Ophthalmol"},{"issue":"10","key":"10.1016\/j.identj.2026.109557_bib0032","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140551","article-title":"Extracellular vesicles derived from bone marrow mesenchymal stem cells protect against experimental colitis via attenuating colon inflammation, oxidative stress and apoptosis","volume":"10","author":"Yang","year":"2015","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0033","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/s12951-023-02218-1","article-title":"Inhibitory effects of the nanoscale lysate derived from xenogenic dental pulp stem cells in lung cancer models","volume":"21","author":"He","year":"2023","journal-title":"J Nanobiotechnol"},{"issue":"20","key":"10.1016\/j.identj.2026.109557_bib0034","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.3390\/ijms21207533","article-title":"Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms","volume":"21","author":"Anjum","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.identj.2026.109557_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcyt.2025.102009","article-title":"Implantation of human mesenchymal stromal cell pellet for therapeutic angiogenesis","volume":"28","author":"Mammoto","year":"2026","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0036","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s13287-025-04172-1","article-title":"Intranasal delivery of hMSC-derived supernatant for treatment of ischemic stroke by inhibiting the pro-inflammatory polarization of neutrophils","volume":"16","author":"Jiang","year":"2025","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0037","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s40820-020-00423-3","article-title":"Metal-organic framework nanocarriers for drug delivery in biomedical applications","volume":"12","author":"Sun","year":"2020","journal-title":"Nano Micro Lett"},{"issue":"22","key":"10.1016\/j.identj.2026.109557_bib0038","doi-asserted-by":"crossref","first-page":"5330","DOI":"10.3390\/molecules29225330","article-title":"pH-responsive metal-organic framework for targeted delivery of fungicide, release behavior, and sustainable plant protection","volume":"29","author":"Yang","year":"2024","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0039","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-07752-6","article-title":"Antibacterial, self-healing, and pH-responsive PVA\/ZIF-8@tannic acid nanocomposite hydrogel for sustained delivery of garlic extract","volume":"15","author":"Behjat","year":"2025","journal-title":"Sci Rep"},{"issue":"Pt 4","key":"10.1016\/j.identj.2026.109557_bib0040","article-title":"Synthesis and characterization of injectable thermosensitive hydrogel based on pluronic-grafted silk fibroin copolymer containing hydroxyapatite nanoparticles as potential for bone tissue engineering","volume":"277","author":"Daneshvar","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.identj.2026.109557_bib0041","article-title":"Extracellular vesicle-loaded hydrogels for tissue repair and regeneration","volume":"18","author":"Ju","year":"2022","journal-title":"Mater Today Biol"},{"key":"10.1016\/j.identj.2026.109557_bib0042","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1479-5876-9-29","article-title":"Risk factors in the development of stem cell therapy","volume":"9","author":"Herberts","year":"2011","journal-title":"J Transl Med"},{"key":"10.1016\/j.identj.2026.109557_bib0043","article-title":"Extracellular vesicles in osteoarthritis: mechanisms, therapeutic potential, and diagnostic applications","volume":"16","author":"Sun","year":"2025","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.identj.2026.109557_bib0044","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/s10620-020-06359-3","article-title":"Filtrated adipose tissue-derived mesenchymal stem cell lysate ameliorates experimental acute colitis in mice","volume":"66","author":"Nishikawa","year":"2021","journal-title":"Digest Dis Sci"},{"issue":"10","key":"10.1016\/j.identj.2026.109557_bib0045","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1021\/acsbiomaterials.7b00435","article-title":"ZnO-DOX@ZIF-8 core-shell nanoparticles for ph-responsive drug delivery","volume":"3","author":"Zheng","year":"2017","journal-title":"ACS Biomater Sci Eng"},{"issue":"17","key":"10.1016\/j.identj.2026.109557_bib0046","doi-asserted-by":"crossref","first-page":"4837","DOI":"10.1039\/D2BM00603K","article-title":"pH-Responsive hyaluronic acid-enveloped ZIF-8 nanoparticles for anti-atherosclerosis therapy","volume":"10","author":"Obaid","year":"2022","journal-title":"Biomater Sci"},{"key":"10.1016\/j.identj.2026.109557_bib0047","first-page":"3533","article-title":"Development of pluronic F127 and folic acid coated TiO(2) nanoparticles for antimicrobial and anticancer applications","volume":"339","author":"Kunal","year":"2025","journal-title":"Naunyn-Schmiedeberg\u2019s Archiv Pharmacol"},{"issue":"4","key":"10.1016\/j.identj.2026.109557_bib0048","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s11064-018-02706-z","article-title":"Sinomenine attenuates traumatic spinal cord injury by suppressing oxidative stress and inflammation via Nrf2 pathway","volume":"44","author":"Zhang","year":"2019","journal-title":"Neurochem Res"},{"issue":"6","key":"10.1016\/j.identj.2026.109557_bib0049","doi-asserted-by":"crossref","first-page":"e5786","DOI":"10.1371\/journal.pone.0005786","article-title":"SOD3 reduces inflammatory cell migration by regulating adhesion molecule and cytokine expression","volume":"4","author":"Laurila","year":"2009","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2010.178","article-title":"Crosstalk of reactive oxygen species and NF-\u03baB signaling","volume":"21","author":"Morgan","year":"2011","journal-title":"Cell Res"},{"issue":"1","key":"10.1016\/j.identj.2026.109557_bib0051","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2025.2585221","article-title":"Monoammonium glycyrrhizinate ameliorates mitochondrial dysfunction-mediated oxidative stress and neuroinflammation via the NRF2\/NQO1 axis after spinal cord injury","volume":"30","author":"Wang","year":"2025","journal-title":"Redox Rep"},{"key":"10.1016\/j.identj.2026.109557_bib0052","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jconrel.2022.04.047","article-title":"Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy","volume":"347","author":"Yu","year":"2022","journal-title":"J Control Release"},{"issue":"12","key":"10.1016\/j.identj.2026.109557_bib0053","doi-asserted-by":"crossref","first-page":"15530","DOI":"10.1007\/s12035-025-05226-4","article-title":"Melatonin attenuates spinal cord injury by regulating ferroptosis through the Nrf2\/HO-1\/GPX4 pathway","volume":"62","author":"Yu","year":"2025","journal-title":"Mol Neurobiol"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926001516?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926001516?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:18:28Z","timestamp":1787847508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653926001516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S0020653926001516"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2026.109557","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal Stem Cell-Lysate Sustained-Release Nano-Hydrogel Alleviates Spinal Cord Injury by Inhibiting Ferroptosis and Mitochondrial Intrinsic Apoptosis","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2026.109557","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"109557"}}