{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:08:53Z","timestamp":1790683733487,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101074"],"award-info":[{"award-number":["82101074"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.identj.2026.109572","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:28:17Z","timestamp":1776893297000},"page":"109572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Parathyroid Hormone Modulates Alveolar Bone Metabolism via Inducing Periodontal Ligament Stem Cells Aerobic Glycolysis"],"prefix":"10.1016","volume":"76","author":[{"given":"Xiaowei","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunguo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-4526","authenticated-orcid":false,"given":"Xiaogang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.identj.2026.109572_bib0001","first-page":"115","article-title":"Worldwide prevalence of malocclusion in the different stages of dentition: a systematic review and meta-analysis","volume":"21","author":"Lombardo","year":"2020","journal-title":"Eur J Paediatr Dentistry"},{"issue":"2","key":"10.1016\/j.identj.2026.109572_bib0002","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/00220345211021534","article-title":"FOXO3 mediates tooth movement by regulating force-induced osteogenesis","volume":"101","author":"Jin","year":"2021","journal-title":"J Dent Res"},{"issue":"6","key":"10.1016\/j.identj.2026.109572_bib0003","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1177\/00220345211062585","article-title":"Axin2+ PDL cells directly contribute to new alveolar bone formation in response to orthodontic tension force","volume":"101","author":"Wang","year":"2022","journal-title":"J Dent Res"},{"key":"10.1016\/j.identj.2026.109572_bib0004","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.coph.2015.03.005","article-title":"Parathyroid hormone: anabolic and catabolic actions on the skeleton","volume":"22","author":"Silva","year":"2015","journal-title":"Curr Opin Pharmacol"},{"issue":"1","key":"10.1016\/j.identj.2026.109572_bib0005","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1038\/s41467-019-08778-x","article-title":"TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodelling and blunts the anabolic response to parathyroid hormone","volume":"10","author":"Saito","year":"2019","journal-title":"Nat Comm"},{"issue":"6","key":"10.1016\/j.identj.2026.109572_bib0006","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201905876","article-title":"Parathyroid hormone derivative with reduced osteoclastic activity promoted bone regeneration via synergistic bone remodelling and angiogenesis","volume":"16","author":"Huang","year":"2020","journal-title":"Small"},{"issue":"2","key":"10.1016\/j.identj.2026.109572_bib0007","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/odi.13519","article-title":"Intermittent parathyroid hormone improves orthodontic retention via insulin-like growth factor-1","volume":"27","author":"Li","year":"2020","journal-title":"Oral Dis"},{"issue":"1","key":"10.1016\/j.identj.2026.109572_bib0008","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41368-020-00104-2","article-title":"Parathyroid hormone increases alveolar bone homoeostasis during orthodontic tooth movement in rats with periodontitis via crosstalk between STAT3 and \u03b2-catenin","volume":"12","author":"Zhang","year":"2020","journal-title":"Int J Oral Sci"},{"issue":"9","key":"10.1016\/j.identj.2026.109572_bib0009","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1177\/00220345000790091301","article-title":"Local and chronic application of PTH accelerates tooth movement in rats","volume":"79","author":"Soma","year":"2000","journal-title":"J Dent Res"},{"issue":"4","key":"10.1016\/j.identj.2026.109572_bib0010","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ajodo.2013.05.010","article-title":"Effect of parathyroid hormone on experimental tooth movement in rats","volume":"144","author":"Li","year":"2013","journal-title":"Am J Orthodont Dentofac Orthoped"},{"issue":"4","key":"10.1016\/j.identj.2026.109572_bib0011","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s11914-014-0235-y","article-title":"Aerobic glycolysis in osteoblasts","volume":"12","author":"Esen","year":"2014","journal-title":"Curr Osteoporosis Rep"},{"key":"10.1016\/j.identj.2026.109572_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.bonr.2023.101705","article-title":"Effects of PTH on osteoblast bioenergetics in response to glucose","volume":"19","author":"DeMambro","year":"2023","journal-title":"Bone Reports"},{"issue":"11","key":"10.1016\/j.identj.2026.109572_bib0013","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1002\/jbmr.2727","article-title":"Parathyroid hormone reprograms osteoblast metabolism","volume":"30","author":"Riddle","year":"2015","journal-title":"J Bone Mineral Res"},{"issue":"3","key":"10.1016\/j.identj.2026.109572_bib0014","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41368-018-0029-7","article-title":"Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response","volume":"10","author":"Wang","year":"2018","journal-title":"Int J Oral Sci"},{"issue":"3","key":"10.1016\/j.identj.2026.109572_bib0015","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201600901","article-title":"Preprogrammed long-term systemic pulsatile delivery of parathyroid hormone to strengthen bone","volume":"6","author":"Dang","year":"2017","journal-title":"Adv Healthc Mater"},{"issue":"4","key":"10.1016\/j.identj.2026.109572_bib0016","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1172\/JCI133473","article-title":"Parathyroid hormone\u2013dependent bone formation requires butyrate production by intestinal microbiota","volume":"130","author":"Li","year":"2020","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.identj.2026.109572_bib0017","doi-asserted-by":"crossref","first-page":"E725","DOI":"10.1073\/pnas.1120735109","article-title":"Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH","volume":"109","author":"Bedi","year":"2012","journal-title":"Proc Nat Acad Sci"},{"issue":"5","key":"10.1016\/j.identj.2026.109572_bib0018","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/0022034520910127","article-title":"Akt2 Affects Periodontal Inflammation via Altering the M1\/M2 Ratio","volume":"99","author":"Wu","year":"2020","journal-title":"J Dent Res"},{"issue":"7","key":"10.1016\/j.identj.2026.109572_bib0019","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1016\/j.cell.2015.05.029","article-title":"Glucose uptake and Runx2 synergize to orchestrate osteoblast differentiation and bone formation","volume":"161","author":"Wei","year":"2015","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.identj.2026.109572_bib0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41368-018-0029-7","article-title":"Transcriptional activation of glucose transporter 1 in orthodontic tooth movement-associated mechanical response","volume":"10","author":"Wang","year":"2018","journal-title":"Int J Oral Sci"},{"issue":"12","key":"10.1016\/j.identj.2026.109572_bib0021","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1007\/s00198-015-3189-8","article-title":"Treatment with intermittent PTH increases Wnt10b production by T cells in osteoporotic patients","volume":"26","author":"D\u2019Amelio","year":"2015","journal-title":"Osteoporosis Int"},{"issue":"7375","key":"10.1016\/j.identj.2026.109572_bib0022","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature10598","article-title":"Nuclear PKM2 regulates \u03b2-catenin transactivation upon EGFR activation","volume":"480","author":"Yang","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.identj.2026.109572_bib0023","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s41467-023-36651-5","article-title":"mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs","volume":"14","author":"Chen","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.identj.2026.109572_bib0024","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1038\/s41467-025-59064-y","article-title":"PKA plays a conserved role in regulating gene expression and metabolic adaptation by phosphorylating Rpd3\/HDAC1","volume":"16","author":"Dai","year":"2025","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.identj.2026.109572_bib0025","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1038\/s41467-022-33423-5","article-title":"Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy","volume":"13","author":"Yu","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.identj.2026.109572_bib0026","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fimmu.2016.00057","article-title":"The role of IL-17 and TH17 cells in the bone catabolic activity of PTH","volume":"7","author":"Pacifici","year":"2016","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.identj.2026.109572_bib0027","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/jbmr.3600","article-title":"IL-17 receptor signalling in osteoblasts\/osteocytes mediates PTH-induced bone loss and enhances osteocytic RANKL production","volume":"34","author":"Li","year":"2019","journal-title":"J Bone Mineral Res"},{"key":"10.1016\/j.identj.2026.109572_bib0028","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1476-4598-12-78","article-title":"TNF\u03b1 and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells","volume":"12","author":"Straus","year":"2013","journal-title":"Mol Cancer"},{"issue":"7859","key":"10.1016\/j.identj.2026.109572_bib0029","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.identj.2026.109572_bib0030","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/1873-3468.13963","article-title":"Dynamin-related protein 1 positively regulates osteoclast differentiation and bone loss","volume":"595","author":"Jeong","year":"2021","journal-title":"FEBS Lett"},{"issue":"2","key":"10.1016\/j.identj.2026.109572_bib0031","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2023.01.003","article-title":"Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis","volume":"35","author":"Suh","year":"2023","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.identj.2026.109572_bib0032","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2018.01.011","article-title":"Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics","volume":"27","author":"Schmitt","year":"2018","journal-title":"Cell Metab"},{"issue":"17","key":"10.1016\/j.identj.2026.109572_bib0033","article-title":"Autophagy related 5 promotes mitochondrial fission and inflammation via HSP90-HIF-1\u03b1-mediated glycolysis in kidney fibrosis","volume":"12","author":"Hu","year":"2025","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/j.identj.2026.109572_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012872","article-title":"Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation","volume":"21","author":"Sun","year":"2025","journal-title":"PLoS Pathog"},{"issue":"1","key":"10.1016\/j.identj.2026.109572_bib0035","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/s12931-024-03083-8","article-title":"Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia","volume":"25","author":"Sun","year":"2024","journal-title":"Respir Res"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926001668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926001668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:38:59Z","timestamp":1790681939000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653926001668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0020653926001668"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2026.109572","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parathyroid Hormone Modulates Alveolar Bone Metabolism via Inducing Periodontal Ligament Stem Cells Aerobic Glycolysis","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2026.109572","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"109572"}}