{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:03:03Z","timestamp":1790683383219,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["2022-12582"],"award-info":[{"award-number":["2022-12582"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.identj.2026.109596","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T05:28:19Z","timestamp":1780205299000},"page":"109596","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Differential Expression Analysis of Key Inflammatory Mediators in Irreversible Pulpitis for Diagnostic Biomarkers"],"prefix":"10.1016","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1173-0802","authenticated-orcid":false,"given":"Raksha","family":"Bhat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0420-9381","authenticated-orcid":false,"given":"Sean Prinson","family":"D\u2019souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8045-1893","authenticated-orcid":false,"given":"Preethesh","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2851-0080","authenticated-orcid":false,"given":"Shruthi","family":"Padavu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-4178","authenticated-orcid":false,"given":"Praveen","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7821-7419","authenticated-orcid":false,"given":"Ballamoole","family":"Krishna Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4777-9942","authenticated-orcid":false,"given":"Shishir","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.identj.2026.109596_bib0001","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/jcb.25437","article-title":"Kallikrein promotes inflammation in human dental pulp cells via protease-activated receptor-1","volume":"117","author":"Hayama","year":"2016","journal-title":"J Cell Biochem"},{"issue":"12","key":"10.1016\/j.identj.2026.109596_bib0002","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/j.joen.2018.08.003","article-title":"Pentraxin 3 modulates the inflammatory response in human dental pulp cells","volume":"44","author":"Kim","year":"2018","journal-title":"J Endod"},{"issue":"7","key":"10.1016\/j.identj.2026.109596_bib0003","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-2591.2012.02016.x","article-title":"Diagnosis of the condition of the dental pulp: a systematic review","volume":"45","author":"Mej\u00e0re","year":"2012","journal-title":"Int Endod J"},{"issue":"1","key":"10.1016\/j.identj.2026.109596_bib0004","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.dental.2018.09.008","article-title":"Pulp capping materials modulate the balance between inflammation and regeneration","volume":"35","author":"Giraud","year":"2019","journal-title":"Dent Mater"},{"issue":"7","key":"10.1016\/j.identj.2026.109596_bib0005","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.joen.2017.02.009","article-title":"Pulp inflammation diagnosis from clinical to inflammatory mediators: a systematic review","volume":"43","author":"Zanini","year":"2017","journal-title":"J Endod"},{"key":"10.1016\/j.identj.2026.109596_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154896","article-title":"Role(s) of cytokines in pulpitis: latest evidence and therapeutic approaches","volume":"126","author":"Khorasani","year":"2020","journal-title":"Cytokine"},{"issue":"7","key":"10.1016\/j.identj.2026.109596_bib0007","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.joen.2012.11.011","article-title":"Evaluation of gelatinases, tissue inhibitor of matrix metalloproteinase-2, and myeloperoxidase protein in healthy and inflamed human dental pulp tissue","volume":"39","author":"Accorsi-Mendon\u00e7a","year":"2013","journal-title":"J Endod"},{"issue":"1","key":"10.1016\/j.identj.2026.109596_bib0008","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12903-020-01266-5","article-title":"Diagnostic biomarker candidates for pulpitis revealed by bioinformatics analysis of merged microarray gene expression datasets","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Oral Health"},{"issue":"7","key":"10.1016\/j.identj.2026.109596_bib0009","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.joen.2015.02.024","article-title":"Outcome of direct pulp capping with mineral trioxide aggregate: a prospective study","volume":"41","author":"Marques","year":"2015","journal-title":"J Endod"},{"issue":"1","key":"10.1016\/j.identj.2026.109596_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00016350600963640","article-title":"The role of matrix metalloproteinases in the oral environment","volume":"65","author":"Hannas","year":"2007","journal-title":"Acta Odontol Scand"},{"issue":"2","key":"10.1016\/j.identj.2026.109596_bib0011","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.joen.2015.10.020","article-title":"A prospective clinical pilot study on the level of matrix metalloproteinase-9 in dental pulpal blood as a marker for the state of inflammation in the pulp tissue","volume":"42","author":"Mente","year":"2016","journal-title":"J Endod"},{"issue":"9","key":"10.1016\/j.identj.2026.109596_bib0012","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/iej.13343","article-title":"Inflammatory biomarkers in dentinal fluid as an approach to molecular diagnostics in pulpitis","volume":"53","author":"Brizuela","year":"2020","journal-title":"Int Endod J"},{"issue":"3","key":"10.1016\/j.identj.2026.109596_bib0013","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/iej.13228","article-title":"Effect of intercellular adhesion molecule 1 deficiency on the development of apical periodontitis","volume":"53","author":"De Rossi","year":"2020","journal-title":"Int Endod J"},{"issue":"1","key":"10.1016\/j.identj.2026.109596_bib0014","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.joen.2011.10.005","article-title":"Dentin matrix protein-1 activates dental pulp fibroblasts","volume":"38","author":"Abd-Elmeguid","year":"2012","journal-title":"J Endod"},{"issue":"1","key":"10.1016\/j.identj.2026.109596_bib0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/1753425909348527","article-title":"Expression of NOD2 is increased in inflamed human dental pulps and lipoteichoic acid-stimulated odontoblast-like cells","volume":"17","author":"Keller","year":"2011","journal-title":"Innate Immun"},{"issue":"8","key":"10.1016\/j.identj.2026.109596_bib0016","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1002\/jcp.22538","article-title":"Role of bone marrow-derived progenitor cells in the maintenance and regeneration of dental mesenchymal tissues","volume":"226","author":"Zhou","year":"2011","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.identj.2026.109596_bib0017","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.archoralbio.2017.10.004","article-title":"EZH2 regulates dental pulp inflammation by direct effect on inflammatory factors","volume":"85","author":"Hui","year":"2018","journal-title":"Arch Oral Biol"},{"issue":"10","key":"10.1016\/j.identj.2026.109596_bib0018","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/j.joen.2012.06.036","article-title":"Effects of calcium hydroxide on cytokine expression in endodontic infections","volume":"38","author":"Tavares","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.identj.2026.109596_bib0019","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-2094-7-27","article-title":"TNF-alpha and neuropathic pain\u2014a review","volume":"7","author":"Leung","year":"2010","journal-title":"J Neuroinflammation"},{"issue":"2","key":"10.1016\/j.identj.2026.109596_bib0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.11607\/ofph.2007","article-title":"Acute dental pain and salivary biomarkers for stress and inflammation in patients with pulpal or periapical inflammation","volume":"33","author":"Haug","year":"2019","journal-title":"J Oral Facial Pain Headache"},{"key":"10.1016\/j.identj.2026.109596_bib0021","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.archoralbio.2019.05.003","article-title":"Interleukin-17 plays a role in pulp inflammation partly by WNT5A protein induction","volume":"103","author":"Liu","year":"2019","journal-title":"Arch Oral Biol"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926001905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926001905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:30:32Z","timestamp":1790681432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653926001905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0020653926001905"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2026.109596","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential Expression Analysis of Key Inflammatory Mediators in Irreversible Pulpitis for Diagnostic Biomarkers","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2026.109596","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"109596"}}