{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:09:26Z","timestamp":1790683766821,"version":"4.1.0"},"reference-count":101,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.identj.2026.109682","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:07:54Z","timestamp":1781460474000},"page":"109682","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial Metabolic Biomarkers in Periodontitis: Discovery and Clinical Validation"],"prefix":"10.1016","volume":"76","author":[{"given":"Jiahua","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijia","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2987-8975","authenticated-orcid":false,"given":"Mu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.identj.2026.109682_bib0001","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jcpe.13189","article-title":"Periodontitis and cardiovascular diseases: consensus report","volume":"47","author":"Sanz","year":"2020","journal-title":"J Clin Periodontol"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0002","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4103\/aam.aam_53_22","article-title":"Periodontitis treatment (surgical and nonsurgical) effects on glycemic control: a review and meta-analysis","volume":"22","author":"Elnour","year":"2023","journal-title":"Ann Afr Med"},{"key":"10.1016\/j.identj.2026.109682_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.jormas.2025.102291","article-title":"Identification of ferroptosis-related genes in periodontitis through bioinformatics analysis and experimental validation","author":"Zhou","year":"2025","journal-title":"J Stomatol Oral Maxillofac Surg"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2026.109447","article-title":"Association of gingival crevicular fluid leptin levels with stages of periodontitis: a cross-sectional study","volume":"76","author":"Xie","year":"2026","journal-title":"Int Dent J"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/prd.12612","article-title":"Inflammation indices in association with periodontitis and cancer","volume":"96","author":"Walther","year":"2024","journal-title":"Periodontol 2000"},{"issue":"Suppl 1)","key":"10.1016\/j.identj.2026.109682_bib0006","first-page":"S173","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J Periodontol"},{"issue":"6","key":"10.1016\/j.identj.2026.109682_bib0007","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/idj.12630","article-title":"Current concepts in the management of periodontitis","volume":"71","author":"Kwon","year":"2021","journal-title":"Int Dent J"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0008","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12920-024-01864-0","article-title":"Bioinformatics analysis revealed the potential crosstalk genes and molecular mechanisms between intracranial aneurysms and periodontitis","volume":"17","author":"Chen","year":"2024","journal-title":"BMC Med Genomics"},{"key":"10.1016\/j.identj.2026.109682_bib0009","article-title":"Identification of hub cuproptosis related genes and immune cell infiltration characteristics in periodontitis","volume":"14","author":"Liu","year":"2023","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.identj.2026.109682_bib0010","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.identj.2026.109682_bib0011","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-physiol-021115-105011","article-title":"Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function","volume":"78","author":"Pernas","year":"2016","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100904","article-title":"Mitochondrial metabolism regulates macrophage biology","volume":"297","author":"Wang","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1016\/j.identj.2026.109682_bib0013","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2147\/JIR.S492041","article-title":"Mitochondrial dysfunction in diabetic periodontitis: mechanisms and therapeutic potential","volume":"18","author":"Meng","year":"2025","journal-title":"J Inflamm Res"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0014","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3390\/ijms25021024","article-title":"Mitochondrial dysfunction in periodontitis and associated systemic diseases: implications for pathomechanisms and therapeutic strategies","volume":"25","author":"Deng","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12342","article-title":"Periodontitis is an inflammatory disease of oxidative stress: we should treat it that way","volume":"84","author":"Sczepanik","year":"2020","journal-title":"Periodontol 2000"},{"issue":"6","key":"10.1016\/j.identj.2026.109682_bib0016","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s10541-005-0161-9","article-title":"Reactive oxygen species and human inflammatory periodontal diseases","volume":"70","author":"Canakci","year":"2005","journal-title":"Biochemistry (Mosc)"},{"issue":"21","key":"10.1016\/j.identj.2026.109682_bib0017","doi-asserted-by":"crossref","first-page":"11338","DOI":"10.3390\/ijms222111338","article-title":"Mitochondria as a cellular hub in infection and inflammation","volume":"22","author":"Andrieux","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.identj.2026.109682_bib0018","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1111\/odi.14286","article-title":"PINK1-mediated mitophagy reduced inflammatory responses to Porphyromonas gingivalis in macrophages","volume":"29","author":"Jiang","year":"2023","journal-title":"Oral Dis"},{"issue":"5","key":"10.1016\/j.identj.2026.109682_bib0019","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1111\/jre.13152","article-title":"The role of mitochondrial dysfunction in periodontitis: from mechanisms to therapeutic strategy","volume":"58","author":"Jiang","year":"2023","journal-title":"J Periodontal Res"},{"key":"10.1016\/j.identj.2026.109682_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.103023","article-title":"PINK1 restrains periodontitis-induced bone loss by preventing osteoclast mitophagy impairment","volume":"69","author":"Jang","year":"2024","journal-title":"Redox Biol"},{"issue":"14","key":"10.1016\/j.identj.2026.109682_bib0021","doi-asserted-by":"crossref","first-page":"7955","DOI":"10.3390\/ijms25147955","article-title":"Causal relationship between mitochondrial biological function and periodontitis: evidence from a Mendelian randomization study","volume":"25","author":"Zhou","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.identj.2026.109682_bib0022","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/01478885.2023.2188705","article-title":"Perturbation of mitochondrial dynamics links to the aggravation of periodontitis by diabetes","volume":"46","author":"Fu","year":"2023","journal-title":"J Histotechnol"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2025.103983","article-title":"Single-cell and machine learning analysis reveal novel inflammatory macrophage subtypes and biomarkers in periodontitis","volume":"76","author":"Chen","year":"2026","journal-title":"Int Dent J"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2025.109378","article-title":"SERPINA1 as a shared biomarker in periodontitis and oral squamous cell carcinoma","volume":"76","author":"Zhang","year":"2026","journal-title":"Int Dent J"},{"key":"10.1016\/j.identj.2026.109682_bib0025","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1144430","article-title":"Establishment of a prognostic model for ovarian cancer based on mitochondrial metabolism-related genes","volume":"13","author":"Meng","year":"2023","journal-title":"Front Oncol"},{"issue":"7","key":"10.1016\/j.identj.2026.109682_bib0026","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"15","key":"10.1016\/j.identj.2026.109682_bib0027","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1093\/bioinformatics\/btac409","article-title":"ggtranscript: an R package for the visualization and interpretation of transcript isoforms using ggplot2","volume":"38","author":"Gustavsson","year":"2022","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.identj.2026.109682_bib0028","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1093\/bioinformatics\/btab806","article-title":"Make interactive complex heatmaps in R","volume":"38","author":"Gu","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.identj.2026.109682_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.906753","article-title":"Ferroptosis and autophagy-related genes in the pathogenesis of ischemic cardiomyopathy","volume":"9","author":"Zheng","year":"2022","journal-title":"Front Cardiovasc Med"},{"issue":"3","key":"10.1016\/j.identj.2026.109682_bib0030","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0031","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/21691401.2023.2185627","article-title":"Exploration of effective biomarkers and infiltrating immune cells in osteoarthritis based on bioinformatics analysis","volume":"51","author":"Cheng","year":"2023","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J Stat Softw"},{"issue":"5","key":"10.1016\/j.identj.2026.109682_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v028.i05","article-title":"Building predictive models in R using the caret package","volume":"28","author":"Kuhn","year":"2008","journal-title":"J Stat Softw"},{"key":"10.1016\/j.identj.2026.109682_bib0034","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinformatics"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0035","first-page":"1","article-title":"plotROC: a tool for plotting ROC curves","volume":"79","author":"Sachs","year":"2017","journal-title":"J Stat Softw"},{"issue":"4","key":"10.1016\/j.identj.2026.109682_bib0036","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1016\/S1470-2045(14)71116-7","article-title":"Nomograms in oncology: more than meets the eye","volume":"16","author":"Balachandran","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.identj.2026.109682_bib0037","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s41512-019-0064-7","article-title":"A simple, step-by-step guide to interpreting decision curve analysis","volume":"3","author":"Vickers","year":"2019","journal-title":"Diagn Progn Res"},{"issue":"7","key":"10.1016\/j.identj.2026.109682_bib0038","first-page":"135","article-title":"Translation and adaptation of the Adult Developmental Coordination Disorder\/Dyspraxia Checklist (ADC) into Asian Uzbekistan","volume":"11","author":"Orifjon","year":"2023","journal-title":"Sports (Basel)"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0039","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s12041-019-1103-4","article-title":"Association between KIAA0319 SNPs and risk of dyslexia: a meta-analysis","volume":"98","author":"Deng","year":"2019","journal-title":"J Genet"},{"key":"10.1016\/j.identj.2026.109682_bib0040","article-title":"Integration of scRNA-seq and TCGA RNA-seq to analyze the heterogeneity of HPV+ and HPV- cervical cancer immune cells and establish molecular risk models","volume":"12","author":"Wei","year":"2022","journal-title":"Front Oncol"},{"issue":"5","key":"10.1016\/j.identj.2026.109682_bib0041","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"issue":"5","key":"10.1016\/j.identj.2026.109682_bib0042","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and Autodock\/Vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J Comput Aided Mol Des"},{"issue":"5","key":"10.1016\/j.identj.2026.109682_bib0043","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat Biotechnol"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0044","doi-asserted-by":"crossref","first-page":"946","DOI":"10.3390\/ijms23020946","article-title":"Common and distinctive intercellular communication patterns in human obstructive and nonobstructive hypertrophic cardiomyopathy","volume":"23","author":"Codden","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.identj.2026.109682_bib0045","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1074\/mcp.TIR120.002155","article-title":"ReactomeGSA\u2014efficient multi-omics comparative pathway analysis","volume":"19","author":"Griss","year":"2020","journal-title":"Mol Cell Proteomics"},{"issue":"9","key":"10.1016\/j.identj.2026.109682_bib0046","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1002\/bit.28431","article-title":"Reconstructing the cell-cell interaction network among mouse immune cells","volume":"120","author":"Azadian","year":"2023","journal-title":"Biotechnol Bioeng"},{"issue":"6190","key":"10.1016\/j.identj.2026.109682_bib0047","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","volume":"344","author":"Patel","year":"2014","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0048","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12967-023-04033-6","article-title":"Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma","volume":"21","author":"Chang","year":"2023","journal-title":"J Transl Med"},{"issue":"3","key":"10.1016\/j.identj.2026.109682_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2024.152146","article-title":"Cancer-induced morphological changes in enteric glial cells in the jejunum of Walker-256 tumor-bearing rats","volume":"126","author":"Lima","year":"2024","journal-title":"Acta Histochem"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2025.109390","article-title":"Exploration novel therapeutic targets for periodontitis via stress granules biomarkers","volume":"76","author":"Wang","year":"2026","journal-title":"Int Dent J"},{"key":"10.1016\/j.identj.2026.109682_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148476","article-title":"Regulatory role of PDK1 via integrated gene analysis of mitochondria-immune response in periodontitis","volume":"918","author":"Sun","year":"2024","journal-title":"Gene"},{"issue":"10","key":"10.1016\/j.identj.2026.109682_bib0052","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1158\/2159-8290.CD-19-1008","article-title":"Extracellular ATP and CD39 activate cAMP-mediated mitochondrial stress response to promote cytarabine resistance in acute myeloid leukemia","volume":"10","author":"Aroua","year":"2020","journal-title":"Cancer Discov"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0053","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41419-018-1242-1","article-title":"Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D","volume":"10","author":"Hu","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.identj.2026.109682_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.110841","article-title":"Kynurenine pathway, NAD(+) synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan","volume":"132","author":"Castro-Portuguez","year":"2020","journal-title":"Exp Gerontol"},{"issue":"5","key":"10.1016\/j.identj.2026.109682_bib0055","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/ATVBAHA.116.307282","article-title":"miRNA targeting of oxysterol-binding protein-like 6 regulates cholesterol trafficking and efflux","volume":"36","author":"Ouimet","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.identj.2026.109682_bib0056","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1038\/ncomms8871","article-title":"Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2","volume":"6","author":"Carter","year":"2015","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0057","doi-asserted-by":"crossref","DOI":"10.1177\/2045894020924994","article-title":"Sustained adenosine exposure causes endothelial mitochondrial dysfunction via equilibrative nucleoside transporters","volume":"10","author":"Ko","year":"2020","journal-title":"Pulm Circ"},{"issue":"3","key":"10.1016\/j.identj.2026.109682_bib0058","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3390\/ijms19030730","article-title":"The balance of Th17 versus Treg cells in autoimmunity","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.identj.2026.109682_bib0059","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2217\/bmm-2023-0202","article-title":"CD39 (ENTPD1) in tumors: a potential therapeutic target and prognostic biomarker","volume":"17","author":"Li","year":"2023","journal-title":"Biomark Med"},{"issue":"17","key":"10.1016\/j.identj.2026.109682_bib0060","doi-asserted-by":"crossref","first-page":"9578","DOI":"10.3390\/ijms25179578","article-title":"Mesenchymal stem\/stromal cells derived from dental tissues mediate the immunoregulation of T cells through the purinergic pathway","volume":"25","author":"Poblano-Perez","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.identj.2026.109682_bib0061","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1438998","article-title":"Analysis of immunogenic cell death in periodontitis based on scRNA-seq and bulk RNA-seq data","volume":"15","author":"Wu","year":"2024","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.identj.2026.109682_bib0062","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cell.2019.03.016","article-title":"B cell responses: cell interaction dynamics and decisions","volume":"177","author":"Cyster","year":"2019","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.identj.2026.109682_bib0063","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1177\/00220345221099442","article-title":"Dissecting B\/plasma cells in periodontitis at single-cell\/bulk resolution","volume":"101","author":"Liu","year":"2022","journal-title":"J Dent Res"},{"issue":"7","key":"10.1016\/j.identj.2026.109682_bib0064","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/0022034519847443","article-title":"IL-37- and IL-35\/IL-37-producing plasma cells in chronic periodontitis","volume":"98","author":"Jing","year":"2019","journal-title":"J Dent Res"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0065","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/odi.12122","article-title":"Dendritic cells and their role in periodontal disease","volume":"20","author":"Wilensky","year":"2014","journal-title":"Oral Dis"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0066","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1186\/s12903-020-01287-0","article-title":"Differential immune cell infiltrations between healthy periodontal and chronic periodontitis tissues","volume":"20","author":"Li","year":"2020","journal-title":"BMC Oral Health"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0067","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"Meyle","year":"2015","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.identj.2026.109682_bib0068","article-title":"Metabolic regulation of dendritic cell activation and immune function during inflammation","volume":"14","author":"Wu","year":"2023","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0069","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.abb.2011.11.003","article-title":"25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D","volume":"523","author":"Jones","year":"2012","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1152\/physrev.00014.2015","article-title":"Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects","volume":"96","author":"Christakos","year":"2016","journal-title":"Physiol Rev"},{"issue":"7","key":"10.1016\/j.identj.2026.109682_bib0071","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1080\/07391102.2018.1464958","article-title":"In silico identification and screening of CYP24A1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis","volume":"37","author":"Jayaraj","year":"2019","journal-title":"J Biomol Struct Dyn"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0072","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10572","article-title":"Vitamin D modulation of mitochondrial oxidative metabolism and mTOR enforces stress adaptations and anticancer responses","volume":"6","author":"Quigley","year":"2022","journal-title":"JBMR Plus"},{"issue":"5","key":"10.1016\/j.identj.2026.109682_bib0073","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1007\/s10753-023-01851-0","article-title":"Integrated machine learning and bioinformatic analyses constructed a network between mitochondrial dysfunction and immune microenvironment of periodontitis","volume":"46","author":"Chen","year":"2023","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0074","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12903-024-03912-8","article-title":"Exploring the potential link between MitoEVs and the immune microenvironment of periodontitis based on machine learning and bioinformatics methods","volume":"24","author":"Yang","year":"2024","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.identj.2026.109682_bib0075","doi-asserted-by":"crossref","first-page":"goad041","DOI":"10.1093\/gastro\/goad041","article-title":"Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease: evidence from transcriptome data","volume":"11","author":"Zhan","year":"2023","journal-title":"Gastroenterol Rep (Oxf)"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0076","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12885-017-3148-1","article-title":"In search of druggable targets for GBM amino acid metabolism","volume":"17","author":"Panosyan","year":"2017","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0077","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40170-023-00307-1","article-title":"Dual inhibition of IDO1\/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer","volume":"11","author":"Wu","year":"2023","journal-title":"Cancer Metab"},{"issue":"19","key":"10.1016\/j.identj.2026.109682_bib0078","doi-asserted-by":"crossref","first-page":"e157649","DOI":"10.1172\/JCI157649","article-title":"TDO2+ myofibroblasts mediate immune suppression in malignant transformation of squamous cell carcinoma","volume":"132","author":"Hu","year":"2022","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.identj.2026.109682_bib0079","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/jre.12958","article-title":"The Th17\/Treg cell balance: crosstalk among the immune system, bone and microbes in periodontitis","volume":"57","author":"Deng","year":"2022","journal-title":"J Periodontal Res"},{"issue":"6","key":"10.1016\/j.identj.2026.109682_bib0092","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/procel\/pwae039","article-title":"Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targets","volume":"16","author":"Cheng","year":"2025","journal-title":"Protein Cell"},{"issue":"8","key":"10.1016\/j.identj.2026.109682_bib0093","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.3390\/ijms27083617","article-title":"Phospholipid transfer protein (PLTP) in cholesterol handling: implications for mitochondrial lipid homeostasis in human iPSC-derived cardiomyocytes","volume":"27","author":"Shahannaz","year":"2026","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.identj.2026.109682_bib0094","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1021\/acs.biochem.8b00950","article-title":"Crystal structure and substrate specificity of the 8-oxo-dGTP hydrolase NUDT1 from Arabidopsis thaliana","volume":"58","author":"Jemth","year":"2019","journal-title":"Biochemistry"},{"key":"10.1016\/j.identj.2026.109682_bib0095","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jdsr.2022.09.001","article-title":"Pathogenesis of periodontitis\u2014a potential role for epithelial-mesenchymal transition","volume":"58","author":"Saliem","year":"2022","journal-title":"Jpn Dent Sci Rev"},{"issue":"3","key":"10.1016\/j.identj.2026.109682_bib0096","doi-asserted-by":"crossref","first-page":"311","DOI":"10.17219\/dmp\/133514","article-title":"Epithelial-mesenchymal transition in gingival tissues from chronic periodontitis patients: a case-control study","volume":"58","author":"Wadie","year":"2021","journal-title":"Dent Med Probl"},{"issue":"3","key":"10.1016\/j.identj.2026.109682_bib0097","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1080\/15548627.2022.2109286","article-title":"Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity","volume":"19","author":"Datta","year":"2023","journal-title":"Autophagy"},{"issue":"14","key":"10.1016\/j.identj.2026.109682_bib0098","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.3390\/ijms20143394","article-title":"Th17 cells and the IL-23\/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases","volume":"20","author":"Bunte","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.identj.2026.109682_bib0099","doi-asserted-by":"crossref","first-page":"e159498","DOI":"10.1172\/JCI159498","article-title":"Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction","volume":"133","author":"Cai","year":"2023","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.identj.2026.109682_bib0100","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.3390\/ijms21113820","article-title":"Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis, import, and assembly pathways","volume":"21","author":"Tang","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.identj.2026.109682_bib0101","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108208","article-title":"Mitochondrial metabolism mediated macrophage polarization in chronic lung diseases","volume":"239","author":"Dong","year":"2022","journal-title":"Pharmacol Ther"},{"issue":"11","key":"10.1016\/j.identj.2026.109682_bib0102","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1016\/j.apsb.2024.07.008","article-title":"Immunometabolic rewiring in macrophages for periodontitis treatment via nanoquercetin-mediated leverage of glycolysis and OXPHOS","volume":"14","author":"Zhang","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.identj.2026.109682_bib0103","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121439","article-title":"Role of molybdenum in material immunomodulation and periodontal wound healing: targeting immunometabolism and mitochondrial function for macrophage modulation","volume":"283","author":"He","year":"2022","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0104","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/prd.12404","article-title":"Human and herpesvirus microRNAs in periodontal disease","volume":"87","author":"Naqvi","year":"2021","journal-title":"Periodontol 2000"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0105","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/prd.12325","article-title":"Primer on etiology and treatment of progressive\/severe periodontitis: a systemic health perspective","volume":"83","author":"Slots","year":"2020","journal-title":"Periodontol 2000"},{"issue":"6","key":"10.1016\/j.identj.2026.109682_bib0106","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.3390\/microorganisms11061402","article-title":"Persister cell formation and elevated lsrA and lsrC gene expression upon hydrogen peroxide exposure in a periodontal pathogen Aggregatibacter actinomycetemcomitans","volume":"11","author":"Nakamura","year":"2023","journal-title":"Microorganisms"},{"issue":"3","key":"10.1016\/j.identj.2026.109682_bib0107","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/08820139.2016.1138967","article-title":"Th17 and Th1 lymphocytes are correlated with chronic periodontitis","volume":"45","author":"Chen","year":"2016","journal-title":"Immunol Invest"},{"issue":"1","key":"10.1016\/j.identj.2026.109682_bib0108","first-page":"55","article-title":"Effect of type 2 diabetes mellitus and periodontitis on the Th1\/Th2 and Th17\/Treg paradigm","volume":"35","author":"Li","year":"2022","journal-title":"Am J Dent"},{"issue":"6","key":"10.1016\/j.identj.2026.109682_bib0109","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1600-051X.2011.01712.x","article-title":"Effect of non-surgical periodontal therapy on the levels of Th17\/Th1\/Th2 cytokines and their transcription factors in Chinese chronic periodontitis patients","volume":"38","author":"Zhao","year":"2011","journal-title":"J Clin Periodontol"},{"issue":"23","key":"10.1016\/j.identj.2026.109682_bib0110","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.3748\/wjg.15.2855","article-title":"CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract","volume":"15","author":"Beswick","year":"2009","journal-title":"World J Gastroenterol"},{"issue":"6","key":"10.1016\/j.identj.2026.109682_bib0111","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/jcpe.12538","article-title":"Host-derived salivary biomarkers in diagnosing periodontal disease: systematic review and meta-analysis","volume":"43","author":"de Lima","year":"2016","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2026.109682_bib0112","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.cca.2019.04.076","article-title":"The potentiality of salivary peptide biomarkers for screening patients with periodontal diseases by mass spectrometry","volume":"495","author":"Tang","year":"2019","journal-title":"Clin Chim Acta"},{"issue":"1\u20132","key":"10.1016\/j.identj.2026.109682_bib0113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-019-03624-6","article-title":"Salivary extracellular vesicles can modulate purinergic signalling in oral tissues by combined ectonucleoside triphosphate diphosphohydrolases and ecto-5\u2019-nucleotidase activities","volume":"463","author":"Gonzalez","year":"2020","journal-title":"Mol Cell Biochem"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926002753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926002753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:40:23Z","timestamp":1790682023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653926002753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":101,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0020653926002753"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2026.109682","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial Metabolic Biomarkers in Periodontitis: Discovery and Clinical Validation","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2026.109682","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"109682"}}