{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:02:59Z","timestamp":1789862579305,"version":"4.0.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017501","name":"Science-Health Joint Medical Scientific Research Project of Chongqing","doi-asserted-by":"publisher","award":["2025GDRC001"],"award-info":[{"award-number":["2025GDRC001"]}],"id":[{"id":"10.13039\/100017501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170989"],"award-info":[{"award-number":["82170989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401114"],"award-info":[{"award-number":["82401114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571067"],"award-info":[{"award-number":["82571067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.identj.2026.109708","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:33:37Z","timestamp":1784248417000},"page":"109708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemerin Promotes Obesity-Accelerated Orthodontic Tooth Movement by Activating IRE1\u03b1-Dependent ER Stress in PDL Fibroblasts"],"prefix":"10.1016","volume":"76","author":[{"given":"Danlan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaju","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5590-1701","authenticated-orcid":false,"given":"Lan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41368-023-00268-7","article-title":"Force-induced caspase-1-dependent pyroptosis regulates orthodontic tooth movement","volume":"16","author":"Chen","year":"2024","journal-title":"Int J Oral Sci"},{"issue":"2","key":"10.1016\/j.identj.2026.109708_bib0002","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s11914-023-00774-x","article-title":"Osteoimmunology in periodontitis and orthodontic tooth movement","volume":"21","author":"Alghamdi","year":"2023","journal-title":"Curr Osteoporos Rep"},{"issue":"5","key":"10.1016\/j.identj.2026.109708_bib0003","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2319\/031520-182.1","article-title":"Osteoblast lineage cells and periodontal ligament fibroblasts regulate orthodontic tooth movement that is dependent on nuclear factor-kappa B (NF-kB) activation","volume":"91","author":"Jeon","year":"2021","journal-title":"Angle Orthod"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41368-017-0004-8","article-title":"RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement","volume":"10","author":"Yang","year":"2018","journal-title":"Int J Oral Sci"},{"issue":"12","key":"10.1016\/j.identj.2026.109708_bib0005","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1177\/00220345241280743","article-title":"Periodontitis and diabetes differentially affect inflammation in obesity","volume":"103","author":"SantaCruz-Calvo","year":"2024","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI92035","article-title":"Inflammatory mechanisms linking obesity and metabolic disease","volume":"127","author":"Saltiel","year":"2017","journal-title":"J Clin Invest"},{"issue":"723","key":"10.1016\/j.identj.2026.109708_bib0007","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf9382","article-title":"Metaflammation in obesity and its therapeutic targeting","volume":"15","author":"Schleh","year":"2023","journal-title":"Sci Transl Med"},{"issue":"3","key":"10.1016\/j.identj.2026.109708_bib0008","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00125-021-05605-1","article-title":"Association between weight change and incidence of cardiovascular disease events and mortality among adults with type 2 diabetes: a systematic review of observational studies and behavioural intervention trials","volume":"65","author":"Strelitz","year":"2022","journal-title":"Diabetologia"},{"issue":"5","key":"10.1016\/j.identj.2026.109708_bib0009","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1177\/0022034516688448","article-title":"Impact of obesity on orthodontic tooth movement in adolescents: a prospective clinical cohort study","volume":"96","author":"Saloom","year":"2017","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4041\/kjod24.001","article-title":"Evaluation of the effects of obesity on orthodontic tooth movement","volume":"55","author":"Uzun","year":"2025","journal-title":"Korean J Orthod"},{"issue":"4","key":"10.1016\/j.identj.2026.109708_bib0011","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.ajodo.2019.12.025","article-title":"Effects of obesity on periodontal tissue remodeling during orthodontic movement","volume":"159","author":"Marcantonio","year":"2021","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"4","key":"10.1016\/j.identj.2026.109708_bib0012","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ortho.2021.10.002","article-title":"Acceleration of orthodontic tooth movement and root resorption with near and distant surgical insults: an in-vivo study on a rat model","volume":"19","author":"Mehta","year":"2021","journal-title":"Int Orthod"},{"issue":"4","key":"10.1016\/j.identj.2026.109708_bib0013","doi-asserted-by":"crossref","DOI":"10.1093\/ejo\/cjaf035","article-title":"Root resorption associated with minimally invasive surgical acceleration of orthodontic tooth movement: a systematic review","volume":"47","author":"Sirri","year":"2025","journal-title":"Eur J Orthod"},{"key":"10.1016\/j.identj.2026.109708_bib0014","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cca.2020.02.008","article-title":"Chemerin in immune response and gastrointestinal pathophysiology","volume":"504","author":"Jacenik","year":"2020","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.identj.2026.109708_bib0015","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cca.2021.02.010","article-title":"Chemerin in inflammatory diseases","volume":"517","author":"Su","year":"2021","journal-title":"Clin Chim Acta"},{"issue":"10","key":"10.1016\/j.identj.2026.109708_bib0016","doi-asserted-by":"crossref","first-page":"4687","DOI":"10.1210\/en.2007-0175","article-title":"Chemerin is a novel adipokine associated with obesity and metabolic syndrome","volume":"148","author":"Bozaoglu","year":"2007","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.identj.2026.109708_bib0017","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/obr.12009","article-title":"Towards an integrative approach to understanding the role of chemerin in human health and disease","volume":"14","author":"Rourke","year":"2013","journal-title":"Obes Rev"},{"key":"10.1016\/j.identj.2026.109708_bib0018","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-025-02343-z","article-title":"Chemerin exacerbates pulmonary inflammation in type 2 diabetes and mycobacterium tuberculosis infection comorbidity","author":"Corr\u00eaa","year":"2025","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.identj.2026.109708_bib0019","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1186\/ar3475","article-title":"Chemerin activates fibroblast-like synoviocytes in patients with rheumatoid arthritis","volume":"13","author":"Kaneko","year":"2011","journal-title":"Arthritis Res Ther"},{"issue":"50","key":"10.1016\/j.identj.2026.109708_bib0020","doi-asserted-by":"crossref","first-page":"83554","DOI":"10.18632\/oncotarget.13446","article-title":"Senescent fibroblast-derived chemerin promotes squamous cell carcinoma migration","volume":"7","author":"Farsam","year":"2016","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.identj.2026.109708_bib0021","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1902\/jop.2016.150657","article-title":"Chemerin as a novel crevicular fluid marker of patients with periodontitis and type 2 diabetes mellitus","volume":"87","author":"Do\u011fan \u015e","year":"2016","journal-title":"J Periodontol"},{"issue":"6","key":"10.1016\/j.identj.2026.109708_bib0022","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/jre.12476","article-title":"Salivary, gingival crevicular fluid and serum levels of ghrelin and chemerin in patients with periodontitis and overweight","volume":"52","author":"Jentsch","year":"2017","journal-title":"J Periodontal Res"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0023","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"7203","key":"10.1016\/j.identj.2026.109708_bib0024","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.identj.2026.109708_bib0025","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri.2016.62","article-title":"The unfolded protein response in immunity and inflammation","volume":"16","author":"Grootjans","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"5","key":"10.1016\/j.identj.2026.109708_bib0026","doi-asserted-by":"crossref","DOI":"10.3390\/cells9051160","article-title":"Role of endoplasmic reticulum stress sensor IRE1\u03b1 in cellular physiology, calcium, ROS signaling, and metaflammation","volume":"9","author":"Riaz","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.identj.2026.109708_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112056","article-title":"IRE1\u03b1 regulates macrophage polarization in type 2 diabetic periodontitis through promoting endoplasmic reticulum stress","volume":"133","author":"Zhang","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.identj.2026.109708_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2025.102128","article-title":"Microglial ER stress response via IRE1\u03b1 regulates diet-induced metabolic imbalance and obesity in mice","volume":"95","author":"Stilgenbauer","year":"2025","journal-title":"Mol Metab"},{"issue":"2","key":"10.1016\/j.identj.2026.109708_bib0029","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.diabres.2012.02.023","article-title":"Downregulation of chemerin and alleviation of endoplasmic reticulum stress by metformin in adipose tissue of rats","volume":"97","author":"Pei","year":"2012","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0030","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s12020-014-0480-y","article-title":"Protective effect of liraglutide against ER stress in the liver of high-fat diet-induced insulin-resistant rats","volume":"49","author":"Yang","year":"2015","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0031","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41368-025-00359-7","article-title":"Macrophage ATF6 accelerates corticotomy-assisted orthodontic tooth movement through promoting Tnf\u03b1 transcription","volume":"17","author":"Jin","year":"2025","journal-title":"Int J Oral Sci"},{"issue":"9","key":"10.1016\/j.identj.2026.109708_bib0032","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1021\/acsnano.5c01877","article-title":"Microneedles loaded with nitric-oxide driven nanomotors improve force-induced efferocytosis impairment and sterile inflammation by revitalizing macrophage energy metabolism","volume":"19","author":"Tan","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0033","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40510-024-00530-6","article-title":"KAT6A\/YAP\/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL\/OPG ratio on the compression side during orthodontic tooth movement","volume":"25","author":"Tan","year":"2024","journal-title":"Prog Orthod"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0034","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41368-021-00125-5","article-title":"Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade","volume":"13","author":"Li","year":"2021","journal-title":"Int J Oral Sci"},{"issue":"3","key":"10.1016\/j.identj.2026.109708_bib0035","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.7150\/thno.65694","article-title":"Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.identj.2026.109708_bib0036","doi-asserted-by":"crossref","DOI":"10.1177\/00220345251334583","article-title":"Single-cell atlas of immune microenvironment in orthodontic tooth movement","author":"Wang","year":"2025","journal-title":"J Dent Res"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0037","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41387-022-00202-6","article-title":"Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs\/NF-\u03baB\/KLF7 pathway","volume":"12","author":"Qiu","year":"2022","journal-title":"Nutr Diabetes"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0038","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13287-020-01607-9","article-title":"Mechanical load-induced H(2)S production by periodontal ligament stem cells activates M1 macrophages to promote bone remodeling and tooth movement via STAT1","volume":"11","author":"He","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"10","key":"10.1016\/j.identj.2026.109708_bib0039","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41419-019-1992-4","article-title":"Intermittent compressive force promotes osteogenic differentiation in human periodontal ligament cells by regulating the transforming growth factor-\u03b2 pathway","volume":"10","author":"Manokawinchoke","year":"2019","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/j.identj.2026.109708_bib0040","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1530\/JOE-18-0174","article-title":"Chemerin: a multifaceted adipokine involved in metabolic disorders","volume":"238","author":"Helfer","year":"2018","journal-title":"J Endocrinol"},{"issue":"29","key":"10.1016\/j.identj.2026.109708_bib0041","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205574119","article-title":"Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase","volume":"119","author":"Lin","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.identj.2026.109708_bib0042","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1111\/jcmm.14237","article-title":"Chemerin\/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy","volume":"23","author":"Shang","year":"2019","journal-title":"J Cell Mol Med"},{"issue":"3","key":"10.1016\/j.identj.2026.109708_bib0043","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/ard-2022-223237","article-title":"Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis","volume":"82","author":"Sanges","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.identj.2026.109708_bib0068","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/s41423-024-01152-y","article-title":"The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous staphylococcus aureus infection","volume":"21","author":"Chen","year":"2024","journal-title":"Cell Mol Immunol"},{"issue":"17","key":"10.1016\/j.identj.2026.109708_bib0044","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26178203","article-title":"Shaping orthodontics of the future: concepts and implications from a cellular and molecular perspective","volume":"26","author":"Steinberg","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"5\u20136","key":"10.1016\/j.identj.2026.109708_bib0045","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2011.11.004","article-title":"Chemerin and its receptors in leukocyte trafficking, inflammation and metabolism","volume":"22","author":"Bondue","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"issue":"12","key":"10.1016\/j.identj.2026.109708_bib0046","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.2337\/db09-0277","article-title":"Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells","volume":"58","author":"Sell","year":"2009","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.identj.2026.109708_bib0047","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1111\/odi.14130","article-title":"Chemerin contributes to inflammatory responses and suppresses osteogenic differentiation in chronic periodontitis","volume":"29","author":"Wang","year":"2023","journal-title":"Oral Dis"},{"issue":"11","key":"10.1016\/j.identj.2026.109708_bib0048","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/jemt.24382","article-title":"Reactive oxygen species-mediated endoplasmic reticulum stress contributes to osteocyte death induced by orthodontic compressive force","volume":"86","author":"Yan","year":"2023","journal-title":"Microsc Res Tech"},{"issue":"4","key":"10.1016\/j.identj.2026.109708_bib0049","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2319\/061318-443.1","article-title":"Tooth movement rate and anchorage lost during canine retraction: a maxillary and mandibular comparison","volume":"89","author":"Da","year":"2019","journal-title":"Angle Orthod"},{"issue":"4","key":"10.1016\/j.identj.2026.109708_bib0050","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s00784-020-03502-2","article-title":"Highly variable rate of orthodontic tooth movement measured by a novel 3D method correlates with gingival inflammation","volume":"25","author":"de Gouyon Matignon de Pontouraude","year":"2021","journal-title":"Clin Oral Investig"},{"issue":"4","key":"10.1016\/j.identj.2026.109708_bib0051","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ortho.2020.08.003","volume":"18","author":"Kumar","year":"2020","journal-title":"Int Orthod"},{"issue":"3","key":"10.1016\/j.identj.2026.109708_bib0052","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.ajodo.2015.09.020","article-title":"How long does treatment with fixed orthodontic appliances last? A systematic review","volume":"149","author":"Tsichlaki","year":"2016","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"9","key":"10.1016\/j.identj.2026.109708_bib0053","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1177\/0022034515589714","article-title":"M1-like macrophage polarization promotes orthodontic tooth movement","volume":"94","author":"He","year":"2015","journal-title":"J Dent Res"},{"key":"10.1016\/j.identj.2026.109708_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113868","article-title":"Cell microparticles loaded with pro-inflammatory factors and chloroquine collaborate with mechanical force to facilitate orthodontic tooth movement","volume":"384","author":"Sun","year":"2025","journal-title":"J Control Release"},{"issue":"10","key":"10.1016\/j.identj.2026.109708_bib0055","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/JPER.20-0675","article-title":"Chemerin\/ChemR23 regulates cementoblast function and tooth resorption in mice via inflammatory factors","volume":"92","author":"Ye","year":"2021","journal-title":"J Periodontol"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0056","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12967-023-04813-0","article-title":"ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke","volume":"22","author":"Liu","year":"2024","journal-title":"J Transl Med"},{"issue":"2","key":"10.1016\/j.identj.2026.109708_bib0057","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41419-019-1374-y","article-title":"Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23\/CAMKK2\/AMPK pathway in neonatal hypoxic-ischemic encephalopathy","volume":"10","author":"Zhang","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.identj.2026.109708_bib0058","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101322","article-title":"Loss of chemerin triggers bone remodeling in vivo and in vitro","volume":"53","author":"Han","year":"2021","journal-title":"Mol Metab"},{"issue":"5","key":"10.1016\/j.identj.2026.109708_bib0059","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/jbmr.3072","article-title":"Adipokine chemerin bridges metabolic dyslipidemia and alveolar bone loss in mice","volume":"32","author":"Ramos-Junior","year":"2017","journal-title":"J Bone Miner Res"},{"issue":"8","key":"10.1016\/j.identj.2026.109708_bib0060","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.cellsig.2016.04.003","article-title":"PERK-eIF2\u03b1-ATF4 pathway mediated by endoplasmic reticulum stress response is involved in osteodifferentiation of human periodontal ligament cells under cyclic mechanical force","volume":"28","author":"Yang","year":"2016","journal-title":"Cell Signal"},{"issue":"9","key":"10.1016\/j.identj.2026.109708_bib0061","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqaf123","article-title":"Navigating the strengths and constraints of mouse models in obesity research","volume":"166","author":"Delhanty","year":"2025","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.identj.2026.109708_bib0062","doi-asserted-by":"crossref","first-page":"243","DOI":"10.23736\/S0391-1977.19.03058-X","article-title":"Rodent models of obesity","volume":"45","author":"Doulberis","year":"2020","journal-title":"Minerva Endocrinol"},{"key":"10.1016\/j.identj.2026.109708_bib0063","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.abb.2018.12.028","article-title":"17-\u03b2-estradiol enhances neutrophil extracellular trap formation by interaction with estrogen membrane receptor","volume":"663","author":"Yasuda","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.identj.2026.109708_bib0064","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1478819","article-title":"Estrogen: the forgotten player in metaflammation","volume":"15","author":"Zhu","year":"2024","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.identj.2026.109708_bib0065","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cell.2019.02.005","article-title":"Unleashing type-2 dendritic cells to drive protective antitumor CD4(+) T cell immunity","volume":"177","author":"Binnewies","year":"2019","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0066","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00006254-199201000-00015","article-title":"Estrogen and bone metabolism","volume":"47","author":"Duursma","year":"1992","journal-title":"Obstet Gynecol Surv"},{"issue":"1","key":"10.1016\/j.identj.2026.109708_bib0067","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a031211","article-title":"Regulation of bone metabolism by sex steroids","volume":"8","author":"Khosla","year":"2018","journal-title":"Cold Spring Harb Perspect Med"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926003011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926003011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:28:58Z","timestamp":1789860538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653926003011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0020653926003011"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2026.109708","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemerin Promotes Obesity-Accelerated Orthodontic Tooth Movement by Activating IRE1\u03b1-Dependent ER Stress in PDL Fibroblasts","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2026.109708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"109708"}}