{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:04:08Z","timestamp":1789862648572,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","award":["1350022008"],"award-info":[{"award-number":["1350022008"]}],"id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370999"],"award-info":[{"award-number":["82370999"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.identj.2026.109803","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:38:17Z","timestamp":1787053097000},"page":"109803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ferroptosis-Regulated Osteoblasts Under Compression Via GPX4\/RUNX1 Pathway"],"prefix":"10.1016","volume":"76","author":[{"given":"Mengjia","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongrui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaohui","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.identj.2026.109803_bib0001","doi-asserted-by":"crossref","first-page":"297","DOI":"10.11005\/jbm.2023.30.4.297","article-title":"Mechanisms of osteoclastogenesis in orthodontic tooth movement and orthodontically induced tooth root resorption","volume":"30","author":"Nakai","year":"2023","journal-title":"J Bone Metab"},{"issue":"11","key":"10.1016\/j.identj.2026.109803_bib0002","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1002\/jemt.24382","article-title":"Reactive oxygen species-mediated endoplasmic reticulum stress contributes to osteocyte death induced by orthodontic compressive force","volume":"86","author":"Yan","year":"2023","journal-title":"Microsc Res Tech"},{"issue":"7","key":"10.1016\/j.identj.2026.109803_bib0003","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18231","article-title":"GPX4-mediated bone ferroptosis under mechanical stress decreased bone formation via the YAP-TEAD signalling pathway","volume":"28","author":"Mengjia","year":"2024","journal-title":"J Cell Mol Med"},{"issue":"2","key":"10.1016\/j.identj.2026.109803_bib0004","first-page":"256","article-title":"Latest fndings on the role of RUNX1 in bone development and disorders","volume":"55","author":"Pan","year":"2024","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"issue":"24","key":"10.1016\/j.identj.2026.109803_bib0005","doi-asserted-by":"crossref","first-page":"13617","DOI":"10.3390\/ijms252413617","article-title":"The potential regulatory role of ferroptosis in orthodontically induced inflammatory root resorption","volume":"25","author":"Wang","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.identj.2026.109803_bib0006","doi-asserted-by":"crossref","first-page":"1234563","DOI":"10.3389\/fendo.2023.1234563","article-title":"Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-kappaB signaling","volume":"14","author":"Xue","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"2","key":"10.1016\/j.identj.2026.109803_bib0007","doi-asserted-by":"crossref","first-page":"166961","DOI":"10.1016\/j.bbadis.2023.166961","article-title":"The sonic hedgehog pathway suppresses oxidative stress and senescence in nucleus pulposus cells to alleviate intervertebral disc degeneration via GPX4","volume":"1870","author":"Zhuang","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"10.1016\/j.identj.2026.109803_bib0008","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s13018-022-03152-y","article-title":"Upregulation of runt related transcription factor 1 (RUNX1) contributes to tendon-bone healing after anterior cruciate ligament reconstruction using bone mesenchymal stem cells","volume":"17","author":"Kang","year":"2022","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"10.1016\/j.identj.2026.109803_bib0009","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12672-023-00652-z","article-title":"RUNX1-IT1 favors breast cancer carcinogenesis through regulation of IGF2BP1\/GPX4 axis","volume":"14","author":"Wang","year":"2023","journal-title":"Discov Oncol"},{"issue":"6","key":"10.1016\/j.identj.2026.109803_bib0010","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s11914-016-0330-3","article-title":"Osteoporosis and Periodontitis","volume":"14","author":"Wang","year":"2016","journal-title":"Curr Osteoporos Rep"},{"issue":"5","key":"10.1016\/j.identj.2026.109803_bib0011","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/odi.13651","article-title":"Osteopenic effects of high-fat diet-induced obesity on mechanically induced alveolar bone remodeling","volume":"27","author":"Luo","year":"2021","journal-title":"Oral Dis"},{"issue":"6","key":"10.1016\/j.identj.2026.109803_bib0012","article-title":"Medications and orthodontic tooth movement: what accelerates and diminishes tooth movement?","volume":"16","author":"Alrehaili","year":"2024","journal-title":"Cureus"},{"issue":"19","key":"10.1016\/j.identj.2026.109803_bib0013","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26199396","article-title":"Recent advances in the role of osteocytes in orthodontic tooth movement","volume":"26","author":"Marahleh","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.identj.2026.109803_bib0014","doi-asserted-by":"crossref","first-page":"1460168","DOI":"10.3389\/fphys.2024.1460168","article-title":"The age-related effects on orthodontic tooth movement and the surrounding periodontal environment","volume":"15","author":"Wang","year":"2024","journal-title":"Front Physiol"},{"key":"10.1016\/j.identj.2026.109803_bib0015","doi-asserted-by":"crossref","first-page":"1174817","DOI":"10.3389\/fendo.2023.1174817","article-title":"Iron overload triggering ECM-mediated Hippo\/YAP pathway in follicle development: a hypothetical model endowed with therapeutic implications","volume":"14","author":"Xia","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"10.1016\/j.identj.2026.109803_bib0016","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41432-025-01131-w","article-title":"Application of pulp tissue genetic profile in orthodontic tooth movement: a needle in a haystack?","volume":"26","author":"Thirumoorthy","year":"2025","journal-title":"Evid Based Dent"},{"issue":"4","key":"10.1016\/j.identj.2026.109803_bib0017","first-page":"1026","article-title":"High frequency acceleration: a new tool for alveolar bone regeneration","volume":"2","author":"Alikhani","year":"2017","journal-title":"JSM Dent Surg"},{"issue":"2","key":"10.1016\/j.identj.2026.109803_bib0018","first-page":"ZC46","article-title":"Evaluation of the stress induced in tooth, periodontal ligament & alveolar bone with varying degrees of bone loss during various types of orthodontic tooth movements","volume":"10","author":"Agarwal","year":"2016","journal-title":"J Clin Diagn Res"},{"issue":"39","key":"10.1016\/j.identj.2026.109803_bib0019","article-title":"PIEZO1-GPX4 axis mediates mechanical stress-induced vertebral growth plate dysplasia via ferroptosis activation","volume":"12","author":"Chen","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.identj.2026.109803_bib0020","doi-asserted-by":"crossref","first-page":"152439","DOI":"10.1016\/j.bbrc.2025.152439","article-title":"Osteoblast ferroptosis driven by iron overload: implications for osteoporosis pathogenesis and FTH1\/GPX4-targeted therapy","volume":"779","author":"Wan","year":"2025","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"10.1016\/j.identj.2026.109803_bib0021","doi-asserted-by":"crossref","first-page":"2533429","DOI":"10.1080\/07853890.2025.2533429","article-title":"The role of fat-soluble vitamins on bone metabolism and osteoporosis: a literature review","volume":"57","author":"Li","year":"2025","journal-title":"Ann Med"},{"key":"10.1016\/j.identj.2026.109803_bib0022","doi-asserted-by":"crossref","first-page":"155282","DOI":"10.1016\/j.phymed.2023.155282","article-title":"Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1\/Nrf2\/SLC7A11\/GPX4 pathway","volume":"124","author":"Deng","year":"2024","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.identj.2026.109803_bib0023","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1002\/tox.24239","article-title":"Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2\/HO-1\/GPX4 pathway","volume":"39","author":"Huang","year":"2024","journal-title":"Environ Toxicol"},{"issue":"5","key":"10.1016\/j.identj.2026.109803_bib0024","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/jleuko\/qiae011","article-title":"Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2\/GPX4 signaling pathway","volume":"115","author":"Qu","year":"2024","journal-title":"J Leukoc Biol"},{"issue":"1","key":"10.1016\/j.identj.2026.109803_bib0025","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41413-024-00369-x","article-title":"Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene","volume":"12","author":"Khan","year":"2024","journal-title":"Bone Res"},{"issue":"1","key":"10.1016\/j.identj.2026.109803_bib0026","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1186\/s40001-025-03392-8","article-title":"METTL3 inhibits osteoporosis by promoting osteoblast differentiation through m6A-mediated activation of the FZD3\/RUNX1 signaling axis","volume":"30","author":"Wang","year":"2025","journal-title":"Eur J Med Res"},{"key":"10.1016\/j.identj.2026.109803_bib0027","doi-asserted-by":"crossref","first-page":"124026","DOI":"10.1016\/j.ijbiomac.2023.124026","article-title":"The transcription factor RUNX1 affects the maturation of porcine oocytes via the BMP15\/TGF-beta signaling pathway","volume":"238","author":"Li","year":"2023","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"10.1016\/j.identj.2026.109803_bib0028","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/mrd.22141","article-title":"Estrus synchronization and ovarian hyper-stimulation treatments have negligible effects on cumulus oocyte complex gene expression whereas induction of ovulation causes major expression changes","volume":"80","author":"Agca","year":"2013","journal-title":"Mol Reprod Dev"},{"issue":"9","key":"10.1016\/j.identj.2026.109803_bib0029","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10791","article-title":"A novel RUNX1 genetic variant identified in a young male with severe osteoporosis","volume":"7","author":"Block","year":"2023","journal-title":"JBMR Plus"},{"issue":"4","key":"10.1016\/j.identj.2026.109803_bib0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12308-024-00597-4","article-title":"WNT inhibitory factor 1 (WIF1) is a novel fusion partner of RUNX family transcription factor 1 (RUNX1) in acute myeloid leukemia with t(12;21)(q14;q22)","volume":"17","author":"Yang","year":"2024","journal-title":"J Hematop"},{"issue":"1","key":"10.1016\/j.identj.2026.109803_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009233","article-title":"Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways","volume":"17","author":"Tang","year":"2021","journal-title":"PLoS Genet"},{"issue":"5","key":"10.1016\/j.identj.2026.109803_bib0032","first-page":"1200","article-title":"RUNX1 regulates transcription activity of WNT5A in mouse bone marrow derived mesenchymal stem cells","volume":"19","author":"Liang","year":"2011","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"issue":"4","key":"10.1016\/j.identj.2026.109803_bib0033","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s13258-023-01478-3","article-title":"Human umbilical cord mesenchymal stem cells overexpressing RUNX1 promote tendon-bone healing by inhibiting osteolysis, enhancing osteogenesis and promoting angiogenesis","volume":"46","author":"Guo","year":"2024","journal-title":"Genes Genomics"},{"issue":"1","key":"10.1016\/j.identj.2026.109803_bib0034","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41419-024-06481-4","article-title":"RUNX1\/NPM1\/H3K4me3 complex contributes to extracellular matrix remodeling via enhancing FOSL2 transcriptional activation in glioblastoma","volume":"15","author":"Cui","year":"2024","journal-title":"Cell Death Dis"},{"issue":"12","key":"10.1016\/j.identj.2026.109803_bib0035","article-title":"Ferroptosis in osteocytes as a target for protection against postmenopausal osteoporosis","volume":"11","author":"Jiang","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"11","key":"10.1016\/j.identj.2026.109803_bib0036","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1080\/15384101.2023.2211830","article-title":"The effect of ROS-YAP crosstalk on osteoimmune response orchestrating osteogenesis","volume":"22","author":"Yu","year":"2023","journal-title":"Cell Cycle"},{"issue":"6","key":"10.1016\/j.identj.2026.109803_bib0037","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009574","article-title":"Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets","volume":"17","author":"Hass","year":"2021","journal-title":"PLoS Genet"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926003965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926003965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:38:44Z","timestamp":1789861124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653926003965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0020653926003965"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2026.109803","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ferroptosis-Regulated Osteoblasts Under Compression Via GPX4\/RUNX1 Pathway","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2026.109803","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"109803"}}