{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:03:26Z","timestamp":1789862606381,"version":"4.0.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8246031044"],"award-info":[{"award-number":["8246031044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Dental Journal"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.identj.2026.111100","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:33:50Z","timestamp":1788471230000},"page":"111100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sema3A Restores Bone Homeostasis in Peri-Implantitis by Activating Osteoblasts and Suppressing Osteoclasts via PI3K\/AKT"],"prefix":"10.1016","volume":"76","author":[{"given":"Chenjiang","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fancheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1638-7388","authenticated-orcid":false,"given":"Li","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 20","key":"10.1016\/j.identj.2026.111100_bib0001","first-page":"S286","article-title":"Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"45","author":"Berglundh","year":"2018","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.identj.2026.111100_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.jdent.2025.105914","article-title":"The prevalence of peri-implant mucositis and peri-implantitis based on the world workshop criteria: a systematic review and meta-analysis","volume":"160","author":"Reis","year":"2025","journal-title":"J Dent"},{"key":"10.1016\/j.identj.2026.111100_bib0003","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jdsr.2021.05.002","article-title":"Prevalence and risk indicators for peri-implant diseases: a literature review","volume":"57","author":"Wada","year":"2021","journal-title":"Jpn Dent Sci Rev"},{"issue":"2","key":"10.1016\/j.identj.2026.111100_bib0004","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/0022034514559128","article-title":"The pathology of bone tissue during peri-implantitis","volume":"94","author":"Schminke","year":"2015","journal-title":"J Dent Res"},{"issue":"5","key":"10.1016\/j.identj.2026.111100_bib0005","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/clr.13725","article-title":"Intra-individual cytokine profile in peri-implantitis and periodontitis: a cross-sectional study","volume":"32","author":"Jansson","year":"2021","journal-title":"Clin Oral Implants Res"},{"issue":"13","key":"10.1016\/j.identj.2026.111100_bib0006","doi-asserted-by":"crossref","first-page":"10912","DOI":"10.3390\/ijms241310912","article-title":"Skeletal-vascular interactions in bone development, homeostasis, and pathological destruction","volume":"24","author":"Watanabe","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.identj.2026.111100_bib0007","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.2147\/IJN.S413692","article-title":"Osteoclast-derived exosomal miR-5134-5p interferes with alveolar bone homeostasis by targeting the JAK2\/STAT3 axis","volume":"18","author":"Pan","year":"2023","journal-title":"Int J Nanomed"},{"issue":"2","key":"10.1016\/j.identj.2026.111100_bib0008","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.identj.2026.111100_bib0009","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.2174\/0929867325666180801145614","article-title":"Cellular communication in bone homeostasis and the related anti-osteoporotic drug development","volume":"27","author":"Zhang","year":"2020","journal-title":"Curr Med Chem"},{"issue":"2","key":"10.1016\/j.identj.2026.111100_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2026.109434","article-title":"SHED-derived exosomes attenuate osteoclastogenesis to ameliorate apical periodontitis in rats","volume":"76","author":"Wang","year":"2026","journal-title":"Int Dent J"},{"issue":"1","key":"10.1016\/j.identj.2026.111100_bib0011","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1038\/s41467-021-23541-x","article-title":"Architecture of the Sema3A\/PlexinA4\/neuropilin tripartite complex","volume":"12","author":"Lu","year":"2021","journal-title":"Nat Commun"},{"issue":"7396","key":"10.1016\/j.identj.2026.111100_bib0012","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature11000","article-title":"Osteoprotection by semaphorin 3A","volume":"485","author":"Hayashi","year":"2012","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.identj.2026.111100_bib0013","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1089\/scd.2019.0031","article-title":"Periodontal ligament stem cells: regenerative potency in periodontium","volume":"28","author":"Tomokiyo","year":"2019","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.identj.2026.111100_bib0014","doi-asserted-by":"crossref","first-page":"147195","DOI":"10.1016\/j.cej.2023.147195","article-title":"A sequential sustained-release hydrogel with potent antimicrobial, anti-inflammatory, and osteogenesis-promoting properties for the treatment of periodontitis","volume":"477","author":"Xu","year":"2023","journal-title":"Chem Eng J"},{"issue":"6","key":"10.1016\/j.identj.2026.111100_bib0015","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s10735-020-09941-1","article-title":"Semaphorin 3A promotes the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells in inflammatory environments by suppressing the Wnt\/\u03b2-catenin signaling pathway","volume":"52","author":"Sun","year":"2021","journal-title":"J Mol Histol"},{"issue":"6","key":"10.1016\/j.identj.2026.111100_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.identj.2025.103941","article-title":"P. gingivalis LPS drives osteoclastogenesis and impairs osteoblast differentiation by suppressing Sema3A\/Nrp1 Via TLR-4","volume":"75","author":"Feng","year":"2025","journal-title":"Int Dent J"},{"issue":"3","key":"10.1016\/j.identj.2026.111100_bib0017","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.7150\/thno.65694","article-title":"Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis","volume":"12","author":"Chen","year":"2022","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.identj.2026.111100_bib0018","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s13059-019-1874-1","article-title":"Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression","volume":"20","author":"Hafemeister","year":"2019","journal-title":"Genome Biol"},{"issue":"12","key":"10.1016\/j.identj.2026.111100_bib0019","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat Methods"},{"issue":"1","key":"10.1016\/j.identj.2026.111100_bib0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"1","key":"10.1016\/j.identj.2026.111100_bib0021","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/s41467-021-21246-9","article-title":"Inference and analysis of cell-cell communication using CellChat","volume":"12","author":"Jin","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.identj.2026.111100_bib0022","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/prd.12052","article-title":"Animal models for periodontal regeneration and peri-implant responses","volume":"68","author":"Kantarci","year":"2015","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.identj.2026.111100_bib0023","doi-asserted-by":"crossref","unstructured":"de Ara\u00fajo Silva DN, Casarin M, Monajemzadeh S, et al. Experimental model of ligature-induced peri-implantitis in mice. J Vis Exp 2024;(207):e66316.","DOI":"10.3791\/66316"},{"issue":"2","key":"10.1016\/j.identj.2026.111100_bib0024","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2131\/jts.41.185","article-title":"miR-23b targets Smad 3 and ameliorates the LPS-inhibited osteogenic differentiation in preosteoblast MC3T3-E1 cells","volume":"41","author":"Liu","year":"2016","journal-title":"J Toxicol Sci"},{"issue":"10","key":"10.1016\/j.identj.2026.111100_bib0025","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1101\/gr.6202607","article-title":"A systems biology approach for pathway level analysis","volume":"17","author":"Draghici","year":"2007","journal-title":"Genome Res"},{"issue":"4","key":"10.1016\/j.identj.2026.111100_bib0026","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1039\/D5FO05057J","article-title":"Konjac oligosaccharides promote calcium absorption and bone health in growing mice","volume":"17","author":"Zhou","year":"2026","journal-title":"Food Funct"},{"key":"10.1016\/j.identj.2026.111100_bib0027","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6910312","article-title":"RANKL\/RANK\/OPG pathway: a mechanism involved in exercise-induced bone remodeling","volume":"2020","author":"Tobeiha","year":"2020","journal-title":"Biomed Res Int"},{"issue":"4","key":"10.1016\/j.identj.2026.111100_bib0028","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1302\/2046-3758.104.BJR-2020-0255.R2","article-title":"LY3023414 inhibits both osteogenesis and osteoclastogenesis through the PI3K\/Akt\/GSK3 signalling pathway","volume":"10","author":"Chen","year":"2021","journal-title":"Bone Joint Res"},{"issue":"8","key":"10.1016\/j.identj.2026.111100_bib0029","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1002\/jcb.25878","article-title":"The novel mTOR complex 1\/2 inhibitor p529 inhibits human lung myofibroblast differentiation","volume":"118","author":"Ferguson","year":"2017","journal-title":"J Cell Biochem"},{"issue":"1","key":"10.1016\/j.identj.2026.111100_bib0030","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1186\/s12967-025-06925-1","article-title":"Multi-omics data reveal that SAA1\u2009+\u2009fibroblasts exacerbate periodontitis by regulating macrophage inflammation and chemotaxis","volume":"23","author":"Li","year":"2025","journal-title":"J Transl Med"},{"issue":"4","key":"10.1016\/j.identj.2026.111100_bib0031","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41563-025-02463-9","article-title":"Long-range chemical signalling in vivo is regulated by mechanical signals","volume":"25","author":"Pillai","year":"2026","journal-title":"Nat Mater"},{"issue":"9","key":"10.1016\/j.identj.2026.111100_bib0032","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.2174\/011574888X343230250107145153","article-title":"Semaphorin 3A confers protection against oxidative stress-induced damage in periodontal ligament stem cells through the activation of the Wnt\/\u03b2-catenin signaling pathway","volume":"20","author":"He","year":"2025","journal-title":"Curr Stem Cell Res Ther"},{"issue":"4","key":"10.1016\/j.identj.2026.111100_bib0033","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1111\/odi.14748","article-title":"The role of semaphorin 3A in oral diseases","volume":"30","author":"Zhang","year":"2024","journal-title":"Oral Dis"},{"issue":"6","key":"10.1016\/j.identj.2026.111100_bib0034","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.7150\/ijbs.129449","article-title":"Cellular and molecular neuro-bone cell interactions drive alveolar bone remodeling during orthodontic mechanical loading","volume":"22","author":"Fang","year":"2026","journal-title":"Int J Biol Sci"},{"issue":"1","key":"10.1016\/j.identj.2026.111100_bib0035","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41368-023-00269-6","article-title":"Sema3A secreted by sensory nerve induces bone formation under mechanical loads","volume":"16","author":"Mei","year":"2024","journal-title":"Int J Oral Sci"}],"container-title":["International Dental Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926016928?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0020653926016928?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:34:42Z","timestamp":1789860882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0020653926016928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S0020653926016928"],"URL":"https:\/\/doi.org\/10.1016\/j.identj.2026.111100","relation":{},"ISSN":["0020-6539"],"issn-type":[{"value":"0020-6539","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sema3A Restores Bone Homeostasis in Peri-Implantitis by Activating Osteoblasts and Suppressing Osteoclasts via PI3K\/AKT","name":"articletitle","label":"Article Title"},{"value":"International Dental Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.identj.2026.111100","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of FDI World Dental Federation.","name":"copyright","label":"Copyright"}],"article-number":"111100"}}