{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:12:11Z","timestamp":1793059931142,"version":"4.5.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2024A03J0885"],"award-info":[{"award-number":["2024A03J0885"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003785","name":"Guangdong Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003785","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004509","name":"Guangdong Province Department of Health","doi-asserted-by":"publisher","award":["A2024644"],"award-info":[{"award-number":["A2024644"]}],"id":[{"id":"10.13039\/501100004509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases Now"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.idnow.2026.105282","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:16:09Z","timestamp":1778109369000},"page":"105282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increasing HEV-RNA detection in the serum of acute HEV-infected immunocompetent patients, with alanine aminotransferase as a biomarker"],"prefix":"10.1016","volume":"56","author":[{"given":"Haohui","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuxiang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.idnow.2026.105282_bib46","article-title":"Acute hepatitis E virus infection in adults, Cayenne, French Guiana, 2015-2022","volume":"55","author":"de Colnet","year":"2025","journal-title":"Infect Dis Now"},{"key":"10.1016\/j.idnow.2026.105282_b0005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1053\/j.gastro.2015.10.048","article-title":"Chronic infection with camelid hepatitis E virus in a liver transplant recipient who regularly consumes camel meat and milk","volume":"150","author":"Lee","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.idnow.2026.105282_b0010","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.29777","article-title":"Near full-length genome analysis of HEV 4b subtype in pigs showed a similarity up to 99.944% compared to a patient in Guangdong province, China","volume":"96","author":"Deng","year":"2024","journal-title":"J Med Virol"},{"key":"10.1016\/j.idnow.2026.105282_b0015","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1016\/j.jhep.2018.03.005","article-title":"EASL clinical practice guidelines on hepatitis E virus infection","volume":"68","author":"European Association for the Study of the Liver","year":"2018","journal-title":"J Hepatol"},{"key":"10.1016\/j.idnow.2026.105282_b0020","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0140-6736(00)02737-9","article-title":"Duration of viraemia and faecal viral excretion in acute hepatitis E","volume":"356","author":"Aggarwal","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.idnow.2026.105282_b0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1186\/1743-422X-7-213","article-title":"Dynamics of HEV viremia, fecal shedding and its relationship with transaminases and antibody response in patients with sporadic acute hepatitis E","volume":"7","author":"Chandra","year":"2010","journal-title":"Virol J"},{"key":"10.1016\/j.idnow.2026.105282_b0030","first-page":"735","article-title":"Research progress on diagnosis and treatment of hepatitis E virus infection","volume":"56","author":"Deng","year":"2025","journal-title":"Guangzhou Med J"},{"key":"10.1016\/j.idnow.2026.105282_b0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12560-025-09645-3","article-title":"Validation of an optimised method for quantitative detection of hepatitis E virus in pork sausage","volume":"17","author":"Persson","year":"2025","journal-title":"Food Environ Virol"},{"key":"10.1016\/j.idnow.2026.105282_b0040","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3390\/v16030413","article-title":"Duplex droplet digital PCR assay for quantification of Hepatitis E virus in food","volume":"16","author":"La Bella","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.idnow.2026.105282_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.diagmicrobio.2026.117335","article-title":"Characteristics of mutations associated with ribavirin treatment failure in hepatitis E virus genotype 4 derived from swine and humans","volume":"115","author":"Deng","year":"2026","journal-title":"Diagn Microbiol Infect Dis"}],"container-title":["Infectious Diseases Now"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666991926000394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666991926000394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:44:32Z","timestamp":1783071872000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666991926000394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S2666991926000394"],"URL":"https:\/\/doi.org\/10.1016\/j.idnow.2026.105282","relation":{},"ISSN":["2666-9919"],"issn-type":[{"value":"2666-9919","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increasing HEV-RNA detection in the serum of acute HEV-infected immunocompetent patients, with alanine aminotransferase as a biomarker","name":"articletitle","label":"Article Title"},{"value":"Infectious Diseases Now","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.idnow.2026.105282","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.idnow.2025.105087","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105282"}}