{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:50:38Z","timestamp":1792691438669,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,28]],"date-time":"2016-01-28T00:00:00Z","timestamp":1453939200000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Indian Heart Journal"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.ihj.2015.06.024","type":"journal-article","created":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T19:39:37Z","timestamp":1442000377000},"page":"S30-S35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"S3","title":["Spontaneous subdural hematoma and antiplatelet therapy: Does efficacy of Ticagrelor come with added risk?"],"prefix":"10.1016","volume":"67","author":[{"given":"Pattanagere Manjunatha","family":"Suryanarayana Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniruddha","family":"Tekkatte Jagannatha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra","family":"Javali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1858-3550","authenticated-orcid":false,"given":"Anupama Venkatasubba","family":"Hegde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Mahale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Madhusudhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rangasetty","family":"Srinivasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ihj.2015.06.024_bib0155","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ahj.2004.11.012","article-title":"Predictors and 1-year outcome of major bleeding in patients with non-ST-elevation acute coronary syndromes: insights from the Canadian Acute Coronary Syndrome Registries","volume":"150","author":"Segev","year":"2005","journal-title":"Am Heart J"},{"key":"10.1016\/j.ihj.2015.06.024_bib0160","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0828-282X(07)70229-5","article-title":"The impact of bleeding in patients with acute coronary syndromes: how to optimize the benefits of treatment and minimize the risk","volume":"23","author":"Fitchett","year":"2007","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.ihj.2015.06.024_bib0165","unstructured":"US Food and Drug Administration. The FDA ticagrelor review of complete response. Available at: http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2011\/022433Orig1s000TOC.cfm [accessed 10.05.12]."},{"key":"10.1016\/j.ihj.2015.06.024_bib0170","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/eurheartj\/ehr422","article-title":"Bleeding complications with the P2Y12 receptor antagonists clopidogrel and ticagrelor in the PLATelet inhibition and patient Outcomes (PLATO) trial","volume":"32","author":"Becker","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.ihj.2015.06.024_bib0175","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized bleeding definitions for cardiovascular clinical trials: a consensus report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.ihj.2015.06.024_bib0180","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1161\/CIRCULATIONAHA.106.612812","article-title":"Adverse impact of bleeding on prognosis in patients with acute coronary syndromes","volume":"114","author":"Eikelboom","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.ihj.2015.06.024_bib0185","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1056\/NEJMoa0904327","article-title":"Ticagrelor versus clopidogrel in patients with acute coronary syndromes","volume":"361","author":"Wallentin","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ihj.2015.06.024_bib0190","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1161\/01.CIR.100.15.1593","article-title":"Enoxaparin prevents death and cardiac ischemic events in unstable angina\/non-Q-wave myocardial infarction. Results of the thrombolysis in myocardial infarction (TIMI) 11B trial","volume":"100","author":"Antman","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.ihj.2015.06.024_bib0195","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1056\/NEJM199309023291001","article-title":"An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. The GUSTO investigators","volume":"329","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ihj.2015.06.024_bib0200","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.01.007","article-title":"Aspirin therapy and risk of subdural hematoma: meta-analysis of randomized clinical trials","volume":"22","author":"Connolly","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.ihj.2015.06.024_bib0205","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1212\/WNL.54.12.2298","article-title":"Aspirin-associated intracerebral hemorrhage: clinical and radiologic features","volume":"54","author":"Wong","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.ihj.2015.06.024_bib0210","article-title":"Effect of addition of clopidogrel to aspirin on subdural hematoma: meta-analysis of randomized clinical trials","author":"Bakheet","year":"2014","journal-title":"Int J Stroke"},{"key":"10.1016\/j.ihj.2015.06.024_bib0215","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.ijcard.2013.06.135","article-title":"Editorial. Clopidogrel is safer than ticagrelor in regard to bleeds: a closer look at the PLATO trial","volume":"168","author":"DiNicolantonio","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.ihj.2015.06.024_bib0220","unstructured":"BRILINTA\u00ae Ticagrelor prescribing information, USFDA approved. Astra Zeneca. 2013."},{"key":"10.1016\/j.ihj.2015.06.024_bib0225","first-page":"188","article-title":"Antiplatelet therapy in difficult clinical conditions","author":"Manoria","year":"2012","journal-title":"Med Update"},{"key":"10.1016\/j.ihj.2015.06.024_bib0230","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1001\/jama.295.16.1912","article-title":"Association between hospital process performance and outcomes among patients with acute coronary syndromes","volume":"295","author":"Peterson","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.ihj.2015.06.024_bib0235","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/01.STR.24.7.987","article-title":"Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality","volume":"24","author":"Broderick","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.ihj.2015.06.024_bib0240","series-title":"Falls: Assessment and Prevention of Falls in Older People. NICE Clinical Guideline","first-page":"1","year":"2013"},{"key":"10.1016\/j.ihj.2015.06.024_bib0245","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.amjmed.2005.10.039","article-title":"Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials","volume":"119","author":"McQuaid","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.ihj.2015.06.024_bib0250","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.jacc.2008.04.002","volume":"51","author":"Antman","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.ihj.2015.06.024_bib0255","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0140-6736(96)09457-3","article-title":"A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)","volume":"348","author":"CAPRIE Steering Committee","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.ihj.2015.06.024_bib0260","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa060989","article-title":"Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events","volume":"354","author":"Bhatt","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ihj.2015.06.024_bib0265","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1001\/jama.290.12.1593","article-title":"Evaluation of prolonged antiplatelet pretreatment (cooling off strategy) before intervention in patients with unstable coronary syndromes: a randomized controlled trial","volume":"290","author":"Neumann","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.ihj.2015.06.024_bib0270","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/jama.292.1.89","article-title":"Efficacy and bleeding complications among patients randomized to enoxaparin or unfractionated heparin for antithrombin therapy in non-ST-segment elevation acute coronary syndromes: a systematic overview","volume":"292","author":"Petersen","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.ihj.2015.06.024_bib0275","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0002-9343(00)00453-8","article-title":"Incidence of intracranial hemorrhage complicating treatment with glycoprotein IIb\/IIIa receptor inhibitors: a pooled analysis of major clinical trials","volume":"109","author":"Memon","year":"2000","journal-title":"Am J Med"},{"key":"10.1016\/j.ihj.2015.06.024_bib0280","first-page":"687","article-title":"Stroke Prevention in Atrial Fibrillation Investigators. Warfarin versus aspirin for prevention of thromboembolism in atrial fibrillation: Stroke Prevention in Atrial Fibrillation II Study","volume":"343","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ihj.2015.06.024_bib0285","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1161\/01.CIR.94.9.2107","article-title":"AREVA: multicenter randomized comparison of low dose versus standard dose anticoagulation in patients with mechanical prosthetic heart valves","volume":"94","author":"Acar","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.ihj.2015.06.024_bib0290","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation","volume":"361","author":"Connolly","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ihj.2015.06.024_bib0295","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ihj.2015.06.024_bib0300","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa1107039","article-title":"Apixaban versus warfarin in patients with atrial fibrillation","volume":"365","author":"Granger","year":"2011","journal-title":"N Engl J Med"}],"container-title":["Indian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019483215002503?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019483215002503?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T09:58:24Z","timestamp":1537351104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0019483215002503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":30,"alternative-id":["S0019483215002503"],"URL":"https:\/\/doi.org\/10.1016\/j.ihj.2015.06.024","relation":{},"ISSN":["0019-4832"],"issn-type":[{"value":"0019-4832","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Spontaneous subdural hematoma and antiplatelet therapy: Does efficacy of Ticagrelor come with added risk?","name":"articletitle","label":"Article Title"},{"value":"Indian Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ihj.2015.06.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Cardiological Society of India. Published by Elsevier, a division of Reed Elsevier India, Pvt. Ltd.","name":"copyright","label":"Copyright"}]}}