{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T22:50:44Z","timestamp":1778453444882,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T00:00:00Z","timestamp":1673222400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Indian Heart Journal"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.ihj.2023.01.004","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T02:26:23Z","timestamp":1673576783000},"page":"9-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prior statin use and the incidence of in-hospital arrhythmia in acute coronary syndrome: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2975-1900","authenticated-orcid":false,"given":"Kevin","family":"Wibawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raditya","family":"Dewangga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kintan Sari","family":"Nastiti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pangeran Akbar","family":"Syah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhendiwijaya","family":"Suhendiwijaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yandi","family":"Ariffudin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ihj.2023.01.004_bib1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5455\/msm.2018.30.10-14","article-title":"Seasonal incidence of acute coronary syndrome and its features","volume":"30","author":"Hodzic","year":"2018","journal-title":"Mater Sociomed"},{"issue":"7","key":"10.1016\/j.ihj.2023.01.004_bib2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/jama.2022.0358","article-title":"Diagnosis and treatment of acute coronary syndromes: a review","volume":"327","author":"Bhatt","year":"2022","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.ihj.2023.01.004_bib3","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1093\/europace\/euu208","article-title":"Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force","volume":"16","author":"Gorenek","year":"2014","journal-title":"EP Europace"},{"issue":"6","key":"10.1016\/j.ihj.2023.01.004_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.hrtlng.2013.07.010","article-title":"Arrhythmias in patients with acute coronary syndrome in the first 24 hours of hospitalization","volume":"42","author":"Winkler","year":"2013","journal-title":"Heart Lung"},{"issue":"12","key":"10.1016\/j.ihj.2023.01.004_bib5","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.amjcard.2008.08.009","article-title":"Magnitude and prognosis associated with ventricular arrhythmias in patients hospitalized with acute coronary syndromes (from the GRACE registry)","volume":"102","author":"Avezum","year":"2008","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.ihj.2023.01.004_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1161\/CIRCULATIONAHA.111.071860","article-title":"Sustained ventricular tachycardia and ventricular fibrillation complicating non\u2013ST-segment\u2013elevation acute coronary syndromes","volume":"126","author":"Piccini","year":"2012","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.ihj.2023.01.004_bib7","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1093\/eurheartj\/ehu357","article-title":"High-grade atrioventricular block in acute coronary syndromes: insights from the Global Registry of Acute Coronary Events","volume":"36","author":"Singh","year":"2015","journal-title":"Eur Heart J"},{"issue":"3","key":"10.1016\/j.ihj.2023.01.004_bib8","first-page":"218","article-title":"Complete atrioventricular block in acute coronary syndrome: prevalence, characterisation and implication on outcome","volume":"7","author":"Aguiar Rosa","year":"2018","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"2","key":"10.1016\/j.ihj.2023.01.004_bib9","first-page":"141","article-title":"Prognostic impact of atrial fibrillation in acute coronary syndromes: results from the ARIAM registry","volume":"3","author":"Almendro-Delia","year":"2014","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"issue":"1","key":"10.1016\/j.ihj.2023.01.004_bib10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/CIRCRESAHA.116.308537","article-title":"Pleiotropic effects of statins on the cardiovascular system","volume":"120","author":"Oesterle","year":"2017","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.ihj.2023.01.004_bib11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","volume":"39","author":"Ibanez","year":"2017","journal-title":"Eur Heart J"},{"issue":"14","key":"10.1016\/j.ihj.2023.01.004_bib12","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","volume":"42","author":"Collet","year":"2020","journal-title":"Eur Heart J"},{"issue":"4","key":"10.1016\/j.ihj.2023.01.004_bib13","first-page":"e362","article-title":"ACCF\/AHA guideline for the management of ST-elevation myocardial infarction","volume":"127","author":"O'Gara","year":"2013","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.ihj.2023.01.004_bib14","first-page":"e344","article-title":"AHA\/ACC guideline for the management of patients with non\u2013ST-elevation acute coronary syndromes","volume":"130","author":"Amsterdam","year":"2014","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.ihj.2023.01.004_bib15","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4103\/2230-8210.163106","article-title":"Pleiotropic effects of statins","volume":"19","author":"Kavalipati","year":"2015","journal-title":"Indian J Endocrinol Metab"},{"issue":"22","key":"10.1016\/j.ihj.2023.01.004_bib16","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1136\/hrt.2010.201574","article-title":"Impact of early statin therapy on development of atrial fibrillation at the acute stage of myocardial infarction: data from the FAST-MI register","volume":"96","author":"Danchin","year":"2010","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.ihj.2023.01.004_bib17","first-page":"381","article-title":"The effect of early and intensive statin therapy on ventricular premature beat or non-sustained ventricular tachycardia in patients with acute coronary syndrome","volume":"17","author":"He","year":"2010","journal-title":"Cardiol J"},{"issue":"10","key":"10.1016\/j.ihj.2023.01.004_bib18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/clc.20435","article-title":"Statins as anti-arrhythmics: a systematic review Part II: effects on risk of ventricular arrhythmias","volume":"32","author":"Abuissa","year":"2009","journal-title":"Clin Cardiol"},{"issue":"8","key":"10.1016\/j.ihj.2023.01.004_bib19","doi-asserted-by":"crossref","first-page":"458","DOI":"10.4070\/kcj.2011.41.8.458","article-title":"Effect of previous statin therapy in patients with acute coronary syndrome and percutaneous coronary intervention","volume":"41","author":"Yun","year":"2011","journal-title":"Korean Circ J"},{"issue":"11","key":"10.1016\/j.ihj.2023.01.004_bib20","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1016\/j.clinthera.2006.11.003","article-title":"Effects of receipt of chronic statin therapy before the onset of acute myocardial infarction: a retrospective study in patients undergoing primary percutaneous coronary intervention","volume":"28","author":"Ishii","year":"2006","journal-title":"Clin Therapeut"},{"issue":"12","key":"10.1016\/j.ihj.2023.01.004_bib21","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.amjcard.2015.09.016","article-title":"Myocardial infarct size in patients on long-term statin therapy undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction","volume":"116","author":"Marenzi","year":"2015","journal-title":"Am J Cardiol"},{"issue":"1","key":"10.1016\/j.ihj.2023.01.004_bib22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1136\/heartasia-2012-010225","article-title":"Association of statin therapy with ventricular arrhythmias among patients with acute coronary syndrome","volume":"5","author":"Apiyasawat","year":"2013","journal-title":"Heart Asia"},{"issue":"4","key":"10.1016\/j.ihj.2023.01.004_bib23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.13105\/wjma.v5.i4.80","article-title":"Assessing the quality of studies in meta-analyses: advantages and limitations of the newcastle Ottawa scale","volume":"5","author":"Luchini","year":"2017","journal-title":"World J Meta-Anal"},{"key":"10.1016\/j.ihj.2023.01.004_bib24","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","year":"2021"},{"issue":"14","key":"10.1016\/j.ihj.2023.01.004_bib25","first-page":"4054","article-title":"Effect of bariatric surgery on flow-mediated vasodilation as a measure of endothelial function: a systematic review and meta-analysis","volume":"11","author":"Jamialahmadi","year":"2022","journal-title":"J\u00a0Clin Med"},{"issue":"5","key":"10.1016\/j.ihj.2023.01.004_bib26","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/ije\/dyn065","article-title":"Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation","volume":"37","author":"Patsopoulos","year":"2008","journal-title":"Int J Epidemiol"},{"issue":"3","key":"10.1016\/j.ihj.2023.01.004_bib27","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.amjcard.2007.03.034","article-title":"Comparison of frequency of new-onset atrial fibrillation or flutter in patients on statins versus not on statins presenting with suspected acute coronary syndrome","volume":"100","author":"Ramani","year":"2007","journal-title":"Am J Cardiol"},{"issue":"12","key":"10.1016\/j.ihj.2023.01.004_bib28","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.amjcard.2009.07.045","article-title":"Impact of prior statin therapy on arrhythmic events in patients with acute coronary syndromes (from the Global Registry of Acute Coronary Events [GRACE])","volume":"104","author":"Vedre","year":"2009","journal-title":"Am J Cardiol"},{"issue":"2","key":"10.1016\/j.ihj.2023.01.004_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijcard.2008.11.172","article-title":"The association between previous statin use and development of atrial fibrillation in patients presenting with acute coronary syndrome","volume":"141","author":"Ozaydin","year":"2010","journal-title":"Int J Cardiol"},{"issue":"1","key":"10.1016\/j.ihj.2023.01.004_bib30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5152\/akd.2011.005","article-title":"Effect of previous statin use on the incidence of sustained ventricular tachycardia and ventricular fibrillation in patients presenting with acute coronary syndrome","volume":"11","author":"Ozayd\u0131n","year":"2011","journal-title":"Anadolu Kardiyol Derg"},{"issue":"9","key":"10.1016\/j.ihj.2023.01.004_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163068","article-title":"Impact of prior use of four preventive medications on outcomes in patients hospitalized for acute coronary syndrome--results from CPACS-2 study","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.ihj.2023.01.004_bib32","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1177\/0003319718775902","article-title":"Lower in-hospital ventricular tachyarrhythmia in patients with acute myocardial infarction receiving prior statin therapy","volume":"69","author":"Park","year":"2018","journal-title":"Angiology"},{"issue":"2","key":"10.1016\/j.ihj.2023.01.004_bib33","doi-asserted-by":"crossref","first-page":"198","DOI":"10.7150\/ijms.5248","article-title":"Statins therapy can reduce the risk of atrial fibrillation in patients with acute coronary syndrome: a meta-analysis","volume":"10","author":"Zhou","year":"2013","journal-title":"Int J Med Sci"},{"issue":"13","key":"10.1016\/j.ihj.2023.01.004_bib34","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1001\/jama.285.13.1711","article-title":"Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial","volume":"285","author":"Schwartz","year":"2001","journal-title":"JAMA"},{"issue":"19","key":"10.1016\/j.ihj.2023.01.004_bib35","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1001\/jama.294.19.2437","article-title":"High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial","volume":"294","author":"Pedersen","year":"2005","journal-title":"JAMA"},{"issue":"3","key":"10.1016\/j.ihj.2023.01.004_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2165\/11536690-000000000-00000","article-title":"Statins and the reduction of sudden cardiac death","volume":"10","author":"Beri","year":"2010","journal-title":"Am J Cardiovasc Drugs"},{"issue":"8","key":"10.1016\/j.ihj.2023.01.004_bib37","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1540-8159.2009.02440.x","article-title":"Is there a role for statins in atrial fibrillation?","volume":"32","author":"Dawe","year":"2009","journal-title":"Pacing Clin Electrophysiol"},{"issue":"3","key":"10.1016\/j.ihj.2023.01.004_bib38","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2147\/VHRM.S4841","article-title":"Pleiotropic effects of statins in atrial fibrillation patients: the evidence","volume":"5","author":"Hadi","year":"2009","journal-title":"Vasc Health Risk Manag"},{"issue":"1","key":"10.1016\/j.ihj.2023.01.004_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cardiores.2007.02.029","article-title":"Do statins have an antiarrhythmic activity?","volume":"75","author":"Kostapanos","year":"2007","journal-title":"Cardiovasc Res"},{"issue":"6","key":"10.1016\/j.ihj.2023.01.004_bib40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2165\/11315710-000000000-00000","article-title":"Non-atheroprotective effects of statins: a systematic review","volume":"9","author":"Beri","year":"2009","journal-title":"Am J Cardiovasc Drugs"},{"issue":"1","key":"10.1016\/j.ihj.2023.01.004_bib41","first-page":"551","article-title":"Atrial fibrillation in acute coronary syndrome","volume":"5","author":"Rubenstein","year":"2012","journal-title":"J\u00a0Atr Fibrillation"},{"issue":"7","key":"10.1016\/j.ihj.2023.01.004_bib42","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1586\/erc.10.61","article-title":"New-onset atrial fibrillation and acute coronary syndrome","volume":"8","author":"Lau","year":"2010","journal-title":"Expet Rev Cardiovasc Ther"},{"issue":"1","key":"10.1016\/j.ihj.2023.01.004_bib43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/cce2.51","article-title":"Ventricular arrhythmias in acute coronary syndromes\u2014mechanisms and management","volume":"3","author":"Thomas","year":"2017","journal-title":"Cont Cardiol Educ"},{"issue":"1","key":"10.1016\/j.ihj.2023.01.004_bib44","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1592\/phco.29.1.31","article-title":"Role of angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and aldosterone antagonists in the prevention of atrial and ventricular arrhythmias","volume":"29","author":"Makkar","year":"2009","journal-title":"Pharmacotherapy"},{"issue":"3","key":"10.1016\/j.ihj.2023.01.004_bib45","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1590\/S1807-59322010000300005","article-title":"Effect of \u03b2-blockers on the risk of atrial fibrillation in patients with acute myocardial infarction","volume":"65","author":"Pesaro","year":"2010","journal-title":"Clinics"}],"container-title":["Indian Heart Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019483223000044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0019483223000044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T03:57:11Z","timestamp":1758081431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0019483223000044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S0019483223000044"],"URL":"https:\/\/doi.org\/10.1016\/j.ihj.2023.01.004","relation":{},"ISSN":["0019-4832"],"issn-type":[{"value":"0019-4832","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prior statin use and the incidence of in-hospital arrhythmia in acute coronary syndrome: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Indian Heart Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ihj.2023.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Cardiological Society of India. Published by Elsevier, a division of RELX India, Pvt. Ltd.","name":"copyright","label":"Copyright"}]}}