{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:50:03Z","timestamp":1778655003998,"version":"3.51.4"},"reference-count":10,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.ijantimicag.2005.03.003","type":"journal-article","created":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T12:01:32Z","timestamp":1115294492000},"page":"88-91","source":"Crossref","is-referenced-by-count":24,"title":["Predictive factors of lopinavir\/ritonavir discontinuation for drug-related toxicity: results from a cohort of 416 multi-experienced HIV-infected individuals"],"prefix":"10.1016","volume":"26","author":[{"given":"Marco","family":"Bongiovanni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cicconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Landonio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Meraviglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letizia","family":"Testa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Di Biagio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Chiesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Tordato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Bini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella d\u2019Arminio","family":"Monforte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2005.03.003_bib1","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection","volume":"338","author":"Palella","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijantimicag.2005.03.003_bib2","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/S0140-6736(05)62505-6","article-title":"Decline in deaths from AIDS due to new antiretrovirals","volume":"349","author":"Hoggs","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.ijantimicag.2005.03.003_bib3","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1097\/00002030-199816000-00011","article-title":"Predictors of a viral response and subsequent virological treatment failure in patients with HIV starting a protease inhibitor","volume":"12","author":"Mocroft","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.ijantimicag.2005.03.003_bib4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/00002030-200003310-00005","article-title":"Insight into the reasons for discontinuation of the first highly active antiretroviral therapy (HAART) regimen in a cohort of antiretroviral na\u00efve patients","volume":"14","author":"d\u2019Arminio Monforte","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.ijantimicag.2005.03.003_bib5","unstructured":"US Department of Health and Human Services. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. http:\/\/www.aidsinfo.nih.gov\/ [accessed 9 March 2005]."},{"key":"10.1016\/j.ijantimicag.2005.03.003_bib6","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1056\/NEJMoa012354","article-title":"Lopinavir\u2013ritonavir versus nelfinavir for the initial treatment of HIV infection","volume":"346","author":"Walmsley","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijantimicag.2005.03.003_bib7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1086\/339014","article-title":"Safety and antiviral activity at week 48 of lopinavir\/ritonavir plus nevirapine and 2 nucleoside reverse transcriptase inhibitors in human immunodeficiency virus type-1 infected protease inhibitor-experienced patients","volume":"185","author":"Benson","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijantimicag.2005.03.003_bib8","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1086\/382531","article-title":"Risk of metabolic abnormalities in patients infected with HIV receiving antiretroviral therapy that contains lopinavir\u2013ritonavir","volume":"38","author":"Martinez","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2005.03.003_bib9","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.antiviral.2003.12.002","article-title":"Lopinavir\/ritonavir vs. indinavir\/ritonavir in antiretroviral naive HIV-infected patients: immunovirological outcome and side effects","volume":"62","author":"Bongiovanni","year":"2004","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ijantimicag.2005.03.003_bib10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1001\/jama.283.1.74","article-title":"Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B infection","volume":"284","author":"Sulkowski","year":"2000","journal-title":"JAMA"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857905001020?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857905001020?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T19:25:21Z","timestamp":1548530721000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857905001020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0924857905001020"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2005.03.003","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}