{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:37:58Z","timestamp":1785307078216,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1016\/j.ijantimicag.2005.08.021","type":"journal-article","created":{"date-parts":[[2005,11,29]],"date-time":"2005-11-29T12:47:26Z","timestamp":1133268446000},"page":"20-26","source":"Crossref","is-referenced-by-count":81,"title":["Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype"],"prefix":"10.1016","volume":"27","author":[{"given":"Masatoshi","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozaburo","family":"Huruya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Konomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Irie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Kanayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Saika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Intetsu","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2005.08.021_bib1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1128\/JCM.38.2.521-525.2000","article-title":"Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998","volume":"38","author":"Tanaka","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib2","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.ijantimicag.2004.02.005","article-title":"Antimicrobial resistance of Neisseria gonorrhoeae in Japan, 1993 to 2002: continuous increasing of ciprofloxacin-resistant isolates","volume":"24S","author":"Tanaka","year":"2004","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/00007435-198810000-00008","article-title":"Antibiotic resistance in Neisseria gonorrhoeae: genetics and mechanisms of resistance","volume":"15","author":"Johnson","year":"1988","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1128\/AAC.19.2.316","article-title":"Properties of penicillin-binding proteins in Neisseria gonorrhoeae","volume":"19","author":"Barbour","year":"1981","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/332173a0","article-title":"Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae","volume":"332","author":"Spratt","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1099\/13500872-141-3-611","article-title":"Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system","volume":"141","author":"Hagman","year":"1995","journal-title":"Microbiology"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1128\/IAI.52.2.529-533.1986","article-title":"Recombination near the antibiotic resistance locus penB results in antigenic variation of gonococcal outer membrane protein I","volume":"52","author":"Danielsson","year":"1986","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib8","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1128\/AAC.42.11.2799","article-title":"Gonococcal resistance to beta-lactams and tetracycline involves mutation in loop 3 of the porin encoded at the penB locus","volume":"42","author":"Gill","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib9","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1128\/jb.179.8.2783-2787.1997","article-title":"Cloning and characterization of the ponA gene encoding penicillin-binding protein 1 from Neisseria gonorrhoeae and Neisseria meningitidis","volume":"179","author":"Ropp","year":"1997","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1128\/AAC.46.3.769-777.2002","article-title":"Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae","volume":"46","author":"Ropp","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1128\/JCM.14.1.61-66.1981","article-title":"Preservation and transportation of bacteria by a simple gelatin disk method","volume":"14","author":"Obara","year":"1981","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib12","unstructured":"National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing. 12th Informational Supplement. Document M100-S11. Wayne, PA: NCCLS; 2002."},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib13","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1128\/AAC.45.9.2651-2654.2001","article-title":"Multidrug-resistant strains of Neisseria gonorrhoeae in Greece","volume":"45","author":"Mavroidi","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib14","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1073\/pnas.82.7.1999","article-title":"Sequences of the active-site peptides of three of the high-Mr penicillin-binding proteins of Escherichia coli K-12","volume":"82","author":"Keck","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib15","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1086\/377500","article-title":"Multidrug-resistant Neisseria gonorrhoeae with decreased susceptibility to cefixime\u2014Hawaii, 2001","volume":"37","author":"Wang","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/01.olq.0000154490.40381.15","article-title":"Antimicrobial resistance of Neisseria gonorrhoeae in selected World Health Organization Southeast Asia Region countries: an overview","volume":"32","author":"Ray","year":"2005","journal-title":"Sex Transm Dis"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib17","unstructured":"Australian Gonococcal Surveillance Programme. Annual report of the Australian Gonococcal Surveillance Programme, 2002. Commun Dis Intell 2003;27:189\u201395."},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib18","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1128\/AAC.46.12.3744-3749.2002","article-title":"Mosaic-like structure of penicillin-binding protein 2 gene (penA) in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime","volume":"46","author":"Ameyama","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1128\/AAC.49.1.137-143.2005","article-title":"Emergence and spread of Neisseria gonorrhoeae clinical isolates harboring mosaic-like structure of penicillin-binding protein 2 in central Japan","volume":"49","author":"Ito","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib20","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1128\/AAC.34.11.2269","article-title":"Neisseria lactamica and Neisseria polysaccharea as possible sources of meningococcal beta-lactam resistance by genetic transformation","volume":"34","author":"Saez-Nieto","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib21","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1128\/AAC.35.2.300","article-title":"Penicillin-resistant isolates of Neisseria lactamica produce altered forms of penicillin-binding protein 2 that arose by interspecies horizontal gene transfer","volume":"35","author":"Lujan","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00013542-200101000-00005","article-title":"The resistance of Neisseria meningitidis to antimicrobial agents: an issue still in evolution","volume":"12","author":"Vazquez","year":"2001","journal-title":"Rev Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib23","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1365-2958.1990.tb00664.x","article-title":"Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae","volume":"4","author":"Brannigan","year":"1990","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/1046-5928(91)90092-W","article-title":"Expression and purification of a soluble form of penicillin-binding protein 2 from both penicillin-susceptible and penicillin-resistant Neisseria gonorrhoeae","volume":"2","author":"Schultz","year":"1991","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib25","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1128\/jb.177.14.4162-4165.1995","article-title":"Transcriptional control of the mtr efflux system of Neisseria gonorrhoeae","volume":"177","author":"Hagman","year":"1995","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ijantimicag.2005.08.021_bib26","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1128\/AAC.43.10.2468","article-title":"Decreased azithromycin susceptibility of Neisseria gonorrhoeae due to mtrR mutations","volume":"43","author":"Zarantonelli","year":"1999","journal-title":"Antimicrob Agents Chemother"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857905002670?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857905002670?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T06:58:38Z","timestamp":1586588318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857905002670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["S0924857905002670"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2005.08.021","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}