{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:56:32Z","timestamp":1791424592170,"version":"4.3.3"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.ijantimicag.2006.05.008","type":"journal-article","created":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T14:46:43Z","timestamp":1153493203000},"page":"30-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":87,"special_numbering":"S1","title":["A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection"],"prefix":"10.1016","volume":"28","author":[{"given":"Shinya","family":"Uehara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Monden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nomoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Seno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Kariyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Kumon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2006.05.008_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/00365549009023118","article-title":"Effect on urogenital flora of antibiotic therapy for urinary tract infection","volume":"22","author":"Reid","year":"1990","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s003450050161","article-title":"Potential preventive strategies and therapies in urinary tract infection","volume":"17","author":"Reid","year":"1999","journal-title":"World J Urol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib3","unstructured":"Food and Agriculture Organization of the United Nations (FAO) and World Health Organization (WHO). Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria, a joint FAO\/WHO expert consultation. October 1\u20134 2001; Cordoba, Argentina. http:\/\/www.who.int\/foodsafety\/publications\/fs_management\/en\/probiotics.pdf."},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0022-5347(17)60454-3","article-title":"The role of introital enterobacteria in recurrent urinary infections","volume":"109","author":"Stamey","year":"1973","journal-title":"J Urol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0022-5347(17)57950-1","article-title":"Studies of introital colonization in women with recurrent urinary infections. IX. The role of antimicrobial therapy","volume":"118","author":"Schaeffer","year":"1977","journal-title":"J Urol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1464-410X.1976.tb10203.x","article-title":"Introital bacterial flora\u2014effect of increased frequency of micturition","volume":"48","author":"Seddon","year":"1976","journal-title":"Br J Urol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1128\/iai.49.2.320-324.1985","article-title":"Prevention of urinary tract infection in rats with an indigenous Lactobacillus casei strain","volume":"49","author":"Reid","year":"1985","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib8","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1574-695X.2001.tb01549.x","article-title":"Oral probiotics can resolve urogenital infections","volume":"30","author":"Reid","year":"2001","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"Suppl. 2","key":"10.1016\/j.ijantimicag.2006.05.008_bib9","doi-asserted-by":"crossref","first-page":"S437","DOI":"10.1093\/ajcn\/73.2.437s","article-title":"Probiotic agents to protect the urogenital tract against infection","volume":"73","author":"Reid","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib10","first-page":"11","article-title":"Influence of three-day antimicrobial therapy and lactobacillus vaginal suppositories on recurrence of urinary tract infections","volume":"14","author":"Reid","year":"1992","journal-title":"Clin Ther"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3109\/02813439409029247","article-title":"Vaginal application of lactobacilli in the prophylaxis of recurrent lower urinary tract infection in women","volume":"12","author":"Baerheim","year":"1994","journal-title":"Scand J Prim Health Care"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib12","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1086\/315109","article-title":"The identification of vaginal Lactobacillus species and the demographic and microbiologic characteristics of women colonized by these species","volume":"180","author":"Antonio","year":"1999","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib13","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1159\/000049813","article-title":"Current microbiological and clinical aspects of urinary tract infections","volume":"40","author":"Bonadio","year":"2001","journal-title":"Eur Urol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib14","first-page":"432","article-title":"Drug resistance amongst uropathogens isolated from women in a suburban population: laboratory findings over 7 years","volume":"4","author":"Reid","year":"1997","journal-title":"Can J Urol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib15","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1001\/jama.281.8.736","article-title":"Increasing prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated cystitis in women","volume":"281","author":"Gupta","year":"1999","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib16","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/jac\/dkf255","article-title":"Spanish members of the European Antimicrobial Resistance Surveillance System. Antibiotic resistance in 1962 invasive isolates of Escherichia coli in 27 Spanish hospitals participating in the European Antimicrobial Resistance Surveillance System","volume":"50","author":"Oteo","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1139\/m88-060","article-title":"Effect of antibiotic treatment on receptivity of uroepithelial cells to uropathogens","volume":"34","author":"Reid","year":"1988","journal-title":"Can J Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib18","first-page":"661","article-title":"Elie Metchnikoffs bacillus of long life","volume":"54","author":"Bibel","year":"1988","journal-title":"Am Soc Microbiol News"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib19","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0002-9378(60)90240-4","article-title":"Bacterial flora in vaginitis: a study before and after treatment with pure cultures of Doederlein bacillus","volume":"79","author":"Butler","year":"1960","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1574-695X.2001.tb00531.x","article-title":"Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora","volume":"32","author":"Reid","year":"2001","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib21","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1286-4579(02)01544-7","article-title":"Use of Lactobacillus to prevent infection by pathogenic bacteria","volume":"4","author":"Reid","year":"2002","journal-title":"Microbes Infect"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib22","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0966-842X(01)02132-1","article-title":"Can bacterial interference prevent infection?","volume":"9","author":"Reid","year":"2001","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib23","first-page":"767","article-title":"Vaginal colonization by orally administered Lactobacillus rhamnosus GG","volume":"5","author":"Colodner","year":"2003","journal-title":"Isr Med Assoc J"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0928-8244(02)00465-0","article-title":"Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women","volume":"35","author":"Reid","year":"2003","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib25","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00006250-199203000-00008","article-title":"The relationship of hydrogen peroxide-producing lactobacilli to bacterial vaginosis and genital microflora in pregnant women","volume":"79","author":"Hillier","year":"1992","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib26","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1139\/m88-171","article-title":"Detection of a Lactobacillus substance that inhibits Escherichia coli","volume":"34","author":"McGroarty","year":"1988","journal-title":"Can J Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib27","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1128\/aem.62.6.1958-1963.1996","article-title":"Inhibition of initial adhesion of uropathogenic Enterococcus faecalis by biosurfactants from Lactobacillus isolates","volume":"62","author":"Verlaeds","year":"1996","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib28","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1139\/m88-063","article-title":"Lactobacillus inhibitor production against Escherichia coli and coaggregation ability with uropathogens","volume":"34","author":"Reid","year":"1988","journal-title":"Can J Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0022-5347(17)43137-5","article-title":"Examination of strains of lactobacilli for properties that may influence bacterial interference in the urinary tract","volume":"138","author":"Reid","year":"1987","journal-title":"J Urol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jbm.820240105","article-title":"Exclusion of uropathogen adhesion to polymer surfaces by Lactobacillus acidophilus","volume":"24","author":"Hawthorn","year":"1990","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib31","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1099\/00222615-47-12-1081","article-title":"Interference in initial adhesion of uropathogenic bacteria and yeasts to silicone rubber by a Lactobacillus acidophilus biosurfactant","volume":"47","author":"Velraeds","year":"1998","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib32","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1128\/AEM.65.9.3763-3766.1999","article-title":"The scientific basis for probiotic strains of Lactobacillus","volume":"65","author":"Reid","year":"1999","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib33","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1128\/jcm.27.2.251-256.1989","article-title":"Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis","volume":"27","author":"Eschenbach","year":"1989","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2006.05.008_bib34","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1086\/428288","article-title":"Factors associated with absence of H2O2-producing Lactobacillus among women with bacterial vaginosis","volume":"191","author":"Beigi","year":"2005","journal-title":"J Infect Dis"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857906001750?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857906001750?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:29:58Z","timestamp":1760376598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857906001750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":34,"alternative-id":["S0924857906001750"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2006.05.008","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2006.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}