{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:23:43Z","timestamp":1791307423697,"version":"4.3.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.ijantimicag.2008.01.017","type":"journal-article","created":{"date-parts":[[2008,3,13]],"date-time":"2008-03-13T11:48:30Z","timestamp":1205408910000},"page":"523-526","source":"Crossref","is-referenced-by-count":127,"title":["Carbapenem-resistant Escherichia coli and Klebsiella pneumoniae isolates from Turkey with OXA-48-like carbapenemases and outer membrane protein loss"],"prefix":"10.1016","volume":"31","author":[{"given":"Dolunay","family":"G\u00fclmez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Woodford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-France I.","family":"Palepou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shazad","family":"Mushtaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Metan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuf","family":"Yakupogullari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sesin","family":"Kocagoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omrum","family":"Uzun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsen","family":"Hascelik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Livermore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2008.01.017_bib1","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1128\/CMR.14.4.933-951.2001","article-title":"Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat","volume":"14","author":"Bradford","year":"2001","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/jac\/dkl483","article-title":"CTX-M: changing the face of ESBLs in Europe","volume":"59","author":"Livermore","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/jac\/39.6.673","article-title":"Acquired carbapenemases","volume":"39","author":"Livermore","year":"1997","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib4","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1128\/CMR.00001-07","article-title":"Carbapenemases: the versatile beta-lactamases","volume":"20","author":"Quenaan","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib5","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1128\/AAC.48.12.4793-4799.2004","article-title":"Outbreak of Klebsiella pneumoniae producing a new carbapenem-hydrolyzing class A beta-lactamase, KPC-3, in a New York medical center","volume":"48","author":"Woodford","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1469-0691.2002.00401.x","article-title":"Emerging carbapenemases in Gram-negative aerobes","volume":"8","author":"Nordmann","year":"2002","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.diagmicrobio.2003.09.012","article-title":"Spread of blaVIM-1-producing E. coli in a university hospital in Greece. Genetic analysis of the integron carrying the blaVIM-1 metallo-beta-lactamase gene","volume":"48","author":"Scoulica","year":"2004","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib8","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1128\/JCM.43.10.5344-5347.2005","article-title":"Outbreaks in distinct regions due to a single Klebsiella pneumoniae clone carrying a blaVIM-1 metallo-beta-lactamase gene","volume":"43","author":"Ikonomidis","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib9","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1469-0691.2006.01456.x","article-title":"Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology","volume":"12","author":"Poirel","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1128\/AAC.48.1.15-22.2004","article-title":"Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae","volume":"48","author":"Poirel","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib11","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1128\/AAC.49.5.2146-2147.2005","article-title":"Further identification of plasmid-mediated quinolone resistance determinant in Enterobacteriaceae in Turkey","volume":"49","author":"Nazic","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib12","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1128\/AAC.46.6.2004-2006.2002","article-title":"Chromosome-encoded class D beta-lactamase OXA-23 in Proteus mirabilis","volume":"46","author":"Bonnet","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib13","unstructured":"Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. Fifteenth informational supplement. Wayne, PA: CLSI; 2005."},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib14","doi-asserted-by":"crossref","first-page":"3798","DOI":"10.1128\/JCM.40.10.3798-3801.2002","article-title":"Imipenem\u2013EDTA disk method for differentiation of metallo-beta-lactamase-producing clinical isolates of Pseudomonas spp. and Acinetobacter spp","volume":"40","author":"Yong","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/jac\/dkl277","article-title":"BSAC Working Party on Susceptibility Testing. BSAC standardized disc susceptibility testing method (version 5)","volume":"58","author":"Andrews","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib16","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1093\/jac\/dkl481","article-title":"Multiplex PCR for rapid detection of genes encoding acquired metallo-\u03b2-lactamases","volume":"59","author":"Ellington","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib17","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jac\/dki412","article-title":"Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum beta-lactamases","volume":"57","author":"Woodford","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib18","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1128\/JCM.40.6.2153-2162.2002","article-title":"Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR","volume":"40","author":"P\u00e9rez-P\u00e9rez","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib19","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1128\/AAC.45.4.1151-1161.2001","article-title":"Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae","volume":"45","author":"Yigit","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib20","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/jac\/dkf240","article-title":"Biochemical analysis of the ceftazidime-hydrolysing extended-spectrum beta-lactamase CTX-M-15 and of its structurally related beta-lactamase CTX-M-3","volume":"50","author":"Poirel","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib21","first-page":"161","article-title":"Diversity of CTX-M beta-lactamases and their promoter regions from Enterobacteriaceae isolated in three Parisian hospitals","volume":"209","author":"Saladin","year":"2002","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib22","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib23","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1093\/nar\/7.6.1513","article-title":"A rapid alkaline extraction procedure for screening recombinant plasmid DNA","volume":"7","author":"Bimboim","year":"1979","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib24","series-title":"Methods in practical laboratory bacteriology","year":"1994"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib25","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1128\/JCM.00699-06","article-title":"Occurrence of carbapenem-resistant Acinetobacter baumannii clones at multiple hospitals in London and Southeast England","volume":"44","author":"Coelho","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib26","doi-asserted-by":"crossref","first-page":"5314","DOI":"10.1128\/JB.185.17.5314-5319.2003","article-title":"IS1999 increases expression of the extended-spectrum beta-lactamase VEB-1 in Pseudomonas aeruginosa","volume":"185","author":"Aubert","year":"2003","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib27","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1086\/503264","article-title":"In vivo development of ertapenem resistance in a patient with pneumonia caused by Klebsiella pneumoniae with an extended-spectrum beta-lactamase","volume":"42","author":"Elliott","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib28","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1128\/JCM.42.8.3831-3833.2004","article-title":"In vivo acquisition of high-level resistance to imipenem in Escherichia coli","volume":"42","author":"Poirel","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib29","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1128\/AAC.49.10.4400-4403.2005","article-title":"Genetic and enzymatic properties of metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae","volume":"49","author":"Gacar","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib30","unstructured":"Poirel L, Carrer A, Eraksoy H, Cagatay A, Badur S, Nordmann P. Nosocomial outbreak of carbapenem-resistant Klebsiella pneumoniae isolates producing OXA-48 in Turkey. In: 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC); 17\u201320 September 2007; Chicago, IL. Poster no. C2-2063."},{"key":"10.1016\/j.ijantimicag.2008.01.017_bib31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijantimicag.2005.06.012","article-title":"Clinical outcomes and therapeutic options of bloodstream infections caused by extended-spectrum beta-lactamase-producing Escherichia coli","volume":"26","author":"Metan","year":"2005","journal-title":"Int J Antimicrob Agents"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857908000472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857908000472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T03:21:12Z","timestamp":1546226472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857908000472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0924857908000472"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2008.01.017","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}