{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:13:01Z","timestamp":1786990381283,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.ijantimicag.2008.05.013","type":"journal-article","created":{"date-parts":[[2008,8,21]],"date-time":"2008-08-21T09:17:06Z","timestamp":1219310226000},"page":"405-410","source":"Crossref","is-referenced-by-count":83,"title":["A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria"],"prefix":"10.1016","volume":"32","author":[{"given":"Varsha","family":"Shriram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Jahagirdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Latha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedavati","family":"Puranik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supada","family":"Rojatkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant K.","family":"Dhakephalkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.","family":"Shitole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2008.05.013_bib1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.arcmed.2005.06.009","article-title":"Resistance to antibiotics: are we in the post-antibiotic era?","volume":"36","author":"Alanis","year":"2005","journal-title":"Arch Med Res"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nrd940","article-title":"The future challenges facing the development of new antimicrobial drugs","volume":"1","author":"Coates","year":"2002","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2165\/00003495-200059040-00007","volume":"59","author":"Clemet","year":"2000","journal-title":"Linezolid Drugs"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0732-8893(01)00333-9","article-title":"Linezolid-resistant Enterococcus faecium isolated from a patient without prior exposure to an oxazolidinone: report from the SENTRY Antimicrobial Surveillance Program","volume":"42","author":"Jones","year":"2002","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/jac\/dkg104","article-title":"Linezolid resistance in clinical isolates of Staphylococcus aureus","volume":"51","author":"Wilson","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.fitote.2006.03.013","article-title":"Antimicrobial and antiplasmid activities of essential oils","volume":"77","author":"Schelz","year":"2006","journal-title":"Fitoterapia"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0924-8579(03)00206-1","article-title":"Antiplasmid effect of promethazine in mixed bacterial cultures","volume":"22","author":"Molnar","year":"2003","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0924-8579(00)00131-X","article-title":"Interaction between antibiotics and non-conventional antibiotics on different bacteria","volume":"14","author":"Gunics","year":"2000","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib9","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1359-6446(03)02989-1","article-title":"Shooting the messenger of antibiotic resistance: plasmid elimination as a potential counter-evolutionary tactic","volume":"9","author":"Am\u00e1bile-Cuevas","year":"2004","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1039\/a902202c","article-title":"The influence of natural products upon drug discovery","volume":"17","author":"Newman","year":"2000","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF01568396","article-title":"Elimination of multidrug-resistant plasmid in bacteria by plumbagin, a compound derived from a plant","volume":"16","author":"Lakshmi","year":"1987","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib12","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/np030409c","article-title":"Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria","volume":"67","author":"Belofsky","year":"2004","journal-title":"J Nat Prod"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib13","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1023\/A:1008991724288","article-title":"Effect of Plumbago zeylanica extract and certain curing agents on multidrug resistance bacteria of clinical origin","volume":"16","author":"Beg","year":"2004","journal-title":"World J Microbiol Biotechnol"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib14","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1016\/j.phytochem.2005.06.008","article-title":"Multidrug resistance reversal agent from Jatropha ellliptica","volume":"66","author":"Marquez","year":"2005","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib15","unstructured":"The wealth of India: raw materials, vol. III. New Delhi, India: Council of Scientific and Industrial Research; 1952. p. 71."},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib16","series-title":"Glossary of Indian medicinal plants","author":"Chopra","year":"1956"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib17","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.phytochem.2006.06.019","article-title":"Bafoudiosbulbins A, and B, two anti-salmonellal clerodane diterpenoids from Dioscorea bulbifera L. var sativa","volume":"67","author":"Teponno","year":"2006","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib18","first-page":"2117","article-title":"New antifeedant neo-clerodane triol.","volume":"51","author":"Urones","year":"1995","journal-title":"Semisynthesis and antifeedant activity of neo-clerodane diterpenoids, Tetrahedron"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1055\/s-2002-23138","article-title":"Croblongifolin, a new anticancer clerodane from Croton oblongifolius","volume":"68","author":"Roengsunran","year":"2002","journal-title":"Planta Medica"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF00205197","article-title":"High levels of multiple metal resistance and its correlation to antibiotic resistance in environmental isolates of Acinetobacter","volume":"7","author":"Dhakephalkar","year":"1994","journal-title":"Biometals"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1046\/j.1472-765X.2001.00995.x","article-title":"Plasmid-mediated dimethoate degradation in Pseudomonas aeruginosa MCMB-427","volume":"33","author":"Deshpande","year":"2001","journal-title":"Lett Appl Microbiol"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib22","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1023\/A:1015099409563","article-title":"Plasmid-associated biodegradation of an organophosphorus pesticide, Monocrotophos, by Pseudomonas mendocina","volume":"24","author":"Bhadbhade","year":"2002","journal-title":"Biotechnol Lett"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib23","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bbrc.2004.04.037","article-title":"Carboplatin induces apoptotic cell death through downregulation of constitutively active nuclear factor-\u03baB in human HPV-18 E6-positive HEp-2 cells","volume":"318","author":"Singh","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib24","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0031-9422(00)80394-5","article-title":"Diosbulbin D and 8-epidiosbulbin E acetate, norclerodane diterpenoids from Dioscorea bulbifera tubers","volume":"23","author":"Murray","year":"1984","journal-title":"Phytochemistry"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib25","doi-asserted-by":"crossref","first-page":"10753","DOI":"10.1016\/j.tet.2004.08.065","article-title":"Antibiotics from Australian terrestrial invertebrates. Part 1: antibacterial trinervitadienes from the termite Nasutitermes triodiae","volume":"60","author":"Zhao","year":"2004","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ijantimicag.2008.05.013_bib26","doi-asserted-by":"crossref","first-page":"9835","DOI":"10.1016\/j.tet.2004.08.071","article-title":"Tubiferal A, a backbone-rearranged triterpenoid lactone isolated from the myxomycete Tubifera dimorphotheca, possessing reversal of drug resistance activity","volume":"60","author":"Kamata","year":"2004","journal-title":"Tetrahedron"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857908002434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857908002434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T03:59:30Z","timestamp":1545796770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857908002434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0924857908002434"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2008.05.013","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}