{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:09:48Z","timestamp":1787656188574,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18050006"],"award-info":[{"award-number":["18050006"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18073001"],"award-info":[{"award-number":["18073001"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["18GS0314"],"award-info":[{"award-number":["18GS0314"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["20590429"],"award-info":[{"award-number":["20590429"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007416","name":"Japan Health Sciences Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1016\/j.ijantimicag.2009.08.016","type":"journal-article","created":{"date-parts":[[2009,11,13]],"date-time":"2009-11-13T10:06:59Z","timestamp":1258106819000},"page":"56-61","source":"Crossref","is-referenced-by-count":44,"title":["Cytotoxic effect of amide derivatives of trifluoromethionine against the enteric protozoan parasite Entamoeba histolytica"],"prefix":"10.1016","volume":"35","author":[{"given":"Dan","family":"Sato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Toru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaichi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gensuke","family":"Tokoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahab","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyoshi","family":"Soga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Suematsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyoshi","family":"Nozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2009.08.016_bib1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1128\/CMR.00019-06","article-title":"Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by \u201camitochondriate\u201d protozoan parasites","volume":"20","author":"Ali","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib2","doi-asserted-by":"crossref","first-page":"679","DOI":"10.2165\/00003495-199754050-00003","article-title":"Metronidazole. A therapeutic review and update","volume":"54","author":"Freeman","year":"1997","journal-title":"Drugs"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib3","doi-asserted-by":"crossref","first-page":"26051","DOI":"10.1074\/jbc.274.37.26051","article-title":"Metronidazole resistance in the protozoan parasite Entamoeba histolytica is associated with increased expression of iron-containing superoxide dismutase and peroxiredoxin and decreased expression of ferredoxin 1 and flavin reductase","volume":"274","author":"Wassmann","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/0141-0229(85)90094-8","article-title":"A versatile bacterial enzyme: l-methionine \u03b3-lyase","volume":"7","author":"Tanaka","year":"1985","journal-title":"Enzyme Microb Technol"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib5","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1742-4658.2007.06221.x","article-title":"Kinetic characterization of methionine \u03b3-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis","volume":"275","author":"Sato","year":"2008","journal-title":"FEBS J"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1139\/m66-020","article-title":"dl-S-Trifluoromethylhomocysteine, a novel inhibitor of microbial growth","volume":"12","author":"Zygmunt","year":"1966","journal-title":"Can J Microbiol"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib7","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1006\/bbrc.2002.6747","article-title":"l-Methionine-\u03b3-lyase, as a target to inhibit malodorous bacterial growth by trifluoromethionine","volume":"292","author":"Yoshimura","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib8","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1128\/AAC.45.6.1743-1745.2001","article-title":"Trifluoromethionine, a prodrug designed against methionine \u03b3-lyase-containing pathogens, has efficacy in vitro and in vivo against Trichomonas vaginalis","volume":"45","author":"Coombs","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib9","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1074\/jbc.M212414200","article-title":"Identification and characterization of two isoenzymes of methionine \u03b3-lyase from Entamoeba histolytica: a key enzyme of sulfur-amino acid degradation in an anaerobic parasitic protist that lacks forward and reverse trans-sulfuration pathways","volume":"278","author":"Tokoro","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1128\/CMR.15.3.329-341.2002","article-title":"Methods for cultivation of luminal parasitic protists of clinical importance","volume":"15","author":"Clark","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib11","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1158\/0008-5472.CAN-08-4806","article-title":"Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry","volume":"69","author":"Hirayama","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/j.1574-6968.1995.tb07728.x","article-title":"Amino acid consumption by the parasitic, amoeboid protists Entamoeba histolytica and E. invadens","volume":"130","author":"Zuo","year":"1995","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib13","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/jac\/32.3.483","article-title":"Comparative pharmacokinetics and amoebicidal activity of metronidazole and satranidazole in the golden hamster, Mesocricetus auratus","volume":"32","author":"Pargal","year":"1993","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib14","doi-asserted-by":"crossref","first-page":"e211","DOI":"10.1371\/journal.pbio.0050211","article-title":"Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase","volume":"5","author":"Leitsch","year":"2007","journal-title":"PLoS Biol"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib15","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1128\/AAC.00909-08","article-title":"Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases)","volume":"53","author":"Pal","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib16","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1128\/AAC.43.7.1533","article-title":"Why metronidazole is active against both bacteria and parasites","volume":"43","author":"Samuelson","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib17","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/jac\/40.6.833","article-title":"Involvement of superoxide dismutase and pyruvate:ferredoxin oxidoreductase in mechanisms of metronidazole resistance in Entamoeba histolytica","volume":"40","author":"Samarawickrema","year":"1997","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2009.08.016_bib18","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1128\/AAC.45.6.1810-1814.2001","article-title":"Drug susceptibility testing of anaerobic protozoa","volume":"45","author":"Upcroft","year":"2001","journal-title":"Antimicrob Agents Chemother"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857909004130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857909004130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T15:51:40Z","timestamp":1656863500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857909004130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S0924857909004130"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2009.08.016","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}