{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T17:09:49Z","timestamp":1763572189195},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.ijantimicag.2012.10.020","type":"journal-article","created":{"date-parts":[[2013,1,6]],"date-time":"2013-01-06T09:31:03Z","timestamp":1357464663000},"page":"229-235","source":"Crossref","is-referenced-by-count":15,"title":["In vivo pharmacokinetics and in vitro antifungal activity of iodiconazole, a new triazole, determined by microdialysis sampling"],"prefix":"10.1016","volume":"41","author":[{"given":"Ning","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunquan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongbing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wannian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongzhuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guorong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0005","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ijantimicag.2007.07.019","article-title":"Recent advances and challenges in the treatment of invasive fungal infections","volume":"30","author":"Shao","year":"2007","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0010","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S1043-6618(02)00088-9","article-title":"Itraconazole solution: summary of pharmacokinetic features and review of activity in the treatment of fluconazole-resistant oral candidosis in HIV-infected persons","volume":"46","author":"Koks","year":"2002","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0015","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/s11908-011-0220-x","article-title":"Long-term voriconazole and skin cancer: is there cause for concern?","volume":"13","author":"Clancy","year":"2011","journal-title":"Curr Infect Dis Rep"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0020","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1358\/dot.2003.39.10.799473","article-title":"Clinical impact of drug\u2013drug interactions with systemic azole antifungals","volume":"39","author":"Bates","year":"2003","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0025","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1128\/AAC.05900-11","article-title":"Posaconazole exposure\u2013response relationship: evaluating the utility of therapeutic drug monitoring","volume":"56","author":"Dolton","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0030","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1021\/jm990589g","article-title":"A three-dimensional model of lanosterol 14\u03b1-demethylase of Candida albicans and its interaction with azole antifungals","volume":"43","author":"Ji","year":"2000","journal-title":"J Med Chem"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0035","first-page":"984","article-title":"Synthesis and antifungal activity of novel triazole antifungal agents","volume":"39","author":"Sheng","year":"2004","journal-title":"Yao Xue Xue Bao [Acta Pharm Sin]"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0040","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.aca.2012.01.007","article-title":"Computer-aided molecular modeling study of enantioseparation of iodiconazole and structurally related triadimenol analogues by capillary electrophoresis: chiral recognition mechanism and mathematical model for predicting chiral separation","volume":"718","author":"Li","year":"2012","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0045","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jpba.2006.07.043","article-title":"High performance liquid chromatographic determination of a new antifungal compound, ADKZ in rat plasma","volume":"43","author":"Wen","year":"2007","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0050","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.jchromb.2008.12.034","article-title":"A liquid chromatography\u2013tandem mass spectrometry assay for determination of trace amount of new antifungal drug iodiconazole in human plasma","volume":"877","author":"Gao","year":"2009","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0055","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0924-8579(02)00024-9","article-title":"Rational dosing of antibiotics: the use of plasma concentrations versus tissue concentrations","volume":"19","author":"Liu","year":"2002","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0060","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.coph.2005.04.010","article-title":"Microdialysis for in vivo pharmacokinetic\/pharmacodynamic characterization of anti-infective drugs","volume":"98","author":"Brunner","year":"2005","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0065","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/jac\/46.5.733","article-title":"A combined in vivo pharmacokinetic\u2013in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans","volume":"46","author":"Delacher","year":"2000","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0070","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ijantimicag.2004.09.012","article-title":"Pharmacokinetic\u2013pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in vitro kinetic models","volume":"25","author":"Liu","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0075","series-title":"Essentials of clinical mycology","first-page":"121","article-title":"Antifungal pharmacokinetics and pharmacodynamics","author":"Andes","year":"2011"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0080","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/AAC.00663-08","article-title":"Intrapulmonary pharmacokinetics and pharmacodynamics of posaconazole at steady state in healthy subjects","volume":"53","author":"Conte","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0085","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijantimicag.2011.05.007","article-title":"Clinical pharmacokinetic\/pharmacodynamic profile of linezolid in severely ill intensive care unit patients","volume":"38","author":"Dong","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0090","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1128\/AAC.00694-11","article-title":"Pharmacokinetic\u2013pharmacodynamic model for gentamicin and its adaptive resistance with predictions of dosing schedules in newborn infants","volume":"56","author":"Mohamed","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0095","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jpba.2009.07.016","article-title":"An ultra-fast LC method for the determination of iodiconazole in microdialysis samples and its application in the calibration of laboratory-made linear probes","volume":"51","author":"Sun","year":"2010","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0100","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1570-0232(02)00961-3","article-title":"On-line determination of fluconazole in blood and dermal rat microdialysates by microbore high-performance liquid chromatography","volume":"787","author":"Mathy","year":"2003","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0105","unstructured":"Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard. 3rd ed. Document M27-A3. Wayne, PA: CLSI; 2008."},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0110","unstructured":"Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard. 2nd ed. Document M38-A2. Wayne, PA: CLSI; 2008."},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0115","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1128\/AAC.49.12.4974-4979.2005","article-title":"Lack of effect of experimental hypovolemia on imipenem muscle distribution in rats assessed by microdialysis","volume":"49","author":"Marchand","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0120","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1128\/AAC.00190-06","article-title":"Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of Acinetobacter baumannii-infected rats","volume":"50","author":"Dahyot","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1128\/AAC.50.1.34-37.2006","article-title":"Microdialysis study of imipenem distribution in the intraperitoneal fluid of rats with or without experimental peritonitis","volume":"50","author":"Lefeuvre","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0130","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0168-3659(99)00214-X","article-title":"Intradermal microdialysis: kinetics of iontophoretically delivered propranolol in forearm dermis","volume":"63","author":"Stagni","year":"2000","journal-title":"J Control Release"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0135","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0928-0987(00)00155-X","article-title":"Microdialysis for the evaluation of penetration through the human skin barrier\u2014a promising tool for future research?","volume":"12","author":"Schnetz","year":"2001","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0140","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1128\/AAC.48.5.1441-1453.2004","article-title":"Issues in pharmacokinetics and pharmacodynamics of anti-infective agents: distribution in tissue","volume":"48","author":"M\u00fcller","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2174\/138920006774832578","article-title":"Tissue distribution and pharmacodynamics: a complicated relationship","volume":"7","author":"Lin","year":"2006","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0150","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.drup.2004.06.002","article-title":"Antifungal pharmacokinetics and pharmacodynamics: understanding the implications for antifungal drug resistance","volume":"7","author":"Andes","year":"2004","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0155","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.coph.2007.05.004","article-title":"Pharmacodynamic implications for use of antifungal agents","volume":"7","author":"Lewis","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0160","doi-asserted-by":"crossref","first-page":"805","DOI":"10.4065\/mcp.2011.0247","article-title":"Current concepts in antifungal pharmacology","volume":"86","author":"Lewis","year":"2011","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.ijantimicag.2012.10.020_bib0165","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2165\/00003088-199834020-00001","article-title":"Drug distribution. The forgotten relative in clinical pharmacokinetics","volume":"34","author":"Eichler","year":"1998","journal-title":"Clin Pharmacokinet"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857912004311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857912004311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T17:53:38Z","timestamp":1539971618000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857912004311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S0924857912004311"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2012.10.020","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}