{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T17:04:37Z","timestamp":1772298277572,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1016\/j.ijantimicag.2012.12.009","type":"journal-article","created":{"date-parts":[[2013,2,8]],"date-time":"2013-02-08T19:45:57Z","timestamp":1360352757000},"page":"330-336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["Galleria mellonella as a model system to test the pharmacokinetics and efficacy of antibiotics against Burkholderia pseudomallei"],"prefix":"10.1016","volume":"41","author":[{"given":"Rachael J.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karleigh A.","family":"Hamblin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart J.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia M.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Bokori-Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stan","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen S.","family":"Atkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Titball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0005","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.micinf.2007.02.016","article-title":"Galleria mellonella as a model host to study infection by the Francisella tularensis live vaccine strain","volume":"9","author":"Aperis","year":"2007","journal-title":"Microbes Infect"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0010","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1099\/jmm.0.026658-0","article-title":"Galleria mellonella as an infection model for Campylobacter jejuni virulence","volume":"60","author":"Senior","year":"2011","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0015","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1099\/mic.0.026823-0","article-title":"Galleria mellonella as an alternative infection model for Yersinia pseudotuberculosis","volume":"155","author":"Champion","year":"2009","journal-title":"Microbiology"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0020","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1128\/AEM.01301-09","article-title":"Galleria mellonella as a model system for studying Listeria pathogenesis","volume":"76","author":"Mukherjee","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0025","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1128\/AAC.01533-08","article-title":"Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics","volume":"53","author":"Peleg","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0030","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.femsre.2003.09.002","article-title":"Exploiting the potential of insects for in vivo pathogenicity testing of microbial pathogens","volume":"28","author":"Kavanagh","year":"2004","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0035","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0965-1748(02)00092-9","article-title":"Insect hemocytes and their role in immunity","volume":"32","author":"Lavine","year":"2002","journal-title":"Insect Biochem Mol Biol"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0040","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.cellsig.2008.08.014","article-title":"Regulators and signalling in insect haemocyte immunity","volume":"21","author":"Marmaras","year":"2009","journal-title":"Cell Signal"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.imbio.2006.01.001","article-title":"Pathogen recognition and signalling in the Drosophila innate immune response","volume":"211","author":"Wang","year":"2006","journal-title":"Immunobiology"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0050","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1128\/IAI.73.7.4161-4170.2005","article-title":"Superoxide production in Galleria mellonella hemocytes: identification of proteins homologous to the NADPH oxidase complex of human neutrophils","volume":"73","author":"Bergin","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2180-11-11","article-title":"Macrophage and Galleria mellonella infection models reflect the virulence of naturally occurring isolates of B pseudomallei, B. thailandensis and B. oklahomensis","volume":"11","author":"Wand","year":"2011","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/CMR.4.1.52","article-title":"Melioidosis: the tip of the iceberg?","volume":"4","author":"Dance","year":"1991","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0065","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.4269\/ajtmh.2010.10-0306","article-title":"Pathogenicity of high-dose enteral inoculation of Burkholderia pseudomallei to mice","volume":"83","author":"West","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0070","doi-asserted-by":"crossref","first-page":"e327","DOI":"10.1371\/journal.pntd.0000327","article-title":"A simple scoring system to differentiate between relapse and re-infection in patients with recurrent melioidosis","volume":"2","author":"Limmathurotsakul","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0075","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1586\/14787210.4.3.445","article-title":"Management of melioidosis","volume":"4","author":"Wuthiekanun","year":"2006","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0080","doi-asserted-by":"crossref","first-page":"744","DOI":"10.4161\/auto.6246","article-title":"Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines","volume":"4","author":"Cullinane","year":"2008","journal-title":"Autophagy"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0085","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1365-2958.2004.04528.x","article-title":"Identification of a bacterial factor required for actin-based motility of Burkholderia pseudomallei","volume":"56","author":"Stevens","year":"2005","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0090","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1186\/gb-2010-11-8-r89","article-title":"Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates","volume":"11","author":"Sim","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0095","doi-asserted-by":"crossref","first-page":"12095","DOI":"10.1073\/pnas.1107183108","article-title":"Dissection of the Burkholderia intracellular life cycle using a photothermal nanoblade","volume":"108","author":"French","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0100","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.1128\/JCM.01585-06","article-title":"Pneumonia and septicemia caused by Burkholderia thailandensis in the United States","volume":"44","author":"Glass","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0105","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1574-6968.2007.00946.x","article-title":"Virulence of clinical and environmental isolates of Burkholderia oklahomensis and Burkholderia thailandensis in hamsters and mice","volume":"277","author":"Deshazer","year":"2007","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0110","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1099\/jmm.0.47043-0","article-title":"Polysaccharides and virulence of Burkholderia pseudomallei","volume":"56","author":"Sarkar-Tyson","year":"2007","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0115","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1046\/j.1365-2125.2000.00179.x","article-title":"Pharmacokinetic\u2013pharmacodynamic evaluation of ceftazidime continuous infusion vs intermittent bolus injection in septicaemic melioidosis","volume":"49","author":"Angus","year":"2000","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0120","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1128\/AAC.26.5.715","article-title":"Multiple-dose pharmacokinetics of imipenem\u2013cilastatin","volume":"26","author":"Drusano","year":"1984","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0125","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/jac\/46.5.669","article-title":"Application of fluoroquinolone pharmacodynamics","volume":"46","author":"Wright","year":"2000","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0130","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/jac\/dkl224","article-title":"Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines","volume":"58","author":"Agwuh","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0022-3565(24)37553-6","article-title":"Pharmacodynamic activities of ciprofloxacin and sparfloxacin in a murine pneumococcal pneumonia model: relevance for drug efficacy","volume":"286","author":"Bedos","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0140","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/jac\/dki039","article-title":"Comparison of gatifloxacin, moxifloxacin and ciprofloxacin for treatment of experimental Burkholderia pseudomallei infection","volume":"55","author":"Steward","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2012.12.009_bib0145","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ijantimicag.2010.01.023","article-title":"Class-dependent relevance of tissue distribution in the interpretation of anti-infective pharmacokinetic\/pharmacodynamic indices","volume":"35","author":"Barbour","year":"2010","journal-title":"Int J Antimicrob Agents"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857913000058?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857913000058?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:31:27Z","timestamp":1760376687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857913000058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0924857913000058"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2012.12.009","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2013,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Galleria mellonella as a model system to test the pharmacokinetics and efficacy of antibiotics against Burkholderia pseudomallei","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2012.12.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown copyright \u00a9 2013 Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}