{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:18:59Z","timestamp":1792624739680,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.ijantimicag.2013.02.018","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T08:41:30Z","timestamp":1366620090000},"page":"521-523","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["In vitro susceptibility to antibiotics of staphylococci in biofilms isolated from orthopaedic infections"],"prefix":"10.1016","volume":"41","author":[{"given":"Diana","family":"Molina-Manso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"del Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ortiz-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Manrubia-Cobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"G\u00f3mez-Barrena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Cordero-Ampuero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0005","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1172\/JCI200320365","article-title":"The application of biofilm science to the study and control of chronic bacterial infections","volume":"112","author":"Costerton","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0010","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1056\/NEJMcp0905029","article-title":"Clinical practice. Infection associated with prosthetic joints","volume":"361","author":"Del Pozo","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0015","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4248\/IJOS11026","article-title":"The clinical impact of bacterial biofilms","volume":"3","author":"H\u00f8iby","year":"2011","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0020","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1128\/JCM.37.6.1771-1776.1999","article-title":"The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms","volume":"37","author":"Ceri","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1524-475X.2010.00651.x","article-title":"Antimicrobial tolerance and the significance of persister cells in recalcitrant chronic wound biofilms","volume":"19","author":"Percival","year":"2011","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0030","doi-asserted-by":"crossref","first-page":"e19036","DOI":"10.1371\/journal.pone.0019036","article-title":"Development of a high-throughput Candida albicans biofilm chip","volume":"6","author":"Srinivasan","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0035","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1574-695X.2012.00938.x","article-title":"Pathogenesis and treatment concepts of orthopaedic biofilm infections","volume":"65","author":"Zimmerli","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0040","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1086\/322972","article-title":"Biofilm formation: a clinically relevant microbiological process","volume":"33","author":"Donlan","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0045","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ppul.21011","article-title":"Pseudomonas aeruginosa biofilms in the respiratory tract of cystic fibrosis patients","volume":"44","author":"Bjarnsholt","year":"2009","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0050","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1177\/089686080302300111","article-title":"Biofilm infections in peritoneal dialysis-related peritonitis: comparison of standard MIC and MBEC in evaluation of antibiotic sensitivity of coagulase-negative staphylococci","volume":"23","author":"Sepandj","year":"2003","journal-title":"Perit Dial Int"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0055","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1128\/AAC.39.5.1038","article-title":"Combination effect of fosfomycin and ofloxacin against Pseudomonas aeruginosa growing in a biofilm","volume":"39","author":"Kumon","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0060","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S1995-7645(12)60026-1","article-title":"In vitro biofilm formation by uropathogenic Escherichia coli and their antimicrobial susceptibility pattern","volume":"5","author":"Ponnusamy","year":"2012","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0065","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1128\/AAC.39.11.2397","article-title":"Antibiotics and prevention of microbial colonization of catheters","volume":"39","author":"Raad","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0070","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1128\/AAC.39.10.2262","article-title":"Modulation of biofilms of Pseudomonas aeruginosa by quinolones","volume":"39","author":"Yassien","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0075","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1251\/bpo127","article-title":"The use of microscopy and three-dimensional visualization to evaluate the structure of microbial biofilms cultivated in the Calgary Biofilm Device","volume":"8","author":"Harrison","year":"2006","journal-title":"Biol Proced Online"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0080","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/jor.22065","article-title":"Evaluation of MBEC\u2122-HTP biofilm model for studies of implant associated infections","volume":"30","author":"Coraca-Huber","year":"2012","journal-title":"J Orthop Res"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0085","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/089686080402400107","article-title":"Minimum inhibitory concentration (MIC) versus minimum biofilm eliminating concentration (MBEC) in evaluation of antibiotic sensitivity of Gram-negative bacilli causing peritonitis","volume":"24","author":"Sepandj","year":"2004","journal-title":"Perit Dial Int"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0090","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/ja.2012.62","article-title":"In vitro susceptibility of Staphylococcus aureus and Staphylococcus epidermidis isolated from prosthetic joint infections","volume":"65","author":"Molina-Manso","year":"2012","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0095","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1046\/j.1365-2958.2003.03493.x","article-title":"SarA and not \u03c3B is essential for biofilm development by Staphylococcus aureus","volume":"48","author":"Valle","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0100","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1128\/JCM.01762-07","article-title":"Evaluation of quantitative analysis of cultures from sonicated retrieved orthopedic implants in diagnosis of orthopedic infection","volume":"46","author":"Esteban","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0105","doi-asserted-by":"crossref","first-page":"674","DOI":"10.3109\/17453674.2010.537810","article-title":"Biofilm development by clinical isolates of Staphylococcus spp. from retrieved orthopedic prostheses","volume":"81","author":"Esteban","year":"2010","journal-title":"Acta Orthop"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0110","series-title":"Performance standards for antimicrobial susceptibility testing; twenty-first informational supplement. Document M100-S21","author":"Clinical and Laboratory Standards Institute","year":"2011"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0115","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1086\/383472","article-title":"Daptomycin: another novel agent for treating infections due to drug-resistant Gram-positive pathogens","volume":"38","author":"Carpenter","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0120","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1128\/AAC.37.6.1214","article-title":"Oral rifampin plus ofloxacin for treatment of Staphylococcus-infected orthopedic implants","volume":"37","author":"Drancourt","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0125","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1469-0691.2008.02663.x","article-title":"Antibiotic susceptibility among Staphylococcus epidermidis isolated from prosthetic joint infections with special focus on rifampicin and variability of the rpoB gene","volume":"15","author":"Hellmark","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0130","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00402-008-0772-x","article-title":"Daptomycin in bone and joint infections: a review of the literature","volume":"129","author":"Rice","year":"2009","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1128\/AAC.50.1.55-61.2006","article-title":"Multiple combination bactericidal testing of staphylococcal biofilms from implant-associated infections","volume":"50","author":"Saginur","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0140","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/jac\/dkp398","article-title":"Prosthetic joint infections: single versus combination therapy","volume":"65","author":"Samuel","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0145","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1128\/CMR.15.3.430-438.2002","article-title":"Vancomycin resistance in staphylococci","volume":"15","author":"Srinivasan","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0150","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1128\/AAC.00350-06","article-title":"Comparative activities of daptomycin, linezolid, and tigecycline against catheter-related methicillin-resistant Staphylococcus bacteremic isolates embedded in biofilm","volume":"51","author":"Raad","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0155","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1007\/s10096-010-0952-9","article-title":"Efficacy and safety of rifampin containing regimen for staphylococcal prosthetic joint infections treated with debridement and retention","volume":"29","author":"El Helou","year":"2010","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0160","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1093\/cid\/cir402","article-title":"Outcome and predictors of treatment failure in total hip\/knee prosthetic joint infections due to Staphylococcus aureus","volume":"53","author":"Senneville","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0165","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1002\/jbm.a.34220","article-title":"DLC coatings for UHMWPE: relationship between bacterial adherence and surface properties","volume":"100","author":"Del Prado","year":"2012","journal-title":"J Biomed Mater Res A"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0170","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1007\/s10856-011-4340-5","article-title":"Bacterial adherence on UHMWPE with vitamin E: an in vitro study","volume":"22","author":"G\u00f3mez-Barrena","year":"2011","journal-title":"J Mater Sci Mater Med"},{"key":"10.1016\/j.ijantimicag.2013.02.018_bib0175","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1128\/AAC.00045-11","article-title":"Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo","volume":"55","author":"Brackman","year":"2011","journal-title":"Antimicrob Agents Chemother"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857913000794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857913000794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T17:31:11Z","timestamp":1760376671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857913000794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0924857913000794"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2013.02.018","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro susceptibility to antibiotics of staphylococci in biofilms isolated from orthopaedic infections","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2013.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}