{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:33:49Z","timestamp":1793093629976,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["ijaaonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.ijantimicag.2014.03.016","type":"journal-article","created":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T15:37:31Z","timestamp":1400859451000},"page":"125-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Ecological impact of MCB3837 on the normal human microbiota"],"prefix":"10.1016","volume":"44","author":[{"given":"Mamun-Ur","family":"Rashid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Dalhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"B\u00e4ckstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Bj\u00f6rkhem-Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Panagiotidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Weintraub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl Erik","family":"Nord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0005","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1473-3099(01)00066-4","article-title":"Effect of antimicrobial agents on the ecological balance of human microflora","volume":"1","author":"Sullivan","year":"2001","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0010","doi-asserted-by":"crossref","first-page":"147S","DOI":"10.1007\/BF01295996","article-title":"The human intestinal microflora","volume":"31","author":"Simon","year":"1986","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0015","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: at the interface of health and disease","volume":"13","author":"Cho","year":"2012","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0020","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.anaerobe.2011.11.005","article-title":"Effect of new antimicrobial agents on the ecological balance of human microflora","volume":"18","author":"Rashid","year":"2012","journal-title":"Anaerobe"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0025","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1128\/CMR.00033-13","article-title":"Investigational antimicrobial agents of 2013","volume":"26","author":"Pucci","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0030","series-title":"46th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)","article-title":"In vitro activity of the novel antibacterial MCB3681 against selected Gram-positive and -negative bacteria compared to established antibiotics","author":"Kresken","year":"2006"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0035","series-title":"46th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)","article-title":"Low propensity for development of resistance to MCB3681, the active moiety of Oxaquin (MCB3837), in Gram-positive bacteria with vancomycin-, linezolid-, methicillin-, and\/or ciprofloxacin-resistance","author":"Schubert","year":"2006"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0040","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1016\/j.bmcl.2003.07.021","article-title":"Novel oxazolidinone\u2013quinolone hybrid antimicrobials","volume":"13","author":"Gordeev","year":"2003","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0045","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1517\/17460441.2010.508069","article-title":"Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance","volume":"5","author":"Pokrovskaya","year":"2010","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0050","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.coph.2008.06.008","article-title":"How many modes of action should an antibiotic have?","volume":"8","author":"Br\u00f6tz-Oesterhelt","year":"2008","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1179\/joc.2011.23.3.145","article-title":"Comparative effects of the immediate and the extended release formulations of ciprofloxacin on normal human intestinal microflora","volume":"23","author":"Rashid","year":"2011","journal-title":"J Chemother"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0060","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1128\/AAC.00373-06","article-title":"Effect of tigecycline on normal oropharyngeal and intestinal microflora","volume":"50","author":"Nord","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0065","series-title":"Manual of clinical microbiology","author":"Murray","year":"2007"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0070","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1128\/JCM.01280-09","article-title":"Comparison of a commercial multiplex real-time PCR to the cell cytotoxicity neutralization assay for diagnosis of Clostridium difficile infections","volume":"47","author":"Huang","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0075","series-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard","author":"Clinical and Laboratory Standards Institute","year":"2012"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0080","series-title":"Methods for antimicrobial susceptibility testing of anaerobic bacteria; approved standard","author":"Clinical and Laboratory Standards Institute","year":"2012"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0085","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S1473-3099(05)01283-1","article-title":"Lack of development of new antimicrobial drugs: a potential serious threat to public health","volume":"5","author":"Norrby","year":"2005","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0090","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1007\/s000180200004","article-title":"The role of Bacteroides conjugative transposons in the dissemination of antibiotic resistance genes","volume":"59","author":"Whittle","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0095","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1098\/rstb.2000.0597","article-title":"Questions about the behaviour of bacterial pathogens in vivo","volume":"355","author":"Smith","year":"2000","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/516284","article-title":"Pharmacokinetic\/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men","volume":"26","author":"Craig","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0105","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1086\/510079","article-title":"Pharmacokinetics\u2013pharmacodynamics of antimicrobial therapy: it's not just for mice anymore","volume":"44","author":"Ambrose","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0110","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1086\/513755","article-title":"Effect of vancomycin on intestinal flora of patients who previously received antimicrobial therapy","volume":"25","author":"Edlund","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0115","doi-asserted-by":"crossref","first-page":"S132","DOI":"10.1093\/cid\/cis338","article-title":"Fidaxomicin preserves the intestinal microbiome during and after treatment of Clostridium difficile infection (CDI) and reduces both toxin reexpression and recurrence of CDI","volume":"55","author":"Louie","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0120","first-page":"75","article-title":"Clostridium difficile infection prevention: biotherapeutics, immunologics, and vaccines","volume":"13","author":"Gerding","year":"2012","journal-title":"Discov Med"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0125","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1600-065X.2011.01075.x","article-title":"The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA","volume":"245","author":"Surana","year":"2012","journal-title":"Immunol Rev"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0130","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.anaerobe.2006.09.004","article-title":"The Bacteroides fragilis cell envelope: quarterback, linebacker, coach \u2013 or all three?","volume":"12","author":"Pumbwe","year":"2006","journal-title":"Anaerobe"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0135","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1128\/AAC.01716-09","article-title":"Effect of ceftaroline on normal human intestinal microflora","volume":"54","author":"Panagiotidis","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0140","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ijantimicag.2010.07.021","article-title":"Effect of ceftobiprole on the normal human intestinal microflora","volume":"36","author":"Backstrom","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0145","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ijantimicag.2011.08.012","article-title":"Effect of telavancin on human intestinal microflora","volume":"38","author":"Rashid","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2014.03.016_bib0150","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1080\/00365540110076714","article-title":"Ecological effects of linezolid versus amoxicillin\/clavulanic acid on the normal intestinal microflora","volume":"33","author":"Lode","year":"2001","journal-title":"Scand J Infect Dis"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857914001393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857914001393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T21:34:54Z","timestamp":1565472894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857914001393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0924857914001393"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2014.03.016","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ecological impact of MCB3837 on the normal human microbiota","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2014.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}