{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:06:59Z","timestamp":1793502419946,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["ijaaonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.ijantimicag.2014.07.004","type":"journal-article","created":{"date-parts":[[2014,8,10]],"date-time":"2014-08-10T06:17:49Z","timestamp":1407651469000},"page":"477-485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Colistin for the treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"44","author":[{"given":"Wan-Jie","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0005","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1164\/ajrccm.165.7.2105078","article-title":"Ventilator-associated pneumonia","volume":"165","author":"Chastre","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0010","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1097\/00003246-200112000-00012","article-title":"Mortality rate attributable to ventilator-associated nosocomial pneumonia in an adult intensive care unit: a prospective case-control study","volume":"29","author":"Bercault","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jcrc.2008.02.001","article-title":"Ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas aeruginosa: prevalence, incidence, risk factors, and outcomes","volume":"23","author":"Parker","year":"2008","journal-title":"J Crit Care"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America","volume":"48","author":"Boucher","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0025","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1086\/374337","article-title":"Treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP) with intravenous colistin: a comparison with imipenem-susceptible VAP","volume":"36","author":"Garnacho-Montero","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0030","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1007\/s00134-007-0675-2","article-title":"Safety and efficacy of colistin compared with imipenem in the treatment of ventilator-associated pneumonia: a matched case-control study","volume":"33","author":"Kallel","year":"2007","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0035","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1183\/09031936.00156906","article-title":"Ventilator-associated pneumonia due to colistin susceptible-only microorganisms","volume":"30","author":"Rios","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0040","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.jinf.2008.04.002","article-title":"Efficacy and safety of high-dose ampicillin\/sulbactam vs. colistin as monotherapy for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia","volume":"56","author":"Betrosian","year":"2008","journal-title":"J Infect"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"Jadad","year":"1996","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0180","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle\u2013Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analysis. \u3008http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp\u3009 [accessed 25 July 2014]."},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0055","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta4100","article-title":"Publication and related biases","volume":"4","author":"Song","year":"2000","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0065","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/ppul.21324","article-title":"Safety in treatment of ventilator-associated pneumonia due to extensive drug-resistant Acinetobacter baumannii with aerosolized colistin in neonates: a preliminary report","volume":"46","author":"Nakwan","year":"2011","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0070","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1093\/jac\/dkq360","article-title":"Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria","volume":"65","author":"Rattanaumpawan","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0075","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s10156-012-0430-7","article-title":"Use of high-dose IV and aerosolized colistin for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia: do we really need this treatment?","volume":"18","author":"Kalin","year":"2012","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0080","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/ALN.0b013e31827515de","article-title":"Efficacy of high-dose nebulized colistin in ventilator-associated pneumonia caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii","volume":"117","author":"Lu","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0085","doi-asserted-by":"crossref","DOI":"10.1097\/MJT.0b013e3182a32df3","article-title":"Treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia: retrospective comparison between intravenous colistin and intravenous ampicillin\u2013sulbactam","author":"Zalts","year":"2013","journal-title":"Am J Ther"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0090","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1086\/657242","article-title":"Aerosolized plus intravenous colistin versus intravenous colistin alone for the treatment of ventilator-associated pneumonia: a matched case-control study","volume":"51","author":"Kofteridis","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0095","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/j.1469-0691.2009.03040.x","article-title":"Inhaled colistin as adjunctive therapy to intravenous colistin for the treatment of microbiologically documented ventilator-associated pneumonia: a comparative cohort study","volume":"16","author":"Korbila","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0100","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1378\/chest.13-1018","article-title":"Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible Gram-negative bacteria","volume":"144","author":"Tumbarello","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0105","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4046\/trd.2009.67.3.212","article-title":"The comparative efficacy of colistin monotherapy and combination therapy based on in vitro antimicrobial synergy in ventilator-associated pneumonia caused by multi-drug resistant Acinetobacter baumannii","volume":"67","author":"Jang","year":"2009","journal-title":"Tuberc Respir Dis"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0110","doi-asserted-by":"crossref","first-page":"448","DOI":"10.4103\/0255-0857.103767","article-title":"Colistin against colistin-only-susceptible Acinetobacter baumannii-related infections: monotherapy or combination therapy?","volume":"30","author":"Simsek","year":"2012","journal-title":"Indian J Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0115","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1017\/S095026881200194X","article-title":"Colistin vs. the combination of colistin and rifampicin for the treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia","volume":"141","author":"Aydemir","year":"2013","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s15010-013-0495-y","article-title":"Comparison of colistin and colistin\/sulbactam for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia","volume":"42","author":"Kalin","year":"2014","journal-title":"Infection"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0125","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/cid\/cir934","article-title":"What is the efficacy and safety of colistin for the treatment of ventilator-associated pneumonia? A systematic review and meta-regression","volume":"54","author":"Florescu","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0130","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1378\/chest.10-0463","article-title":"Steady-state pharmacokinetics and BAL concentration of colistin in critically ill patients after IV colistin methanesulfonate administration","volume":"138","author":"Imberti","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0135","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.4187\/respcare.01556","article-title":"Use of adjunctive aerosolized antimicrobial therapy in the treatment of Pseudomonas aeruginosa and Acinetobacter baumannii ventilator-associated pneumonia","volume":"57","author":"Arnold","year":"2012","journal-title":"Respir Care"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0140","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1586\/eri.11.126","article-title":"Aerosolized antibiotics for treating hospital-acquired and ventilator-associated pneumonia","volume":"9","author":"Wood","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0145","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1093\/cid\/cis286","article-title":"High-dose, extended-interval colistin administration in critically ill patients: is this the right dosing strategy? A preliminary study","volume":"54","author":"Dalfino","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0150","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ijantimicag.2010.10.031","article-title":"Activity of tigecycline alone and in combination with colistin and meropenem against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains by time-kill assay","volume":"37","author":"Pournaras","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0155","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/cid\/cis588","article-title":"Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy","volume":"55","author":"Tumbarello","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0160","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ijantimicag.2011.10.001","article-title":"Synergistic activity of sulbactam combined with colistin against colistin-resistant Acinetobacter baumannii","volume":"39","author":"Kempf","year":"2012","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0165","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00134-010-1824-6","article-title":"Attributable mortality of ventilator-associated pneumonia: respective impact of main characteristics at ICU admission and VAP onset using conditional logistic regression and multi-state models","volume":"36","author":"Nguile-Makao","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0170","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.coph.2011.07.004","article-title":"Dosing of colistin\u2014back to basic PK\/PD","volume":"11","author":"Bergen","year":"2011","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.ijantimicag.2014.07.004_bib0175","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1128\/AAC.01707-09","article-title":"Colistin dosing and nephrotoxicity in a large community teaching hospital","volume":"54","author":"Deryke","year":"2010","journal-title":"Antimicrob Agents Chemother"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857914002350?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857914002350?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T15:06:52Z","timestamp":1565708812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857914002350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0924857914002350"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2014.07.004","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colistin for the treatment of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2014.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}