{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T14:57:01Z","timestamp":1773068221761,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","ijaaonline.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.ijantimicag.2015.01.017","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T10:29:01Z","timestamp":1425637741000},"page":"617-621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cph1p negatively regulates MDR1 involved in drug resistance in Candida albicans"],"prefix":"10.1016","volume":"45","author":[{"given":"Hsiu-Jung","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Yun","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeong-Yi","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Yang","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Lun","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Liang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0155","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1128\/JCM.39.9.3254-3259.2001","volume":"39","author":"Pfaller","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0160","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1128\/JCM.43.4.1600-1603.2005","article-title":"Colonization of human immunodeficiency virus-infected outpatients in Taiwan with Candida species","volume":"43","author":"Hung","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0165","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/CMR.11.2.382","article-title":"Clinical, cellular, and molecular factors that contribute to antifungal drug resistance","volume":"11","author":"White","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0170","first-page":"79","article-title":"Mechanisms of antifungal agent resistance","volume":"34","author":"Yang","year":"2001","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0175","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF00352101","article-title":"Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals","volume":"27","author":"Prasad","year":"1995","journal-title":"Curr Genet"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0180","doi-asserted-by":"crossref","first-page":"4505","DOI":"10.1128\/AAC.48.12.4505-4512.2004","article-title":"CaNdt80 is involved in drug resistance in Candida albicans by regulating CDR1","volume":"48","author":"Chen","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0185","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1128\/EC.3.6.1639-1652.2004","article-title":"TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2","volume":"3","author":"Coste","year":"2004","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0190","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1099\/jmm.0.46650-0","article-title":"The DNA binding domain of CaNdt80p is required to activate CDR1 involved in drug resistance in Candida albicans","volume":"55","author":"Wang","year":"2006","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0195","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00018-011-0849-5","article-title":"R432 is a key residue for the multiple functions of Ndt80p in Candida albicans","volume":"69","author":"Yang","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0200","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/BF00259685","article-title":"Analysis of a Candida albicans gene that encodes a novel mechanism for resistance to benomyl and methotrexate","volume":"227","author":"Fling","year":"1991","journal-title":"Mol Gen Genet"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0205","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1128\/AAC.38.4.648","article-title":"Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene","volume":"38","author":"Ben Yaacov","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0210","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1128\/AAC.41.7.1482","article-title":"Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus","volume":"41","author":"White","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0215","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1371\/journal.ppat.0030164","article-title":"The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans","volume":"3","author":"Morschhauser","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0220","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1128\/JB.181.3.700-708.1999","article-title":"The bZip transcription factor Cap1p is involved in multidrug resistance and oxidative stress response in Candida albicans","volume":"181","author":"Alarco","year":"1999","journal-title":"J Bacteriol"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0225","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.fgb.2009.06.003","article-title":"Rep1p negatively regulating MDR1 efflux pump involved in drug resistance in Candida albicans","volume":"46","author":"Chen","year":"2009","journal-title":"Fungal Genet Biol"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0230","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1128\/AAC.42.2.241","article-title":"Amino acid substitutions in the cytochrome P-450 lanosterol 14\u03b1-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents","volume":"42","author":"Sanglard","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0235","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1128\/AAC.47.8.2404-2412.2003","article-title":"Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents","volume":"47","author":"Sanglard","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0240","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1126\/science.7992058","article-title":"Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog","volume":"266","author":"Liu","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0245","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1046\/j.1365-2958.2002.03263.x","article-title":"Many of the genes required for mating in Saccharomyces cerevisiae are also required for mating in Candida albicans","volume":"46","author":"Magee","year":"2002","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0250","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)80358-X","article-title":"Nonfilamentous C. albicans mutants are avirulent","volume":"90","author":"Lo","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0255","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1177\/039463200601900312","article-title":"Non-lethal Candida albicans cph1\/cph1 efg1\/efg1 transcription factor mutant establishing restricted zone of infection in a mouse model of systemic infection","volume":"19","author":"Chen","year":"2006","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0260","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1128\/AAC.49.3.1213-1215.2005","article-title":"Efg1 involved in drug resistance by regulating the expression of ERG3 in Candida albicans","volume":"49","author":"Lo","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0265","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1128\/EC.00325-09","article-title":"Role of transcription factor CaNdt80p in cell separation, hyphal growth, and virulence in Candida albicans","volume":"9","author":"Sellam","year":"2010","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0270","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1128\/EC.00243-06","article-title":"Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site","volume":"5","author":"Riggle","year":"2006","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0275","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00328721","article-title":"Isolation of the Candida albicans gene for orotidine-5\u2032-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations","volume":"198","author":"Gillum","year":"1984","journal-title":"Mol Gen Genet"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0280","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(02)50954-X","article-title":"Getting started with yeast","volume":"350","author":"Sherman","year":"2002","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0285","series-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard. Document M27-A","author":"Clinical and Laboratory Standards Institute","year":"1997"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0290","doi-asserted-by":"crossref","first-page":"5759","DOI":"10.1242\/dev.126.24.5759","article-title":"Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGF\u03b2 growth factors","volume":"126","author":"Kofron","year":"1999","journal-title":"Development"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0295","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1128\/AAC.42.12.3065","article-title":"Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains","volume":"42","author":"Franz","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.01.017_bib0300","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/genetics\/155.1.57","article-title":"TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans","volume":"155","author":"Braun","year":"2000","journal-title":"Genetics"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857915000813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857915000813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T15:36:24Z","timestamp":1651419384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857915000813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0924857915000813"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2015.01.017","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cph1p negatively regulates MDR1 involved in drug resistance in Candida albicans","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2015.01.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}