{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T03:56:35Z","timestamp":1791172595802,"version":"4.1.0"},"reference-count":15,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","ijaaonline.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.ijantimicag.2015.02.020","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T03:02:00Z","timestamp":1429153320000},"page":"88-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts"],"prefix":"10.1016","volume":"46","author":[{"given":"Joachim","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vreni","family":"Balmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Winzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahbubur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Manser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hemphill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.exppara.2014.02.015","article-title":"Vaccines against neosporosis: what can we learn from the past studies?","volume":"140","author":"Monney","year":"2014","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0085","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1017\/S0031182014000158","article-title":"Control options for Neospora caninum\u2014is there anything new or are we going backwards?","volume":"141","author":"Reichel","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0090","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nrmicro3240","article-title":"Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development","volume":"12","author":"Paddon","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0095","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1871526513666131129155708","article-title":"Considerations on the mechanism of action of artemisinin antimalarials: Part 1\u2014The \u2018carbon radical\u2019 and \u2018heme\u2019 hypotheses","volume":"13","author":"Haynes","year":"2013","journal-title":"Infect Disord Drug Targets"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0100","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1128\/AAC.00502-09","article-title":"Artemisone and artemiside control acute and reactivated toxoplasmosis in a murine model","volume":"53","author":"Dunay","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0105","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/jac\/dkn451","article-title":"Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle","volume":"63","author":"D\u2019Angelo","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0110","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2307\/3283010","article-title":"Effects of sulfadiazine and amprolium on Neospora caninum (Protozoa: Apicomplexa) infections in mice","volume":"76","author":"Lindsay","year":"1990","journal-title":"J Parasitol"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0115","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1017\/S0031182012000066","article-title":"Effects of miltefosine treatment in fibroblast cell cultures and in mice experimentally infected with Neospora caninum tachyzoites","volume":"139","author":"Debache","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0120","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijpddr.2012.03.001","article-title":"Di-cationic arylimidamides act against Neospora caninum tachyzoites by interference in membrane structure and nucleolar integrity and are active against challenge infection in mice","volume":"2","author":"Schorer","year":"2012","journal-title":"Int J Parasitol Drugs Drug Resist"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0125","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.exppara.2011.07.010","article-title":"Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide","volume":"129","author":"Debache","year":"2011","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0130","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.vetpar.2011.12.020","article-title":"Neospora caninum: in vivo and in vitro treatment with artemisone","volume":"187","author":"Mazuz","year":"2012","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.exppara.2011.02.007","article-title":"Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs","volume":"128","author":"M\u00fcller","year":"2011","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0140","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0020-7519(02)00126-1","article-title":"Exogenous nitric oxide triggers Neospora caninum tachyzoite-to-bradyzoite stage conversion in murine epidermal keratinocyte cell cultures","volume":"32","author":"Vonlaufen","year":"2002","journal-title":"Int J Parasitol"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-4017(01)00580-5","article-title":"In vitro antiprotozoal effects of artemisinin on Neospora caninum","volume":"103","author":"Kim","year":"2002","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.ijantimicag.2015.02.020_bib0150","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2174\/156802606776743129","article-title":"From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements","volume":"6","author":"Haynes","year":"2006","journal-title":"Curr Top Med Chem"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857915001193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857915001193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T13:23:25Z","timestamp":1537709005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857915001193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0924857915001193"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2015.02.020","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2015.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}