{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:33:50Z","timestamp":1790487230774,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","ijaaonline.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.ijantimicag.2015.12.004","type":"journal-article","created":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T04:17:29Z","timestamp":1451362649000},"page":"140-145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"title":["Production of extended-spectrum \u03b2 -lactamases and the potential indirect pathogenic role of Prevotella isolates from the cystic fibrosis respiratory microbiota"],"prefix":"10.1016","volume":"47","author":[{"given":"Laura J.","family":"Sherrard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stef J.","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"McIlreavey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hatch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Wolfgang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne S.","family":"Muhlebach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre F.","family":"Gilpin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Stuart","family":"Elborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Tunney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0150","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1164\/rccm.200708-1151OC","article-title":"Detection of anaerobic bacteria in high numbers in sputum from patients with cystic fibrosis","volume":"177","author":"Tunney","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0155","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1164\/rccm.201210-1937OC","article-title":"The lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation","volume":"18","author":"Tunney","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0160","doi-asserted-by":"crossref","first-page":"e45001","DOI":"10.1371\/journal.pone.0045001","article-title":"The adult cystic fibrosis airway microbiota is stable over time and infection type, and highly resilient to antibiotic treatment of exacerbations","volume":"7","author":"Fodor","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0165","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1136\/thx.2010.137281","article-title":"Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis","volume":"66","author":"Tunney","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0170","doi-asserted-by":"crossref","first-page":"20529","DOI":"10.1073\/pnas.0709804104","article-title":"Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis","volume":"104","author":"Harris","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0175","doi-asserted-by":"crossref","first-page":"e2908","DOI":"10.1371\/journal.pone.0002908","article-title":"Molecular detection of multiple emerging pathogens in sputa from cystic fibrosis patients","volume":"3","author":"Bittar","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0180","doi-asserted-by":"crossref","first-page":"5809","DOI":"10.1073\/pnas.1120577109","article-title":"Decade-long bacterial community dynamics in cystic fibrosis airways","volume":"109","author":"Zhao","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1089\/omi.2009.0100","article-title":"A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations","volume":"14","author":"Huang","year":"2010","journal-title":"OMICS"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0190","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1093\/jac\/dkt191","article-title":"Antibiotic resistance in Prevotella species isolated from patients with cystic fibrosis","volume":"68","author":"Sherrard","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0195","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.2217\/fmb.10.126","article-title":"New insights into Prevotella diversity and medical microbiology","volume":"5","author":"Alauzet","year":"2010","journal-title":"Future Microbiol"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0200","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0140-6736(14)61137-5","article-title":"Antimicrobial resistance in the respiratory microbiota of people with cystic fibrosis","volume":"384","author":"Sherrard","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0205","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of \u03b2-lactamases","volume":"54","author":"Bush","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0210","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1128\/JCM.39.6.2206-2212.2001","article-title":"Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum \u03b2-lactamases: implications for the clinical microbiology laboratory","volume":"39","author":"Paterson","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0215","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1086\/420816","article-title":"Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum \u03b2-lactamases","volume":"39","author":"Paterson","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0220","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1198-743X.2004.00962.x","article-title":"\u03b2-Lactamase-producing bacteria in mixed infections","volume":"10","author":"Brook","year":"2004","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0225","unstructured":"Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; twenty-third Informational supplement. Document M100-S23. Wayne, PA: CLSI; 2013."},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0230","unstructured":"UK Cystic Fibrosis Trust. Antibiotic treatment for cystic fibrosis. Report of the UK Cystic Fibrosis Trust Working Group. Bromley, UK: UK Cystic Fibrosis Trust; 2009."},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0235","unstructured":"Clinical and Laboratory Standards Institute. Methods for antimicrobial susceptibility testing of anaerobic bacteria; approved standard\u2014eighth edition. Document M11-A8. Wayne, PA: CLSI; 2012."},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0240","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1093\/jac\/dku192","article-title":"Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients","volume":"69","author":"Sherrard","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0245","unstructured":"Clinical and Laboratory Standards Institute. Methods for determining bactericidal activity of antimicrobial agents; approved guideline. Document M26-A. Wayne, PA: CLSI; 1999."},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0250","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/ppul.20671","article-title":"Sputum antibiotic concentrations: implications for treatment of cystic fibrosis lung infection","volume":"42","author":"Moriarty","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0255","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1128\/AAC.40.8.1914","article-title":"Comparison of three different in vitro methods of detecting synergy: time\u2013kill, checkerboard, and E test","volume":"40","author":"White","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0260","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1093\/jac\/dkq321","article-title":"German multicentre survey of the antibiotic susceptibility of Bacteroides fragilis group and Prevotella species isolated from intra-abdominal infections: results from the PRISMA study","volume":"65","author":"Seifert","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0265","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1128\/JCM.43.10.5380-5383.2005","article-title":"Bacteremia caused by a metronidazole-resistant Prevotella sp strain","volume":"43","author":"Mory","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0270","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.anaerobe.2012.10.001","article-title":"Antibiotic resistance genes in anaerobic bacteria isolated from primary dental root canal infections","volume":"18","author":"Rocas","year":"2012","journal-title":"Anaerobe"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0275","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1128\/JCM.42.7.2902-2906.2004","article-title":"Molecular characterization of extended-spectrum \u03b2-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli from a Korean nationwide survey","volume":"42","author":"Jeong","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0280","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1128\/AAC.45.8.2386-2389.2001","article-title":"Cloning and biochemical characterization of a class A \u03b2-lactamase from Prevotella intermedia","volume":"45","author":"Madinier","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0285","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1093\/jac\/dkg221","article-title":"Sequence analysis of cfxA2-like \u03b2-lactamases in Prevotella species","volume":"51","author":"Giraud-Morin","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2015.12.004_bib0290","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1128\/AAC.03719-14","article-title":"Metallo-\u03b2-lactamase-producing Bacteroides species can shield other members of the gut microbiota from antibiotics","volume":"59","author":"Stiefel","year":"2015","journal-title":"Antimicrob Agents Chemother"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857915004197?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857915004197?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T21:05:06Z","timestamp":1567458306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857915004197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["S0924857915004197"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2015.12.004","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Production of extended-spectrum \u03b2-lactamases and the potential indirect pathogenic role of Prevotella isolates from the cystic fibrosis respiratory microbiota","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2015.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}