{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:14:09Z","timestamp":1790000049988,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71073098"],"award-info":[{"award-number":["71073098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004441","name":"Swedish International Development Cooperation Agency","doi-asserted-by":"publisher","award":["2010-001861"],"award-info":[{"award-number":["2010-001861"]}],"id":[{"id":"10.13039\/100004441","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","ijaaonline.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.ijantimicag.2016.12.018","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T16:16:55Z","timestamp":1488471415000},"page":"493-497","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["Prevalence of the mcr-1 colistin resistance gene in extended-spectrum \u03b2-lactamase-producing Escherichia coli from human faecal samples collected in 2012 in rural villages in Shandong Province, China"],"prefix":"10.1016","volume":"49","author":[{"given":"Zhenwang","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Berglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3056-2322","authenticated-orcid":false,"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-9541","authenticated-orcid":false,"given":"Baoli","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"T\u00e4rnberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"St\u00e5lsby Lundborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenqiang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Tomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanying","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengqiang","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart E.","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0010","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S1473-3099(13)70318-9","article-title":"Antibiotic resistance\u2014the need for global solutions","volume":"13","author":"Laxminarayan","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0015","series-title":"Antimicrobial resistance: global report on surveillance 2014","author":"World Health Organization","year":"2014"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0020","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/joim.12342","article-title":"Global dissemination of extensively drug-resistant carbapenemase-producing Enterobacteriaceae: clinical perspectives on detection, treatment and infection control","volume":"277","author":"T\u00e4ngd\u00e9n","year":"2015","journal-title":"J Intern Med"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study","volume":"16","author":"Liu","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0030","doi-asserted-by":"crossref","first-page":"30155","DOI":"10.2807\/1560-7917.ES.2016.21.9.30155","article-title":"Plasmid-mediated colistin resistance (mcr-1 gene): three months later, the story unfolds","volume":"21","author":"Skov","year":"2016","journal-title":"Euro Surveill"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0035","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.1128\/AAC.01267-16","article-title":"Detection of mcr-1 among Escherichia coli clinical isolates collected worldwide as part of the SENTRY Antimicrobial Surveillance Program during 2014 and 2015","volume":"60","author":"Castanheira","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0140-6736(08)61956-X","article-title":"Antibiotic resistance in China\u2014a major future challenge","volume":"373","author":"Heddini","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0045","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1473-3099(16)00056-6","article-title":"Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae","volume":"16","author":"Du","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0050","doi-asserted-by":"crossref","first-page":"e00177","DOI":"10.1128\/mBio.00177-16","article-title":"Diversified mcr-1-harbouring plasmid reservoirs confer resistance to colistin in human gut microbiota","volume":"7","author":"Ye","year":"2016","journal-title":"MBio"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0055","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S1473-3099(16)00062-1","article-title":"Dissemination of the mcr-1 colistin resistance gene","volume":"16","author":"Zhang","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0060","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1128\/AAC.00440-16","article-title":"Detection of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae from different hospitals in China","volume":"60","author":"Yu","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0065","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3201\/eid2209.160464","article-title":"Possible transmission of mcr-1-harboring Escherichia coli between companion animals and human","volume":"22","author":"Zhang","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0113121","article-title":"Varying high levels of faecal carriage of extended-spectrum \u03b2-lactamase producing Enterobacteriaceae in rural villages in Shandong, China: implications for global health","volume":"9","author":"Sun","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0075","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1574-6968.2007.00948.x","article-title":"Comparison of five rep-PCR genomic fingerprinting methods for differentiation of fecal Escherichia coli from human, poultry and wild birds","volume":"277","author":"Mohapatra","year":"2007","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0080","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S1473-3099(16)00061-X","article-title":"Early emergence of mcr-1 in Escherichia coli from food-producing animals","volume":"16","author":"Shen","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0085","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/phar.1505","article-title":"Susceptibility testing of the polymyxins: where are we now?","volume":"35","author":"Humphries","year":"2015","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0090","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S1473-3099(16)00057-8","article-title":"Carbapenem-resistant and colistin-resistant Escherichia coli co-producing NDM-9 and MCR-1","volume":"16","author":"Yao","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijantimicag.2016.12.018_bib0095","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/cid\/ciw553","article-title":"Coexistence of MCR-1 and NDM-1 in clinical Escherichia coli isolates","volume":"63","author":"Zheng","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"Suppl. 1","key":"10.1016\/j.ijantimicag.2016.12.018_bib0100","article-title":"National epidemiology of carbapenem-resistant and extensively drug-resistant Gram-negative bacteria isolated from blood samples in China in 2013","volume":"22","author":"Xu","year":"2016","journal-title":"Clin Microbiol Infect"},{"issue":"Suppl. 1","key":"10.1016\/j.ijantimicag.2016.12.018_bib0105","article-title":"Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005\u20132014","volume":"22","author":"Hu","year":"2016","journal-title":"Clin Microbiol Infect"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857917300754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857917300754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T18:21:39Z","timestamp":1535998899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857917300754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0924857917300754"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2016.12.018","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevalence of the mcr-1 colistin resistance gene in extended-spectrum \u03b2-lactamase-producing Escherichia coli from human faecal samples collected in 2012 in rural villages in Shandong Province, China","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2016.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}