{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T09:12:52Z","timestamp":1790500372269,"version":"4.1.0"},"reference-count":147,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","ijaaonline.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.ijantimicag.2017.05.020","type":"journal-article","created":{"date-parts":[[2017,6,28]],"date-time":"2017-06-28T16:01:41Z","timestamp":1498665701000},"page":"283-298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":156,"title":["16-membered macrolide antibiotics: a review"],"prefix":"10.1016","volume":"51","author":[{"given":"Biljana","family":"Arsic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Barber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"\u010ciko\u0161","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Mladenovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nevena","family":"Stankovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Predrag","family":"Novak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0010","first-page":"61","article-title":"Effect of spiramycin and tulathromycin on abomasal emptying rate in milk-fed calves","volume":"78","author":"Rashnavadi","year":"2014","journal-title":"Can J Vet Res"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0015","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2174\/138527211794072588","article-title":"Modifications and biological activity of natural and semisynthetic 16-membered macrolide antibiotics","volume":"15","author":"Przybylski","year":"2011","journal-title":"Curr Org Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0020","doi-asserted-by":"crossref","first-page":"401","DOI":"10.7164\/antibiotics.28.401","article-title":"Chemical and biological studies on 16-membered macrolide antibiotics","volume":"28","author":"Omura","year":"1975","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0025","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0079-6468(08)70022-5","article-title":"Semi-synthetic derivatives of 16-membered macrolide antibiotics","volume":"31","author":"Kirst","year":"1994","journal-title":"Prog Med Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1517\/13543776.8.2.111","article-title":"Recent developments with macrolide antibiotics","volume":"8","author":"Kirst","year":"1998","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0035","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1517\/13543776.13.6.787","article-title":"Recent progress in the field of macrolide antibiotics","volume":"13","author":"Henninger","year":"2003","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0040","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2174\/138955711797247734","article-title":"Recent advances in the field of 16-membered macrolide antibiotics","volume":"11","author":"Cui","year":"2011","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0045","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1517\/13543784.17.3.387","article-title":"Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections","volume":"17","author":"Hammerschlag","year":"2008","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0050","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.bmcl.2013.12.029","article-title":"Synthesis and antibacterial activity of a series of novel 9-O-acetyl-4'-substituted 16-membered macrolides derived from josamycin","volume":"24","author":"Zhao","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0055","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1128\/AAC.33.1.78","article-title":"New macrolides active against Streptococcus pyogenes with inducible or constitutive type of macrolide-lincosamide-streptogramin B resistance","volume":"33","author":"Fernandes","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0060","doi-asserted-by":"crossref","first-page":"949","DOI":"10.2174\/1568026033452159","article-title":"Macrolide antibiotics: binding site, mechanism of action, resistance","volume":"3","author":"Gaynor","year":"2003","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0065","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.mib.2008.08.003","article-title":"Macrolide myths","volume":"11","author":"Mankin","year":"2008","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0070","doi-asserted-by":"crossref","first-page":"3501","DOI":"10.1038\/ncomms4501","article-title":"Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide","volume":"5","author":"Arenz","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0075","series-title":"Antibiotic discovery and development","first-page":"455","article-title":"Inducible resistance to macrolide antibiotics","author":"Subramanian","year":"2012"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0080","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1749-6632.2011.06315.x","article-title":"Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action","volume":"1241","author":"Kannan","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0085","series-title":"Macrolide antibiotics (milestones in drug therapy)","author":"Schonfeld","year":"2012"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0090","series-title":"Macrolide antibiotics: chemistry, biology, and practice","author":"Omura","year":"2002"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0095","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00253-013-5317-8","article-title":"Characterization of mutations in regulatory genes of Tyl cluster leading to overexpression of tylosin in mutant \u03b3-1 of Streptomyces fradiae NRRL-2702","volume":"98","author":"Khaliq","year":"2014","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0100","doi-asserted-by":"crossref","first-page":"14658","DOI":"10.1073\/pnas.232580599","article-title":"Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy","volume":"99","author":"Liu","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0105","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S1074-5521(01)00095-3","article-title":"Expression analysis of the tylosin-biosynthetic gene-cluster: pivotal regulatory role of the tylQ product","volume":"9","author":"Stratigopoulos","year":"2002","journal-title":"Chem Biol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0110","first-page":"1485","article-title":"Control of tylosin biosynthesis in Streptomyces fradiae","volume":"18","author":"Cundliffe","year":"2008","journal-title":"J Microbiol Biotechnol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0115","series-title":"Macrolide antibiotics","first-page":"1","article-title":"Introduction to the macrolide antibiotics","author":"Schonfeld","year":"2002"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0120","author":"Lewicki"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0125","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/859473","article-title":"Application of different analytical techniques and microbiological assays for the analysis of macrolide antibiotics from pharmaceutical dosage forms and biological matrices","author":"Bekele","year":"2012","journal-title":"ISRN Anal Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0130","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/0731-7085(95)01522-M","article-title":"Study of the stability of tylosin A in aqueous solutions","volume":"13","author":"Paesen","year":"1995","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0135","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.talanta.2012.12.008","article-title":"Characterization of impurities in tylosin using dual liquid chromatography combined with ion trap mass spectrometry","volume":"106","author":"Chopra","year":"2013","journal-title":"Talanta"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1752-153X-8-5","article-title":"Assessing antibiotic sorption in soil: a literature review and new case studies on sulfonamides and macrolides","volume":"8","author":"Wegst-Uhrich","year":"2014","journal-title":"Chem Cent J"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0150","doi-asserted-by":"crossref","first-page":"7121","DOI":"10.1021\/jf301403f","article-title":"A novel green chemistry method for nonaqueous extraction and high-performance liquid chromatography detection of first-, second-, and third-generation tetracyclines, 4-epitetracycline, and tylosin in animal feeds","volume":"60","author":"Granados-Chinchilla","year":"2012","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0155","first-page":"328","article-title":"Tylosin, a new antibiotic. II. Isolation, properties, and preparation of desmycosin, a microbiologically active degradation product","volume":"11","author":"Hamill","year":"1961","journal-title":"Antibiot Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0160","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1751-0813.1974.tb05273.x","article-title":"Principles of drug distribution","volume":"50","author":"Baggot","year":"1974","journal-title":"Aust Vet J"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0165","series-title":"Veterinary pharmacology and therapeutics","first-page":"958","author":"Riviere","year":"2009"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0170","first-page":"26","article-title":"Intra-cellular accumulation and trans-epithelial transport of aivlosin, tylosin and tilmicosin","volume":"60","author":"Stuart","year":"2007","journal-title":"Pig J"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0175","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/00034983.1984.11811831","article-title":"Evaluation of a range of antimicrobial agents against the parasitic protozoa, Plasmodium falciparum, Babesia rodhaini and Theileria parva in vitro","volume":"78","author":"McColm","year":"1984","journal-title":"Ann Trop Med Parasitol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0180","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ja.2012.113","article-title":"Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry","volume":"66","author":"Tsutsui","year":"2013","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0185","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1128\/AAC.05039-11","article-title":"In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species","volume":"56","author":"Wittlin","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0190","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1128\/AAC.01250-12","article-title":"Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides","volume":"56","author":"Andersen","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0195","series-title":"Committee for Medicinal Products for Veterinary Use","year":"2011"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0200","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0021-9673(01)87075-8","article-title":"Pharmacopoeial procedure for the determination of tylosin factors by high-performance liquid chromatography","volume":"353","author":"Fish","year":"1986","journal-title":"J Chromatogr"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0205","series-title":"Tylosin monograph, European pharmacopoeia","first-page":"3165","author":"European Directorate for the Quality of Medicines (EDQM)","year":"2011"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0210","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0021-9673(93)80452-E","article-title":"Quantitative analysis of tylosin by column liquid chromatography","volume":"630","author":"Roets","year":"1993","journal-title":"J Chromatogr"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0215","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0021-9673(94)01268-J","article-title":"Liquid chromatography of tylosin A and related substances on poly(styrene-divinylbenzene)","volume":"699","author":"Paesen","year":"1995","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0220","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1002\/jssc.201100340","article-title":"An improved liquid chromatographic method for the analysis of tylosin and its impurities","volume":"34","author":"Ashenafi","year":"2011","journal-title":"J Sep Sci"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0225","doi-asserted-by":"crossref","first-page":"8534","DOI":"10.1007\/s11356-014-2771-5","article-title":"Electro-Fenton pretreatment for the improvement of tylosin biodegradability","volume":"21","author":"Ferrag-Siagh","year":"2014","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0230","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.aca.2014.02.038","article-title":"Multi-residue quantification of veterinary drugs in milk with a novel extraction and cleanup technique: salting out supported liquid extraction (SOSLE)","volume":"820","author":"Kaufmann","year":"2014","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0235","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.foodchem.2011.11.029","article-title":"Simultaneous separate and group determination of tylosin and tilmicosin in foodstuffs using single antibody-based immunoassay","volume":"132","author":"Burkin","year":"2012","journal-title":"Food Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0240","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1752-153X-8-37","article-title":"Simultaneous determination of tylosin and josamycin residues in muscles, liver, eggs and milk by MLC with a monolithic column and time-programmed UV detection: application to baby food and formulae","volume":"8","author":"Nasr","year":"2014","journal-title":"Chem Cent J"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0245","first-page":"174","article-title":"A new antibiotic, josamycin. I. Isolation and physico-chemical characteristics","volume":"20","author":"Osono","year":"1967","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0250","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/mrc.2574","article-title":"Structure elucidation, complete NMR assignment and PM5 theoretical studies of new hydroxyl-aminoalkyl-alpha,beta-unsaturated derivatives of the macrolide antibiotic josamycin","volume":"48","author":"Przybylski","year":"2010","journal-title":"Magn Reson Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0255","first-page":"87","article-title":"Leucomycin, a new antibiotic","volume":"6","author":"Hata","year":"1953","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0260","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7164\/antibiotics.23.511","article-title":"Chemistry of leucomycin. IX. Identification of leucomycin A3 with josamycin","volume":"23","author":"Omura","year":"1970","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0265","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1128\/AAC.15.5.738","article-title":"Biosynthesis of kitasamycin (leucomycin) by leucine analog-resistant mutants of Streptomyces kitasatoensis","volume":"15","author":"V\u00e9zina","year":"1979","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0270","doi-asserted-by":"crossref","first-page":"192","DOI":"10.7164\/antibiotics.30.192","article-title":"Induction of the bioconversion of leucomycins by glucose in a producing strain","volume":"30","author":"Omura","year":"1977","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0275","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.7164\/antibiotics.29.1131","article-title":"Bioconversion of leucomycins and its regulation by butyrate in a producing strain","volume":"29","author":"Omura","year":"1976","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0280","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1128\/MMBR.40.3.681-697.1976","article-title":"The antibiotic cerulenin, a novel tool for biochemistry as an inhibitor of fatty acid synthesis","volume":"40","author":"Omura","year":"1976","journal-title":"Bacteriol Rev"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0285","first-page":"833","article-title":"Induction of the bioconversion of leucomycins by glucose and its regulation by butyrate","volume":"43","author":"Kitao","year":"1979","journal-title":"Agric Biol Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0290","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/oxfordjournals.jbchem.a131537","article-title":"Inhibition of the biosynthesis of leucomycin, a macrolide antibiotic, by cerulenin","volume":"81","author":"Takeshima","year":"1977","journal-title":"J Biochem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0295","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.7164\/antibiotics.32.1055","article-title":"Bioconversion and biosynthesis of 16-membered macrolide antibiotics. XV. Final steps in the biosynthesis of leucomycins","volume":"32","author":"Kitao","year":"1979","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0300","first-page":"593","article-title":"Bioconversion and biosynthesis of 16-membered macrolide antibiotics. XII. Isolation and property of spiramycin I 3-hydroxyl acylase","volume":"32","author":"Omura","year":"1979","journal-title":"J Biochem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0305","series-title":"Chemical structure of leucomycin","first-page":"145","author":"Watanabe","year":"1964"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0310","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0040-4039(00)90682-8","article-title":"Chemistry of leucomycins. II. Structure and stereochemistry of leucomycin A3","volume":"8","author":"Omura","year":"1967","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0315","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0040-4039(00)90558-6","article-title":"The chemistry of the leucomycins. I. Partial structure of leucomycin A3","volume":"7","author":"Omura","year":"1967","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0320","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1248\/cpb.15.358","article-title":"Structure of leucomycin A1","volume":"15","author":"Hata","year":"1967","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0325","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1248\/cpb.18.1501","article-title":"Chemistry of leucomycins. VIII. Absolute configuration of leucomycin and isoleucomycin","volume":"18","author":"Omura","year":"1970","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib9005","first-page":"234","article-title":"The structures of leucomycin A4A5A6A7A8 and A9","volume":"20","author":"Omura","year":"1967","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0335","doi-asserted-by":"crossref","first-page":"199","DOI":"10.7164\/antibiotics.21.199","article-title":"The chemistry of leucomycins. IV. Structure of leucomycin A1","volume":"21","author":"Omura","year":"1968","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0330","doi-asserted-by":"crossref","first-page":"272","DOI":"10.7164\/antibiotics.21.272","article-title":"The chemistry of leucomycins. VI. Structures of leucomycin A4, A5, A6, A7, A8 and A9","volume":"21","author":"Omura","year":"1968","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0340","doi-asserted-by":"crossref","first-page":"9221","DOI":"10.1016\/0040-4020(93)80009-I","article-title":"Macrolide antibiotic structure determination by fast atom bombardment\/tandem mass spectrometry","volume":"49","author":"Shida","year":"1993","journal-title":"Tetrahedron"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0345","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/jms.612","article-title":"Application of liquid chromatography-ion trap mass spectrometry to the characterization of the 16-membered ring macrolide josamycin propionate","volume":"39","author":"Govaerts","year":"2004","journal-title":"J Mass Spectrom"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0350","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.aca.2004.11.062","article-title":"Identification of the components of 16-membered macrolide antibiotics by LC\/MS","volume":"535","author":"Hu","year":"2005","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0355","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jpba.2012.01.012","article-title":"Characterization of impurities in josamycin using dual liquid chromatography combined with mass spectrometry","volume":"73","author":"Van den Bossche","year":"2013","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0360","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1039\/a808309f","article-title":"Conformational analysis of josamycin, a 16-membered macrolide free in solution and bound to bacterial ribosomes","author":"Gharbi-Benarous","year":"1999","journal-title":"J Chem Soc Perkin Trans 2"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0365","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1039\/b003000g","article-title":"The conformations of the macrolide antibiotics erythromycin A, azithromycin and clarithromycin in aqueous solution: a 1H NMR study","author":"Awan","year":"2000","journal-title":"J Chem Soc Perkin Trans 2"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0370","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1039\/c39910001471","article-title":"The binding of erythromycin A to bacterial ribosomes: a 1H transferred NOE study","author":"Gyi","year":"1991","journal-title":"J Chem Soc, Chem Commun"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0375","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1039\/C4MD00220B","article-title":"Theoretical and experimental investigation on clarithromycin, erythromycin A and azithromycin and descladinosyl derivatives of clarithromycin and azithromycin with 3-O-substitution as anti-bacterial agents","volume":"5","author":"Arsic","year":"2014","journal-title":"Med Chem Commun"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0380","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1515\/BC.2003.156","article-title":"Ribosomal tolerance and peptide bond formation","volume":"384","author":"Yonath","year":"2003","journal-title":"Biol Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0385","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1021\/jp0526243","article-title":"Systematic approach to understanding macrolide-ribosome interactions: NMR and modelling studies of oleandomycin and its derivatives","volume":"110","author":"Novak","year":"2006","journal-title":"J Phys Chem A"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0390","doi-asserted-by":"crossref","first-page":"5857","DOI":"10.1016\/j.bmc.2009.07.013","article-title":"Free and bound state structures of 6-O-methyl homoerythromycins and epitope mapping of their interactions with ribosomes","volume":"17","author":"Novak","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0395","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1051\/jcp:1998155","article-title":"Conformation of macrolides antibiotics bound to ribosomes as determined from transferred nuclear Overhauser effect spectroscopy","volume":"95","author":"Bertho","year":"1998","journal-title":"J Chim Phys"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0400","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0968-0896(97)10028-1","article-title":"Transferred nuclear Overhauser effect study of macrolide-ribosome interactions: correlation between antibiotic activities and bound conformations","volume":"6","author":"Bertho","year":"1998","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0405","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0141-8130(98)00005-1","article-title":"Solution conformation of methylated derivatives of macrolide antibiotics roxithromycin and erythromycin using NMR and molecular modelling. Ribosome-bound conformation determined by TRNOE and formation of cytochrome P450-metabolite complex","volume":"22","author":"Bertho","year":"1998","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0410","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1039\/B412294A","article-title":"Conformational analysis of oleandomycin and its 8-methylene-9-oxime derivative by NMR and molecular modelling","volume":"3","author":"Novak","year":"2005","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0415","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.str.2008.03.002","article-title":"Exit biology: battle for the nascent chain","volume":"16","author":"Selmer","year":"2008","journal-title":"Structure"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0420","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0928-0987(93)90019-7","article-title":"The pH-stability and acid degradation of the macrolide antibiotic, josamycin","volume":"1","author":"Skinner","year":"1993","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0425","series-title":"Kucer's the use of antibiotics: a clinical review of antibacterial, antifungal and antiviral drugs","first-page":"819","author":"Grayson","year":"2010"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0430","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0378-4347(98)00430-7","article-title":"Sensitive and specific method for the determination of josamycin in human plasma by liquid chromatography-mass spectrometry","volume":"720","author":"Kikuchi","year":"1998","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0435","series-title":"Critically important antimicrobials for human medicine","author":"WHO","year":"2011"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0440","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1111\/j.1469-0691.2010.03155.x","article-title":"In vitro activities of tetracyclines, macrolides, fluoroquinolones and clindamycin against Mycoplasma hominis and Ureaplasma spp. isolated in Germany over 20 years","volume":"16","author":"Krausse","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0445","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/jclinpath-2014-202248","article-title":"Epidemiological investigation and antimicrobial susceptibility analysis of ureaplasma species and Mycoplasma hominis in outpatients with genital manifestations","volume":"67","author":"Song","year":"2014","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0450","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1128\/AAC.36.4.870","article-title":"In vitro susceptibilities of Mycoplasma genitalium to antibiotics","volume":"36","author":"Renaudin","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0455","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12879-015-0781-7","article-title":"Treatment efficacy, treatment failures and selection of macrolide resistance in patients with high load of Mycoplasma genitalium during treatment of male urethritis with josamycin","volume":"15","author":"Guschin","year":"2015","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0460","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1258\/ijsa.2010.010302","article-title":"2010 European guideline for the management of Chlamydia trachomatis infections","volume":"21","author":"Lanjouw","year":"2010","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0465","first-page":"47","article-title":"Secretome of obligate intracellular Rickettsia","volume":"39","author":"Gillespie","year":"2015","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0470","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1128\/AAC.10.3.450","article-title":"Comparative pharmacology of josamycin and erythromycin stearate","volume":"10","author":"Strausbaugh","year":"1976","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0475","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0006-2952(90)90682-B","article-title":"In vivo effects of erythromycin, oleandomycin and erythralosamine derivatives on hepatic cytochrome P-450","volume":"40","author":"Delaforge","year":"1990","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0480","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2133\/dmpk.19.55","article-title":"Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors","volume":"19","author":"Naritomi","year":"2004","journal-title":"Drug Metab Pharmacokinet"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0485","series-title":"Macrolides: chemistry, pharmacology and clinical uses","first-page":"67","author":"Bryskier","year":"1993"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0490","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0024-3205(01)01199-7","article-title":"Enhancement of endogenous corticosterone levels by a macrolide antibiotic, roxithromycin in mice","volume":"69","author":"Yamamoto","year":"2001","journal-title":"Life Sci"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0495","doi-asserted-by":"crossref","first-page":"53506","DOI":"10.1074\/jbc.M401625200","article-title":"Kinetics of macrolide action. The josamycin and erythromycin cases","volume":"279","author":"Lovmar","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0500","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0505","doi-asserted-by":"crossref","first-page":"13682","DOI":"10.1073\/pnas.0603236103","article-title":"Structural basis for ligand promiscuity in cytochrome P450 3A4","volume":"103","author":"Ekroos","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0510","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1351\/pac200779060955","article-title":"Chemical parameters influencing fine tuning in the binding of macrolide antibiotics to the ribosomal tunnel","volume":"79","author":"Pyetan","year":"2007","journal-title":"Pure Appl Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0515","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0022-2836(03)00662-4","article-title":"The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome","volume":"330","author":"Tenson","year":"2003","journal-title":"J Mol Biol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0520","series-title":"Macrolide antibiotics in bacterial protein synthesis","author":"Lovmar","year":"2005"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0525","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1097-2765(02)00570-1","article-title":"The structures of four macrolide antibiotics bound to the large ribosomal subunit","volume":"10","author":"Hansen","year":"2002","journal-title":"Mol Cell"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0530","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.45.1.1-12.2001","article-title":"Macrolide resistance conferred by base substitutions in 23S rRNA","volume":"45","author":"Vester","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0535","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1006\/jmbi.2000.4229","article-title":"Inhibition of the ribosomal peptidyl tranferase reaction by the mycarose moiety of the antibiotics carbomycin, spiramycin and tylosin","volume":"304","author":"Poulsen","year":"2000","journal-title":"J Mol Biol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0540","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/cmdc.201600250","article-title":"16-membered macrolide lactone derivatives bearing a triazole-functionalized arm at the aglycone C13 position as antibacterial and anticancer agents","volume":"11","author":"Domagalska","year":"2016","journal-title":"Chem Med Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0545","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1128\/AAC.40.11.2562","article-title":"Detection of erythromycin-resistant determinants by PCR","volume":"40","author":"Sutcliffe","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0550","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1093\/jac\/dkr268","article-title":"Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit","volume":"66","author":"Li","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0555","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1128\/AAC.41.5.1162","article-title":"Clinical resistance to erythromycin and clindamycin in cutaneous propionibacteria isolated from acne patients is associated with mutations in 23S rRNA","volume":"41","author":"Ross","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0560","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jpba.2008.02.002","article-title":"Development of a liquid chromatographic method for the analysis of josamycin","volume":"48","author":"Daidone","year":"2008","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0565","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/BF00323067","article-title":"Liquid chromatography of josamycin on poly (styrene-divinylbenzene)","volume":"352","author":"Paesen","year":"1995","journal-title":"Frensius J Anal Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0570","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0378-4347(97)00456-8","article-title":"Development of a capillary electrophoresis method for the separation of the macrolide antibiotics, erythromycin, josamycin and oleandomycin","volume":"704","author":"Lalloo","year":"1997","journal-title":"J Chromatogr B Biomed Sci Appl"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0575","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.jpba.2006.12.008","article-title":"Sample preparation strategy for the simultaneous determination of macrolide antibiotics in animal feedingstuffs by liquid chromatography with electrochemical detection (HPLC-ECD)","volume":"43","author":"Gonzalez de la Huebra","year":"2007","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0580","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0021-9673(98)00004-1","article-title":"Simultaneous determination of five macrolide antibiotics in meat by high-performance liquid chromatography","volume":"812","author":"Horie","year":"1998","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0585","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0003-2670(03)00891-2","article-title":"Determination of macrolide antibiotics in meat and fish by liquid chromatography\u2013electrospray mass spectrometry","volume":"492","author":"Horie","year":"2003","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0590","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.fct.2014.12.020","article-title":"Occurrence of erythromycin residues in sheep milk. Validation of an analytical method","volume":"78","author":"Garcia-Mayor","year":"2015","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0595","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jchromb.2014.07.031","article-title":"Performance characterization of a quantitative liquid chromatography-tandem mass spectrometric method for 12 macrolide and lincosamide antibiotics in salmon, shrimp and tilapia","volume":"967","author":"Dickson","year":"2014","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0600","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.chroma.2006.04.019","article-title":"Liquid chromatography-UV diode-array detection method for multi-residue determination of macrolide antibiotics in sheep's milk","volume":"1122","author":"Garc\u00eda-Mayor","year":"2006","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0605","first-page":"195","article-title":"A rapid and sensitive high-pressure liquid chromatographic method for monitoring josamycin levels in plasma","volume":"4","author":"Ducci","year":"1984","journal-title":"Int J Clin Pharmacol Res"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0610","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0378-4347(00)82051-4","article-title":"Determination of josamycin in plasma, erythrocytes and leukocytes via high-performance liquid chromatography by direct injection of plasma or homogenized blood cells, using alternation sample clean-up columns","volume":"344","author":"R\u00e4der","year":"1985","journal-title":"J Chromatogr"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0615","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0021-9673(01)82035-5","article-title":"High-performance liquid chromatographic analysis of josamycin in serum and urine","volume":"459","author":"Skinner","year":"1988","journal-title":"J Chromatogr"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0620","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.aca.2004.04.042","article-title":"A multiresidue method for the simultaneous determination of ten macrolide antibiotics in human urine based on gradient elution liquid chromatography coupled to coulometric detection (HPLC\u2013ECD)","volume":"517","author":"Gonz\u00e1lez de la Huebra","year":"2004","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0625","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jchromb.2007.09.014","article-title":"Determination of josamycin in rat plasma by capillary electrophoresis coupled with post-column electrochemiluminescence detection","volume":"859","author":"Deng","year":"2007","journal-title":"J Chromatogr B"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0630","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/elps.200900302","article-title":"A sensitive method for simultaneous determination of four macrolides by CE with electrochemiluminescence detection and its applications in human urine and tablets","volume":"31","author":"Liu","year":"2010","journal-title":"Electrophoresis"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0635","series-title":"Directorate for the quality of medicines of the Council of Europe (EDQM)","first-page":"5963","year":"2010"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0640","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0021-9673(00)01231-0","article-title":"Determination of macrolide antibiotics by liquid chromatography","volume":"910","author":"Leal","year":"2001","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0645","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.jpba.2005.04.031","article-title":"Analysis of macrolide antibiotics by liquid chromatography","volume":"39","author":"Gonz\u00e1lez de la Huebra","year":"2005","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0650","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3987\/REV-13-785","article-title":"Sixteen-membered macrolides: chemical modifications and future applications","volume":"89","author":"Ajito","year":"2014","journal-title":"Heterocycles"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0655","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2174\/156802608784221532","article-title":"Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern","volume":"8","author":"M\u00e9ndez","year":"2008","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0660","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.7164\/antibiotics.35.1675","article-title":"Structure-activity studies among 16-membered macrolide antibiotics related to tylosin","volume":"35","author":"Kirst","year":"1982","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0665","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.7164\/antibiotics.42.1253","article-title":"Synthesis and antimicrobial evaluation of 20-deoxo-20-(3,5-Dimethylpiperidin-1-yl)desmycosin (tilmicosin, EL-870) and related cyclic amino derivatives","volume":"42","author":"Debono","year":"1989","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0670","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1365-2885.1995.tb00601.x","article-title":"Tilmicosin antibacterial activity and pharmacokinetics in cows","volume":"18","author":"Ziv","year":"1995","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0675","first-page":"11","article-title":"Efficacy of tilmicosin, and a combination of tylosin and sulfamethazine, for control of swine atrophic rhinitis involving infection with toxigenic Pasteurella multocida type D","volume":"2","author":"B\u00e4ckstr\u00f6m","year":"1994","journal-title":"Swine Health Prod"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0680","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ijantimicag.2005.12.010","article-title":"Tilmicosin and tylosin have anti-inflammatory properties via modulation of COX-2 and iNOS gene expression and production of cytokines in LPS-induced macrophages and monocytes","volume":"27","author":"Cao","year":"2006","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0685","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1016\/j.bmc.2008.02.064","article-title":"Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3-O-(3-aryl-2-propenyl)leucomycin analogues","volume":"16","author":"Furuuchi","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0690","doi-asserted-by":"crossref","first-page":"6203","DOI":"10.1016\/j.tetlet.2009.08.118","article-title":"Unexpected \u03b1,\u03b2-unsaturated products of reductive amination of the macrolide antibiotic josamycin","volume":"50","author":"Przybylski","year":"2009","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0695","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1016\/j.bmc.2008.01.027","article-title":"Novel 16-membered macrolides modified at C-12 and C-13 positions of midecamycin A1 and miokamycin. Part 1: synthesis and evaluation of 12,13-carbamate and 12-arylalkylamino-13-hydroxy analogues","volume":"16","author":"Miura","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0700","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1039\/B922450E","article-title":"Preparation and biological evaluation of novel leucomycin analogs derived from nitroso Diels\u2013Alder reactions","volume":"8","author":"Yang","year":"2010","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0705","doi-asserted-by":"crossref","first-page":"370","DOI":"10.7164\/antibiotics.27.370","article-title":"A new bicyclo lactone from leucomycin-A3 by alkali treatment","volume":"27","author":"Omura","year":"1974","journal-title":"J Antibiot"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0710","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1016\/j.tetlet.2011.09.086","article-title":"Transformation of josamycin in alkaline solution\u2014intramolecular SN2 substitution or E1cB elimination and intramolecular Michael addition?","volume":"52","author":"Przybylski","year":"2011","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0715","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/j.tetlet.2016.02.113","article-title":"Conversion of leucomycin-A3 antibiotic into novel triazole analogues via regio- and diastereoselective SN1' substitution with allylic rearrangement and 1,3-dipolar cycloaddition of CuAAC type","volume":"57","author":"Domagalska","year":"2016","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0720","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/mrc.1260330313","article-title":"1H and 13C NMR spectra of spiramycin I in organic and aqueous solutions","volume":"33","author":"Alam","year":"1995","journal-title":"Magn Reson Chem"},{"issue":"Suppl.B","key":"10.1016\/j.ijantimicag.2017.05.020_bib0725","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/jac\/22.Supplement_B.193","article-title":"Prophylaxis of congenital toxoplasmosis. Effects of spiramycin on placental infection","volume":"22","author":"Couvreur","year":"1988","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0730","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1128\/AAC.38.9.1930","article-title":"Effectiveness of spiramycin for treatment of congenital Toxoplasma gondii infection in rhesus monkeys","volume":"38","author":"Schoondermark-Van de Ven","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0735","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1006\/expr.1993.1077","article-title":"Congenital toxoplasmosis: an experimental study in rhesus monkeys for transmission and prenatal diagnosis","volume":"77","author":"Schoondermark-Van de Ven","year":"1993","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.ijantimicag.2017.05.020_bib0740","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1086\/590149","article-title":"Management of Toxoplasma gondii infection during pregnancy","volume":"47","author":"Montoya","year":"2008","journal-title":"Clin Infect Dis"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857917302388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857917302388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T02:03:58Z","timestamp":1750385038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857917302388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":147,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0924857917302388"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2017.05.020","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"16-membered macrolide antibiotics: a review","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2017.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}