{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T00:12:45Z","timestamp":1775347965410,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006162","name":"FACEPE","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Antimicrobial Agents"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.ijantimicag.2017.08.016","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T18:45:56Z","timestamp":1502390756000},"page":"718-725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["The thiopurine nucleoside analogue 6-methylmercaptopurine riboside (6MMPr) effectively blocks Zika virus replication"],"prefix":"10.1016","volume":"50","author":[{"given":"Otavio Val\u00e9rio","family":"de Carvalho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele Mendes","family":"F\u00e9lix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila Rodrigues","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina Maria Cataldi Sabino","family":"de Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Freitas","family":"de Oliveira Franca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marli Ten\u00f3rio","family":"Cordeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abelardo","family":"Silva J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindomar Jos\u00e9","family":"Pena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004978","article-title":"Nonstructural proteins are preferential positive selection targets in Zika virus and related Flaviviruses","volume":"10","author":"Sironi","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0015","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nm.4184","article-title":"Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen","volume":"22","author":"Xu","year":"2016","journal-title":"Nat Med"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0020","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s15010-016-0935-6","article-title":"Zika virus disease: a current review of the literature","volume":"44","author":"Atif","year":"2016","journal-title":"Infection"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0025","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3201\/eid2207.151990","article-title":"A literature review of Zika virus","volume":"22","author":"Plourde","year":"2016","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0030","article-title":"Radiological characterization of cerebral phenotype in newborn microcephaly cases from 2015 outbreak in Brazil","volume":"8","author":"Ramalho Rocha","year":"2016","journal-title":"PLoS Curr"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0035","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0140-6736(16)30058-7","article-title":"Guillain\u2013Barre syndrome associated with Zika virus infection","volume":"387","author":"Brasil","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0040","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0140-6736(16)00644-9","article-title":"Acute myelitis due to Zika virus infection","volume":"387","author":"M\u00e9charles","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0045","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jcv.2016.08.297","article-title":"Fatal encephalitis associated with Zika virus infection in an adult","volume":"83","author":"Soares","year":"2016","journal-title":"J Clin Virol"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0050","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s13337-016-0307-y","article-title":"Zika virus outbreak: an overview of the experimental therapeutics and treatment","volume":"27","author":"Saxena","year":"2016","journal-title":"Virusdisease"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0055","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1517\/17460441.2016.1160887","article-title":"New developments in flavivirus drug discovery","volume":"11","author":"Kok","year":"2016","journal-title":"Expert Opin Dug Discov"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jmgm.2016.08.011","article-title":"In-silico screening for anti-Zika virus phytochemicals","volume":"69","author":"Byler","year":"2016","journal-title":"J Mol Graph Model"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0065","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.chom.2016.07.004","article-title":"A screen of FDA-approved drugs for inhibitors of Zika virus infection","volume":"20","author":"Barrows","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0070","doi-asserted-by":"crossref","DOI":"10.3791\/54767","article-title":"Zika virus infectious cell culture system and the in vitro prophylactic effect of interferons","author":"Contreras","year":"2016","journal-title":"J Vis Exp"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0075","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/infdis\/jiw226","article-title":"Nucleoside inhibitors of Zika virus","volume":"214","author":"Eyer","year":"2016","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0080","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5808\/GI.2016.14.3.104","article-title":"Virtual screening for potential inhibitors of NS3 protein of Zika virus","volume":"14","author":"Sahoo","year":"2016","journal-title":"Genomics Inform"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004695","article-title":"The viral polymerase inhibitor 7-deaza-2'-C-methyladenosine is a potent inhibitor of in vitro Zika virus replication and delays disease progression in a robust mouse infection model","volume":"10","author":"Zmurko","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005737","article-title":"Potent allosteric dengue virus NS5 polymerase inhibitors: mechanism of action and resistance profiling","volume":"12","author":"Lim","year":"2016","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0095","doi-asserted-by":"crossref","first-page":"e3326","DOI":"10.1097\/MD.0000000000003326","article-title":"Prospective evaluation of pharmacogenomics and metabolite measurements upon azathioprine therapy in inflammatory bowel disease: an observational study","volume":"95","author":"Fangbin","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0100","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1099\/vir.0.83381-0","article-title":"Thiopurines inhibit bovine viral diarrhea virus production in a thiopurine methyltransferase-dependent manner","volume":"89","author":"Hoover","year":"2008","journal-title":"J Gen Virol"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0105","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/01.TP.0000114610.40412.C6","article-title":"Effect of antimetabolite immunosuppressants on Flaviviridae, including hepatitis C virus","volume":"77","author":"Stangl","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026697","article-title":"A thiopurine drug inhibits West Nile virus production in cell culture, but not in mice","volume":"6","author":"Lim","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005048","article-title":"Full genome sequence and sfRNA interferon antagonist activity of Zika virus from Recife, Brazil","volume":"10","author":"Donald","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0120","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.aje.a118408","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0125","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.antiviral.2008.05.008","article-title":"Modulation of influenza virus replication by alteration of sodium ion transport and protein kinase C activity","volume":"80","author":"Hoffmann","year":"2008","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0130","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007","volume":"14","author":"Lanciotti","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0135","doi-asserted-by":"crossref","first-page":"315","DOI":"10.15585\/mmwr.mm6512e2","article-title":"Update: interim guidance for health care providers caring for women of reproductive age with possible Zika virus exposure\u2014United States, 2016","volume":"65","author":"Petersen","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.antiviral.2016.11.018","article-title":"Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay","volume":"138","author":"Adcock","year":"2017","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0145","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.antiviral.2016.11.003","article-title":"Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model","volume":"137","author":"Julander","year":"2017","journal-title":"Antiviral Res"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0150","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/nm1726","article-title":"Engineering attenuated virus vaccines by controlling replication fidelity","volume":"14","author":"Vignuzzi","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0155","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/82191","article-title":"The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen","volume":"6","author":"Crotty","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jmb.2004.01.030","article-title":"Excision of incorporated nucleotide analogue chain-terminators can diminish their inhibitory effects on viral RNA-dependent RNA polymerases","volume":"337","author":"D'Abramo","year":"2004","journal-title":"J Mol Biol"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0165","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s40506-016-0083-7","article-title":"Zika virus: where is the treatment?","volume":"8","author":"Mumtaz","year":"2016","journal-title":"Curr Treat Options Infect Dis"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0170","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.reprotox.2003.10.014","article-title":"Review of the potential effects of three commonly used antineoplastic and immunosuppressive drugs (cyclophosphamide, azathioprine, doxorubicin on the embryo and placenta)","volume":"18","author":"Matalon","year":"2004","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0175","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1365-2036.2006.03162.x","article-title":"Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: a Danish nationwide cohort study","volume":"25","author":"Langagergaard","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0180","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/bdra.20583","article-title":"Early pregnancy azathioprine use and pregnancy outcomes","volume":"85","author":"Cleary","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.4292\/wjgpt.v5.i2.63","article-title":"Use of thiopurines in inflammatory bowel disease: safety issues","volume":"5","author":"Konidari","year":"2014","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"10.1016\/j.ijantimicag.2017.08.016_bib0190","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1136\/gut.2003.032896","article-title":"Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease","volume":"53","author":"Wright","year":"2004","journal-title":"Gut"}],"container-title":["International Journal of Antimicrobial Agents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857917303084?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0924857917303084?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T19:31:45Z","timestamp":1668713505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0924857917303084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0924857917303084"],"URL":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2017.08.016","relation":{},"ISSN":["0924-8579"],"issn-type":[{"value":"0924-8579","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The thiopurine nucleoside analogue 6-methylmercaptopurine riboside (6MMPr) effectively blocks Zika virus replication","name":"articletitle","label":"Article Title"},{"value":"International Journal of Antimicrobial Agents","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijantimicag.2017.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.","name":"copyright","label":"Copyright"}]}}